Parasites Eating Us Alive
Zusammenfassung
TLDRThe video provides a detailed overview of the impact of parasitic infections on human health, noting that billions are affected globally by various forms of parasites. It highlights the 1993 Milwaukee outbreak of cryptosporidium, revealing how contaminated water can lead to a public health crisis. The film explores different types of parasites, including malaria, schistosomiasis, and hookworms, discussing their transmission methods, symptoms, and the challenges in developing treatments or vaccines. The evolution of these parasites poses ongoing difficulties for public health efforts, necessitating innovative research and preventive measures to control and reduce infections.
Mitbringsel
- π Three and a half billion people are infected with parasitic worms.
- β³ Malaria kills a child every 30 seconds globally.
- π° The Milwaukee outbreak was caused by water contamination.
- π¦ Malaria is transmitted through Anopheles mosquitoes.
- π¬ Parasites are evolving and challenging treatment methods.
- π§ Clean water is crucial to prevent parasitic infections.
- π‘οΈ Vaccination against parasites remains a significant challenge.
- β€οΈ Humanitarian motives drive research in parasitology.
- π Malaria significantly impacts economic productivity in affected regions.
- π‘ Innovative control programs have shown success in reducing infections.
Zeitleiste
- 00:00:00 - 00:05:00
The documentary highlights the global scale of parasitic infections, affecting billions of people and leading to severe health issues such as malformations, blindness, and death. Parasitic diseases, particularly malaria, are depicted as significant threats to public health around the world, with rates of infection staggering and often going untreated due to their complexity.
- 00:05:00 - 00:10:00
In April 1993, Milwaukee faced a terrifying outbreak of cryptosporidiosis, urging health authorities to rapidly seek answers as hundreds of thousands became infected. The cityβs water system was discovered to be contaminated, demonstrating the ease with which parasites can spread through water, leading to widespread illness and panic.
- 00:10:00 - 00:15:00
The outbreak exposed the unexpected vulnerability of the municipal water supply to parasites, with cryptosporidium identified as the main culprit. This outbreak resulted in a significant number of illnesses and ultimately, deaths, particularly among individuals with weakened immune systems.
- 00:15:00 - 00:20:00
Parasitic organisms are defined, highlighting their often harmful presence in hosts, with humans being common victims. The documentary identifies how nearly all humans harbor some form of parasites, and notes their historical persistence in human evolution.
- 00:20:00 - 00:25:00
The documentary explains the nature of parasitic infections and differentiates between types, focusing on single-celled organisms and multicellular worms. It emphasizes the evolutionary skill of parasites to invade hosts, adapt, and elude medical treatments, showcasing their complex life cycles and survival mechanisms.
- 00:25:00 - 00:30:00
The transmission of parasites to humans is discussed, primarily through ingestion or bites from arthropods. The risk posed by vectors is underscored, especially in tropical regions, where these organisms thrive and often lead to debilitating diseases such as lymphatic filariasis and schistosomiasis.
- 00:30:00 - 00:35:00
Imported foods and contaminated drinking water increase exposure to parasites, including sushi-borne anasakis. The documentary highlights both the human and environmental risks parasites pose in modern-day societies and emphasizes the existing challenge in combating foodborne infections.
- 00:35:00 - 00:40:00
The impact of malarial infections is examined through personal stories, illustrating the real consequences of malaria on human lives, particularly on children. Despite medical advances, malaria remains a major killer globally, with many failing to recover once severely infected due to the parasite's virulence and the immune response triggered within the host.
- 00:40:00 - 00:45:39
While some approaches have succeeded in controlling certain parasitic infections, eradication remains elusive. The documentary showcases examples of control efforts like the oncochiasis control program and highlights the ongoing need for research, surveillance, and innovative strategies to manage and treat parasitic diseases effectively.
Mind Map
Video-Fragen und Antworten
What is the estimated number of people infected with parasitic worms globally?
Three and a half billion people worldwide are infected with parasitic worms.
How often does malaria kill a child?
Malaria kills a child every 30 seconds.
What was the cause of the Milwaukee outbreak in 1993?
The Milwaukee outbreak in 1993 was caused by the cryptosporidium parasite that contaminated the city's water supply.
What is the primary method of transmission for malaria?
Malaria is primarily transmitted by the bite of infected female Anopheles mosquitoes.
What complex issues are associated with parasitic infections?
Parasitic infections present complexities like evolving resistance against treatments, difficulty in vaccination development, and challenges in water safety.
What are some examples of ectoparasites?
Examples of ectoparasites include mosquitoes, fleas, head lice, and pubic lice.
How do parasites invade the human body?
Parasites invade the human body typically through ingestion of contaminated food or water, sexual intercourse, or bites from arthropod vectors.
What is one successful program mentioned for controlling parasitic infections?
The oncochiasis control program is mentioned as a successful initiative that protected the vision of over 600,000 Africans.
Are there any effective vaccines for malaria?
Research is ongoing, but no practical vaccine against malaria currently exists.
What motivates researchers in the field of parasitology?
Researchers in parasitology are often motivated by humanitarian goals to better the world and control parasitic spread.
