How to Treat and Cure Breast Cancer: Alternatives and Traditional Options | Dr. Kristi Funk
Zusammenfassung
TLDRIn a conversation led by renowned surgeon Dr. Christy Funk, the episode addresses the significant role lifestyle and dietary changes play in breast cancer prevention, stating that up to 90% of cases could potentially be avoided. The discussion covers the current treatment landscape, including surgery, chemotherapy, and radiation, alongside the importance of personalized care for individual needs. Emphasizing the intersection of prevention and treatment, Dr. Funk advocates for understanding the disease's nuances, making informed choices, and integrating holistic practices whenever possible to enhance patient outcomes. There is a strong focus on the potential impact of diet, exercise, and the identification of personal risk factors in designing effective health strategies against breast cancer.
Mitbringsel
- ποΈ Up to 90% of breast cancer cases could be prevented.
- π₯ A whole food plant-based diet is essential for prevention.
- ποΈββοΈ Regular exercise can enhance treatment outcomes.
- π Chemotherapy may not be necessary for 65% of patients.
- β³ Fasting during chemotherapy may reduce side effects.
- π Ki-67 marker indicates cancer cell division rate.
- π΅οΈ Personalized treatment is crucial for effective care.
- πΊ Emotional support is vital in the cancer journey.
- π¬ Hormonal receptors play a significant role in treatment decisions.
- π©Ί Surgery options include lumpectomy and mastectomy, both with similar survival rates.
Zeitleiste
- 00:00:00 - 00:05:00
Introduction of the conversation surrounding breast cancer prevention, treatment options, and the importance of lifestyle changes. Dr. Christy Funk, a breast cancer expert, discusses the prevalence of breast cancer and the need for prevention through lifestyle modifications.
- 00:05:00 - 00:10:00
Dr. Funk shares statistics that indicate a significant increase in breast cancer incidences and emphasizes the importance of prevention, risk reduction via diet, exercise, and lifestyle choices, aligning with the Let's Beat Breast Cancer campaign.
- 00:10:00 - 00:15:00
An overview of common surgical and medical treatment options for breast cancer, including the significance of individualized treatment plans based on unique patient circumstances and the type of breast cancer diagnosed.
- 00:15:00 - 00:20:00
The discussion transitions to alternative approaches to treatment and the critical nature of conventional therapies, like chemotherapy and radiation, as part of the treatment toolkit.
- 00:20:00 - 00:25:00
Dr. Funk illustrates the effectiveness of radiation therapy in reducing local recurrence rates and outlines potential risks associated with opting out of recommended treatments, necessitating informed discussions between patients and physicians.
- 00:25:00 - 00:30:00
Anatomical and procedural insights are provided, explaining the structure of breast tissue and how various forms of cancer originate, primarily in the ducts; this information emphasizes the need for awareness and early intervention.
- 00:30:00 - 00:35:00
Discussion on the different stages of breast cancer, especially ductal carcinoma in situ (DCIS), which, while not life-threatening, requires monitoring due to its potential to become invasive if untreated.
- 00:35:00 - 00:40:00
The analysis of hormone receptor-positive breast cancers and the importance of understanding the biology behind the cancer cells, which influences treatment effectiveness and patient outcomes.
- 00:40:00 - 00:45:00
The conversation highlights the need for exercise, dietary consideration, and the potential benefits of fasting during chemotherapy as methods to mitigate side effects and improve treatment efficacy.
- 00:45:00 - 00:50:00
Exploration of surgical options such as lumpectomy and mastectomy, detailing how modern approaches have evolved to ensure equivalent survival rates while minimizing local recurrence through targeted therapies and lifestyle interventions.
- 00:50:00 - 00:59:19
Conclusion emphasizing the mission of the Let's Beat Breast Cancer campaign and the importance of utilizing both conventional and holistic strategies for prevention and treatment.
Mind Map
Video-Fragen und Antworten
What percentage of breast cancer cases are preventable?
Studies suggest that about 50% of breast cancer cases are preventable, with estimates by experts like Dr. Christy Funk suggesting up to 80-90% could be preventable.
What are the main treatment options for breast cancer?
Treatment options include surgery, radiation, chemotherapy, anti-estrogen therapy, and lifestyle changes such as diet and exercise.
How important is diet and lifestyle in preventing breast cancer?
Diet and lifestyle are crucial; a whole food plant-based diet, regular exercise, and maintaining an ideal body weight are emphasized as key factors in prevention.
Is it possible to avoid chemotherapy?
Yes, about 65% of breast cancer patients may not need chemotherapy based on specific criteria such as tumor characteristics and genomic score.
What role does fasting play during chemotherapy?
Fasting during chemotherapy has been shown to reduce collateral damage and may increase the likelihood of achieving a complete pathologic response (PCR).
Can breast cancer recur after treatment?
Yes, between 25-28% of early stage breast cancer patients may experience recurrence.
What is the significance of the Ki-67 marker?
The Ki-67 marker indicates how quickly cancer cells are dividing; a higher percentage suggests a more aggressive cancer and could influence treatment decisions.
What is the difference between lumpectomy and mastectomy?
Lumpectomy involves removing the tumor with some surrounding tissue and is often followed by radiation, while mastectomy involves removing an entire breast. They have similar survival rates.
How does estrogen influence breast cancer?
Estrogen fuels certain types of breast cancer through receptors on cancer cells; targeting these receptors can help manage or treat the cancer.
Is emotional support important for breast cancer patients?
Yes, emotional support and guidance in decision-making are critical for patients coping with their diagnosis and treatment options.
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- 00:00:05[Music]
- 00:00:22Studies have shown that half of all
- 00:00:24breast cancer cases are preventable and
- 00:00:27my guest today estimates that the true
- 00:00:29number could be somewhere between 80 and
- 00:00:31even
- 00:00:3390% but what happens when you do
- 00:00:35everything right and you still get the
- 00:00:38diagnosis you have been trying so hard
- 00:00:41to avoid or maybe you're currently in
- 00:00:44the battle already and you're just
- 00:00:45learning about the power of lifestyle
- 00:00:48and diet and the connection there with
- 00:00:50your cancer well for hundreds of
- 00:00:52thousands of women currently battling
- 00:00:54breast cancer today's episode is for you
- 00:00:57because today we are talking about how
- 00:00:59to treat and cure breast cancer what are
- 00:01:03the current methods and then what are
- 00:01:04some effective Alternatives and helping
- 00:01:07guide us on our journey today is our
- 00:01:09friend breast cancer treatment and
- 00:01:12prevention expert renowned surgeon
- 00:01:14best-selling author Dr Christy Funk is
- 00:01:18here with us today Dr Funk thanks so
- 00:01:19much for joining us again as we continue
- 00:01:22our let's beat breast cancer series chff
- 00:01:24thanks for having me I love the exam
- 00:01:26room podcast it's always fun to be here
- 00:01:28with you and it is truly my delight um
- 00:01:32especially in the month of October
- 00:01:34obviously you're welcome anytime but I
- 00:01:36feel like with all of the focus this
- 00:01:38month on breast cancer we really need to
- 00:01:40get this message out because it's never
- 00:01:42lost on me about how many of these cases
- 00:01:44are preventable so today Dr Funk we're
- 00:01:47talking about treating and curing breast
- 00:01:50cancer and I'm curious in your
- 00:01:53estimation how much closer are we today
- 00:01:55to having a cure than when you began
- 00:01:58your career no closer not even an inch
- 00:02:02no yeah no we are better at expanding at
- 00:02:08prolonging the lifespan so in other
- 00:02:10words our treatments are better so
- 00:02:12people are getting cured more often
- 00:02:15there are now over four million American
- 00:02:18women walking around who either have or
- 00:02:21have had breast cancer and when I
- 00:02:24started my career 23 years ago I
- 00:02:26remember quoting that number and it was
- 00:02:29about 1. five million so we are getting
- 00:02:32better at treatment but that's the whole
- 00:02:36like aggravating part right the numbers
- 00:02:38are getting higher the incidence is
- 00:02:41higher the age at which women are
- 00:02:43getting breast cancer is getting lower
- 00:02:45in fact in August 2023 jamama published
- 00:02:48an article online looking at all of the
