Your Body Is BEGGING For Vitamin D!!

00:53:13
https://www.youtube.com/watch?v=QAQ7r6jLEww

Ringkasan

TLDRThe conversation with Professor Bruce Hollis explores the dual pathways of Vitamin D functionality in the body, delineating its roles in bone health through the endocrine system and its broader physiological effects through a separate paracrine and autocrine system. Dr. Hollis emphasizes the common misconceptions regarding Vitamin D, particularly in the context of medical research which often fails to show positive results due to flawed dosing strategies. He criticizes many clinical trials for misunderstanding Vitamin D's mechanism and for administering doses that are insufficient to realize its potential benefits beyond bone health. The discussion also touches on the need for daily intake of Vitamin D to enable its full spectrum of effects, especially in pregnancy, cancer prevention, and general immune functionality. Emerging evidence suggests the crucial role of Vitamin D in health outcomes, such as mitigating complications during childbirth and influencing gene regulation that could aid in cancer therapy. Hollis highlights that traditional supplementation often neglects the paracrine system's needs, and underscores the importance of ongoing, high-quality research to better understand Vitamin D's comprehensive benefits, despite current financial and pharmaceutical industry barriers. A substantial portion of the interview addresses the logistical and scientific challenges in vitamin D research, such as population variability and ethical care standards limiting rigorous trial designs, which informs why it is considered a contentious area with many existing studies deemed inconclusive, not necessarily reflective of vitamin D's therapeutic potential.

Takeaways

  • 🦴 Vitamin D has dual roles: bone health and broader cellular functions.
  • 🧪 Standard blood tests measure inactive Vitamin D, not its full potential.
  • 🔍 Research often misinterprets Vitamin D's broader effects due to improper dosing.
  • 💊 Regular daily doses of Vitamin D are crucial for overall health benefits.
  • 🌞 Sun exposure contributes significantly to Vitamin D production.
  • 🤰 Adequate Vitamin D can reduce pregnancy complications.
  • 🛡 Vitamin D plays a role in cancer prevention and therapy.
  • 🔬 High doses might be needed for therapeutic effects on diseases like MS.
  • 📝 Major medical journals show resistance towards positive Vitamin D findings.
  • ⚙️ Magnesium is crucial for optimizing Vitamin D metabolism.

Garis waktu

  • 00:00:00 - 00:05:00

    The discussion introduces Professor Bruce Hollis as a pioneer in vitamin D research, revealing little-known truths about vitamin D's dual systems in the body: one for skeletal integrity and another for cellular functions, controlling around 2,000 genes. Dr. Hollis discusses the misconception that blood tests accurately reflect vitamin D's role in cellular functions.

  • 00:05:00 - 00:10:00

    Dr. Hollis elaborates on the different forms of vitamin D: the supplement form that is crucial for cellular function and the intermediate form that is tested in blood, which focuses on blood calcium and skeletal maintenance. He emphasizes the importance of daily intake of vitamin D, as the supplement form doesn't last long in the body.

  • 00:10:00 - 00:15:00

    Hollis critiques the methodology of some vitamin D studies, particularly highlighting the misinterpretation of vitamin D's effectiveness when administered infrequently. He provides insight into flawed research designs where baseline vitamin D levels aren't considered, leading to misrepresented outcomes.

  • 00:15:00 - 00:20:00

    Illustrating how randomized drug trials differ from nutrient trials, he explains that nutrient trials like for vitamin D are challenging due to varying baseline levels in participants. He references successful overseas studies where vitamin D showed significant health benefits due to prevalent deficiencies.

  • 00:20:00 - 00:25:00

    Further discussing research limitations, Hollis criticizes the way some studies, including those in major journals, dismiss significant findings by enforcing study designs that obscure beneficial outcomes. He shares successful studies on vitamin D's impact on pregnancy outcomes but laments the challenges in funding and publication.

  • 00:25:00 - 00:30:00

    Hollis talks about a prostate cancer study where vitamin D showed significant tumor regression, yet faced publication challenges. He mentions vitamin D's potential in extending life for chemotherapy patients but critiques the restrictive doses allowed in trials, emphasizing the need for higher doses to see real effects.

  • 00:30:00 - 00:35:00

    Discussing vitamin D storage and supposed toxicity, Hollis explains that vitamin D is not extensively stored in fat tissue, countering a common belief. He discusses studies that link vitamin D to reduced vascular permeability and shares successes in pediatric studies around vitamin D and breastfeeding.

  • 00:35:00 - 00:40:00

    The conversation touches on the regulation and testing barriers for vitamin D research, with governmental and industry resistance due to financial interests. The role of vitamin D in disease prevention is acknowledged, but trial opportunities are dwindling due to funding issues and systemic opposition.

  • 00:40:00 - 00:45:00

    Hollis reflects on his motivations for studying vitamin D, citing its essential role from his early research in animal health. He shares how safety and efficacy findings in vitamin D led to breakthroughs in understanding its broader health benefits, despite professional skepticism.

  • 00:45:00 - 00:53:13

    Concluding the interview, Hollis stresses the importance of vitamin D education, addressing systemic flaws in how health guidelines are set. He advocates for informed supplementation policies, noting that government and scientific institutions must overcome biases to improve public health.

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Peta Pikiran

Mind Map

Pertanyaan yang Sering Diajukan

  • What are the two systems that handle Vitamin D in the body?

    One system is related to bone and skeletal health (endocrine function), and the other involves various cellular functions (paracrine and autocrine systems) affecting immune cells, cancer cells, etc.

  • Why is measuring Vitamin D levels in the blood not enough?

    Blood tests typically measure an inactive form of Vitamin D, which doesn't reflect its availability and activity for non-skeletal systems.

  • What are the common misconceptions about Vitamin D supplementation?

    Many people think a single blood measurement suffices for all needs, confusing skeletal health with other health aspects requiring daily Vitamin D intake.

  • Why do some studies about Vitamin D show no benefits?

    Studies often use inadequate dosing or improper research models, such as single large doses instead of regular smaller doses.

  • How does Vitamin D affect cancer prevention or management?

    Vitamin D can influence cancer cell activity, immune response, and potentially act as part of cancer prevention or supportive care, especially at higher doses.

  • Why are Vitamin D research and funding declining?

    Despite evidence of wide-ranging benefits, vitamin D trials are underfunded due to the prevailing influence of unsuccessful trials and pharmaceutical interests.

  • What role does Vitamin D play in pregnancy and lactation?

    Proper Vitamin D levels reduce pregnancy complications and improve lactation by providing sufficient levels in breast milk.

  • Is Vitamin D toxicity a real concern?

    True toxicity is rare, and Vitamin D is generally safe even at higher doses, unless specific metabolic defects are present.

  • What role does magnesium play in Vitamin D metabolism?

    Magnesium acts as a co-factor, enhancing Vitamin D metabolism and function within the body.

  • How does the body's storage of Vitamin D actually work?

    Vitamin D doesn't extensively store in fat tissues but is continuously needed, necessitating regular intake for optimal function.