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- 00:00:07three and a half billion people
- 00:00:09worldwide are infected with parasitic
- 00:00:11worms
- 00:00:13malaria kills a child every 30 seconds
- 00:00:18entire african villages are taken down
- 00:00:20by predatory parasites
- 00:00:22that leave villagers grossly deformed
- 00:00:25blind
- 00:00:26or dead deadly waterborne illness
- 00:00:30infested fruits and vegetables and
- 00:00:32debilitating lyme disease threaten
- 00:00:35communities throughout america
- 00:00:38every day hookworm sucked the blood of
- 00:00:411.5 million people
- 00:00:44[Music]
- 00:00:45parasites voracious animals that live
- 00:00:48off the very essence of our being
- 00:00:51thriving since the dawn of man so
- 00:00:54complex no vaccine will touch them
- 00:00:58parasites are evolving they appear to be
- 00:01:02indomitable and they are
- 00:01:05eating us alive
- 00:01:17april 1993 a strange illness creeped
- 00:01:21across milwaukee
- 00:01:23personnel called in sick to hospitals
- 00:01:25and businesses
- 00:01:27school classrooms stood eerily empty
- 00:01:30paul nanas
- 00:01:31was head of wisconsin's health
- 00:01:32department as the numbers grew
- 00:01:35from see there were 100 people that
- 00:01:37presented to the emergency rooms to
- 00:01:39several hundred people
- 00:01:41to now a thousand people obviously by
- 00:01:44then we knew there was something
- 00:01:45significant going on
- 00:01:47for five days doctors scientists and
- 00:01:49administrators
- 00:01:50desperately looked for answers while
- 00:01:53hundreds of thousands of the city's
- 00:01:54residents were writhing
- 00:01:56wretching and rapidly wasting away
- 00:02:00if it was a contained neighborhood
- 00:02:02likely to be food
- 00:02:03if it was uniformly dispersed across the
- 00:02:06city given wind patterns it would be air
- 00:02:08but what began to emerge was a pattern
- 00:02:10of illness that kind of mirrored
- 00:02:13the water distribution in milwaukee
- 00:02:17the pressure mounted from a terrified
- 00:02:19public in a frenzied media
- 00:02:21the city's water system was infested
- 00:02:24but with what finally one doctor on
- 00:02:27milwaukee's east side
- 00:02:29remembered his medical school training
- 00:02:30in tropical disease
- 00:02:32he checked his patients for parasites
- 00:02:35the lab tests came back
- 00:02:36positive cryptosporidium
- 00:02:39a tiny one-celled parasite had lodged
- 00:02:42itself in the intestines of 400
- 00:02:44000 of this city's residents and even
- 00:02:47when we learned that it was
- 00:02:48cryptosporidium
- 00:02:50we still didn't know what the source was
- 00:02:52and whether our current water was
- 00:02:54currently infected
- 00:02:55and until we knew that we only knew part
- 00:02:57of the equation
- 00:02:59they had their culprit but the scare was
- 00:03:02just beginning
- 00:03:04paul nanus and the city of milwaukee
- 00:03:06were in the midst of the largest
- 00:03:08parasitic outbreak ever recorded in the
- 00:03:10united states
- 00:03:13nausea cramping some vomiting but
- 00:03:16particularly diarrhea and the diarrhea
- 00:03:19in this instance the diarrheal disease
- 00:03:21was terribly severe
- 00:03:23there were people that had 20 and 25
- 00:03:25episodes
- 00:03:27of diarrhea in a day i mean they just
- 00:03:30couldn't
- 00:03:31get out of their homes they had to stay
- 00:03:33home
- 00:03:34nobody ever believed i mean even when we
- 00:03:37knew
- 00:03:37it was waterborne we identified the
- 00:03:40source we knew what it was
- 00:03:42there was still this almost incredulous
- 00:03:45kind of reactions that how could our
- 00:03:47water
- 00:03:48be the source of this i mean nobody
- 00:03:50believed that it could be water
- 00:03:53the shock deepened at the news of the
- 00:03:55first death
- 00:03:56then another by the time the epidemic
- 00:03:59played itself out
- 00:04:00200 people were dead from complications
- 00:04:03from the cryptosporidium parasite
- 00:04:08it was difficult for healthy people to
- 00:04:10recover
- 00:04:11from the episode so you can understand
- 00:04:15what happened to people that didn't have
- 00:04:16healthy immune systems they just
- 00:04:18couldn't
- 00:04:19shed it those who died had compromised
- 00:04:22immune systems
- 00:04:23people with hiv people already sick the
- 00:04:26very old
- 00:04:27and the very young that first three
- 00:04:29weeks of it
- 00:04:31were incredibly intense media wise the
- 00:04:33public the aids
- 00:04:35activist community that were marching
- 00:04:37down through the city of milwaukee
- 00:04:39wanting to know why people that they
- 00:04:42knew and cared about were dying and what
- 00:04:43were we doing about it
- 00:04:45as i mentioned here we didn't have
- 00:04:46answers that's a terrible feeling
- 00:04:52parasitism is kind of a lifestyle
- 00:04:55and uh and a parasite is an organism
- 00:04:58that
- 00:04:59lives on or in another organism which we
- 00:05:03refer to as the host
- 00:05:05and does so either at the detriment of
- 00:05:09the host or
- 00:05:10certainly at no benefit of the host so
- 00:05:12you can have some parasites that really
- 00:05:14don't cause a lot of harm
- 00:05:16but they certainly aren't beneficial to
- 00:05:18the host there are many parasites that
- 00:05:19actually cause
- 00:05:21great harm and in fact can kill the host
- 00:05:25when you look at the human condition and
- 00:05:27you say what is a human being
- 00:05:29you could redefine what a human being is
- 00:05:31in terms of its
- 00:05:32ability to harbor parasites
- 00:05:36almost all of our internal organs all of
- 00:05:39our blood spaces
- 00:05:40all of our hollow organs offers
- 00:05:43opportunities for organisms to live in
- 00:05:45them
- 00:05:46and when they do and when they cause us
- 00:05:48harm
- 00:05:49we call those parasites parasites are
- 00:05:52probably the most common agents
- 00:05:54of human disease on our planet i often
- 00:05:57like to say that if
- 00:05:58carl sagan did not go into astrophysics
- 00:06:01but instead chose to
- 00:06:02launch a career in medicine or
- 00:06:04biological sciences he would have had to
- 00:06:06become a parasitologist
- 00:06:08why because this is the only group of
- 00:06:11organisms where we can really talk about
- 00:06:13billions
- 00:06:14and billions of people being infected
- 00:06:18parasites tenacious behavior toward
- 00:06:20their human hosts
- 00:06:21is nothing new they have been at work
- 00:06:24since the beginning of life
- 00:06:26itself and no matter what form of life
- 00:06:29has
- 00:06:30existed on earth there has always been
- 00:06:32parasites
- 00:06:34always that's the nature of things so
- 00:06:36from the very beginning