- 00:02:50cancers in the United States between
- 00:02:522010 and 19 breast was number
- 00:02:55one but the kicker was there was an
- 00:02:59alarming year aftere increase in women
- 00:03:02under 50
- 00:03:04so you know this we have a lot of work
- 00:03:07to do and a lot of what I like to talk
- 00:03:11about as you mentioned in the opening is
- 00:03:13prevention is maximal risk reduction and
- 00:03:16we have so much more control over this
- 00:03:18disease than people think through diet
- 00:03:20and lifestyle you know that I'm obsessed
- 00:03:23with the let's be breast cancer campaign
- 00:03:28so if you go to Let's beat
- 00:03:30breastcancer.org and sign up for free
- 00:03:33it's free and fun I mean if you don't
- 00:03:35like those two things I don't think we
- 00:03:37can be friends so let's be
- 00:03:39breastcancer.org sign up you will get a
- 00:03:42free e-cookbook and a tutorial on how to
- 00:03:48and why to eat a whole food plant-based
- 00:03:50diet exercise regularly maintain ideal
- 00:03:53body weight and limit alcohol these are
- 00:03:56the four pronged approaches to beating
- 00:03:59breast cancer and this
- 00:04:01year we have hats so get your swag you
- 00:04:04can get the shirt I'm wearing the Hat
- 00:04:07I'm wearing that I now just took off
- 00:04:09because I have to talk about things like
- 00:04:10chemotherapy and it's hard to take
- 00:04:12someone in a baseball hat seriously when
- 00:04:14they're talking chemo um however please
- 00:04:17join the campaign it's fun and
- 00:04:19informative and I think it'll really
- 00:04:20help your transition to a healthier
- 00:04:23lifestyle But Chuck as you were saying
- 00:04:26even when people quote unquote do
- 00:04:27everything right and more often in my
- 00:04:29experience it's the crossroads they
- 00:04:32hadn't been doing anything right because
- 00:04:33they didn't know they were supposed to
- 00:04:34because no one ever told them including
- 00:04:36their own doctors so we have this huge
- 00:04:39intersection the bcac intersection
- 00:04:42before cancer and after cancer and that
- 00:04:44after cancer Road will never be the same
- 00:04:48as the BC road but I'm here to help you
- 00:04:51and encourage you and hold your hand as
- 00:04:53you get into that AC road to help you
- 00:04:56make choices that are going to minimize
- 00:04:59your risk of recurrence but also
- 00:05:01maximize your joy and your fervor for
- 00:05:04life because you
- 00:05:06cannot do and think and eat and drink
- 00:05:09the same way you did on the BC Road and
- 00:05:13think things aren't going to result in a
- 00:05:16recurrence now you might think that the
- 00:05:20things you're employing surgery
- 00:05:21radiation chemo anti-estrogen there's a
- 00:05:23whole bunch of Western medicine stuff
- 00:05:24we're about to dive into and if you
- 00:05:27Embrace some or all of those you might
- 00:05:29think think you're in the clear but
- 00:05:31between 25 and 28% of all early stage
- 00:05:34breast cancer patients eventually recur
- 00:05:36stage four metastatic and do not survive
- 00:05:38their breast cancers I'm here to bring
- 00:05:40that number down with you outstanding
- 00:05:44and so that's the perfect segue to you
- 00:05:47know I would imagine after somebody gets
- 00:05:50that diagnosis the shock wears off
- 00:05:52there's just so many questions that they
- 00:05:55have and chief among them is well what
- 00:05:58is the course of of treatment here so
- 00:06:00can you walk us through what the typical
- 00:06:03course of treatment may be for a breast
- 00:06:05cancer patient or is it really dependent
- 00:06:08upon the individual and each case is a
- 00:06:10little bit different each case is a
- 00:06:12little bit different we have 21 subtypes
- 00:06:14of breast cancer and then we have
- 00:06:1821 million billion types of
- 00:06:21personalities and thought processes and
- 00:06:23feelings that all factor into the
- 00:06:25decision-making process right some
- 00:06:28cancers are biological
- 00:06:30like a little old lady a couch potato
- 00:06:32going nowhere fast so we need to
- 00:06:34recognize which ones those are and be
- 00:06:38wary of over treatments right we don't
- 00:06:41need to tap in a nail using like that
- 00:06:45big Sledgehammer that tries to make the
- 00:06:47ding thing go up at the carnival right
- 00:06:49that is overt treatment and that upsets
- 00:06:52me
- 00:06:53because it has collateral damage every
- 00:06:56single time and it's unnecessary so when
- 00:06:59we think about how to treat and cure
- 00:07:01breast cancer there are seven tools in
- 00:07:03our tool bag all right there is surgery
- 00:07:09radiation
- 00:07:11chemotherapy anti-estrogen therapy
- 00:07:14biologic targeted agents which would
- 00:07:17include drugs like
- 00:07:19herceptin and immunotherapy like
- 00:07:24hruda then there are my two favorites
- 00:07:27diet and lifestyle we're not going to a
- 00:07:29deep dive into those today because
- 00:07:31that's what I normally talk about with
- 00:07:33you and many others so you can research
- 00:07:37that it's all in my book breast the
- 00:07:39owner's manual about how diet and
- 00:07:41lifestyle impact cancer incidents and
- 00:07:44outcome once diagnosed but every once in
- 00:07:48a while more often than not once you're
- 00:07:50diagnosed with
- 00:07:51cancer kale and meditation aren't going
- 00:07:55to kill it so we need to walk on gone
- 00:07:59over to Western medicine and see what
- 00:08:01the offerings are and then be wise and
- 00:08:04thoughtful and individualized about
- 00:08:06which modalities you plan to
- 00:08:10use all right so that's a that's a
- 00:08:12really important conversation and and a
- 00:08:15a delicate one at that because there are
- 00:08:17so many of our viewers and our listeners
- 00:08:20who uh very much would like to go with a
- 00:08:23100% holistic approach to this um
- 00:08:27practical you know medicine here that
- 00:08:30that you you practice yourself here kind
- 00:08:32of tells you that you know maybe a blend
- 00:08:35between the two could be the most
- 00:08:37effective route in a lot of cases but
- 00:08:40how would a person know whether or not
- 00:08:43completely say we'll start with
- 00:08:45radiation treatments how would a person
- 00:08:47know whether or not they would even be a
- 00:08:49candidate to opt not to undergo that
- 00:08:52like what are some Alternatives that
- 00:08:54they may want to try and you know what
- 00:08:56is what is the risk
- 00:08:58there the risk is recurrence and it is
- 00:09:01largely a local recurrence local means
- 00:09:03in the breast or in the armpit lymph
- 00:09:06noes so it's kind of all locally where
- 00:09:08the cancer began it then recurs in the
- 00:09:11absence of radiation your average
- 00:09:13recurrence rate is 40% at the 10-year
- 00:09:16Mark kind of high if you radiate that 40
- 00:09:19drops all the way down to four to six so
- 00:09:23radiation is highly effective at staving
- 00:09:26off a local
- 00:09:27recurrence however there are side
- 00:09:29effects to radiation and there are
- 00:09:31limitations to it as well if you have
- 00:09:33underlying significant um cardio or
- 00:09:37pulmonary disease there is some scatter
- 00:09:40do radiation under the ribs especially
- 00:09:43left-sided cancers are going to scatter
- 00:09:44to your heart both both sides of your
- 00:09:46chest have lungs if you didn't know so
- 00:09:48you can always get some pulmonary issues
- 00:09:50but they are few they are very few I
- 00:09:52mean you have to have underlying disease
- 00:09:54to even notice like say getting more
- 00:09:56shorter breath when you walk up some
- 00:09:58stairs so the the bigger considerations
- 00:10:00with radiation sure it is toxic maybe
- 00:10:02you've already had it maybe you had
- 00:10:04lymphoma as a child and already had um
- 00:10:07mantle cell radiation to your entire
- 00:10:09chest wall you can't do external beam
- 00:10:11radiation twice in a lifetime your
- 00:10:13healthy cells can't take it and it will
- 00:10:16probably become mutagenic and create
- 00:10:18something called angio saroma which is
- 00:10:22like it sounds a saroma bad cancer uh
- 00:10:24related to having had
- 00:10:27radiation um who else who else uh
- 00:10:29implants okay so if you have breast
- 00:10:31augmentation and you like the way you
- 00:10:33look radiating a breast o that is over
- 00:10:36an implant is going to result in
- 00:10:37contracture where the capsule around the
- 00:10:39implant gets thickened and fibrotic and
- 00:10:41it just looks a little bit more like a
- 00:10:43coconut shell stuck to your chest wall
- 00:10:45than you would like and that is almost
- 00:10:48inevitable I say almost because some
- 00:10:49people get away without contracture and
- 00:10:51or there are some tricks I know but they
- 00:10:54are medications that have a whole
- 00:10:56regimen to reduce capsular contracture
- 00:10:59if women are getting their implants