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Gulir Otomatis:
  • 00:00:00
    today we're going to be talking to
  • 00:00:01
    Professor Bruce Hollis the Pioneer in
  • 00:00:04
    vitamin D research you're going to find
  • 00:00:07
    this extremely fascinating let's Dive
  • 00:00:09
    Right In so Dr Hollis I I watched one of
  • 00:00:11
    your videos and I literally had to put
  • 00:00:14
    it on pause because you said something
  • 00:00:17
    that blew me away I've never heard this
  • 00:00:19
    before in my life and I had to spend the
  • 00:00:21
    next eight hours trying to validate what
  • 00:00:24
    you said which is absolutely 100% true
  • 00:00:26
    and this little piece of information
  • 00:00:28
    will explain a lot of I think the
  • 00:00:30
    confusions that people observe when they
  • 00:00:33
    see negative research on vitamin D and a
  • 00:00:36
    lot of other things so that piece of
  • 00:00:39
    information was related to um there's
  • 00:00:41
    actually two different systems in the
  • 00:00:45
    body that deal with vitamin D uh there's
  • 00:00:48
    I guess one with bone and skeleton and
  • 00:00:51
    then there's another system for
  • 00:00:52
    everything else can you kind of just as
  • 00:00:55
    simple as possible kind of explain those
  • 00:00:56
    two
  • 00:00:57
    systems yeah the first system
  • 00:01:00
    uh the one that was discovered decades
  • 00:01:02
    ago that vitamin D was associated with
  • 00:01:05
    skeletal integrity and M maintaining um
  • 00:01:08
    blood calcium levels in a strict fashion
  • 00:01:11
    and and it's very important and it has
  • 00:01:13
    to be it has to be uh maintained all the
  • 00:01:18
    time and so that system involves uh
  • 00:01:21
    vitamin D and parathyroid hormone um
  • 00:01:25
    kidneys and that's basically referred to
  • 00:01:28
    as the endocrine function of vitamin D
  • 00:01:30
    and that's what everybody always
  • 00:01:32
    identified vitamin D with and then as
  • 00:01:36
    time went on um molecular biology came
  • 00:01:39
    into a focus they started finding um
  • 00:01:44
    cells that had the ability to respond to
  • 00:01:46
    vitamin D that had nothing to do with
  • 00:01:49
    the skeleton immune cells cancer
  • 00:01:53
    cells uh uh placental cells uh and list
  • 00:01:58
    goes on and on and it turn turns out
  • 00:02:00
    that that's the second system and is
  • 00:02:01
    called the paracrine and intercrine
  • 00:02:03
    system and that is depending on uh how
  • 00:02:08
    much vitamin D can get into these cells
  • 00:02:10
    and be activated and then carry out
  • 00:02:12
    their function I mean just in the human
  • 00:02:16
    body give or take there are 20,000
  • 00:02:18
    different genes that are controlled um
  • 00:02:21
    uh for various functions vitamin D has
  • 00:02:24
    the ability to control 10% or 2,000 of
  • 00:02:27
    those genes in one fashion or another
  • 00:02:30
    and so to to basically brush that aside
  • 00:02:33
    as a lot of my colleagues did uh just
  • 00:02:37
    saying it's it's an artifact never made
  • 00:02:39
    any sense to me so if we take a look at
  • 00:02:42
    these two systems when you get your
  • 00:02:43
    blood test done in vitamin D you're
  • 00:02:45
    looking at a the inactive version of
  • 00:02:48
    you're not looking at the type of
  • 00:02:49
    vitamin D that's going in the cells and
  • 00:02:52
    how does that relate with these two
  • 00:02:55
    different systems well here we get it
  • 00:02:57
    gets pretty technical so have you have
  • 00:03:01
    when people refer to vitamin D mostly
  • 00:03:03
    when they refer to vitamin D it's the
  • 00:03:05
    form you get when you take a supplement
  • 00:03:07
    or when you make it in your skin when
  • 00:03:10
    the Sun hits your skin um that's the we
  • 00:03:13
    call that the vitamin D or the parent
  • 00:03:15
    compound and then that compound goes
  • 00:03:18
    into the circulation it doesn't stay
  • 00:03:20
    there very long and but it gets turned
  • 00:03:22
    into another compound called 25 hydroxy
  • 00:03:25
    vitamin D and when they test your blood
  • 00:03:28
    right the immediate form
  • 00:03:31
    the intermediate form that stays in your
  • 00:03:33
    blood for weeks okay okay and that's a
  • 00:03:36
    good and a bad thing because it it stays
  • 00:03:38
    around for a long time but it's not very
  • 00:03:40
    accessible to these tissues that need
  • 00:03:43
    it it it's accessible to the kidney that
  • 00:03:46
    maintains blood calcium and then finally
  • 00:03:50
    uh the uh the that compound is turned
  • 00:03:53
    into another compound which is really
  • 00:03:55
    one of the most potent hormones known
  • 00:03:57
    and that's uh the 125 Di hydroxy vitamin
  • 00:04:01
    D and that uh that that's is what drives
  • 00:04:06
    all these Gene functions and all these
  • 00:04:07
    tissues so so the one when you go to the
  • 00:04:10
    doctor and get your blood test you're
  • 00:04:11
    looking at not the active form it's an
  • 00:04:14
    inactive form that can stay around in
  • 00:04:16
    the blood for a c several weeks it's the
  • 00:04:20
    yes it's the I'll call it the
  • 00:04:22
    reservoir okay it's the reservoir of
  • 00:04:24
    vitamin D that's being measured got
  • 00:04:28
    it and then it turns turns into the
  • 00:04:30
    active form or a certain amount will
  • 00:04:32
    turn into the active form but then how
  • 00:04:35
    does that relate to these two different
  • 00:04:38
    systems well so the in that intermediate
  • 00:04:42
    form the reservoir form can turn into
  • 00:04:44
    the active form in the kidney that's
  • 00:04:46
    highly regulated and that's what m
  • 00:04:49
    that's what regulates blood
  • 00:04:50
    calcium
  • 00:04:52
    okay that intermediate form can also go
  • 00:04:56
    into any cell in the body okay and be
  • 00:04:59
    turned in to the active form and
  • 00:05:03
    function in that given cell whether it
  • 00:05:05
    be a cancer cell to stop cancer from
  • 00:05:08
    progressing or immune cells uh to make
  • 00:05:12
    make them function in the appropriate
  • 00:05:15
    fashion and uh also the the problem with
  • 00:05:19
    that intermediate form is it's not very
  • 00:05:22
    accessible to these cells it can it's
  • 00:05:25
    it's it's bound to this protein it keeps
  • 00:05:27
    it out that's why it lasts in the blood
  • 00:05:29
    so long
  • 00:05:31
    so the the parent compound the one that
  • 00:05:34
    you take in the supplement turns out
  • 00:05:38
    it's really important because that form
  • 00:05:40
    can get into any of these cells and be
  • 00:05:43
    activated all the way down the chain to
  • 00:05:45
    the active
  • 00:05:46
    form the problem is that form disappears
  • 00:05:49
    within a
  • 00:05:51
    day yeah so so it needs to be
  • 00:05:53
    replenished every
  • 00:05:55
    day to have the full function of the
  • 00:05:58
    vitamin present say it's very it's
  • 00:06:00
    complicated that's why a lot of
  • 00:06:02
    Physicians don't pay attention to this
  • 00:06:04
    or scientists as
  • 00:06:06
    well so this this this is kind of what I
  • 00:06:08
    want to get into this this point that
  • 00:06:10
    you just mentioned because you have the
  • 00:06:12
    different types and then when people get
  • 00:06:14
    their blood tested they're assuming that
  • 00:06:17
    there's one system oh I have enough in
  • 00:06:19
    the blood so everything's going to be
  • 00:06:21
    satisfied but that's not necessarily
  • 00:06:23
    true no that's true and because the the
  • 00:06:27
    form that's being measured while it's
  • 00:06:29
    important okay it's the reservoir more
  • 00:06:31
    important
  • 00:06:32
    for maintenance of blood calcium and
  • 00:06:35
    skeleton but for the other functions the
  • 00:06:39
    only way that you can you you can be
  • 00:06:41
    sure that you have adequate Amounts is
  • 00:06:44
    basically take it every day either
  • 00:06:47
    orally or get in the Sun every day and
  • 00:06:48
    of course that's really not feasible for
  • 00:06:50
    a lot of
  • 00:06:51
    reasons so the oral consumption of
  • 00:06:54
    vitamin D on a daily or at a minimum on
  • 00:06:58
    a weekly basis
  • 00:07:00
    uh is is important because that that's
  • 00:07:03
    the that's the the Bas the base form and
  • 00:07:06
    that form comes and goes very
  • 00:07:08
    quickly
  • 00:07:10
    wow so this has to do with like halflife
  • 00:07:13
    and um breaking down some of it goes
  • 00:07:16
    down quick some stays in there so
  • 00:07:20
    now in one of your videos you me you
  • 00:07:22
    went through a bunch of studies and you
  • 00:07:24
    showed people step by step um like
  • 00:07:28
    number of studies that were that failed
  • 00:07:30
    that showed no response with vitamin D
  • 00:07:33
    and you correlated that with h well
  • 00:07:35
    that's because they they only let people
  • 00:07:37
    take it once a week or once a month