- 00:06:38we assume parasitism parasites are very
- 00:06:41clever though
- 00:06:42in the way that they've evolved over
- 00:06:44time and the mechanisms they've evolved
- 00:06:46to
- 00:06:47infect new hosts or move into new areas
- 00:06:49where they previously haven't been
- 00:06:52just the the sheer complexity of some of
- 00:06:54the life cycles
- 00:06:55that they've developed or have developed
- 00:06:57over time in their association with
- 00:06:59animals
- 00:07:00it's just amazing as life progresses and
- 00:07:03becomes more complex
- 00:07:04and develops defense mechanisms against
- 00:07:07those parasites
- 00:07:08and excludes the common ones it now
- 00:07:11has to put up with the highly evolved
- 00:07:13parasites which have
- 00:07:14also evolved along with those highly
- 00:07:17evolved defense mechanisms
- 00:07:19for stealth and entry mechanisms and
- 00:07:21cunning and
- 00:07:22guile so to speak we would give them
- 00:07:24human characteristics
- 00:07:27in fact in their own way the physical
- 00:07:30structure of parasites
- 00:07:32resembles that of our own they have
- 00:07:35a complexity of structure and function
- 00:07:38that is hard to believe
- 00:07:42most of the parasites i work with have
- 00:07:44structures that are just like man they
- 00:07:45have
- 00:07:46intestinal systems they have their own
- 00:07:49kidneys they have a complex nervous
- 00:07:51system
- 00:07:53organisms such as bacteria and viruses
- 00:07:56also require nourishment and protection
- 00:07:59from a host
- 00:08:00for survival the difference between
- 00:08:02these microbiological organisms
- 00:08:05and the classic parasite comes down to
- 00:08:08size
- 00:08:09usually when we talk about parasites we
- 00:08:11talk about either single-celled or
- 00:08:13larger organisms
- 00:08:15we don't talk about smaller
- 00:08:18organisms such as viruses for sure
- 00:08:22and usually bacteria bacteria are
- 00:08:24usually considered
- 00:08:25kind of as a separate grouping
- 00:08:29scientists group parasites into three
- 00:08:32different categories
- 00:08:35parasitologists will think about the
- 00:08:38organisms that they study the parasites
- 00:08:41along three major lines these would
- 00:08:44include
- 00:08:45simple single celled organisms
- 00:08:48classically protozoan organisms
- 00:08:51such as organisms that cause african
- 00:08:53sleeping sickness
- 00:08:55plasmodium which causes malaria
- 00:08:57cryptosporidium which causes
- 00:08:59cryptosporidiosis
- 00:09:00which even despite their tiny size can
- 00:09:03still be associated with devastating
- 00:09:05disease
- 00:09:06then there are larger multicellular
- 00:09:09organisms generally referred to as
- 00:09:11worms three different kinds of worms
- 00:09:13that we classify as parasites
- 00:09:15we have round worms uh like asterisk and
- 00:09:18pinworm
- 00:09:19uh we have flat worms that are not
- 00:09:21segmented those are the schistosomes
- 00:09:23and then finally we have the ones that
- 00:09:25everybody is familiar with the tapeworms
- 00:09:26that are segmented flat worms
- 00:09:28and then there is a series of organisms
- 00:09:30that are generally referred to as
- 00:09:32ectoparasites
- 00:09:34ecto meaning on so they don't live in
- 00:09:36the host they live
- 00:09:37on the host mosquitoes take our blood
- 00:09:39for egg production
- 00:09:41black flies suck our blood for egg
- 00:09:42production we would consider fleas the
- 00:09:44same thing
- 00:09:45all of those are ectoparasites but
- 00:09:47they're temporary parasites for the most
- 00:09:49part
- 00:09:50we know of a few that are not so
- 00:09:51temporary though we can talk about head
- 00:09:53lice we can talk about pubic lice and we
- 00:09:55can talk about body lines
- 00:09:56and in those cases they live on us
- 00:09:59and they depend on us and we are their
- 00:10:02home
- 00:10:04in order for a parasitic infection to
- 00:10:07take place
- 00:10:08the parasites must first gain entry into
- 00:10:11a suitable host
- 00:10:13since parasites are perceived as being
- 00:10:15everywhere
- 00:10:16some of us think we can even catch them
- 00:10:18by breathing in the air
- 00:10:19this is not true there are really only
- 00:10:22three different ways we can catch
- 00:10:23the parasites the ones that we're
- 00:10:24discussing and that is
- 00:10:27we can eat them we can drink water
- 00:10:30in which they have stages so that we can
- 00:10:33catch them this way
- 00:10:35there's even one we can catch by sexual
- 00:10:36intercourse
- 00:10:38but the vast majority of the ones that
- 00:10:40we're really afraid of the ones that
- 00:10:42cause the most suffering throughout the
- 00:10:43world
- 00:10:44are the ones that are transmitted by
- 00:10:46arthropod vectors
- 00:10:48a vector is generally thought of as
- 00:10:51an organism that transmits a parasite
- 00:10:55from one place to another from one stage
- 00:10:57of its life cycle to another but we
- 00:11:00don't
- 00:11:00have to go to the parasites the
- 00:11:01parasites will come to us they have
- 00:11:03their own transportation system so to
- 00:11:05speak
- 00:11:08mosquito vectors are responsible for
- 00:11:10transmitting some of the most
- 00:11:11dangerous diseases on earth
- 00:11:15one example is lymphatic filariasis
- 00:11:20lymphatic filariasis which is also known
- 00:11:22by its common name elephantiasis is a
- 00:11:25vector-borne parasitic disease caused by
- 00:11:28a
- 00:11:29roundworm a nematode it's a very
- 00:11:32widespread disease throughout the
- 00:11:34tropics thought to
- 00:11:36involve somewhere in the order of 120
- 00:11:38million people or so
- 00:11:39around the world for most people a
- 00:11:42filariasis infection brings about only
- 00:11:45mild side effects
- 00:11:48but when the disease infests the
- 00:11:50lymphatic system
- 00:11:52severe pain and intense suffering result
- 00:11:56the lymphatic channels can be in various
- 00:11:58parts of the body
- 00:12:01classically it's in the lower
- 00:12:02extremities so the adult worms are in
- 00:12:05the lymphatic channels of the legs
- 00:12:08and it impedes the return flow of lymph
- 00:12:10fluid
- 00:12:12causing buildup of lymph fluid and
- 00:12:16the subsequent swelling and then the
- 00:12:19fibrotic reaction that the body has
- 00:12:21over years and then the infections of
- 00:12:24the skin that are caused
- 00:12:26by the compromised lymphatic flow that
- 00:12:29result in the fairly grotesque
- 00:12:33classic elephantiasis of the lower
- 00:12:35extremities
- 00:12:36the common underlying result is
- 00:12:40debility severe
- 00:12:43inability to to perform one's one's
- 00:12:46daily routine
- 00:12:50the disease is very hard to diagnose in
- 00:12:53its early stages