- 00:11:01radiated in the world of radiation there
- 00:11:03are choices so the tried and true is an
- 00:11:06external beam where you lay down on the
- 00:11:08table and um you get hit with photons
- 00:11:13every day Monday through Friday it's
- 00:11:15either six and a half weeks long with 33
- 00:11:18treatments or three and a half weeks
- 00:11:20long uh with 18
- 00:11:23treatments but there's some nuances to
- 00:11:25that and new protocols happening I have
- 00:11:27a patient now getting just a slightly
- 00:11:28high dose and focally to where the
- 00:11:30cancer was for 10 treatments one of my
- 00:11:34favorite types of radiation is
- 00:11:36intraoperative it is literally you're
- 00:11:39it's one and done just boom you're
- 00:11:41asleep on the table you don't even know
- 00:11:43what's happening I go in to do the
- 00:11:44lumpectomy then I slip in a little
- 00:11:47balloon catheter I step out so I don't
- 00:11:49get radiated but then we radiate through
- 00:11:52the balloon for 12 minutes so it's this
- 00:11:54spherical radiation that is pounding the
- 00:11:58site where the cancer was and this is
- 00:12:00highly effective I take out the balloon
- 00:12:02I fix up your breast so it looks pretty
- 00:12:04again you wake up and two steps are done
- 00:12:06surgery done radiation done and that is
- 00:12:11really cool but you have certain people
- 00:12:13who don't qualify for it so in order to
- 00:12:15do intraoperative radiation one you have
- 00:12:17to have a team that knows how to do it
- 00:12:19two you have to have a ductal cancer not
- 00:12:22lobular which reminds me you should
- 00:12:24probably just beep beep beep rewind a
- 00:12:26bit and go back to the basics of what
- 00:12:29cancer is in a second okay but we need
- 00:12:31ductal not lobular it has to be under 3
- 00:12:33cm you need clear margins which you're
- 00:12:35actually not going to know until after
- 00:12:37this fancy surgery with the radiation so
- 00:12:40in the event that your margins are not
- 00:12:42clear meaning we have a little cancer
- 00:12:45potentially left behind in one or two or
- 00:12:48more
- 00:12:49directions then uh that interoperative
- 00:12:52radiation is not the one and done we
- 00:12:53wanted it to be but it does count for
- 00:12:56some radiations you get to do less on
- 00:12:57the back end and you cannot have
- 00:12:59positive lymph nodes it is a negative
- 00:13:02thing to have positive lymph nodes I
- 00:13:04know it's confusing positive nodes means
- 00:13:07that there is cancer in the lymph notes
- 00:13:09so that's a little radiation 101 it is
- 00:13:13obviously uh multi-layered in lots of
- 00:13:15choices so a fruitful discussion with a
- 00:13:18radiation oncologist to see what's best
- 00:13:20for you yeah and you know what let's go
- 00:13:22back to what it was you you were talking
- 00:13:23about there you wanted to rewind and and
- 00:13:25talk about what is breast cancer I know
- 00:13:28that you send us a graphic I'm going to
- 00:13:30put that up on the screen there so for
- 00:13:31those of you who are watching on
- 00:13:33Facebook and on YouTube by all means
- 00:13:35you're going to be able to see this so
- 00:13:36if you're listening to the podcast hop
- 00:13:38over there as well and you'll be able to
- 00:13:39see this graphic I've got it up on the
- 00:13:41screen right now Dr Funk tell us what is
- 00:13:44it that we're looking at great so for
- 00:13:46those of you who are only audio let me
- 00:13:48tell you we're looking at a breast in
- 00:13:50cross-section and we see all of these
- 00:13:52milk producing lobules that look like a
- 00:13:54big bunch of grapes and then if you're
- 00:13:55holding Those Grapes by a single stem
- 00:13:59and Look Backwards there's lots of tiny
- 00:14:01little stems going to each of the grapes
- 00:14:02those are the milk Ducks so there are
- 00:14:05about 100 in the breast they all coales
- 00:14:07and 8 to 12 emerge out and through the
- 00:14:09nipple 75% of all breast cancers begin
- 00:14:12inside the Ducks about 15 to 20% begin
- 00:14:16in the lobules and for those of you
- 00:14:18quick at math that leaves us with 5 to
- 00:14:2010% of just weird stuff if you take a
- 00:14:24duct so we'll talk through the most
- 00:14:26common um scenario of ductal cancer but
- 00:14:29the same story holds true for lobular
- 00:14:31but let's take a duct transect it and
- 00:14:33look through it like a telescope for
- 00:14:35those who can see the graphic we're now
- 00:14:36going to the upper right and we've got a
- 00:14:40ring of normal cells this is a duct in
- 00:14:43transsection and we're looking through
- 00:14:45it like a telescope and we have a single
- 00:14:48cell layer of cells that are very
- 00:14:51orderly and are very similar one to the
- 00:14:54next one step down we have what's called
- 00:14:56ductal hyperplasia this is when you get
- 00:14:58a a new layer of cells but they're also
- 00:15:00pretty uniform and orderly we don't care
- 00:15:03about ductal hyperplasia it's kind of
- 00:15:05like saying hey you have a new Freckle
- 00:15:06it's not melanoma and I don't care so
- 00:15:08it's just part of aging and we expect to
- 00:15:11see that next up we have atypical ductal
- 00:15:14hyperplasia so now the new layer is
- 00:15:17angrier it's starting to change its cell
- 00:15:19structure it's growing without control
- 00:15:22or order and it's just a matter of
- 00:15:25degree between atipia and the earliest
- 00:15:28form of breath bre cancer one down on
- 00:15:30our Notch there ductal carcinoma inide
- 00:15:32to so when there's enough of the
- 00:15:34atypical junk growing inside the milk
- 00:15:36duck to widen it by 2 millimeters or
- 00:15:39more Bingo that's when the pathologist
- 00:15:42calls it breast cancer ductal carcinoma
- 00:15:45in citu is our earliest stage zero form
- 00:15:48of breast cancer because these cancer
- 00:15:51cells which are cancer are stuck inside
- 00:15:54an intact tube and therefore they can
- 00:15:56never access lymphatics or bloodstream
- 00:15:58and spread so they are never
- 00:16:00life-threatening and they never need
- 00:16:03chemotherapy and it is our easiest
- 00:16:05cancer to cure so that's ductal
- 00:16:08carcinoma in site to if left to its own
- 00:16:11devices and undiagnosed oh by the way
- 00:16:13let me pause to say if you look at the
- 00:16:15crowding and that there's more oh we
- 00:16:17stay on the picture um we look at the
- 00:16:20crowding of the cells there on the D
- 00:16:22ductal carome and siteu as the central
- 00:16:24cells start to get like all these cells
- 00:16:26around it they lose their blood support
- 00:16:28dieye and spit out a Fleck of calcium it
- 00:16:32is uh the this clustering of calcium
- 00:16:35tightly together in one spot on a
- 00:16:37mamogram different shapes and sizes and
- 00:16:40densities of white and gray that raise
- 00:16:42the alarm for a radiologist reading your
- 00:16:45mamogram they have to be like why why
- 00:16:47are all those cells so busy turning over
- 00:16:49there and just like freckles sometimes
- 00:16:51it's benign stuff in fact most of the
- 00:16:52time calcium is just a sign of cell
- 00:16:55turnover and proliferation and benign
- 00:16:57activity every once once in a while
- 00:16:59though especially when there's certain
- 00:17:01ways the calcium can look we go like why
- 00:17:04is everybody dying right there and we
- 00:17:06need a biopsy to see is it atypia is it
- 00:17:09du carcinome and citu or is it just
- 00:17:11something benign but busy in the breast
- 00:17:13right there when you leave dcis alone or
- 00:17:16don't know about it overall it's a 2/3
- 00:17:21oneir probability of invading the duct
- 00:17:24wall or not only onethird of all dcis
- 00:17:28will
- 00:17:28eventually punch through that duct wall
- 00:17:31and invade it the breaking of the duct
- 00:17:33wall right there in your breast where
- 00:17:34this cancer totally entirely started I
- 00:17:37meant to say entirely not totally I grew
- 00:17:39up in the 80s in La what can you say um
- 00:17:42so you break that duct wall That's
- 00:17:44termed Invasion so when you get that
- 00:17:46dreaded phone call and the doctor says
- 00:17:48I'm sorry it came back cancer it's an
- 00:17:50invasive cancer H that word invasive is
- 00:17:53going to send you spiraling
- 00:17:55into a bad place
- 00:17:59but know this it doesn't mean anything
- 00:18:01other than it broke the duct wall inside
- 00:18:03your breast it does not mean it invaded
- 00:18:05your lymph nodes it doesn't not mean it
- 00:18:07invaded lung or liver or bone or brain
- 00:18:09it just means that it broke the wall
- 00:18:12right there and that's the term
- 00:18:14Invasion okay so that's describing the
- 00:18:17Continuum of disease from normal through
- 00:18:19invasive ductal cancer and we can go
- 00:18:22back to not having the picture up and
- 00:18:24then um there are I mentioned 21 types
- 00:18:28of cancer a lot of that subtyping has to
- 00:18:31do with receptors so whether the cancer