  • 00:07:40
    versus there been even been one study on
  • 00:07:44
    skeleton where they took it once a year
  • 00:07:47
    like a million units once a year and
  • 00:07:49
    then they said well this didn't work out
  • 00:07:50
    very well and that continues to be cited
  • 00:07:52
    in some facts as being harmful it's
  • 00:07:54
    idiotic oh my gosh if someone takes a
  • 00:07:58
    million um I use a vitamin D just one
  • 00:08:01
    time um I think um after after a day it
  • 00:08:07
    goes down to half and then the day later
  • 00:08:09
    it goes down to a quarter right it just
  • 00:08:10
    kind of breaks down and then goes away
  • 00:08:12
    or or it just becomes yeah it it'll
  • 00:08:15
    boost the intermediate form for a while
  • 00:08:17
    but it's a very it's horribly
  • 00:08:20
    inefficient uh of way of doing it and it
  • 00:08:22
    becomes more so if you do it once a day
  • 00:08:24
    it's efficient once a week it's less
  • 00:08:26
    efficient once a month even less
  • 00:08:27
    efficient so yeah
  • 00:08:30
    so wow as far as the the the research on
  • 00:08:34
    this
  • 00:08:36
    um what about um you know you have all
  • 00:08:39
    these most of the researchers out there
  • 00:08:42
    they're they kind of look at Cal U
  • 00:08:44
    vitamin D just just related to Bone and
  • 00:08:46
    calcium they're they're kind of just
  • 00:08:49
    almost pretending like this other system
  • 00:08:51
    doesn't exist is that true yeah
  • 00:08:54
    basically yes I mean first you have to
  • 00:08:57
    accept the fact that vitamin D has
  • 00:08:58
    functions on calcium and I mean the data
  • 00:09:02
    are all over but what what ends up
  • 00:09:04
    happening is things are run like the
  • 00:09:06
    vital trial yeah where they they give
  • 00:09:10
    too little vitamin D they give it to
  • 00:09:14
    people who in know in a randomized trial
  • 00:09:16
    who who who don't need it you know it's
  • 00:09:20
    like uh in the the the Townson
  • 00:09:22
    newsletter I mentioned to you when I was
  • 00:09:25
    discussing it with the author of that
  • 00:09:27
    paper so the gold standard for all drug
  • 00:09:31
    trials or randomized control
  • 00:09:33
    trials okay where say you have a
  • 00:09:36
    cholesterol drug and you want to test if
  • 00:09:40
    it truly will depress serum cholesterol
  • 00:09:42
    if you take it so the drug company
  • 00:09:45
    assembles uh assembles a population of
  • 00:09:48
    people and they administer half of those
  • 00:09:50
    people a drug and half of those people
  • 00:09:53
    get
  • 00:09:54
    Placebo and then they they uh analyze
  • 00:09:59
    the
  • 00:09:59
    and and look at it and of course they
  • 00:10:02
    it's in most cases it's it's
  • 00:10:05
    successful and this is how drug trials
  • 00:10:07
    are run but the drug that you're giving
  • 00:10:10
    those people the body has never seen it
  • 00:10:13
    they don't have a base level of
  • 00:10:15
    it unlike nutrients not just vitamin D
  • 00:10:18
    but any nutrient trial okay it's
  • 00:10:21
    impossible in this country to do a true
  • 00:10:24
    randomized trial because the population
  • 00:10:27
    you're dealing with has some some some
  • 00:10:30
    people have very little some people have
  • 00:10:32
    plenty but when you if you just take
  • 00:10:35
    them at random and and and randomize
  • 00:10:39
    them and give these people half of them
  • 00:10:41
    a a level of vitamin D oftentimes not
  • 00:10:43
    even enough and the other half only get
  • 00:10:46
    Placebo or and Placebo in this country
  • 00:10:50
    means they have to get the standard
  • 00:10:51
    daily
  • 00:10:52
    dose so they're not even getting
  • 00:10:56
    zero and what happens is is that it's a
  • 00:11:00
    horribly compromised study so that's
  • 00:11:02
    what vital in all these uh happens is
  • 00:11:06
    that and the other thing is when you
  • 00:11:08
    when you end it and you do your data
  • 00:11:11
    analysis wouldn't you think that you
  • 00:11:13
    might take the basil level into effect
  • 00:11:15
    when you do the analysis of the
  • 00:11:17
    data well that's illegal you can't do
  • 00:11:20
    that that that violates intent to treat
  • 00:11:25
    model okay and it absolutely ensures
  • 00:11:28
    that your trial is going to
  • 00:11:31
    fail so and I'll give you some examples
  • 00:11:34
    and I've worked primarily in pregnancy
  • 00:11:37
    we did pregn pregnancy studies and found
  • 00:11:39
    out that vitamin D decreased
  • 00:11:41
    complications of birth and but the best
  • 00:11:44
    trials were actually done overseas and
  • 00:11:46
    the best one couple were done in
  • 00:11:49
    actually in Iran and where the
  • 00:11:51
    population is generally vitamin D
  • 00:11:53
    deficient across the board and they had
  • 00:11:57
    a fairly large patient population half
  • 00:11:59
    of those women got a substantial dose of
  • 00:12:02
    vitamin D and half of those people got
  • 00:12:04
    nothing which is how you can't run a
  • 00:12:07
    trial like that in the US because you'd
  • 00:12:09
    be violating standard of care but over
  • 00:12:12
    but that's truly how Vitamin D trial
  • 00:12:14
    should be run and and and in those
  • 00:12:18
    trials we saw tremendous effects on on
  • 00:12:22
    decrease in birth complications like
  • 00:12:23
    pre-term birth and preclampsia and and
  • 00:12:27
    and diabetes and and everything else
  • 00:12:30
    fell into the treatment group if you do
  • 00:12:33
    the same trial in the US you you you
  • 00:12:38
    can't do it where our nutrition is
  • 00:12:40
    better people have better vitamin D
  • 00:12:42
    levels but when you randomize
  • 00:12:45
    them like I said everybody has some and
  • 00:12:48
    so it's not like you're given a drug
  • 00:12:50
    that has none and when and when you look
  • 00:12:54
    at the results it's totally blurred and
  • 00:12:57
    it's even you know you could I you can
  • 00:13:00
    overcome that to some degree when when
  • 00:13:02
    the statisticians would take their the
  • 00:13:05
    basil level upon study entry into effect
  • 00:13:08
    and then you analyze it like that you
  • 00:13:10
    can see effects and that and in fact
  • 00:13:12
    that's
  • 00:13:13
    why observational studies uh you know
  • 00:13:17
    when they have these big groups of
  • 00:13:19
    people and they look at vitamin D levels
  • 00:13:22
    and outcomes via cancer via pregnancy
  • 00:13:25
    and and things and it's based on a
  • 00:13:28
    lifestyle
  • 00:13:29
    okay and and uniformly those studies and
  • 00:13:32
    there's thousands of them would show
  • 00:13:36
    really big effects of vitamin D but then
  • 00:13:38
    when you went to do these randomized
  • 00:13:40
    trials and you had all these
  • 00:13:42
    complications and you can't adjust for
  • 00:13:45
    the base level all of that disappears
  • 00:13:47
    and you get no you get no effect at all
  • 00:13:50
    but if you if you submit your paper to
  • 00:13:53
    New England Journal or jamama or British
  • 00:13:55
    medical journal and you and you analyze
  • 00:13:58
    the data
  • 00:13:59
    and want to take into account basil
  • 00:14:01
    levels that violates the intent to treat
  • 00:14:03
    model and it will be rejected outright
  • 00:14:06
    wow wow so so the vital study is
  • 00:14:09
    definitely um the study that certain
  • 00:14:12
    groups are using to to tell people well
  • 00:14:15
    see see it doesn't really work yeah we
  • 00:14:17
    did the study it's
  • 00:14:19
    definitive like I've challenged the
  • 00:14:22
    authors of that
  • 00:14:23
    study to reanalyze their data taking
  • 00:14:26
    Baseline levels into account of their
  • 00:14:28
    patient and they won't do it wow
  • 00:14:32
    incredible and they didn't they even
  • 00:14:34
    call um their the amount of vitamin D
  • 00:14:37
    they were giving people a high dose at
  • 00:14:39
    2,000
  • 00:14:41
    iuse yeah that's
  • 00:14:44
    nothing per to put it in perspective I
  • 00:14:48
    I'm 73 years old I take 10,000 units of
  • 00:14:52
    vitamin D a
  • 00:14:53
    day and I have for years and my level
  • 00:14:56
    vitamin D levels are between 80 and 90
  • 00:14:59
    nanograms per
  • 00:15:01
    ML and my the my personal care physician
  • 00:15:04
    is is pretty um Progressive she uh she's
  • 00:15:08
    all for that not just with me but for
  • 00:15:10
    her entire entire clinical uh uh group
  • 00:15:14
    of of patients that she follows and so
  • 00:15:17
    she wants her patients to have a minimum
  • 00:15:19
    level of 60 that's really out there
  • 00:15:22
    compared to most you know Family Care
  • 00:15:24
    Physicians or Primary Care docs in fact
  • 00:15:27
    they'll get a level back from be at the
  • 00:15:30
    male clinic or Cleveland Clinic or
  • 00:15:32
    whatever and those those levels like
  • 00:15:34
    mine which are 80 or 90 will be flagged
  • 00:15:36
    as too high right and I get those I get