- 00:12:54one of the the very frustrating things
- 00:12:56about this
- 00:12:58this parasitic infection is that in its
- 00:13:01early stages it's it's clinically very
- 00:13:04silent
- 00:13:05so you can get fairly young children
- 00:13:07that actually become infected with this
- 00:13:09parasite
- 00:13:10and unless you look in their blood to
- 00:13:12see the
- 00:13:13embryonic forms of the parasite you
- 00:13:16wouldn't know that they were infected
- 00:13:18and then very gradually over years as
- 00:13:20they enter
- 00:13:21puberty in adult life they will begin to
- 00:13:25manifest
- 00:13:26slight swellings of one leg or
- 00:13:29a hydrocele or a swelling of the scrotum
- 00:13:32that just gradually over time
- 00:13:34gets bigger and bigger inexorably
- 00:13:37once they reach that stage there's not
- 00:13:41much that can be done medically to try
- 00:13:44and cure them of that
- 00:13:47parasites have lived both on and in us
- 00:13:50since the beginning of man they have
- 00:13:53evolved to develop specialized
- 00:13:55techniques
- 00:13:56to invade our bodies and evade our
- 00:13:59defenses
- 00:14:00while medical advances have bolstered
- 00:14:02our ability to detect and treat
- 00:14:04parasitic infections
- 00:14:06the parasites continue their quest for
- 00:14:09shelter
- 00:14:09and sustenance within us
- 00:14:14one method of infection is through our
- 00:14:17dietary intake
- 00:14:20imported foods have played a significant
- 00:14:22part in the increase of parasitic
- 00:14:24infections
- 00:14:25in the u.s today
- 00:14:28after the agricultural revolution and of
- 00:14:30course with rapid transit
- 00:14:32and with the ability to ship products
- 00:14:35from one place to the other
- 00:14:36in less than 18 hours parasites can come
- 00:14:39to us now we don't have to go to them
- 00:14:41any longer
- 00:14:42so this raises the possibility for the
- 00:14:44spread of parasites
- 00:14:46in places that they never existed before
- 00:14:49another interesting aspect of the whole
- 00:14:51phenomenon of foodborne diseases is
- 00:14:54a parasitic disease called anasakis
- 00:14:58it's caused by a fish parasite
- 00:15:01that is transmitted to humans when they
- 00:15:03eat sushi which of course is uncooked
- 00:15:06fish and this parasite which is a
- 00:15:10normal parasite of fish can be acquired
- 00:15:14by humans
- 00:15:15and it causes a local invasion
- 00:15:18of the gastrointestinal tract that in
- 00:15:20some cases can mimic
- 00:15:22stomach disease or appendicitis
- 00:15:26in this country in the united states
- 00:15:28we've had a
- 00:15:29burgeoning sushi industry lots of people
- 00:15:32eat sushi
- 00:15:32in fact i eat sushi i eat it safely
- 00:15:36why because we now know how this
- 00:15:38parasite is transmitted uh
- 00:15:40it requires the fish to sit around for a
- 00:15:43while
- 00:15:44in a non-fresh state now you can define
- 00:15:46that any way you want
- 00:15:47but in fact if you catch a fish and
- 00:15:49place it on ice immediately
- 00:15:51this parasite stays in the gut track to
- 00:15:53those fish
- 00:15:54if on the other hand you catch the fish
- 00:15:56and it sits on the deck of the boat for
- 00:15:57a while and warms up
- 00:15:58the parasites will then crawl out of the
- 00:16:00gut tissue into the meat of the fish
- 00:16:02now when you put it on ice and bring it
- 00:16:04in and make sushi out of that
- 00:16:06you have the option at least of catching
- 00:16:08that worm
- 00:16:10we've become aware of that the fish that
- 00:16:13are served in the sushi parlors of
- 00:16:14america at least and i'm sure in japan
- 00:16:16as well
- 00:16:17is as fresh as the day it was caught
- 00:16:20but not all food-borne parasitic
- 00:16:22infections have been conquered
- 00:16:25because of their insatiable appetite for
- 00:16:27suitable hosts
- 00:16:28parasites will always search out new
- 00:16:31ways of infecting us
- 00:16:33tapeworms are parasitic flatworms
- 00:16:37that live in the intestine of humans
- 00:16:40most commonly they're acquired through
- 00:16:43the ingestion
- 00:16:44of uncooked flesh that has the
- 00:16:47larval stages of the parasite and there
- 00:16:50appears to be
- 00:16:51a tapeworm that corresponds to each type
- 00:16:54of major
- 00:16:55meat that's ingested for instance
- 00:16:57there's a beef tapeworm
- 00:16:58tina saginata there's a fish tapeworm
- 00:17:02known as diphylobathrium latum there is
- 00:17:05a pork tapeworm
- 00:17:06named tinia soleum teeniacolium the pork
- 00:17:10tapeworm has emerged as an
- 00:17:11important infection not only in many
- 00:17:14developing countries
- 00:17:15but also in the united states as well
- 00:17:18the parasite
- 00:17:19is particularly prevalent in central
- 00:17:22america
- 00:17:22and in mexico and now the organism has
- 00:17:26been
- 00:17:27imported over the border to the point
- 00:17:29where it has become a major infection
- 00:17:32in u.s cities that are near these
- 00:17:35countries so we find
- 00:17:36high rates of tesolium infection in los
- 00:17:40angeles and san diego and san antonio
- 00:17:43and tucson arizona reason this is of
- 00:17:46importance to note is because the larval
- 00:17:49stages of the pork tapeworm
- 00:17:52have been linked to an illness in the
- 00:17:54brain
- 00:17:56there is a syndrome associated with
- 00:17:59solium
- 00:18:00known as neurocystic psychosis that has
- 00:18:03now become one of the leading causes of
- 00:18:05epilepsy among children living in these
- 00:18:08cities in the southwestern united states
- 00:18:11the pork tapeworm the egg
- 00:18:14when it's ingested into the human the
- 00:18:16larva that emerges from that egg
- 00:18:19and thinks it's in a pig the larva will
- 00:18:22go and insist
- 00:18:23in various parts of the human anatomy
- 00:18:26unfortunately including and apparently
- 00:18:28the parasite seems to have a tropism
- 00:18:31for human neural tissue
- 00:18:34so you can get cysts in the brain you
- 00:18:37can get cysts in the eyes
- 00:18:39you can get cysts in the musculature as
- 00:18:41well
- 00:18:42this disease is called cysticercosis
- 00:18:47imported and undercooked food is not the
- 00:18:49only way we can ingest a parasite
- 00:18:53fresh clean water can never be taken for
- 00:18:56granted
- 00:18:57and the water we drink in our homes can
- 00:19:00be tainted
- 00:19:01one of the most common parasites in the
- 00:19:03united states
- 00:19:04besides cryptosporidium is giardia
- 00:19:07lamblia
- 00:19:08majority of lamblius is one of our more
- 00:19:12photogenic parasites uh parasitologists
- 00:19:14love to talk about giardia because
- 00:19:16it looks like a little monkey face or it
- 00:19:18has a personality it has a smile it has