- 00:18:34cells are in the duct or outside of it
- 00:18:37they can and often express receptors we
- 00:18:40look at three in particular for estrogen
- 00:18:42progesterone and a growth factor called
- 00:18:44her too estrogen receptors these are
- 00:18:48like little antennas that sit on the
- 00:18:50outside of the cancer and when estrogen
- 00:18:52if you talk about sources there are
- 00:18:54three main sources of estrogen four um
- 00:18:58that when estrogen of any of the sources
- 00:19:00hits this receptor it's going to send a
- 00:19:02signal to the cell to multiply and
- 00:19:04divide all right especially for
- 00:19:05premenopausal woman whose ovaries are
- 00:19:07spewing out High volumes of estrogen all
- 00:19:09day long this sounds awful and not uh
- 00:19:13wanted guess what I love estrogen
- 00:19:16receptors we all do and that is because
- 00:19:19they are associated with less aggressive
- 00:19:20and more curable cancers number two it
- 00:19:23is an absolute necessary musthave to get
- 00:19:27your ticket out of chemo or at least the
- 00:19:30recommendation for chemo um and number
- 00:19:33three ahuh okay so you're saying
- 00:19:35estrogen feeds and fuels this cancer
- 00:19:38what if I get rid of all the estrogen so
- 00:19:41there isn't any fuel flying around what
- 00:19:43if I physically block that receptor with
- 00:19:47like a drug or even a food and then my
- 00:19:51own estrogen can't get in there it's
- 00:19:52like a car in the parking spot that you
- 00:19:54want but this time it's like tamoxifen
- 00:19:57or soy in the parking spot that estrogen
- 00:20:01wanted what if you literally degrade The
- 00:20:03receptors off of the cancer cell so I
- 00:20:07love estrogen receptors because there
- 00:20:08are three definite ways we can come
- 00:20:12after that receptor and stop the fuel
- 00:20:15progesterone receptors same story little
- 00:20:18thing sitting on the outside
- 00:20:19progesterone hits it fuels it but we
- 00:20:22don't have any clear-cut foods and
- 00:20:24certainly no drugs that we aim at
- 00:20:26progesterone receptors so just as a
- 00:20:28trend in terms of aggressiveness know
- 00:20:31this higher is better so the more
- 00:20:34estrogen receptors the higher the
- 00:20:35progesterone receptor the less
- 00:20:38aggressive the cancer third receptor her
- 00:20:40two this is a growth factor it is um
- 00:20:44highly It's associated with a highly
- 00:20:47aggressive cancer so if you
- 00:20:51could self-design your your breast
- 00:20:53cancer you wouldn't add her to however
- 00:20:56uh we don't get to choose so if if it
- 00:20:58shows up her two positive which about 15
- 00:21:00to 20% of cancers do I have to tell you
- 00:21:04the good news there is a silver lining
- 00:21:05we have a drug it is called herceptin it
- 00:21:09goes often hand inand with another one
- 00:21:10called petta and these are missiles
- 00:21:13aimed at that her two receptor so
- 00:21:16effectively so precisely that airr 25
- 00:21:20years ago a her two driven cancer was up
- 00:21:24there with inflammatory breast cancer
- 00:21:25and triple negative as the least curable
- 00:21:27most fatal cancer which we deal with and
- 00:21:31now if you have a hery driven cancer and
- 00:21:35go through these therapies it is among
- 00:21:37the top most curable cancers that we
- 00:21:39deal with that's how effective the
- 00:21:40therapy
- 00:21:42is I would definitely say that qualifies
- 00:21:45as Mega progress that's pretty
- 00:21:46impressive right there I like the way
- 00:21:48that you described that being like
- 00:21:49little missiles that go in there and
- 00:21:51Hyper you know focus on on what they
- 00:21:53what they need to do but I would imagine
- 00:21:56that there are
- 00:21:58a lot of patients who come through your
- 00:22:00doors just as again as we said you know
- 00:22:02a lot of people listening or watching
- 00:22:05this show right now who really just you
- 00:22:08know don't want to have to take a pill
- 00:22:11no matter what you know it I guess it's
- 00:22:15like when when do you have the
- 00:22:18conversation with the person that says
- 00:22:20look you know I I understand and I
- 00:22:22appreciate where you're coming from but
- 00:22:24really given your diagnosis what the
- 00:22:28Alles that we're facing here you know I
- 00:22:30really think it's in your best interest
- 00:22:32to do this so is there a threshold for
- 00:22:35somebody in terms of when they might
- 00:22:36want to explore those Alternatives and
- 00:22:38and when it is time to you know go hard
- 00:22:41with the medicine that is
- 00:22:43available whenever you have an estrogen
- 00:22:45negative cancer so there are no estrogen
- 00:22:47receptors whenever you have a her two
- 00:22:50positive cancer so there's a bunch of
- 00:22:52her two receptors whenever you have a
- 00:22:54high division rate so this is not a
- 00:22:56receptor but it is read on most core
- 00:22:59biopsy path reports um by the
- 00:23:02pathologist if you don't have a
- 00:23:05ki67 on your pathology report from the
- 00:23:08diagnostic core biopsy you can request
- 00:23:11it to be done I love ki67 it answers the
- 00:23:15question hey what percentage of cells
- 00:23:17under the microscope are actively
- 00:23:19dividing here one becoming two it's a
- 00:23:21percent it can be anywhere from one to
- 00:23:23100 and I think I've seen every single
- 00:23:26number so it it's out there you've got
- 00:23:28these wickedly fast dividing cancers I
- 00:23:31would say anything over 30% would give
- 00:23:35me pause for someone to just not do
- 00:23:38anything about the tumor um or anything
- 00:23:41after lumpectomy because that's a fast
- 00:23:44division rate but I have tons
- 00:23:46unfortunately of patients 80 90 even
- 00:23:49100% division rate what does this mean
- 00:23:51the cell is in actively in a phase of
- 00:23:54mitosis uh but the division doesn't mean
- 00:23:57you wake up every morning let's just use
- 00:23:59the example of 10% for easy math on all
- 00:24:02of us uh if 10% of the cells are
- 00:24:04dividing in general it takes between
- 00:24:07three and six months for that cell to
- 00:24:09divide if you are older particularly
- 00:24:12postmenopausal you're more towards six
- 00:24:14months for a cell to divide and if your
- 00:24:17premenopausal it's more toward three
- 00:24:19months for a cell to divide so let's go
- 00:24:21with January you have a 1 cmet cancer
- 00:24:24that you don't know
- 00:24:26about and your
- 00:24:2860 years old in July a 1 cm cancer that
- 00:24:33has a Ki 67 of 10% will be 1.1
- 00:24:38CM okay back up now it's January we have
- 00:24:42a 1 cm cancer in a 40-year-old but that
- 00:24:46cell division rate is
- 00:24:4850% come April that 1 cimeter cancer is
- 00:24:511.5 cmers that person worries me more if
- 00:24:57they don't get more aggressive at
- 00:24:59attacking this
- 00:25:00cancer does that make sense absolutely
- 00:25:03it does absolutely it does and kind of
- 00:25:07along those same lines did the same
- 00:25:09principles apply when it comes to
- 00:25:11chemotherapy treatments which we've
- 00:25:13talked about radiation we haven't
- 00:25:14necessarily gone directly at chemo yet I
- 00:25:17would assume that some of these same
- 00:25:19principles apply here indeed they do so
- 00:25:23here are the four Hoops that you need to
- 00:25:26safely jump through to land on no chemo
- 00:25:30recommended even from your chemol loving
- 00:25:32medical oncologist so here they are you
- 00:25:35have to have a cancer strongly driven by
- 00:25:38estrogen you have to have well you
- 00:25:42cannot have per two
- 00:25:44receptors number three you cannot have
- 00:25:47four or more positive lymph nodes so
- 00:25:50that would be that the cancer got into
- 00:25:51the lymphatics of the breast and made
- 00:25:53its way over to the same side lymph
- 00:25:55nodes under the armpit four or more is a
- 00:25:58definite indication for chemotherapy and
- 00:26:01then the final one is extremely
- 00:26:04interesting because it's called genomics
- 00:26:07we have ways to interrogate the cancer
- 00:26:11and the enco Gen that are on or off what
- 00:26:14genes it expresses or doesn't Express
- 00:26:17this is not an analysis of your genome
- 00:26:19as a person like did you inherit braa or
- 00:26:21cheu from Mom or Dad no this is the
- 00:26:24tumor's OWN internal genetics and we can
- 00:26:28analyze it in a number of um company
- 00:26:32tests there are different companies out
- 00:26:33there the two main ones used in the US
- 00:26:37are called enco type and
- 00:26:39mammaprint mamar print looks at 70
- 00:26:42different markers for recurrence onco
- 00:26:44type looks at 21 fiber control so it
- 00:26:46looks at maybe 16 in total but either
- 00:26:50one that you use or one of the more
- 00:26:53esoteric ones that are up and coming um
- 00:26:55whatever your oncologist which wishes to
- 00:26:58use they get your core biopsy they shove