  • 00:15:40
    those emails from people all the
  • 00:15:43
    time wow it's just level two let's talk
  • 00:15:47
    about the normals for a second because I
  • 00:15:48
    think it's a bit of an arbitrary right
  • 00:15:51
    there's really no agreed upon range
  • 00:15:55
    definitively right there's different
  • 00:15:57
    different ideas on it
  • 00:15:59
    again if you go back to what's the
  • 00:16:01
    agreed upon range it's all based on
  • 00:16:03
    skeletal models right right and and and
  • 00:16:06
    the skeletal models that's something
  • 00:16:09
    that we haven't talked about the ranges
  • 00:16:11
    on those two systems are
  • 00:16:14
    different you can maintain a skeletal
  • 00:16:17
    model on a relatively low amount of you
  • 00:16:20
    know say 25 or 30 nanograms or maybe
  • 00:16:23
    even lower where you can maintain a
  • 00:16:25
    normal skeletal level where the other
  • 00:16:28
    system requires much higher levels in
  • 00:16:30
    that to function in a normal fashion
  • 00:16:32
    incredible what are the ranges for the
  • 00:16:35
    other system uh other than the bone in
  • 00:16:37
    the skeletal oh I I'm I'm saying if you
  • 00:16:40
    want to have cancer prevention or cancer
  • 00:16:42
    treatment it's so if you're trying to
  • 00:16:45
    prevent cancer that's one thing if you
  • 00:16:46
    have active active neoplasia that's a
  • 00:16:49
    different ball game that's that's
  • 00:16:51
    pharmacology so your levels would be
  • 00:16:53
    higher but but for prevention and
  • 00:16:56
    optimal functions I me a Minimum level
  • 00:17:00
    would be 50 so 50 to 100 and that's well
  • 00:17:03
    within the normal physiologic range in
  • 00:17:06
    Sun repleted
  • 00:17:08
    populations so if you spend a lot of
  • 00:17:10
    time and we've looked at this over the
  • 00:17:12
    years and people lifeguards or athletes
  • 00:17:14
    who are outside in the sun in in the
  • 00:17:17
    summer months or people who live in the
  • 00:17:20
    tropics who take their levels are
  • 00:17:21
    routine the 890 100 nigs that is not an
  • 00:17:25
    abnormal level from Human physiology in
  • 00:17:27
    fact that's what we all were at one
  • 00:17:30
    time this is incredible data so um so
  • 00:17:33
    you do have prevention then you have the
  • 00:17:36
    the therapeutic dose when someone has a
  • 00:17:38
    chronic inflammatory condition
  • 00:17:40
    autoimmune or cancer those levels I
  • 00:17:44
    would imagine need to be a bit over a
  • 00:17:46
    hundred right yeah or even higher I mean
  • 00:17:49
    there's a there's a an MS protocol in
  • 00:17:52
    Brazil where uh this I can't remember
  • 00:17:55
    the Cambria protocol yeah
  • 00:17:57
    KRA yeah he he they dose with several
  • 00:18:01
    hundred thousand their their levels are
  • 00:18:03
    you know 5600 nanograms to for the
  • 00:18:06
    suppression of of Ms and it has basis in
  • 00:18:10
    fact because vitamin D at those levels
  • 00:18:13
    is an immune suppressor so excuse me it
  • 00:18:16
    will it will alter the T the t- cells in
  • 00:18:20
    the favor of T2 away from T1 T1 are the
  • 00:18:23
    ones that cause autoimmune attack and so
  • 00:18:27
    vitamin D at H at those levels and and
  • 00:18:31
    some of those people show that uh those
  • 00:18:34
    vitamin D at those levels are more
  • 00:18:36
    effective than the drugs that are
  • 00:18:37
    prescribed of course vitamin D is free
  • 00:18:40
    essentially and those drugs are
  • 00:18:41
    enormously expensive to take every month
  • 00:18:44
    with severe side effects right so what
  • 00:18:47
    what about cancer you mentioned one of
  • 00:18:49
    the videos about prostate
  • 00:18:51
    cancer
  • 00:18:52
    so you know with prostate cancer um we
  • 00:18:57
    did a study more than 10 years ago now
  • 00:19:00
    where we looked at I went to at the time
  • 00:19:03
    I went into uh the chief of our urology
  • 00:19:06
    department at the Medical University of
  • 00:19:07
    South Carolina where I was on on faculty
  • 00:19:10
    and and another fellow and I went in and
  • 00:19:13
    talked to him and uh he it was a friend
  • 00:19:15
    of mine and I said to them I said look
  • 00:19:16
    we want to do a a a study in your P
  • 00:19:20
    group of patients on the patients who
  • 00:19:22
    are have active surveillance or watching
  • 00:19:24
    weight you know what that is so we you
  • 00:19:27
    go in to have your prostate your PSA is
  • 00:19:30
    going up they do a biopsy and and your
  • 00:19:33
    your your uh prostate cancer is low gr
  • 00:19:36
    say leas and six so the doctor says to
  • 00:19:38
    you well we prefer to really do nothing
  • 00:19:42
    you know we want to watch and wait which
  • 00:19:43
    means I'll we'll check back with you in
  • 00:19:46
    a year see if it's
  • 00:19:48
    worse
  • 00:19:49
    okay so we said we want to do a study on
  • 00:19:53
    these guys and what we want to do is we
  • 00:19:55
    at the time every time we did these
  • 00:19:57
    studies you had to propose how much you
  • 00:19:59
    were going to give the patient and so if
  • 00:20:01
    you go back to this period of time which
  • 00:20:03
    is in the 20056 Years some back there we
  • 00:20:07
    wanted to give a really modest dose of
  • 00:20:09
    4,000 units a day I would have liked to
  • 00:20:12
    give more but at the time you have to go
  • 00:20:15
    through an Institutional review board
  • 00:20:17
    and they have to okay it and so um and
  • 00:20:21
    and most of this unfortunately where we
  • 00:20:23
    are and stuff most of the prostate
  • 00:20:25
    cancer occurs in the African-American
  • 00:20:27
    population which are really deficient in
  • 00:20:29
    vitamin D so we approached them and we
  • 00:20:33
    said we want to do this and we want to
  • 00:20:35
    give them 4,000 units of vitamin D at
  • 00:20:37
    day um and it was an Interventional
  • 00:20:40
    trial it wasn't a randomized trial but
  • 00:20:42
    we had historical data on patients that
  • 00:20:44
    were in that in that practice and so we
  • 00:20:48
    put them on 4,000 units a day and we
  • 00:20:51
    monitored their levels and and then at
  • 00:20:54
    the end of the year they got to repeat
  • 00:20:56
    rectal biopsy for like you get for
  • 00:20:59
    prostate cancer and we looked at the the
  • 00:21:01
    cell grade and the retention or or the
  • 00:21:04
    how it progressed and in in
  • 00:21:08
    64% the tumors regressed wow wow and we
  • 00:21:14
    submitted this to Course New England
  • 00:21:15
    Journal and they wanted nothing to do
  • 00:21:17
    with it so we submit it it finally got
  • 00:21:19
    published in the journal of clinical
  • 00:21:21
    endocr endocrinology and Metabolism
  • 00:21:23
    which is a respectable uh endocrine
  • 00:21:26
    journal and uh um
  • 00:21:29
    it really went nowhere I mean if it
  • 00:21:30
    would have been a drug that a drug
  • 00:21:32
    company had it would have been worth
  • 00:21:34
    billions
  • 00:21:35
    yeah so so when when people treat cancer
  • 00:21:39
    like that like prostate cancer 4,000 is
  • 00:21:42
    nothing I'm saying take 20,000 you know
  • 00:21:45
    or more because you got cancer you're
  • 00:21:47
    not dealing in normal physiology here
  • 00:21:50
    you you're in Pharmacology you know and
  • 00:21:52
    and the push back you get if you try to
  • 00:21:54
    put these trials well I'll give you an
  • 00:21:57
    example of a of a study called the
  • 00:21:59
    Sunshine study which is a study on
  • 00:22:03
    non-resectable colon
  • 00:22:05
    cancer okay run out of Harvard and
  • 00:22:08
    several other and and in those studies
  • 00:22:12
    they were they were giving vitamin D
  • 00:22:14
    prior to giving
  • 00:22:17
    chemotherapy and to see if if priming
  • 00:22:20
    these people with a level of vitamin D
  • 00:22:22
    prior to giving them chemal therapy had
  • 00:22:23
    an
  • 00:22:25
    effect and so sure enough I mean the
  • 00:22:28
    file stud being done but the initial
  • 00:22:29
    study that was published a couple of
  • 00:22:31
    years ago after the data was looked at
  • 00:22:34
    it basically extended the patients lives
  • 00:22:37
    by two months if you primed them with
  • 00:22:39
    vitamin D and it was only like 8,000
  • 00:22:43
    maybe 10,000 units a day you know which
  • 00:22:45
    at the time I I said to the primary
  • 00:22:47
    investigator on that study I said why
  • 00:22:49
    don't we really go for you know like
  • 00:22:53
    50,000 no and and the response I got
  • 00:22:56
    back is we can't get that through the
  • 00:22:57
    IRB
  • 00:22:59
    I said these people are D you're giving
  • 00:23:01
    them you know really potent
  • 00:23:03
    chemotherapeutic drugs and you're
  • 00:23:04
    worried about giving them you know
  • 00:23:06
    vitamin D yeah right God yeah they're
  • 00:23:10
    dying they got they're not GNA survive
  • 00:23:12
    you're trying to prolong their life they
  • 00:23:14