- 00:19:20a little flagella
- 00:19:21people like to talk about it they don't
- 00:19:23like to catch it so where do you catch
- 00:19:25giardia
- 00:19:26well you catch it from drinking
- 00:19:27contaminated water by the breakdown
- 00:19:30of public health practices which ensures
- 00:19:32the safety of our drinking water
- 00:19:34it's a constant struggle to maintain
- 00:19:37filtered water supply for communities
- 00:19:39that are
- 00:19:40dependent upon those filtered water
- 00:19:41supplies in reservoirs for instance
- 00:19:44or natural bodies of water they have a
- 00:19:46real problem ensuring the fact that the
- 00:19:48giardia lamblia doesn't enter their
- 00:19:49drinking water supply
- 00:19:51and any time the filtration system fails
- 00:19:54you can get outbreaks of giardia it's
- 00:19:56well known that giardia cysts
- 00:19:58can survive chlorination especially if
- 00:20:02the chlorination
- 00:20:03is not being done to adequate levels
- 00:20:06so there have been large water-borne
- 00:20:10outbreaks of giardiasis in the united
- 00:20:12states
- 00:20:14associated with either malfunctioning
- 00:20:17or poorly designed municipal water
- 00:20:19supplies
- 00:20:20the diarrheal disease caused by giardia
- 00:20:23is
- 00:20:24somewhat different than the usual
- 00:20:27diarrheal illness
- 00:20:28because of where the parasite lives in
- 00:20:30the human host
- 00:20:32and the fact that in especially in heavy
- 00:20:34infections
- 00:20:35the parasite actually adheres to the
- 00:20:38walls of the
- 00:20:39small intestine but generally speaking
- 00:20:41it can be treated with antibiotics
- 00:20:45while gr diocese may cause us temporary
- 00:20:47discomfort
- 00:20:49waterborne disease in the tropics can
- 00:20:51bring crushing illness
- 00:20:54the guinea worm known formally as
- 00:20:57dracunculus medinensis
- 00:20:59is found throughout the tropical world
- 00:21:01is transmitted through ingestion of
- 00:21:03contaminant and water
- 00:21:06there's a certain organism a crustacean
- 00:21:09in that grows in fresh water that serves
- 00:21:12as the intermediate host
- 00:21:14for the disease and when humans ingest
- 00:21:17water that has
- 00:21:18an infected cyclops which is the name of
- 00:21:21the intermediate host
- 00:21:23they will acquire this disease it's a
- 00:21:25worm that's about
- 00:21:27twice the length of a yardstick in some
- 00:21:29cases it lives in your subcutaneous
- 00:21:31tissues and it seeks out the lowest part
- 00:21:33of your body
- 00:21:34and there the head of the worm elicits a
- 00:21:36blister it's a visible blister you can
- 00:21:38actually see the head of this worm under
- 00:21:39the blister
- 00:21:40when you step in the water the blister
- 00:21:43bursts open
- 00:21:44releasing larvae that the worm has
- 00:21:45produced into the water column
- 00:21:47and then you get to see this ugly
- 00:21:49disfiguring blister on the end of your
- 00:21:50foot
- 00:21:51which you now have to do something about
- 00:21:53and in most countries
- 00:21:54what you do is you grab a small stick
- 00:21:57and the head of the worm
- 00:21:58wrap the head of the worm around this
- 00:21:59stick and slowly every day
- 00:22:02turn the stick slowly pulling the worm
- 00:22:05out from your skin
- 00:22:07if it should break you will experience
- 00:22:10the worst anaphylactic reaction you can
- 00:22:13possibly imagine
- 00:22:14you'll get a sloughing of skin in the
- 00:22:16region where the worm is
- 00:22:18it will become secondarily infected with
- 00:22:20bacteria and when it heals you'll have a
- 00:22:22nasty scar for the rest of your life
- 00:22:26another bloodthirsty parasite that
- 00:22:28burrows through our skin
- 00:22:30is the schistosome the schistosome
- 00:22:33is endemic in parts of asia and africa
- 00:22:36and utilizes a snail
- 00:22:38as an intermediate host before infecting
- 00:22:40humans
- 00:22:42juvenile schistosomes called circaria
- 00:22:45emerge from their snail host
- 00:22:47into fresh water where they swim
- 00:22:49frantically looking for the only host
- 00:22:51where they can complete their
- 00:22:52development
- 00:22:53a human once the swimming circaria find
- 00:22:57human skin
- 00:22:58they eject their tail and utilize skin
- 00:23:01dissolving enzymes to burrow through the
- 00:23:03skin of the foot
- 00:23:05and eventually into the bloodstream one
- 00:23:08of its remarkable abilities
- 00:23:11is its capacity to live in what should
- 00:23:14be
- 00:23:14the most inhospitable place on earth
- 00:23:18an individual's bloodstream these worms
- 00:23:20actually
- 00:23:21live in blood vessels now think of it
- 00:23:24if you were an infectious agent where is
- 00:23:26the last place you would want to set up
- 00:23:28shop
- 00:23:29where you're being bombarded daily by
- 00:23:31antibodies
- 00:23:33being bombarded daily by white blood
- 00:23:35cells
- 00:23:36and yet here the schistosome not only
- 00:23:39survives
- 00:23:40but it thrives once the juveniles have
- 00:23:44matured
- 00:23:44the male and females pair up for life
- 00:23:47where they mate
- 00:23:48continuously producing and releasing
- 00:23:50eggs
- 00:23:51let's take the example of the bladder
- 00:23:54schistosome
- 00:23:55known as schistosoma hematobium with
- 00:23:57this type of schistosomiasis
- 00:23:59the egg has the ability to traverse
- 00:24:02through the bladder wall
- 00:24:05as the egg does this it elicits in a
- 00:24:07host inflammatory response
- 00:24:09that's also associated with bleeding as
- 00:24:12a result people who harbor
- 00:24:14bladder schistosomes develop blood in
- 00:24:16their urine a condition known as
- 00:24:18hematuria
- 00:24:20a curious instance where
- 00:24:23the presence of hematuria caused by
- 00:24:26bladder schistosomes affected history
- 00:24:28was when napoleon entered egypt
- 00:24:32napoleon's troops it was prophesied
- 00:24:35would be stricken by pharaoh's curse
- 00:24:39should they choose to enter into egypt
- 00:24:41and what was pharaoh's curse
- 00:24:43it was male menstruation and sure enough
- 00:24:46when many of his troops came into egypt
- 00:24:48they acquired bladder schistosomiasis
- 00:24:51and many of the troops believed that
- 00:24:53this was the prophecy
- 00:24:55of pharaoh's curse fulfilled another
- 00:24:58fascinating parasitic disease
- 00:25:00is one called oncocerciasis
- 00:25:03the common name of which is river
- 00:25:04blindness this is a
- 00:25:06parasitic disease caused by a roundworm
- 00:25:09parasite
- 00:25:10of man that in its clinical
- 00:25:14end stages causes a very devastating and
- 00:25:16irreversible
- 00:25:18blinding disease it's a parasite
- 00:25:21that is transmitted from human to human
- 00:25:24by the bite of a black fly