- 00:27:02those cells into this little assay that
- 00:27:04analyzes all of the genomics of the
- 00:27:06cancer and depending on what's good to
- 00:27:08have or bad to have and what your cancer
- 00:27:10you know expresses or doesn't it throws
- 00:27:11it into an algorithm and spits out the
- 00:27:14percent chance that your cancer will
- 00:27:16come back incurable metastatic in the
- 00:27:19next 10 years so hoop number four to
- 00:27:22jump through to safely avoid the
- 00:27:24recommendation for chemo is to have a
- 00:27:26lowrisk
- 00:27:28genomic score be it through anco typ or
- 00:27:30mamar print or other so we have to have
- 00:27:34estrogen receptors we cannot have her
- 00:27:36two receptors we should not have four or
- 00:27:38more positive lymph nodes and we want a
- 00:27:40low genomic assay
- 00:27:43score it seems like a lot of
- 00:27:45qualifications there I mean what
- 00:27:47percentage of cases do you think fall
- 00:27:50into that it's you
- 00:27:52know that don't fall into one of those
- 00:27:55categories I mean there's so many there
- 00:27:56I would imagine that the percentage is
- 00:27:59rather low that don't check any of those
- 00:28:01boxes actually about 65% of cancers will
- 00:28:05check the boxes and just categorically
- 00:28:07not need chemo the other 35% will
- 00:28:11have like half checks or total checks in
- 00:28:14these boxes and then it becomes a
- 00:28:16thoughtful personalized individualized
- 00:28:18discussion of pros and cons for chemo
- 00:28:21for you there's always a percent risk
- 00:28:24reduction of metastatic dis dis
- 00:28:27occurring and that percent is
- 00:28:31extremely different in terms of How It's
- 00:28:34digested by different people if I told
- 00:28:37you okay if you go through chemo you're
- 00:28:40going to take your risk of recurring
- 00:28:42life-threatening Med lung lever brain
- 00:28:44bone we have yet to be able to cure that
- 00:28:47effectively you're going to take your
- 00:28:49risk of having a stage four recurrence
- 00:28:52from 10% to
- 00:28:552% huh 8% absolutely abolute benefit
- 00:28:59that sounds pretty good let's see how I
- 00:29:00look bald although you could wear a cold
- 00:29:02cap by the way and then not lose your
- 00:29:03hair I also have a whole discussion on
- 00:29:05workarounds for some of the side effects
- 00:29:07and collateral damage that occurs with
- 00:29:09chemo and Other
- 00:29:11Drugs let's say you have
- 00:29:16a uh let's use the same number 10%
- 00:29:19chance of it recurring metastatic and if
- 00:29:21you do the chemo it's
- 00:29:238% okay let's let's flip that on its
- 00:29:26head I have a 90% chance that this isn't
- 00:29:29coming back if I do chemo I have a 92%
- 00:29:33chance it isn't coming
- 00:29:35back if I do chemo baldness nausea
- 00:29:38vomiting diarrhea neuropathy potential
- 00:29:41leukemia down the road bone loss fatigue
- 00:29:45mouth
- 00:29:46sores I'm gonna go with no no thanks but
- 00:29:50someone else might be like 2% Bring It
- 00:29:52On honestly it I all personalities exist
- 00:29:56and they react to these percentages
- 00:29:58differently and a lot of people aren't
- 00:30:00numbers people they're like yeah I just
- 00:30:03feel like I don't want it or I feel like
- 00:30:06I've got a two-year-old and a
- 00:30:07five-year-old and I just started a new
- 00:30:09job and I don't have time to die Bring
- 00:30:11It On throw them all at me like those
- 00:30:13are not reasons to do chemo but they're
- 00:30:17emotional reasons that drive you toward
- 00:30:19quote unquote doing everything possible
- 00:30:21and I can respect all of it and I love
- 00:30:24talking to women in
- 00:30:26this in moment of like do I do I not
- 00:30:30what if what if not I I love this moment
- 00:30:33so I'm happy to consult with anybody who
- 00:30:36needs some clarity on which path to take
- 00:30:39because it feels so do or die right and
- 00:30:42to some people it becomes that so it's a
- 00:30:46big decision that crossroads is
- 00:30:50serious and and let's say that they do
- 00:30:52opt to go forward with chemo treatment
- 00:30:56what do we know in terms of how diet
- 00:30:59Lifestyle Changes there can help
- 00:31:01mitigate some of those unwanted side
- 00:31:03effects you were just talking about so
- 00:31:07oh this is um interesting in that
- 00:31:10believe it or not I don't want you to go
- 00:31:13crazy on the antioxidant scale during
- 00:31:16chemo why chemo is an oxidant if you're
- 00:31:19going to go through the hell of putting
- 00:31:20that stuff through your veins let it do
- 00:31:22its damaging thing however there are
- 00:31:26some things you can do to limit the
- 00:31:28collateral damage that occurs and
- 00:31:30afterwards we're going to become like
- 00:31:32antioxidant superheroes right I it's
- 00:31:35only in this tiny little window of time
- 00:31:38that it is ill advised to have 18
- 00:31:41teaspoons of turmeric one teaspoon in my
- 00:31:44smoothie awesome it's helpful it's
- 00:31:47supportive of your normal cells that got
- 00:31:50a little hit by the chemo but it's not
- 00:31:53overboard it's not gonna one teaspoon of
- 00:31:55turmeric is not going to outcompete
- 00:31:58taxol the Red Devil um so judicious use
- 00:32:04of healthy Whole Foods um and ramping up
- 00:32:07on some of our herbs and spices that we
- 00:32:09know are like anti-estrogenic anti- um
- 00:32:13angiogenic the blood flow increase that
- 00:32:15cancer brings to itself proapoptosis
- 00:32:18cancer cell suicide there are a ton of
- 00:32:20these Foods you hear me talk about it
- 00:32:22all the time and these foods go into
- 00:32:25every meal that I want you to prepare
- 00:32:27now and going forward and but during
- 00:32:30chemo we just don't want to do like an
- 00:32:32overdose and you know what overdoses you
- 00:32:34not overdose like you know get sick and
- 00:32:36die but too too much more than you could
- 00:32:39ever consume like let's just take a
- 00:32:41phytochemical sulphoraphane and say you
- 00:32:44can't eat enough broccoli or broccoli
- 00:32:47Sprouts to get the amount of sorine that
- 00:32:49maybe you'll get in six capsules of pure
- 00:32:53soramee packaged by your friendly
- 00:32:55neutraceutical guy right so no
- 00:32:58supplements that are like super
- 00:33:00physiologic doses of anything fabulous
- 00:33:02like cumin Etc follow ECG e EC EP epig
- 00:33:07Gallo cak
- 00:33:09egcg who forgets the acronym but knows
- 00:33:12the whole word okay
- 00:33:13so so one diet is supportive but we
- 00:33:17can't go too crazy um with super
- 00:33:21physiologic doses of supplements of
- 00:33:23otherwise lovely good antioxidant Laden
- 00:33:27foods and phytochemicals one number two
- 00:33:30a study actually just came out in
- 00:33:32October 2023 showing that women who
- 00:33:36exercise during
- 00:33:39chemotherapy have twice the PCR rate PCR
- 00:33:44path complete response this is the holy
- 00:33:46Grill this is what we dream about
- 00:33:47happening when you have to do chemo and
- 00:33:50we choose to do it before surgery you
- 00:33:52actually have a lot of tumor that we can
- 00:33:54see and measure and then eventually with
- 00:33:57surgery look under the microscope and
- 00:33:59see it shrink shrink shrink and
- 00:34:00disappear PCR means you have a past
- 00:34:03complete response once the lump atomy or
- 00:34:05myectomy is done the pathologist is like
- 00:34:08huh what cancer it's gone the PCR rate
- 00:34:12in women who exercised was twice as high
- 00:34:16versus the women that didn't it was a
- 00:34:17randomized controll trial just in
- 00:34:20October 23 so exercise is important
- 00:34:24people are like are you serious lady I
- 00:34:26am fatigued and vomiting up a storm you
- 00:34:28know be gentle with yourself maybe you
- 00:34:31can just go for a walk that counts
- 00:34:33that's exercise so to the degree that
- 00:34:36you can please do third up oh no go go
- 00:34:40ahead I was just just move your body no
- 00:34:42matter you know some way somehow any
- 00:34:45kind of movement qualifies toward
- 00:34:47exercise in this case right the key is
- 00:34:49just not being 100% sary right
- 00:34:52absolutely just move your body is there
- 00:34:55a song about that so the third one all
- 00:34:58right I'm going to get you in trouble
- 00:35:00with your medical oncologist more likely
- 00:35:02than not but you know me this is super
- 00:35:05research-based evidence-based in humans
- 00:35:08with breast cancer so I'm not talking
- 00:35:11from Petri dishes women with breast
- 00:35:14cancer undergoing chemotherapy were
- 00:35:16randomized to fast or not fast during
- 00:35:21the chemo so in other words getting your
- 00:35:23chemo in that vein in a fasted state
- 00:35:28these people had triple the
- 00:35:31PCR what if we randomized chemo and
- 00:35:34extracise versus okay you're but my
- 00:35:37point is triple the PCR and less
- 00:35:41collateral damage this comes out of the
- 00:35:43work of vter Longo for those of you who