    you can't even operate on them because
  • 00:23:16
    they're too far along and you're worried
  • 00:23:18
    they're worried about giving them you
  • 00:23:19
    know a substantial and so be that as it
  • 00:23:23
    may even that the doses they gave in
  • 00:23:25
    conjunction with the chemotherapy
  • 00:23:26
    extended their lives by two months and
  • 00:23:29
    in cancer chemotherapy that's a big
  • 00:23:32
    deal okay drugs are approved on that
  • 00:23:35
    basis but it was funny because it was
  • 00:23:38
    sent to jam and and it was the initial
  • 00:23:41
    data the way it was analyzed by the
  • 00:23:43
    School of Public Health at Harvard
  • 00:23:44
    showed significance at like
  • 00:23:47
    0.0035 and and then jamama comes back
  • 00:23:50
    and says well we want you to do it this
  • 00:23:52
    way so do it that way and it comes back
  • 00:23:55
    like
  • 00:23:56
    0.045 or something and no no now we want
  • 00:23:59
    you to do it this way so then it comes
  • 00:24:01
    back at
  • 00:24:03
    0.051 and then they say okay that's good
  • 00:24:06
    but you got to say it's it's uh it's not
  • 00:24:10
    significant and we'll publish the
  • 00:24:13
    article the only thing that shows up in
  • 00:24:15
    the news was that vitamin D was not was
  • 00:24:18
    not significant in progressing in
  • 00:24:20
    treating the
  • 00:24:21
    cancer that's completely
  • 00:24:24
    false well it's it's not it's if you
  • 00:24:27
    look at if you look at your level of
  • 00:24:29
    significance like Point difference
  • 00:24:31
    between 0.005 and
  • 00:24:33
    051 so that's a that's 50 patients in a
  • 00:24:37
    thousand versus 51 patients in a I mean
  • 00:24:41
    it's just to get the it's just to get
  • 00:24:44
    the the term not significant into the
  • 00:24:47
    article holy macro so so what you're
  • 00:24:50
    saying all the time so what you're
  • 00:24:53
    saying is there there is some slight
  • 00:24:54
    resistance by these journals and I'm
  • 00:24:57
    being very sarcastic it's in the major
  • 00:24:59
    medical journals there is huge
  • 00:25:01
    resistance to
  • 00:25:02
    it there was an article that just came
  • 00:25:05
    out in Science magazine that showed that
  • 00:25:08
    vitamin D and the mechanism of how
  • 00:25:11
    through the microbiome it regulates
  • 00:25:13
    colon cancer and that actually got
  • 00:25:16
    published it it's h very technical okay
  • 00:25:19
    it's very technical but it shows the
  • 00:25:21
    mechanism how Vitamin D works at at at
  • 00:25:25
    at not at a not at an endocrine level
  • 00:25:27
    but this cellular level to regulate
  • 00:25:30
    cancer immunity in in in these
  • 00:25:33
    patients wow so so um as far as the um
  • 00:25:39
    storage of I I was under the assumption
  • 00:25:42
    that uh all this vitamin D gets stored
  • 00:25:45
    in your fat and then when you need it
  • 00:25:47
    the body pulls it out but that's no that
  • 00:25:49
    that's not that that's not true either
  • 00:25:54
    wow yeah fat soluble vitamin goes into
  • 00:25:57
    your fat when you need here and I've
  • 00:25:59
    even heard people in the old days saying
  • 00:26:00
    well you know what happens when you have
  • 00:26:02
    a bariatric surgery and you have a lot
  • 00:26:04
    of vitamin D and it pours in the vitamin
  • 00:26:06
    D toxic well that was totally
  • 00:26:08
    ridiculous I mean it doesn't it just it
  • 00:26:11
    you know it might Supply a little bit
  • 00:26:12
    but it not I mean maybe enough to to to
  • 00:26:17
    uh Supply the enderin portion for a
  • 00:26:20
    while but it definitely isn't enough to
  • 00:26:23
    supply the the cular portion because one
  • 00:26:26
    one of I think you even studied you you
  • 00:26:28
    tried to find vitamin D stored and you
  • 00:26:30
    couldn't find it or yeah we looked at we
  • 00:26:34
    looked at levels in fat so other things
  • 00:26:36
    are stored as Esters like fatty acid
  • 00:26:38
    esters and fat tissue so we we would
  • 00:26:41
    dose we would dose even humans and take
  • 00:26:44
    fat samples you know and and look for it
  • 00:26:48
    and it there was nothing special about
  • 00:26:50
    fat tissue about vitamin D being in
  • 00:26:52
    there I mean there was some in there
  • 00:26:54
    because it just distributes in tissues
  • 00:26:56
    in general but it wasn't anything
  • 00:26:58
    against a gradient where you had this
  • 00:26:59
    high level of vitamin D and fat tissue
  • 00:27:03
    wow you also mentioned the relationship
  • 00:27:05
    between vitamin D and um even the
  • 00:27:09
    endothelial layer in the inside of your
  • 00:27:11
    artery is becoming a bit
  • 00:27:13
    leaky yes some you know if you go back
  • 00:27:16
    several this wasn't my work but but it
  • 00:27:18
    it happened it was done by a group of
  • 00:27:21
    biochemists in um in
  • 00:27:23
    Utah and what they had uh they I believe
  • 00:27:27
    it's called cavernous M foration
  • 00:27:30
    syndrome where you have uh these leaky
  • 00:27:34
    vessels in your brain uh it's a it's a
  • 00:27:38
    metabolic defect and they leak fluid and
  • 00:27:41
    these guys were looking for compounds
  • 00:27:43
    that would avert or be more therapeutic
  • 00:27:46
    so these endothelial vessels wouldn't
  • 00:27:49
    weak okay my coffee machine is turning
  • 00:27:51
    off here so that's the noise of the bat
  • 00:27:54
    de so anyway they they had this system
  • 00:27:57
    where they ran thousands of compounds
  • 00:27:59
    through this to test for this
  • 00:28:02
    leakage and uh and what they found was
  • 00:28:06
    they found two compounds one of which
  • 00:28:08
    was vitamin D which they were really
  • 00:28:09
    disappointed by because uh you know good
  • 00:28:15
    old vitamin D with a stabilizer of
  • 00:28:17
    endothelial function meaning it stopped
  • 00:28:20
    the leakage and it was and the
  • 00:28:23
    interesting thing there was the parent
  • 00:28:24
    compound vitamin D itself was the most
  • 00:28:26
    potent
  • 00:28:28
    wow not to other forms but vitamin D
  • 00:28:32
    itself so you talk about the ones in
  • 00:28:34
    supplements who getting it from the Sun
  • 00:28:36
    yeah the one we're getting from the Sun
  • 00:28:38
    or in your vitamin supplement was the
  • 00:28:40
    most potent at at overcoming this
  • 00:28:42
    endothelial function you know one of the
  • 00:28:45
    other things that we did in our
  • 00:28:46
    pediatric work was in it has to do with
  • 00:28:49
    human lactation yeah so you know when I
  • 00:28:54
    go back to my graduate school days and I
  • 00:28:56
    was you know I was you know not the best
  • 00:28:59
    student because I always question my
  • 00:29:01
    mentors you know and so we were taught
  • 00:29:04
    and I was a I was a nutritional
  • 00:29:06
    biochemist by training and in the
  • 00:29:08
    training you I they would teach well you
  • 00:29:11
    know cuan milk is the perfect food for
  • 00:29:14
    the nursing infant except for one thing
  • 00:29:16
    they could get rickets if they take it
  • 00:29:18
    so you got to give them a supplement I I
  • 00:29:21
    thought that makes no sense whatsoever
  • 00:29:23
    right why how could that be and so you
  • 00:29:26
    know at time goes on and we we you know
  • 00:29:30
    we we do research and it goes for
  • 00:29:32
    decades and finally we figured out that
  • 00:29:35
    to overcome this
  • 00:29:36
    problem the mothers were taken too
  • 00:29:39
    little vitamin D by the recommendations
  • 00:29:40
    that were being made by the different
  • 00:29:43
    organizations so once we could measure
  • 00:29:46
    the stuff in milk and blood and look at
  • 00:29:48
    how much was passed into the milk from
  • 00:29:50
    the blood and um and it turned out that
  • 00:29:55
    that you a nursing a woman who's
  • 00:29:57
    lactating needs to take about 6,000
  • 00:30:00
    units a
  • 00:30:01
    day to pass enough vitamin D into her
  • 00:30:04
    milk to satisfy her infant and then the
  • 00:30:06
    infant doesn't need any doesn't need
  • 00:30:09
    drops every day she's getting enough
  • 00:30:11
    from the mother mother's taking 6,000
  • 00:30:14
    units a day and actually that has been
  • 00:30:17
    implemented in pediatric practice to
  • 00:30:20
    some degree on Progressive pediatricians
  • 00:30:22
    who actually pay attention so it's an
  • 00:30:25
    option now instead of giving uh instead
  • 00:30:28
    of giving uh the nursing infant 400
  • 00:30:31
    units drops because mother's vitamin D
  • 00:30:33
    is enough because she deficient herself
  • 00:30:36
    I I wonder if this postpartum depression
  • 00:30:38
    is related to this vitamin D because low
  • 00:30:42
    vitamin D it's possible we looked at
  • 00:30:44
    some of that but uh in our studies that
  • 00:30:47
    we ran in pregnancy but you know it's
  • 00:30:50
    it's possible but our numbers we didn't
  • 00:30:52
    have enough to really make an assessment