- 00:25:26which is the vector the black fly breeds
- 00:25:30in fast flowing streams
- 00:25:33and therefore the disease is most
- 00:25:36endemic
- 00:25:37in the valleys of these streams and
- 00:25:40thus the name river blindness after the
- 00:25:43vector
- 00:25:44bites the human it deposits the
- 00:25:47larval worms which invade the skin
- 00:25:51and eventually end up forming a nodule
- 00:25:55under the skin where the adult worms
- 00:25:58develop
- 00:25:59while they're in this fibrous nodule
- 00:26:02under the skin
- 00:26:04the adult worms shed on the order of
- 00:26:06three to five
- 00:26:07thousand microfilarii or larval worms
- 00:26:10per day
- 00:26:12per adult these larval worms
- 00:26:15instead of entering the bloodstream
- 00:26:18remain
- 00:26:18in the subcutaneous tissue and migrate
- 00:26:22through the subcutaneous tissue
- 00:26:24causing changes to the skin that can
- 00:26:27manifest in such ways as
- 00:26:29very hypoelastic skin
- 00:26:33baggy skin as the disease progresses
- 00:26:36and the number of larval worms in the
- 00:26:38subcutaneous tissue increase
- 00:26:40they eventually gain access to the
- 00:26:42tissues of the eye
- 00:26:44and cause microcalcifications which
- 00:26:48over time build up and cause the
- 00:26:50blindness
- 00:26:54[Music]
- 00:27:00this is where they slit my truth and had
- 00:27:03some sort of plastic tube
- 00:27:08the iv site went bad here and they cut
- 00:27:11it out
- 00:27:12and left me with this car and i also
- 00:27:15have the scarf for my feeding tube
- 00:27:17my body is scarred now
- 00:27:21thirty-four-year-old haslam bostwick is
- 00:27:23a native of south america
- 00:27:24who lives in fort lauderdale florida
- 00:27:28hasland knows a lot about one particular
- 00:27:30parasite
- 00:27:31plasmodium falciparum
- 00:27:34it is the most deadly of all parasites
- 00:27:37and more commonly known
- 00:27:39as malaria
- 00:27:40[Music]
- 00:27:42i go into the interior of ghana very
- 00:27:44often i used to
- 00:27:46spend up to 10 days in there at the time
- 00:27:50and in order to make sure that i don't
- 00:27:53come in to cut it doesn't anything
- 00:27:55nothing
- 00:27:55bites me was i would make sure that my
- 00:27:58tent was sprayed before i go to bed at
- 00:28:00night
- 00:28:01while i'm outdoor i make sure that my
- 00:28:03body is totally covered so nothing could
- 00:28:05bite me
- 00:28:08in the spring of 1999 haslam had her
- 00:28:11blood checked for malaria
- 00:28:13when she returned from a trip to oversee
- 00:28:15a gold mine she owns in guyana
- 00:28:18she wasn't feeling well but her tests
- 00:28:20proved negative
- 00:28:22so hasland took her son on a school trip
- 00:28:24to washington dc
- 00:28:27she became weaker more nauseous three
- 00:28:29days into the trip
- 00:28:31haslam took to her bed
- 00:28:36so i lied down and then i got up later
- 00:28:38on went to the bathroom and
- 00:28:39went back to bed and when i went back to
- 00:28:42bed i never got back up again
- 00:28:44haslam bostwick slipped into a coma she
- 00:28:48was taken over by the malaria parasites
- 00:28:51hasland joined the ranks of 250 million
- 00:28:54victims around the globe
- 00:28:56who contract malaria each year
- 00:28:59three million of those people die and
- 00:29:02it's the young who suffer the most
- 00:29:05every 30 seconds of every hour of every
- 00:29:08day
- 00:29:09the malaria parasite kills a child
- 00:29:13the research done over even the last 50
- 00:29:15years
- 00:29:16have not been able to reduce the
- 00:29:18mortality
- 00:29:20the in-hospital fatality rate
- 00:29:23of severe malaria in children in the
- 00:29:25tropics in primary care hospitals in the
- 00:29:28tropics
- 00:29:29one percent nothing that we've done
- 00:29:33has been able to reduce the mortality of
- 00:29:35severe malaria
- 00:29:37malaria had been a mystery for centuries
- 00:29:40no one knew exactly where it came from
- 00:29:43nor how it was passed from victim to
- 00:29:45victim
- 00:29:46the evil illness seemed simply to emerge
- 00:29:49from the stale air around swamps
- 00:29:52in fact the literal translation of
- 00:29:54malaria is
- 00:29:55bad air in 1880
- 00:29:59a protozoan parasite was found living in
- 00:30:02the blood of malaria patients
- 00:30:06the female anopheles mosquito was soon
- 00:30:09identified as the vector
- 00:30:11for the malaria parasite
- 00:30:19sixty years later malaria was still the
- 00:30:22leading cause of sickness and death in
- 00:30:24humans on earth
- 00:30:27the medicine quinine made from the bark
- 00:30:29of the cincona tree
- 00:30:31had been used to ease symptoms for 400
- 00:30:33years
- 00:30:34but it took until the 1950s to find hope
- 00:30:37in a weapon that would wipe out
- 00:30:39malaria's carrier
- 00:30:42chlorinated hydrocarbon insecticide ddt
- 00:30:47there was nothing quite like it before
- 00:30:49and there has been nothing like it since
- 00:30:51here was a chemical that could be
- 00:30:53sprayed on the walls of a house
- 00:30:55and for up to six months any insect that
- 00:30:57rested on that surface
- 00:30:58would die it was then thought to be
- 00:31:01non-toxic to humans
- 00:31:03and it was inexpensive to manufacture
- 00:31:06the female anopheles mosquito was public
- 00:31:08enemy number one
- 00:31:10and world health officials had a brand
- 00:31:12new weapon
- 00:31:14eradication efforts were effective in
- 00:31:16north america and europe
- 00:31:18but after a decade of trying to
- 00:31:19annihilate the mosquito in africa
- 00:31:21india and asia the success of ddt slowed
- 00:31:26war corruption inaction famine
- 00:31:29and a host of other problems detracted
- 00:31:31from the battle
- 00:31:32against malaria by the late 1970s
- 00:31:36the world health organization bitterly
- 00:31:38admitted that malaria was back
- 00:31:40and worse than ever today only the hiv
- 00:31:45virus comes close to the destruction
- 00:31:47malaria brings upon this earth
- 00:31:52it's estimated by some economists that
- 00:31:55malaria alone reduces the gross domestic
- 00:31:57product of the countries in sub-saharan
- 00:31:59africa by about one percent
- 00:32:03perhaps even more that translates into
- 00:32:06billions of dollars of loss
- 00:32:09in those countries every year
- 00:32:13so it has an enormous impact in every
- 00:32:16military campaign
- 00:32:17in which u.s forces have been involved
- 00:32:19in the last hundred years
- 00:32:21where malaria was transmitted we've
- 00:32:24always had more casualties to malaria
- 00:32:26than we've had from hostile fire
- 00:32:28that means from a military perspective
- 00:32:31that malaria has tremendous
- 00:32:33mission aborting potential
- 00:32:36the swamps around haslam bostwick's