- 00:35:45know that name he is big in the um
- 00:35:48anti-aging space he runs the center for
- 00:35:50longevity at USC University of Southern
- 00:35:53California um he is the creator of
- 00:35:55prolon which is that five-day fasting
- 00:35:58kit that you can use to eat and not be
- 00:36:00crazy hangry but your cells don't really
- 00:36:02know you're eating at all so you get a
- 00:36:04full benefit of a five-day fast as if
- 00:36:06you were just drinking water they even
- 00:36:09did prolon versus water and prolon was
- 00:36:11more effective in the biomarker realm
- 00:36:14when they did blood draws to look at
- 00:36:15certain measurements like C reactive
- 00:36:17protein igf1
- 00:36:19Etc discussion for another day back to
- 00:36:22the fasting though it was the exact same
- 00:36:25thing as prolon they call it
- 00:36:28zenagen it is not yet commercially
- 00:36:30available in
- 00:36:322023
- 00:36:34however I know everybody there and I can
- 00:36:38assure you it actually zenagen is prolon
- 00:36:41so I create a regimen for my patients
- 00:36:44using prolon plus or minus to save money
- 00:36:47if they want to we can have days of
- 00:36:49broth and tea or black coffee and we
- 00:36:53create a fasting regimen depends on your
- 00:36:55chemo regimen sometimes you get it every
- 00:36:57two weeks that's called dose dense
- 00:36:58sometimes you get it every three weeks
- 00:37:00sometimes you get it every week tax all
- 00:37:01is often given 12 times weekly for three
- 00:37:04months so anyway I figure out your
- 00:37:06regimen and basically we alternate how
- 00:37:09long you're fasting before you get your
- 00:37:11chemo um and give you some breaks if
- 00:37:13you're doing weekly chemo I'm not going
- 00:37:14to have you fast every week long story
- 00:37:17short when you look at the human studies
- 00:37:19on fasting in chemo as I said triple the
- 00:37:22PCR the Holy Grail but also the
- 00:37:25collateral damage is left and really
- 00:37:27quickly why this happen happens is when
- 00:37:29you fast you're not eating the protein
- 00:37:32and the carbs that make your pancreas go
- 00:37:34oh food let's digest it spit out the
- 00:37:36insulin insulin screams at everybody
- 00:37:39like hey guys food's here like Chow down
- 00:37:41do your thing whatever you do in this
- 00:37:43body like do that right here's your fuel
- 00:37:46here's your glucose and you need to use
- 00:37:49it or store it and the cells get busy
- 00:37:53now you're fasting okay there's no
- 00:37:55insulin there's been no insulin for six
- 00:37:57hours for eight hours for 20 hours your
- 00:38:01body's like hey
- 00:38:03guys I don't know when this lady's going
- 00:38:05to eat again not sure what she's doing
- 00:38:07but there's no food so you need to calm
- 00:38:09down stop dividing so fast that's the
- 00:38:13key let me repeat it stop dividing so
- 00:38:17fast just lay and wait when she eats
- 00:38:20again I'll let you know I'll throw out
- 00:38:22some insulin your way
- 00:38:24okay two points
- 00:38:27guess who doesn't get the
- 00:38:30memo cancer it's deranged it's not
- 00:38:33following the body signals that's the
- 00:38:35definition of cancer it is a mutated
- 00:38:37cell that no longer is subject to the
- 00:38:40regulation and rules of the body so this
- 00:38:43cell is like and everybody else is like
- 00:38:45sh it's a surprise party and guess who's
- 00:38:48gonna get the surprise cancer the chemo
- 00:38:50is going to be
- 00:38:52like that guy's moving too fast it's
- 00:38:55gone and this brings me to point number
- 00:38:57two so point one cancer doesn't follow
- 00:38:59the rules when you fast all of your body
- 00:39:02does follow the rules if it doesn't have
- 00:39:04cancer in it so point two chemo super
- 00:39:09dumb not smart not aimed at receptors
- 00:39:12the way herceptin Missle to a receptor
- 00:39:14chemo no receptors what is chemo doing
- 00:39:18what is this poison in your vein doing
- 00:39:20it's just flying around in your
- 00:39:22bloodstream literally looking for one
- 00:39:24and only one thing what moves fast
- 00:39:27around here oh your hair you that grows
- 00:39:29fast follicles bald your nails you clip
- 00:39:32them every week right brittle and wonky
- 00:39:34your GI tra you turn over your stomach
- 00:39:36cell lining every 24 hours nausea
- 00:39:39vomiting diarrhea your nerves pum pum
- 00:39:41really fast at firing neuropathy
- 00:39:43numbness and tingling in your fingers
- 00:39:45and toes
- 00:39:47okay cancer with a high
- 00:39:51ki67 the higher the ki67 silver lining
- 00:39:55for having a bad de cancer quick
- 00:39:58divider annihilated by the
- 00:40:01chemo if you are fasting when the poison
- 00:40:05goes in your cells are quiet so again
- 00:40:08back to the work of Longo back to the
- 00:40:10studies less collateral damage and by
- 00:40:13that I mean less nausea vomiting
- 00:40:15diarrhea less fatigue fewer mouth sorce
- 00:40:18less
- 00:40:19neuropathy brilliant right freaks your
- 00:40:22medical oncologist out for the most part
- 00:40:24sorry I know they don't know yet but I
- 00:40:27promise you I'm not steering you wrong
- 00:40:29we need to be mindful of your parameters
- 00:40:32you know what I mean like if you're
- 00:40:33severely underweight maybe this is just
- 00:40:36a bad idea altoe um we just have to be
- 00:40:39mindful of like your potassium levels
- 00:40:41and things like that but um it's not
- 00:40:43hard to do and it's free well unless you
- 00:40:45buy the prolong kit it costs a little
- 00:40:47money but the point is uh not eating is
- 00:40:49generally
- 00:40:51free that's that's one way to put it um
- 00:40:54a serious question though let's say that
- 00:40:57you know somebody has kind of opted to
- 00:41:00um not go through chemo or radiation
- 00:41:03they wanted to try the more holistic
- 00:41:05things maybe you know fasting is a part
- 00:41:07of it who knows whatever their their
- 00:41:09treatment plan that they crafted looks
- 00:41:11like um but it's you know that doesn't
- 00:41:15seem to be working as well as it should
- 00:41:19and let's say that the cancer is now
- 00:41:22getting worse maybe it's spreading at
- 00:41:24what point does that person have to have
- 00:41:27a I would imagine a rather difficult
- 00:41:29conversation with not just themselves
- 00:41:31but also with their Health Care
- 00:41:33Professionals and that maybe it's time
- 00:41:35to Pivot over to the things that we were
- 00:41:37trying to avoid in the first
- 00:41:40place this is a really gentle and loving
- 00:41:44space that I love to invite women into
- 00:41:46because I am so non-judgmental I you
- 00:41:50have probably not seen what I have seen
- 00:41:53I mean if you just fungating ble leading
- 00:41:56to just yesterday I got a phone call
- 00:41:58from a patient in that situation but her
- 00:42:02tumor is out in the room little alien it
- 00:42:04it it looks like raw meat and she said
- 00:42:07that that it was bleeding really badly
- 00:42:09and she got Kleenex on it and the
- 00:42:10kleenex was stuck to it she do want to
- 00:42:12pull it off because she knows she's just
- 00:42:13going to start gushing blood again and I
- 00:42:15was like yeah come to the office let me
- 00:42:16stop that bleeding for you um tumors get
- 00:42:20really bad some tumor subtypes right we
- 00:42:23talked about they it's all types the
- 00:42:25fast of fighers the estrogen negatives
- 00:42:28the herto positives if you do literally
- 00:42:31nothing like if your alternative
- 00:42:32approaches
- 00:42:34are here and there I have people they're
- 00:42:36well intentioned they want to follow
- 00:42:38that path but even they fall off their
- 00:42:40little wagon and they're not exercising
- 00:42:42and they're not
- 00:42:43eating they're not even eating
- 00:42:45plant-based let alone like raw
- 00:42:46plant-based which might be um the best
- 00:42:48choice in that moment anyway on and on
- 00:42:50right so the tumor grows and it's burst
- 00:42:52out into the room and it's bleeding it's
- 00:42:54like a it can be I mean tiny like a
- 00:42:56grape just like a little ugly protrusion
- 00:42:59through the skin or it can overtake the
- 00:43:01entire breast like there is no breast
- 00:43:03there is no nipple there's nothing it's
- 00:43:05just a tumor stuck on there um and I see
- 00:43:09it often honestly and people are so
- 00:43:13relieved that I don't even make a face
- 00:43:16and sometimes these things smell like
- 00:43:17from outside the door I already know
- 00:43:19because I could smell it's some smell of
- 00:43:21tumor but uh yeah this face not going to
- 00:43:25I'm not going to make face I'm not going
- 00:43:27to judge you uh we're just going to talk
- 00:43:29about what do you want to do now and
- 00:43:32that is that should be a safe
- 00:43:34conversation for a woman usually surgery
- 00:43:36is waiting do now in that big you know
- 00:43:40exophytic bleeding Advanced tumor no
- 00:43:43drugs going to shrink that down