  • 00:30:54
    if that's true or not but it's possible
  • 00:30:56
    because vitamin D has neural
  • 00:31:00
    effects how does um this this idea of
  • 00:31:04
    vitamin D resistance on top of all these
  • 00:31:06
    other issues we have vitamin D
  • 00:31:08
    resistance you have the vitamin D
  • 00:31:09
    receptor you have certain microbes like
  • 00:31:13
    that are involved in limes disease you
  • 00:31:15
    have epin bar virus that that
  • 00:31:17
    competitively downgrade receptors on top
  • 00:31:20
    of everything else have you looked into
  • 00:31:23
    that uh I haven't I mean they're
  • 00:31:26
    hereditary they're there are people who
  • 00:31:29
    have hereditary resistance because their
  • 00:31:31
    receptors are metabolic metabolically
  • 00:31:33
    inactive yeah uh you know um it again
  • 00:31:38
    it's possible
  • 00:31:40
    but to look at those kinds of studies or
  • 00:31:43
    to run first of all at this point in
  • 00:31:45
    time nobody's getting any money to run
  • 00:31:47
    any more vitamin D trials it's over okay
  • 00:31:50
    really yeah it's over you can't you
  • 00:31:53
    can't even find a student a student who
  • 00:31:56
    would go into somebody LA to study
  • 00:31:58
    vitamin D metabolism is
  • 00:32:00
    committing career
  • 00:32:03
    suicide because you're not and this
  • 00:32:05
    isn't just in the US it's in Britain too
  • 00:32:08
    the vital study and these these articles
  • 00:32:10
    like Scientific American had totally
  • 00:32:13
    decimated vitamin D
  • 00:32:15
    research and trials are expensive to
  • 00:32:18
    run uh the government won't fund them
  • 00:32:21
    drug companies don't want them they
  • 00:32:23
    don't even want them run okay because
  • 00:32:25
    they compete with uh with drug that they
  • 00:32:28
    have in development such as the the
  • 00:32:30
    drugs for prostate cancer you have one
  • 00:32:33
    that's free that is that is pretty good
  • 00:32:35
    at at suppressing prostate cancer and uh
  • 00:32:39
    it doesn't cost anything you think the
  • 00:32:41
    pharmaceutical companies want that
  • 00:32:42
    knowledge out there it's criminal
  • 00:32:45
    totally criminal or or or in vitamin D
  • 00:32:48
    in in preventing pre-term birth or
  • 00:32:52
    complications there was a drug called
  • 00:32:55
    McKenna that was 177 hydroxy
  • 00:32:58
    progesterone remember that one isn't
  • 00:33:00
    that for cancer that was for cancer no
  • 00:33:02
    no this was for prevention of pre-term
  • 00:33:04
    birth okay okay it was injectable it was
  • 00:33:09
    I don't know what company made it it was
  • 00:33:11
    a small biotech company back in
  • 00:33:14
    2010 this company was uh was bought out
  • 00:33:18
    by a bigger company and it was U uh they
  • 00:33:20
    had this one drug 7 17 hydroxy
  • 00:33:23
    progesterone which was called McKenna it
  • 00:33:25
    was approved as a speedy uh approval by
  • 00:33:29
    the FDA there was only one problem it
  • 00:33:32
    never
  • 00:33:33
    worked it was expensive and it was a
  • 00:33:36
    absolute abject failure and two years
  • 00:33:39
    ago the FDA pulled made him pull it from
  • 00:33:41
    the
  • 00:33:43
    market and was it a progesterone or was
  • 00:33:46
    it a it was 17 hydroxy progesterone you
  • 00:33:49
    can look it up you you can you can look
  • 00:33:51
    at the history of it and uh so it was
  • 00:33:55
    doing they were proposing a something
  • 00:33:58
    that vitamin D actually does which was
  • 00:34:00
    appropriate vitamin D levels can reduce
  • 00:34:02
    pre- birth but it's free wow there's no
  • 00:34:07
    money in it no and it's yeah so yeah um
  • 00:34:11
    you also mentioned in in one of your
  • 00:34:13
    videos um um it's important to also
  • 00:34:16
    realize that vitamin D needs magnesium
  • 00:34:18
    as the
  • 00:34:19
    co-actor it does yeah it it uh you know
  • 00:34:24
    I I reviewed a lot of papers years ago
  • 00:34:26
    and I remember reviewing is one that
  • 00:34:28
    clearly showed that magnesium status was
  • 00:34:30
    a was a a potentiator of improving
  • 00:34:35
    metabolism of vitamin D within the
  • 00:34:38
    cells meaning it was a simple thing so
  • 00:34:41
    people who had better magnesium status
  • 00:34:43
    also had higher levels of the
  • 00:34:45
    intermediate form of vitamin D to 25d
  • 00:34:47
    form that you get measured and so I
  • 00:34:50
    myself was taking a a fair amount of
  • 00:34:53
    vitamin D but I really wasn't that
  • 00:34:56
    satisfied of of what my blood levels
  • 00:34:58
    were and there and I I I mentioned that
  • 00:35:02
    what people take is very individualistic
  • 00:35:05
    of how you respond some people are
  • 00:35:07
    really good metabolites some people AR
  • 00:35:10
    aren't as good they need to take a lot
  • 00:35:12
    more to get their blood levels you you
  • 00:35:14
    only know what it is if you haven't
  • 00:35:15
    tested and so I started taking magnesium
  • 00:35:18
    and and instantly increased my blood
  • 00:35:20
    levels by about
  • 00:35:23
    40% and there's no there's really no way
  • 00:35:26
    to know if your magnesium repete because
  • 00:35:28
    it's a blood measures don't really tell
  • 00:35:30
    so the only way to know it is I take I
  • 00:35:33
    think 400 milligrams a day of magnesium
  • 00:35:36
    oxides Ju Just A supplement every day
  • 00:35:39
    that and and then you know your vitamin
  • 00:35:41
    your magnesium repete for now other
  • 00:35:43
    reasons just vitamin
  • 00:35:46
    D so it's a key coor it's a what key
  • 00:35:50
    co-actor yeah and in the metabolism of
  • 00:35:53
    vitamin D so it interacts the enzyme
  • 00:35:57
    that act activates vitamin D that
  • 00:35:59
    there's two or three of them need that
  • 00:36:01
    magnesium it's a proactor absolutely
  • 00:36:04
    have you ever done any research on
  • 00:36:06
    vitamin D and
  • 00:36:08
    mitochondria I I
  • 00:36:10
    haven't well vitamin so vitamin D the
  • 00:36:13
    there's two different enzymes one of
  • 00:36:15
    them is located in the mitochondria and
  • 00:36:17
    one of them is located in the microsomes
  • 00:36:19
    different cellular components so that's
  • 00:36:22
    that's where that's where these enzymes
  • 00:36:24
    that activate vitamin D are within the
  • 00:36:26
    cell one in the mitochondria
  • 00:36:28
    at one of the micr oh wow that's kind of
  • 00:36:30
    important the mitochondria as far as
  • 00:36:34
    I'll have to look where that's what that
  • 00:36:36
    does or what if it how it influences the
  • 00:36:38
    mitochondria which
  • 00:36:40
    is so so much of a problem with so many
  • 00:36:43
    people if someone takes a higher doses
  • 00:36:47
    uh like a large dose of uh vitamin D3
  • 00:36:49
    isn't it isn't there uh some mechanism
  • 00:36:53
    that it does turn turn into inert
  • 00:36:57
    compounds I think I uh it was one was
  • 00:37:00
    called um tacol or
  • 00:37:04
    lumisol well those those are things
  • 00:37:07
    those compounds are made in the skin by
  • 00:37:10
    sun exposure it's probably one of the
  • 00:37:12
    ways that the body regulates how much
  • 00:37:14
    vitamin D so so if you're if you're pale
  • 00:37:17
    as a ghost and you go out in the Summer
  • 00:37:20
    sun and and expose yourself to 20
  • 00:37:23
    minutes or so of intense sunlight on the
  • 00:37:26
    initial exposure you'll you'll make
  • 00:37:28
    about 20,000 units of vitamin D that'll
  • 00:37:31
    be released into your blood over the
  • 00:37:32
    next day okay but then you start tanning
  • 00:37:37
    and that exposure becomes less you know
  • 00:37:40
    you you the next day you'll make less
  • 00:37:42
    and less and less and and that's where
  • 00:37:45
    the the production of these tools and
  • 00:37:48
    and lumisterol and all these things uh
  • 00:37:52
    um probably assist
  • 00:37:55
    in Banting the effect of D made by the
  • 00:37:58
    Sun but in the body once you take once
  • 00:38:02
    you take vitamin
  • 00:38:04
    D I'm not sure it's metabolized into
  • 00:38:07
    those things I think it just disappears
  • 00:38:09
    you know the body will just excrete it
  • 00:38:11
    through the bile acid functions and then
  • 00:38:14
    activate it but those what you're
  • 00:38:16
    mentioning is a control point for the
  • 00:38:18
    sun solar uh production of vitamin D in
  • 00:38:22
    your skin okay and then as far as the
  • 00:38:26
    you know you have hyperal CIA um I think
  • 00:38:29
    they have exaggerated that a bit but U
  • 00:38:31
    what's your take on um toxic doses in in
  • 00:38:35
    the research on the tox you're gonna you
  • 00:38:37
    know even people are saying oh you're
  • 00:38:38
    taking 10,000 you're gonna you're gonna
  • 00:38:40
    get kidney stones like really well
  • 00:38:43
    vitamin D has never been associated in
  • 00:38:45
    studies with getting kidney
  • 00:38:47
    stones wow I mean most kidney stones are