- 00:32:39south american gold mine
- 00:32:40were a perfect breeding ground for the
- 00:32:42anopheles mosquito
- 00:32:45as the mosquito fed on hasland's blood
- 00:32:47in its nightly ritual
- 00:32:49it released thousands of thread-like
- 00:32:51malaria parasites
- 00:32:52that were stored in its salivary glands
- 00:32:56for 12 days haslan would go without
- 00:32:59symptoms while parasites invaded her
- 00:33:01liver
- 00:33:02and transformed into organisms that
- 00:33:04moved on to her red blood cells
- 00:33:06the tiny creatures divided and
- 00:33:08multiplied by the millions
- 00:33:10they became so numerous that her red
- 00:33:12blood cells exploded
- 00:33:14by the time haslin fell into a coma
- 00:33:17parasites were shutting down
- 00:33:18most of her vital organs including her
- 00:33:21brain
- 00:33:22the only organ that was functioning was
- 00:33:24my heart
- 00:33:25everything else had already shut down by
- 00:33:28the time i got to the hospital
- 00:33:30and they had to
- 00:33:33pretty much they had to put catheters
- 00:33:36and whatever else they had to put in me
- 00:33:40dr stephen hoffman was rushed in to work
- 00:33:43with haslan
- 00:33:44so what was going on was these parasites
- 00:33:47were binding to these small blood
- 00:33:48vessels
- 00:33:49in her brain and blocking up blood flow
- 00:33:54if there's no blood flow then no oxygen
- 00:33:56gets to your brain
- 00:33:57and you slip into a coma after centuries
- 00:34:01of suffering
- 00:34:02and death decades after the discovery
- 00:34:04that malaria is a parasite
- 00:34:06and research into a cure there is still
- 00:34:09no effective modern drug to combat
- 00:34:12malaria in its late stages
- 00:34:14and there is no practical vaccine
- 00:34:16against malaria
- 00:34:18we are in a situation where the two
- 00:34:20major drugs
- 00:34:21in this world used for treating severe
- 00:34:24malaria cerebral malaria severe malarial
- 00:34:26anemia
- 00:34:28hyper paracetamia high levels of
- 00:34:30parasites in the bloodstream
- 00:34:32are quinine and artemisinin derivatives
- 00:34:36both of those have been available for
- 00:34:38hundreds if not thousands of years
- 00:34:41it's not that we haven't developed new
- 00:34:43drugs for treating the parasite
- 00:34:45but that the parasite has either
- 00:34:47developed resistance to those drugs or
- 00:34:49they're actually not as good
- 00:34:51as these age-old remedies
- 00:34:55through the developed world's best
- 00:34:57medical efforts hasland did stabilize
- 00:35:00and miraculously she survived after five
- 00:35:03weeks of devastating illness
- 00:35:05haslam responded to treatment and has
- 00:35:08been malaria free
- 00:35:09ever since
- 00:35:13this this particular parasite kills
- 00:35:16and not too many people can survive to
- 00:35:19tell a story
- 00:35:21because especially getting to the point
- 00:35:23where i was
- 00:35:25because i should have been dead
- 00:35:29i should not be here sitting with
- 00:35:31talking to you today i should really be
- 00:35:32dead
- 00:35:35efforts to eradicate and treat the
- 00:35:37terrifying destruction of parasites
- 00:35:40all over the world meet with varied and
- 00:35:42intermittent success
- 00:35:45in the case of vector-borne parasites
- 00:35:48african governments have attempted to
- 00:35:49eliminate the vectors
- 00:35:51the flies and mosquitoes and other
- 00:35:53insects that carry parasites for river
- 00:35:55blindness
- 00:35:56elephantiasis and malaria
- 00:36:02these efforts have slowed the spread of
- 00:36:04some infections
- 00:36:05but many scientists argue that
- 00:36:07eradication of parasites
- 00:36:09may not be possible we've actually never
- 00:36:11been able to control
- 00:36:13to the point of extinction any parasitic
- 00:36:15infection
- 00:36:16the only disease producing agent we've
- 00:36:20ever been able to get rid of is smallpox
- 00:36:22and that's because smallpox only
- 00:36:24infected the human and no other
- 00:36:26host some of these parasites can infect
- 00:36:28multiple
- 00:36:29hosts you can have reservoirs out there
- 00:36:31so even if you could affect cures in
- 00:36:33people
- 00:36:34you still couldn't get rid of it in the
- 00:36:35animal populations it might also harbor
- 00:36:37the same stages
- 00:36:39so even if you could control everything
- 00:36:40in the human population you could still
- 00:36:42reintroduce it every now and then
- 00:36:44because of these animal reservoirs
- 00:36:48if eradication isn't an option then
- 00:36:50controlling the spread of infection is
- 00:36:52the answer to limiting parasitic
- 00:36:54outbreaks
- 00:36:56one control success story is the
- 00:36:58onco-circiasis control program
- 00:37:02when oncochiasis was at its height
- 00:37:06in the late 60s and early 70s
- 00:37:10it became evident that this disease was
- 00:37:12a major
- 00:37:13impediment to successful development
- 00:37:16particularly of these countries in west
- 00:37:18africa where it was so highly endemic
- 00:37:21because of that
- 00:37:22the world bank the who
- 00:37:26and other international organizations
- 00:37:28banded together
- 00:37:29to form the encore crisis control
- 00:37:31program
- 00:37:32which has in its 25 years of existence
- 00:37:35had a
- 00:37:36major impact on blocking the
- 00:37:39transmission of the disease
- 00:37:41protecting the vision of over 600 000
- 00:37:44africans
- 00:37:45in west africa and allowing somewhere in
- 00:37:49the order of 15 million
- 00:37:50children in this area to be able to grow
- 00:37:53up
- 00:37:54without the threat of blinding onco
- 00:37:56psychiatrists
- 00:37:59the guinea worms story is one of our
- 00:38:02shining lights in terms of parasite
- 00:38:04controls
- 00:38:06it's found throughout the tropics
- 00:38:07throughout africa throughout the middle
- 00:38:09east throughout
- 00:38:10india and even in south america as well
- 00:38:13it's intermediate host that is it lives
- 00:38:15in other things besides humans it lives
- 00:38:17in this little water
- 00:38:18flea and by filtering out the water flea
- 00:38:21you can get rid of the guinea one and we
- 00:38:23taught people how to do that
- 00:38:25they went and did it and we've
- 00:38:27controlled this infection now in all but
- 00:38:2813 countries throughout the world
- 00:38:30used to be in hundreds of countries
- 00:38:34in the developed world new water
- 00:38:36treatment practices have been developed
- 00:38:38to keep
- 00:38:38out cryptosporidium parasites
- 00:38:41milwaukee spent 80 million dollars
- 00:38:43building a new water plant
- 00:38:46but the tragedy in milwaukee brought
- 00:38:47attention to the daily efforts being
- 00:38:49made
- 00:38:50on the part of water treatment officials