- 00:43:44effectively and it's an infection issue
- 00:43:47and a hygiene issue so we just get rid
- 00:43:49of it um but thankfully most people
- 00:43:53don't wait that long they just feel this
- 00:43:55little marble under their skin they try
- 00:43:57their things and the marble becomes an
- 00:43:59apricot or a peach and then it's still
- 00:44:02the skin is out normal over it and it's
- 00:44:04just inside the breast um but they know
- 00:44:06it's getting bigger and they come to me
- 00:44:08and then we figure out what to do so
- 00:44:10cheuck what we haven't talked about did
- 00:44:12anybody remember that I am a surgeon we
- 00:44:15didn't talk surgery like this is my
- 00:44:17favorite topic sh we talk chema we
- 00:44:20touched radiation we touched on touched
- 00:44:22on
- 00:44:23anti-estrogens yeah let's let's dive
- 00:44:25into we've got about 10 minutes left
- 00:44:27here so let's talk surgery right so
- 00:44:30surgery is usually step number one we do
- 00:44:34Neo adant chemotherapy or Neo adant
- 00:44:37endocrine therapy Neo adant is fancy way
- 00:44:40of saying before surgery chemo is
- 00:44:43obvious endocrine refers to taking
- 00:44:45anti-estrogen pills so you can do these
- 00:44:47things before surgery to shrink a tumor
- 00:44:50down so that what was a definite
- 00:44:53mastectomy given the tumor size can
- 00:44:55shrink it down down to make a lump
- 00:44:57ectomy possible which allows you to keep
- 00:44:59your breast another reason is you're
- 00:45:02part of a trial and there's a new trial
- 00:45:04drug this was like especially sexy and I
- 00:45:07would push people to please do neoag
- 00:45:09when they had triple negative Cancers
- 00:45:11and imuno theapy was just being
- 00:45:13introduced on the scene turns out
- 00:45:15immunotherapy is a miracle drug when it
- 00:45:17comes to treating triple negatives and
- 00:45:20even our early stage Cancers get to have
- 00:45:22everybody with triple negative gets
- 00:45:23immunotherapy now back in the early days
- 00:45:26when the trials were starting I was like
- 00:45:27please go do the trial because I want
- 00:45:29you to have this immunotherapy it's
- 00:45:30going to be amazing and it's going to
- 00:45:31make you have that coveted PCR way more
- 00:45:34readily than without it but one of the
- 00:45:37trial um uh requirements was that you
- 00:45:41had to keep the tumor intact in your
- 00:45:42breast right so that's another reason is
- 00:45:44to join attractive trials that require
- 00:45:47the cancer to be in your breast another
- 00:45:50good reason to do these treatments be it
- 00:45:52chemo or anti-estrogen therapy before
- 00:45:54surgery um it's just to give your CH
- 00:45:57your self a chance to calm down and
- 00:46:01really contemplate your options without
- 00:46:03a sense of urgency like I'm not doing
- 00:46:05anything this thing is growing while I'm
- 00:46:06sleeping and I'm not doing anything and
- 00:46:08I got to make a decision just take my
- 00:46:10breast off like whoa I don't want you
- 00:46:11ever to make such an irreversible huge
- 00:46:14decision in a moment of sheer panic and
- 00:46:17doing something that we know is
- 00:46:19eventually needed anyway and will be
- 00:46:21effective at staving off tumor
- 00:46:22metastases and probably shrink this
- 00:46:24thing down a bit
- 00:46:26gives you that room to Exhale and more
- 00:46:30levelheaded contemplate your options so
- 00:46:33those are three good reasons the
- 00:46:35surgical choices there's two ways to get
- 00:46:37a tumor out of a breast lumpectomy
- 00:46:39removes the cancer with the rim of
- 00:46:40healthy tissue around it you can kind of
- 00:46:42think about it although it may not be
- 00:46:43this big of a lump ectomy think about it
- 00:46:46like a hard-boiled egg don't eat that
- 00:46:48egg uh we don't eat eggs but a
- 00:46:50hard-boiled egg has a yoke that's the
- 00:46:52cancer the white would be the margin so
- 00:46:56the margin of normal breast tissue is
- 00:46:58what we're after around a cancer to not
- 00:47:01have a positive margin which means I
- 00:47:03slic through the Yol there's a little
- 00:47:04bit of yellow at the edge of what I took
- 00:47:07out which means there's probably some
- 00:47:08yellow I.E cancer left on the other side
- 00:47:11which is still in you in your breast so
- 00:47:13lumpectomy with a clear margin versus
- 00:47:16mastectomy mastectomy does not have to
- 00:47:19be a big gory
- 00:47:23demoralizing horrific slash across your
- 00:47:25chest nipple missing it pictures abound
- 00:47:29on the internet of particularly bad
- 00:47:32operations currently but a lot that
- 00:47:34hearkened back to the 70s when we did
- 00:47:36something literally radical called the
- 00:47:38Hallstead radical myectomy in the 20s
- 00:47:41and Beyond you know when we were really
- 00:47:44taking off the entire breast the muscle
- 00:47:46like a skin on rib we only super
- 00:47:48Advanced cancers end up with that right
- 00:47:50now um everybody else oh mastectomies
- 00:47:53can be actually for someone women a
- 00:47:57cosmetic upgrade not always
- 00:47:59though whenever possible and whenever a
- 00:48:02patient wants to keep her nipple I'm
- 00:48:04game I love nipple sparing mastectomy it
- 00:48:07is probably my favorite operation to do
- 00:48:09with or without reconstruction so let's
- 00:48:12just go first through the why the
- 00:48:15choices so we've got three groups of
- 00:48:18surgery um lumpectomy alone egg with the
- 00:48:23white lumpectomy followed by breast
- 00:48:26radiation of which there are several
- 00:48:28types versus myectomy okay doc stop
- 00:48:31talking I just want to do whatever's
- 00:48:32going to make me live
- 00:48:33longer listen to this in the 1980s there
- 00:48:37were six huge randomized studies
- 00:48:39throughout the world throwing women into
- 00:48:43these three groups of treatment
- 00:48:44lumpectomy lumpectomy plus radiation
- 00:48:46myectomy now it's been 40 years we know
- 00:48:48who lived who died who had to come back
- 00:48:49who didn't and this can inform you right
- 00:48:52now about your choices in a way that's
- 00:48:54very statistically driven and it's going
- 00:48:56to blow your mind because in the 80s the
- 00:48:58results of all Six studies were
- 00:49:00basically identical the results of all
- 00:49:03Six studies forever transformed how we
- 00:49:06treat and cure breast cancer from a
- 00:49:08surgical perspective two shocking things
- 00:49:12shock number one
- 00:49:14survival all three groups
- 00:49:19identical identical so that's why I feel
- 00:49:22so confident in my patients who are like
- 00:49:26I'll let you take the tumor out but I'm
- 00:49:27doing anything else you said or anything
- 00:49:29else anybody else say I got my own plan
- 00:49:31I just lump back to me and I'm like okay
- 00:49:36because survival's the same lumpectomy
- 00:49:40alone you don't have to radiate you
- 00:49:41don't have to take your whole breast off
- 00:49:43what I care about most sister is that
- 00:49:47you don't die from this thing and so far
- 00:49:49as we can stop death I want to stop it
- 00:49:52and lumpectomy accomplishes that but
- 00:49:56there is a butt what about local
- 00:49:58recurrence local recurrence is breast
- 00:50:00cancer as I already talked about coming
- 00:50:01back again generally it comes back
- 00:50:03within a centimeter or two of exactly
- 00:50:05where it was in your breast so if you
- 00:50:07have an upper outer quadrant cancer
- 00:50:10that's why focal radiation like the
- 00:50:12inoperative shot I was talking about
- 00:50:14works so effectively because it it's
- 00:50:15going to come back in the upper outer
- 00:50:17quadrant if it comes back locally at all
- 00:50:19or it can come back in the same side
- 00:50:21armpit lymph nodes a local recurrence is
- 00:50:23definitely disappointing because got to
- 00:50:25deal with this thing all over again um
- 00:50:28except in rare inst instances it doesn't
- 00:50:31uh portend a worse prognosis at all
- 00:50:33remember uh all three groups had same
- 00:50:35survival so what it is is disappointing
- 00:50:39and nobody wants to deal with cancer
- 00:50:41again lumpectomy alone back to the 1980s
- 00:50:45had a recurrence rate of on average 40%
- 00:50:48if you radiated that dropped down to as
- 00:50:51I once mentioned with the radiation talk
- 00:50:524 to 6% that's my modern numbers um back
- 00:50:57in the 80s the recurrence was a little
- 00:50:58higher but the radiation wasn't as good
- 00:51:01here's the key here is shock number two
- 00:51:04you're like I got a pluses all
- 00:51:07throughout High School lady there's no
- 00:51:09four to six% recurrence for me I want
- 00:51:11zero take that breast
- 00:51:13off four to six% recurrence maybe three
- 00:51:16to five in some studies statistically
- 00:51:18not significantly different in other
- 00:51:21words in
- 00:51:23summary lumpectomy plus radi ation
- 00:51:26versus myectomy identical survival