  • 00:38:50
    oxalates I mean it it can I mean so if
  • 00:38:53
    you're taking if you're worried about
  • 00:38:54
    kidney stones and vitamin D uh and if
  • 00:38:58
    people are taking high doses say they're
  • 00:39:00
    taking 30 40 50,000 units for cancer my
  • 00:39:03
    my first my recommendation would be
  • 00:39:05
    limit your Dairy
  • 00:39:07
    intake okay the other thing is that
  • 00:39:10
    before anything happens in the blood it
  • 00:39:12
    happens in the urine
  • 00:39:14
    first so if you're worried about high
  • 00:39:17
    you know high blood calcium or too much
  • 00:39:20
    vitamin D you would have your urinary
  • 00:39:22
    calcium monitored as long as there's no
  • 00:39:25
    calcium being dumped into your urine you
  • 00:39:28
    don't have a
  • 00:39:30
    problem and at 20,000 units I mean there
  • 00:39:33
    are rare genetic defects that would
  • 00:39:36
    cause uh uh uh vitamin D to become toxic
  • 00:39:40
    and one of those is a an enzyme that
  • 00:39:43
    inactivates vitamin B called the 24
  • 00:39:46
    hydroxylase in the kidney and other
  • 00:39:48
    tissues and if you have a defect in that
  • 00:39:51
    enzyme then it's potentially you could
  • 00:39:54
    become toxic but those are really rare
  • 00:39:56
    defects so if we take those out of the
  • 00:39:59
    picture how many people really end up
  • 00:40:01
    getting hypercalcemia from we never saw
  • 00:40:06
    one and all and we our studies that we
  • 00:40:10
    did in pregnancy and lactation when when
  • 00:40:13
    I propose to do these studies and back
  • 00:40:15
    then you could get this is in the early
  • 00:40:16
    2000s so when we propos to do these
  • 00:40:19
    studies in pregnancy and and and
  • 00:40:22
    pregnancy is most sensitive group you
  • 00:40:24
    can do studies in so we were proposing
  • 00:40:27
    in these studies that we were going to
  • 00:40:28
    give pregnant women 4,000 units a day
  • 00:40:30
    because that's what we calculated they
  • 00:40:32
    would need uh to become sufficient it's
  • 00:40:35
    probably low but you know you have to
  • 00:40:36
    start somewhere and at the time 2,000
  • 00:40:39
    units was the UL mean upper limit of
  • 00:40:41
    safety so we proposed 4,000 and and so
  • 00:40:45
    the the granting agency saw yeah this
  • 00:40:47
    Grant's great but we you can't do this
  • 00:40:49
    you'll kill
  • 00:40:51
    people so we said no we won't and so the
  • 00:40:54
    the the funding agency said we
  • 00:40:57
    conditionally approved this grant if you
  • 00:40:58
    go to the FDA and get an IND number
  • 00:41:02
    investigational drug number that's a
  • 00:41:04
    drug companies have to do when they come
  • 00:41:06
    up with new drugs we had to do it for
  • 00:41:08
    vitamin
  • 00:41:09
    D okay and we did it we we submitted an
  • 00:41:12
    IND it delayed the study by a year and
  • 00:41:15
    the U and the FDA granted our indd
  • 00:41:20
    application and as a consequence we had
  • 00:41:23
    massive monitoring we had monitoring
  • 00:41:25
    committees we had to report to FDA every
  • 00:41:28
    month and we never saw an adverse event
  • 00:41:32
    due to vitamin D supplementation and a
  • 00:41:35
    lot of other people used our IND for
  • 00:41:37
    other things other you know there were
  • 00:41:40
    all kinds of studies going on never once
  • 00:41:43
    was a an intake to we saw hyper Calum or
  • 00:41:48
    hypercal if if we saw it usually was due
  • 00:41:51
    to something like dehydration but it was
  • 00:41:53
    never due to vitamin D supplementation
  • 00:41:56
    in
  • 00:41:57
    incredible um know knowing the
  • 00:42:01
    importance of vitamin D like I it's a
  • 00:42:04
    one of the probably the most important
  • 00:42:06
    vitamins how did you stumble on start
  • 00:42:09
    doing research on vitamin D did you know
  • 00:42:11
    this in advance how important vitamin D
  • 00:42:13
    was for the body news started when I was
  • 00:42:15
    a graduate student at Ohio State
  • 00:42:17
    University and at the time I was in I
  • 00:42:19
    was in uh Agriculture and uh my adviser
  • 00:42:23
    at the time they were looking at a at in
  • 00:42:26
    in C CLE there's a disease called milk
  • 00:42:28
    fever it's called parrian paresis and
  • 00:42:31
    what happens is these dairy cattle are
  • 00:42:34
    bred to make massive amounts of
  • 00:42:36
    milk okay physiologically it's it's
  • 00:42:40
    physiologically it's not sustainable and
  • 00:42:43
    what happens in those cattle is they go
  • 00:42:45
    through more and more
  • 00:42:46
    lactations they become they can't
  • 00:42:48
    maintain serum calcium once lactation is
  • 00:42:51
    initiated because their blood levels of
  • 00:42:53
    calcium
  • 00:42:54
    plummet and and it turns out why that
  • 00:42:57
    happens is they're they they need to
  • 00:43:01
    mobilize bone calcium and as they get
  • 00:43:04
    older and into more and more lactation
  • 00:43:06
    Cycles it becomes impossible for them to
  • 00:43:08
    do it so once they initiate lactation
  • 00:43:11
    their blood calcium would drop to four
  • 00:43:13
    or five and they just Keel over and lay
  • 00:43:15
    there because they're you know they're
  • 00:43:18
    paralyzed and then the farmer would have
  • 00:43:20
    to dose them with high doses of calcium
  • 00:43:23
    and then the cow would stand right up
  • 00:43:25
    and then it would fall again the cow
  • 00:43:26
    would fall down so and when this happens
  • 00:43:29
    it's a big economic loss because you
  • 00:43:31
    know they got to get the cow can't breed
  • 00:43:34
    anymore and the cow can't make milk and
  • 00:43:36
    so they looked at ways to make it better
  • 00:43:38
    for the cow not to go into this
  • 00:43:41
    condition and one of the ways was to
  • 00:43:43
    give them really huge levels of vitamin
  • 00:43:46
    D uh to make it stop and it was
  • 00:43:48
    successful to some degree but there were
  • 00:43:50
    other things that were better but that's
  • 00:43:51
    how I got into this and then and then I
  • 00:43:54
    I I of course went more towards human
  • 00:43:56
    nutrition and I got I was interested in
  • 00:43:58
    the milk issue and I was interacting
  • 00:44:01
    with with uh people in in Pediatrics and
  • 00:44:05
    you know the first grant we came up with
  • 00:44:07
    it's interesting so the the first grant
  • 00:44:09
    back in what I was telling you about the
  • 00:44:11
    FDA are it was basically a safety study
  • 00:44:14
    that we were designing to look at and
  • 00:44:16
    and based around skeleton at that time
  • 00:44:19
    we didn't even know to ask the questions
  • 00:44:22
    about does vitamin D prevent pre-term
  • 00:44:24
    birth and and and uh preclampsia and and
  • 00:44:28
    pre-term diabetes and all this other
  • 00:44:30
    stuff so we ran a study and when the
  • 00:44:33
    data were analyzed this was uh uh this
  • 00:44:36
    is where it was it's frowned upon they
  • 00:44:39
    said we analyzed the data and we said
  • 00:44:41
    look at this vitamin D is is uh
  • 00:44:44
    preventing pre-term birth and it's
  • 00:44:46
    preventing complications of birth and I
  • 00:44:48
    presented it at a meeting it was in 2009
  • 00:44:50
    and and I mean the audience went crazy
  • 00:44:54
    in the wrong
  • 00:44:56
    way I mean I was attacked how dare you
  • 00:44:58
    say this you know this is heresy this
  • 00:45:01
    can't be true you know I mean it was
  • 00:45:04
    incredible so when you when you
  • 00:45:06
    introduce data like that you better be
  • 00:45:08
    prepared to be hammered wow
  • 00:45:12
    wow and then and then you know since
  • 00:45:15
    that time it's been basically it's shown
  • 00:45:18
    uh there was an article that's in that
  • 00:45:20
    uh uh that was we did called the vdart
  • 00:45:23
    study at Harvard it was done with Scott
  • 00:45:25
    Weiss who was a world rown asthma
  • 00:45:27
    specialist and we found out that vitamin
  • 00:45:30
    D could you could if you give enough
  • 00:45:32
    vitamin D especially like preconception
  • 00:45:35
    you could basically eliminate childhood
  • 00:45:39
    asthma but no one will you know you know
  • 00:45:42
    the the data are clear if you analyze it
  • 00:45:45
    in the appropriate fashion like is
  • 00:45:47
    discussed in this Townson newsletter
  • 00:45:49
    article and even wise chimes in and and
  • 00:45:52
    we learned a lot from that study like we
  • 00:45:53
    do from all these studies that you
  • 00:45:56
    needed to give more needed to correct
  • 00:45:57
    Baseline levels and you could you could
  • 00:46:01
    you know there would hardly ever be
  • 00:46:02
    another asthma childhood asthma child
  • 00:46:04
    born if the mothers were replete when
  • 00:46:06
    they conceived or even started taking it
  • 00:46:09
    early in in when they found out they're
  • 00:46:11
    pregnant uh you know most of our studies
  • 00:46:14
    were in the first trimester because