- 00:38:52to ensure that our drinking water
- 00:38:54remains safe the lessons that we learned
- 00:38:57in milwaukee is
- 00:38:59you need to be prepared you need to know
- 00:39:01the capabilities and the vulnerabilities
- 00:39:03of your water treatment system
- 00:39:05one can never say this will happen again
- 00:39:07but one can never say it won't
- 00:39:09and so until there's assurance
- 00:39:12between the health department the water
- 00:39:14officials and others that you're as
- 00:39:16prepared as you can be
- 00:39:18you're at risk david leiby of the
- 00:39:22american red cross
- 00:39:23believes the milwaukee outbreak was a
- 00:39:25wake-up call
- 00:39:26the sheer size of the incident suggests
- 00:39:29that
- 00:39:31there's a potential for this type of
- 00:39:32thing to occur in the future
- 00:39:34i mean even though our water supply like
- 00:39:35our blood supply is very safe as well
- 00:39:37and great measures are taken to
- 00:39:39prevent these kind of instances or these
- 00:39:42kind of occurrences from happening
- 00:39:44however it just points out the fact that
- 00:39:46parasites can in fact be very
- 00:39:48opportunistic
- 00:39:50and then if there is a possibility of
- 00:39:53them getting into a system in this case
- 00:39:55a water system
- 00:39:56which they are allowed an opportunity to
- 00:39:59grow and develop
- 00:40:00and to replicate then they certainly can
- 00:40:02take advantage of it
- 00:40:05some see a future in biological controls
- 00:40:08putting parasites at war with each other
- 00:40:12introduce a benign echinostome flute to
- 00:40:15the host of a parasite like the
- 00:40:17schistosome fluke
- 00:40:18in hopes that the benign flute will
- 00:40:21attack and kill
- 00:40:22its harmful cousin
- 00:40:25the snail is infected with this evil
- 00:40:28schistosome
- 00:40:29and along comes this nice a kind of
- 00:40:32stone that has a mouth
- 00:40:34and a gut and it seeks out the
- 00:40:37schistosome in the snail
- 00:40:39and wammo it it sucks it up it swallows
- 00:40:42it
- 00:40:43and the schistosome uh larval stage is
- 00:40:46gone
- 00:40:46uh and this is a marvelous biological
- 00:40:50adaptation
- 00:40:51whereby this tug of war is going on in
- 00:40:54the snail and the
- 00:40:56schistosome this evil schistosome is
- 00:40:59destroyed by this nice
- 00:41:00kind of stone the idea of biological
- 00:41:04control in some respects
- 00:41:05is very attractive as opposed to
- 00:41:08something like ddt which is very harmful
- 00:41:11to the environment if you could have a
- 00:41:13biological control
- 00:41:15for instance another animal eating the
- 00:41:17intermediate host or one of the the
- 00:41:19vectors of a parasite
- 00:41:21you know that's a great idea because
- 00:41:23that doesn't involve something that
- 00:41:24generally harms the environment or
- 00:41:26disrupts the ecology at least in most
- 00:41:28cases
- 00:41:30another avenue of protection is the
- 00:41:32development of a vaccine against
- 00:41:34parasitic infections
- 00:41:38dr stephen hoffman and his team at the
- 00:41:40navy medical research center in bethesda
- 00:41:42maryland
- 00:41:43are developing groundbreaking vaccines
- 00:41:45for malaria
- 00:41:47the team begins with thousands of
- 00:41:49anopheles mosquitoes
- 00:41:51from the research centers in sectary
- 00:41:54volunteers are bitten by
- 00:41:55malaria-infected mosquitoes
- 00:41:57that have been exposed to radiation the
- 00:42:00radiation weakens the malaria parasites
- 00:42:03harbored within the infected mosquitoes
- 00:42:06the weakened parasites evoke responses
- 00:42:08from the volunteers autoimmune system
- 00:42:12after thousands of these responses the
- 00:42:14volunteers develop immunity to malaria
- 00:42:19while progress towards a workable
- 00:42:21vaccine is made every day
- 00:42:24the complex nature of parasites creates
- 00:42:27a moving target for medical science
- 00:42:30they have multiple antigens or proteins
- 00:42:34that are expressed
- 00:42:35on their surface at different courses in
- 00:42:37their life cycle
- 00:42:39that makes the design of a vaccine
- 00:42:41almost impossible
- 00:42:46the more we learn about these parasites
- 00:42:48the more respect we gain for
- 00:42:50their side of the life cycle and the
- 00:42:52more respect we gain
- 00:42:54for the immense amount of selection
- 00:42:57those parasites have caused our biology
- 00:42:59to undergo
- 00:43:04the ability of these organisms to infect
- 00:43:06new hosts and infect virtually every
- 00:43:08animal that we know
- 00:43:09there's just so many different varieties
- 00:43:12of parasites and so many complex things
- 00:43:14that you
- 00:43:15you can learn as well simple things
- 00:43:20there's nothing easy about studying
- 00:43:22parasitic organisms
- 00:43:24they tend to be very difficult to
- 00:43:26maintain in the laboratory
- 00:43:28it tends to be very difficult to get
- 00:43:29large numbers of organisms to study
- 00:43:32as a result doing biochemistry on these
- 00:43:35organisms is difficult doing genetics on
- 00:43:37these organisms are difficult
- 00:43:45parasitologists scientists who study
- 00:43:47parasites
- 00:43:48tend to be of a very special breed
- 00:43:51there's something else that motivates
- 00:43:53parasitologists to study these organisms
- 00:43:56that would not ordinarily motivate
- 00:43:58a person studying another class of
- 00:44:00organisms the wonder of it all and the
- 00:44:02the complexity of what we see in these
- 00:44:05organisms
- 00:44:06going from single cell organisms to very
- 00:44:08complex organisms from
- 00:44:11parasites that you have to look at under
- 00:44:13a microscope to
- 00:44:14tapeworms found in whales that are 100
- 00:44:16feet long
- 00:44:19the ultimate goal of studying parasites
- 00:44:22and to learn about their biologies
- 00:44:24is to ultimately exercise some control
- 00:44:28over the way they spread
- 00:44:32my cousin rabbi felizowski told me about
- 00:44:36a hebrew concept
- 00:44:37which he calls tikkun olam and it means
- 00:44:41to better the world it kind of refers to
- 00:44:44the fact that
- 00:44:47an individual's obligation in life is
- 00:44:50to try to want to better the world and i
- 00:44:52think that's the one unifying feature
- 00:44:54i've always seen
- 00:44:55among my colleagues in parasitology is
- 00:44:58no matter what particular parasite
- 00:45:00they're studying
- 00:45:01there is some humanitarian motivation in
- 00:45:04wanting to study these classic organisms
- 00:45:21[Music]
- 00:45:38you
- parasites
- malaria
- cryptosporidium
- public health
- waterborne diseases
- tropical diseases
- Lyme disease
- vaccine development
- infection control
- schistosomiasis