- 00:51:30identical recurrence with some very tiny
- 00:51:34uh exceptions based on tumor
- 00:51:37biology and if you choose to take an
- 00:51:39anti-estrogen pill so tamoxifen which is
- 00:51:41an estrogen decoy uh that blocks the
- 00:51:44receptor aromatase Inhibitors go out
- 00:51:46into your fat cells if you're
- 00:51:48postmenopausal your ovary is done your
- 00:51:51only self-created source of estrogen is
- 00:51:53coming from your fat cells aromatase is
- 00:51:56the enzyme in there making estrogen out
- 00:51:58of adrenal gland hormones so you take an
- 00:52:01aromatase inhibitor you might recognize
- 00:52:03names like Arimidex aromasin anastrozol
- 00:52:06letrozol famara those are aromatase
- 00:52:09Inhibitors so you take those drugs and
- 00:52:12all of our recurrence
- 00:52:14numbers in this 1980s study World get
- 00:52:18cut in half the 40% lumpectomy alone
- 00:52:21becomes 20% and equally so lumpectomy
- 00:52:24with radiation or myectomy go from 4 to
- 00:52:266% recurrence to 2 to 3% recurrence if
- 00:52:29you add the anti-estrogens which also
- 00:52:32Stave off a distant metastatic
- 00:52:35recurrence um by varying numbers but the
- 00:52:38numbers I'm giving you are for local
- 00:52:40recurrence not metastatic that number
- 00:52:42you get from genomics like enco type or
- 00:52:44mamar print I know it gets confusing
- 00:52:46it's a lot but there you have it in a
- 00:52:49nutshell your surgical choices uh there
- 00:52:52are three of them with two of them being
- 00:52:54Lumpa but when planning to add radiation
- 00:52:57afterwards so all right now I'm hearing
- 00:53:00you all things being equal between
- 00:53:02lumpectomy and radiation versus m why
- 00:53:05would a woman take one or both breasts
- 00:53:06off if she doesn't get any points at all
- 00:53:09no survival points no local recurrence
- 00:53:11points like
- 00:53:13why I'm going to give you four reasons
- 00:53:16one gene mutation so if you have brca
- 00:53:19for example and you have breast cancer
- 00:53:21on average there's a 65% chance you will
- 00:53:23get another breast cancer in your
- 00:53:25lifetime it is not a recurrence of this
- 00:53:27one it is a new one so gene mutation
- 00:53:30carriers depending on their age and
- 00:53:32their own mindset about things they're
- 00:53:33like you know what I I would I didn't
- 00:53:36know I had this gene or I knew and now I
- 00:53:38got bitten by it so I'm done take both
- 00:53:40breasts please next person big tumor
- 00:53:43small breast sometimes we can shrink the
- 00:53:45tumor down using alternative strategies
- 00:53:47using anti-estrogens using chemo I
- 00:53:48talked about Neo adimin therapies one of
- 00:53:50the reasons for that is to take a big
- 00:53:52tumor that would yeah you could do a
- 00:53:54lump back to me but then you'd be
- 00:53:56leaving like this banana rim of breast
- 00:53:58behind and then you should radiate it
- 00:54:00and it just will look prettier to do a
- 00:54:02myectomy and put in a breast shaped
- 00:54:05implant or use your own body fat and
- 00:54:06tissues or go flat and fabulous but it
- 00:54:10will look a little weird to do a
- 00:54:12lumpectomy because the tumor is so big
- 00:54:14okay that's person two person three is
- 00:54:17like oh you know what I love that four
- 00:54:19to six% number that you got going on
- 00:54:21there but ain't no way no how I'm doing
- 00:54:24radiation maybe they've had it before
- 00:54:26maybe they're just categorically opposed
- 00:54:27to it um uh maybe they don't live in an
- 00:54:31area that readily offers it they got to
- 00:54:32drive four hours to and from every day
- 00:54:36you don't want radiation whatever your
- 00:54:38reason but you don't want a 40%
- 00:54:40recurrence even 20 with the pills mctom
- 00:54:44is an excellent choice you get that low
- 00:54:46number no radiation needed with some
- 00:54:49exceptions I mean can I stop having
- 00:54:51exceptions people who choose myectomy
- 00:54:54will still be advised to have radiation
- 00:54:57to their chest wall in lyph nodes after
- 00:55:00myectomy for sure if they have a tumor
- 00:55:04over five centimeters an invasive tumor
- 00:55:06dcis you get away with invasive tumor
- 00:55:09over five centimeters positive margins
- 00:55:11which sometimes I just deal with
- 00:55:12directly like if your skin margin is
- 00:55:14positive after mastectomy rather than
- 00:55:16radiate if I know exactly where that is
- 00:55:18I'd rather just take off that skin and
- 00:55:20have you get radiation but that's not
- 00:55:22always possible four or more positive
- 00:55:24nodes is absolute for radiation one to
- 00:55:27three positive nodes after myectomy is
- 00:55:30wiggle room for discussion of pros and
- 00:55:32cons and the final one is called
- 00:55:35extensive lymphovascular Invasion the
- 00:55:38lymphatics and the blood vessels that
- 00:55:40are in all the other tissue that's not
- 00:55:41the actual breast tissue feed and
- 00:55:44nourish the skin too so it is highly
- 00:55:47possible if there was a ton of tumor
- 00:55:49like the 4053 and la like just tumor
- 00:55:52everywhere in these tubes that it's also
- 00:55:54in the lymphatics and the vessels that
- 00:55:56have been left behind on purpose to
- 00:55:58nourish and keep the skin alive after
- 00:55:59Mist so there are caveats to not needing
- 00:56:03radiation to needing radiation after
- 00:56:06mastectomy so not wanting radiation you
- 00:56:09should have also you should know like if
- 00:56:11you're going to fall in that category
- 00:56:12anyway and finally the most common
- 00:56:15reason for which I do
- 00:56:16myectomy a woman wants it she's like you
- 00:56:19know what I'm not a numbers person or I
- 00:56:22get it I don't have a gene but my mom
- 00:56:23had it my sister had it now I have it I
- 00:56:26don't I don't want the these things
- 00:56:27they're trying to kill me and I don't
- 00:56:29watch them or she is at Baseline like an
- 00:56:33anxious person and she can admit like
- 00:56:35you know what I hear you but showing up
- 00:56:37every six months for a mamogram and
- 00:56:39ultrasound and MRI you to examine me a
- 00:56:42biopsy every time there's a blip on the
- 00:56:43radar like I'm having a panic attack
- 00:56:46just thinking about that future for me
- 00:56:47if you take these off do I have to do
- 00:56:49any of it not really I do chest wall
- 00:56:52exams after myectomy every six months
- 00:56:54for five years and I ultrasound the
- 00:56:55armpit to make sure there's no node
- 00:56:58happening deeper than I can feel but
- 00:57:00that's it there are no squishy
- 00:57:02mammograms there's no MRI um and so that
- 00:57:05can really emancipate a woman and make
- 00:57:07her feel like she's the Conqueror over
- 00:57:09this disease so there are solid reasons
- 00:57:11to choose myectomy over lump ectomy and
- 00:57:14those are the main
- 00:57:16ones boy there is a lot to talk about
- 00:57:20there a lot of numbers certainly a very
- 00:57:22personal decision no matter what and so
- 00:57:25I wish that we had more time to unpack
- 00:57:28that a little bit but the numbers again
- 00:57:31that I want to kind of wrap up today
- 00:57:33with go to what it was we were talking
- 00:57:35about right at the beginning of the show
- 00:57:38and that is the fact that half of all
- 00:57:40breast cancer cases undisputedly are
- 00:57:44preventable and in your estimation
- 00:57:46perhaps even as many as 82 90% of the
- 00:57:50cases and that is what is at the heart
- 00:57:52of our let's beat breast cancer campaign
- 00:57:54this year and every year I love the hat
- 00:57:56you rock it so well let's beat
- 00:57:59breastcancer.org is the website to visit
- 00:58:01to get your hat take the pledge learn
- 00:58:03all about our four prongs our four-step
- 00:58:06approach to preventing and beating
- 00:58:08breast cancer absolutely get involved
- 00:58:11there the free ecook book and speaking
- 00:58:13of books you got to go if you don't
- 00:58:15already have it get Dr funk's book
- 00:58:17breasts the owner's manual there's a
- 00:58:19link to pick up your copy right now in
- 00:58:21the show description and in the episode
- 00:58:23notes and of course all of this
- 00:58:25information and a whole lot more you can
- 00:58:27find at pinklotus.com as well Dr funk's
- 00:58:30website there so Dr Funk thank you so
- 00:58:33very much for your time and walking us
- 00:58:35through this is definitely a different
- 00:58:37approach than what we usually take on
- 00:58:39the show but I love that we're getting
- 00:58:41all of the information out there because
- 00:58:43it's so critical to paint the entire
- 00:58:45picture of what a breast cancer battle
- 00:58:47looks like and I think you did a
- 00:58:48phenomenal job doing that with us today
- 00:58:51thanks it was my pleasure bye
- 00:58:53everyone
- 00:58:57if your health IQ was a couple of points
- 00:58:59higher than it was a few minutes ago go
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