  • 00:46:16
    that's when they walk in and they figure
  • 00:46:18
    out they're pregnant you know you can't
  • 00:46:20
    to do pre-term or preconception studies
  • 00:46:23
    is hugely but that's when it would be
  • 00:46:26
    most
  • 00:46:28
    because the vitamin D deficiency in the
  • 00:46:29
    trials that we run is mostly missed in
  • 00:46:31
    the first trimester because you don't
  • 00:46:32
    even woman don't know they're pregnant
  • 00:46:34
    so you're only getting a hold of 12
  • 00:46:36
    weeks or so or maybe later than
  • 00:46:40
    that I think it's probably the most
  • 00:46:42
    important time to eat healthy and get
  • 00:46:45
    enough nutrition is when you're not born
  • 00:46:48
    before you're born yeah um incredible so
  • 00:46:55
    um wow I'm just
  • 00:46:58
    I mean it leaves you speechless because
  • 00:47:00
    you you you you have this knowledge and
  • 00:47:03
    you know and it's going away because you
  • 00:47:07
    can't nobody else can do followup brants
  • 00:47:09
    on this
  • 00:47:10
    anymore because when it goes to this the
  • 00:47:12
    government first of all the the
  • 00:47:14
    government won't you know these studies
  • 00:47:16
    that we did they cost
  • 00:47:17
    Millions uh the vital study was 30 35
  • 00:47:21
    million maybe more of to me it was
  • 00:47:23
    totally wasted money because it was our
  • 00:47:25
    studies that we did in pregnancy were
  • 00:47:28
    probably over the terms of the grants
  • 00:47:30
    were five or six million doar to do
  • 00:47:32
    these clinical studies and government
  • 00:47:35
    isn't going to Shell out that kind of
  • 00:47:36
    money anymore and the drug companies
  • 00:47:38
    will pay him not to do it
  • 00:47:41
    incredible incredible so you either
  • 00:47:43
    accept the data that we have now and and
  • 00:47:45
    I think that people should also not only
  • 00:47:47
    look at the randomized trial data that
  • 00:47:50
    that we did and and the one in and the
  • 00:47:52
    things that were done overseas where you
  • 00:47:54
    had true vitamin D deficiency you could
  • 00:47:56
    do do a real randomized trial and not
  • 00:48:00
    have it compromised by what levels were
  • 00:48:02
    in these women in the beginning and and
  • 00:48:04
    the the the other thing in our country
  • 00:48:07
    is non-compliance of the patients is a
  • 00:48:09
    serious
  • 00:48:11
    issue they don't comply oh yeah doc I
  • 00:48:14
    took the vitamin one in fact they never
  • 00:48:16
    took it at all and and you know here's
  • 00:48:19
    the other thing in intent to treat if
  • 00:48:20
    you know that those people aren't
  • 00:48:22
    complying you can't eliminate them from
  • 00:48:23
    the data analysis what no that violates
  • 00:48:27
    the intent to treat
  • 00:48:29
    Mar
  • 00:48:31
    wow wow these are this is this is this
  • 00:48:34
    is stuff that people don't know they
  • 00:48:36
    have no clue unless you're in the
  • 00:48:37
    research field so I guess in certain
  • 00:48:40
    parts of other countries around the
  • 00:48:42
    world there's probably maybe places
  • 00:48:44
    where you hopefully they'll continue
  • 00:48:46
    doing vitamin D research I don't know
  • 00:48:48
    yeah I mean you know like I said there's
  • 00:48:50
    stuff still going on in Iran you know
  • 00:48:53
    where where those countries really have
  • 00:48:56
    a really big vitamin D deficiency
  • 00:48:58
    problem because the lifesty women are in
  • 00:48:59
    barkers and they're not allowed to be in
  • 00:49:02
    the Sun and so you have a in in in
  • 00:49:04
    places in India the same way right what
  • 00:49:06
    about Saudi Arabia yeah Saudi Arabia too
  • 00:49:10
    any any of the Muslim countries where
  • 00:49:12
    they where the where the females are are
  • 00:49:15
    restricted uh have a horrible vitamin D
  • 00:49:17
    deficiency problem well you got me
  • 00:49:20
    thinking about that because they you
  • 00:49:22
    have compounded by all the diabetes they
  • 00:49:25
    have no sun no vitamin D yeah
  • 00:49:31
    incredible is there is there anything
  • 00:49:33
    else that that you want to U end off
  • 00:49:35
    with that you want people to know about
  • 00:49:37
    this has just been mind-blowing and I'm
  • 00:49:40
    gonna I I think that the only not that
  • 00:49:42
    you're never going to get well I can't
  • 00:49:44
    say never because my like my physician
  • 00:49:47
    is pretty Progressive on all this stuff
  • 00:49:50
    so there are Physicians that that are
  • 00:49:53
    but the ones who depend on their
  • 00:49:55
    professional organizations for
  • 00:49:56
    recommendations like the geriatric
  • 00:49:58
    Society like
  • 00:49:59
    OBGYN e even in in Pediatrics and if
  • 00:50:02
    they're only looking at the
  • 00:50:03
    recommendations coming out of those
  • 00:50:05
    professional societies which are solely
  • 00:50:08
    based on reports like the endocrine
  • 00:50:11
    Society like which just came out with
  • 00:50:13
    revised recommendations which are
  • 00:50:15
    ridiculous they're again they've they
  • 00:50:17
    they've decreased everything that people
  • 00:50:20
    should be taking uh going back to the
  • 00:50:22
    Institute of medicine 2010 which has
  • 00:50:24
    never been redone uh you know what you
  • 00:50:29
    you have to look at at at programs like
  • 00:50:31
    your own to educate people uh and
  • 00:50:36
    fortification is only done to highly
  • 00:50:38
    motivated
  • 00:50:40
    individuals you know or supplementation
  • 00:50:42
    I think fortification is a different
  • 00:50:44
    matter but until the government would
  • 00:50:45
    change you never you know we always
  • 00:50:47
    sought to get fortification of product
  • 00:50:49
    higher like milk for vitamin D like but
  • 00:50:52
    they don't they don't want to do it no
  • 00:50:55
    so and and and so supplementation is
  • 00:50:57
    only done is done by highly motivated
  • 00:51:00
    individuals and and how do you you know
  • 00:51:04
    how do you prove
  • 00:51:06
    prevention right you know you can look
  • 00:51:08
    at the you can look at uh observational
  • 00:51:10
    retrospective data and a lot of the data
  • 00:51:12
    that came out of the are you familiar
  • 00:51:14
    with the Physicians health study at
  • 00:51:16
    Harvard run by Walter Willet group I
  • 00:51:19
    mean it's been going since the mid 80s
  • 00:51:21
    it's health professional studies
  • 00:51:23
    basically it was Physicians or Nur nures
  • 00:51:27
    participated in this study and every
  • 00:51:29
    year they give a blood sample and every
  • 00:51:31
    year they fill a questionnaire what
  • 00:51:33
    happened to you this year did you have a
  • 00:51:34
    heart attack did you get cancer how you
  • 00:51:37
    know and then they had these blood
  • 00:51:38
    samples Bank millions of these samples
  • 00:51:41
    and what they do is then they say okay
  • 00:51:44
    we want to look at this disease related
  • 00:51:46
    to this compound and there's been a
  • 00:51:48
    number of those studies done on vitamin
  • 00:51:50
    D mostly all positive and and those data
  • 00:51:54
    are really valuable okay because those
  • 00:51:57
    look at lifestyle over a long period of
  • 00:51:59
    change but they're
  • 00:52:00
    discarded when you when studies like
  • 00:52:03
    vital say
  • 00:52:05
    yes are they still doing that study now
  • 00:52:07
    or are they is yes yeah health
  • 00:52:09
    professional study still
  • 00:52:11
    Ono okay yeah I think he's he's he was
  • 00:52:15
    involved in the what the the planetary
  • 00:52:17
    Health diet the new planetary Health
  • 00:52:19
    diet yeah oh yeah well it's involved in
  • 00:52:22
    everything the most cited scientist on
  • 00:52:25
    you know in the history of science
  • 00:52:26
    science incredible and I know Walter
  • 00:52:28
    will I've interacted with him in the
  • 00:52:30
    past quite a bit on this stuff he
  • 00:52:32
    definitely gets a lot of funding but but
  • 00:52:34
    that study that that that that those
  • 00:52:36
    health professional studies were a gold
  • 00:52:38
    mine I mean and extraordinary
  • 00:52:41
    value you know not a randomized trial
  • 00:52:44
    but there's a lot of data in there that
  • 00:52:46
    should be paid to attention should be
  • 00:52:49
    paid attention to yeah well I'm sure
  • 00:52:52
    it'll get published if if vitamin D is
  • 00:52:54
    not favorable
  • 00:53:00
    wow this has been incredible thank you
  • 00:53:02
    so much for taking your time to uh do
  • 00:53:04
    this and you're welcome I'm going to put
  • 00:53:05
    that link down below of that article
  • 00:53:08
    from the Townson report so everyone can
  • 00:53:10
    check it out but thank you so much
Tags
  • Vitamin D
  • Bone Health
  • Cancer Prevention
  • Paracrine System
  • Autocrine System
  • Research Challenges
  • Supplementation
  • Pregnancy
  • Lactation
  • Endocrine Function