Mark Mofid MD - Plastic & Reconstructive Surgeon

00:56:55
https://www.youtube.com/watch?v=nMPtxUKwYeI

Sintesi

TLDRCe podcast explore l'innovation dans le domaine des soins de santé, en mettant l'accent sur une technologie révolutionnaire basée sur la soie pour les pansements et les fermetures de plaies. Le Dr Mark Mori, chirurgien plastique renommé et professeur, partage son expérience avec cette innovation biologique qui réduit les taux d'infection et surpasse les solutions existantes comme les Steri-Strips ou les adhésifs à base de cyanoacrylate. Avec des propriétés uniques telles que l’hypoallergénicité, la soie se positionne comme une alternative économique et efficace pour les pansements, prolongeant même son potentiel aux greffes cutanées et aux applications militaires. En parallèle, le podcast aborde l'utilisation des technologies interdisciplinaires telles que l'holographie pour améliorer le diagnostic et l'éducation médicale.

Punti di forza

  • 🎯 La soie est une innovation majeure dans les pansements modernes.
  • 🔬 Elle réduit le risque d'infections et d'allergies.
  • 💰 Une alternative économique aux techniques actuelles.
  • 🌍 Adaptée aux pays en développement grâce à son coût réduit.
  • 🔗 Collaboration interdisciplinaire essentielle.
  • 📈 Croissance rapide et adoption par les grands systèmes de santé.
  • 🧬 Potentiel pour les zones spécifiques comme les greffes cutanées.
  • 🚑 Efficace dans les soins militaires et d'urgence.
  • 🛠️ Défi : surmonter les technologies obsolètes comme les Steri-Strips.
  • 📡 Holographie utilisée pour l'éducation et le diagnostic.

Linea temporale

  • 00:00:00 - 00:05:00

    Introduction du webcast et présentation de la mission de la chaîne MedBricks visant à combler les lacunes dans les soins de santé grâce à une réflexion interdisciplinaire et des interviews avec les leaders du secteur.

  • 00:05:00 - 00:10:00

    Présentation de l'invité Dr. Mark Mori, chirurgien plasticien reconstruit, et de son parcours académique impressionnant. Mention de son intérêt entrepreneurial pour la technologie à base de soie pour le soin des plaies.

  • 00:10:00 - 00:15:00

    Rappel du parcours éducatif du Dr. Mori allant de Caltech à Harvard et Johns Hopkins, et de son passage à l'industrie pour développer des innovations en soin des plaies basées sur la soie.

  • 00:15:00 - 00:20:00

    Discussion du lancement commercial de la technologie des pansements en soie, de son adoption rapide dans différentes disciplines chirurgicales, et des améliorations significatives constatées dans le soin des plaies.

  • 00:20:00 - 00:25:00

    Description des propriétés uniques de la soie fibroïne, de son historique d'utilisation médicale, et des défis observés avec les technologies actuelles comme le cyanoacrylate.

  • 00:25:00 - 00:30:00

    Explication des nuances autour de la régulation FDA, des essais cliniques sur la soie, et des limitations des technologies concurrentes telles que le Cyanoacrylate.

  • 00:30:00 - 00:35:00

    Examen des coûts des complications chirurgicales associées aux infections et autres problèmes de cicatrisation, et comment les innovations du Dr. Mori visent à réduire ces coûts avec la technologie de la soie.

  • 00:35:00 - 00:40:00

    Analyse comparative de la technologie à base de soie avec d'autres solutions comme le cuivre ou le boron, mettant en avant les avantages biologiques et économiques de la fibroïne de soie.

  • 00:40:00 - 00:45:00

    Discussion avec des experts sur le potentiel de la soie pour d'autres applications, y compris les sites donneurs de greffes de peau, et exploration de son évolutivité et de son coût compétitif.

  • 00:45:00 - 00:50:00

    Description d'innovations médicales futures possibles dans des champs interdisciplinaires et des discussions sur la résistance apparente dans l'adoption de solutions innovantes comme celle du Dr Mori.

  • 00:50:00 - 00:56:55

    Présentation finale des contributions du Dr Mori dans la transformation des soins des plaies grâce à la soie et encouragement des pratiques innovantes dans la médecine en général.

Mostra di più

Mappa mentale

Video Domande e Risposte

  • Quel est l'objectif principal de cette émission ?

    L'objectif de l'émission est d'explorer des approches innovantes en soins de santé, notamment une technologie basée sur la soie pour la cicatrisation des plaies.

  • Qui est le Dr Mark Mori ?

    Le Dr Mark Mori est un chirurgien plastique et reconstructif renommé qui a travaillé sur une technologie à base de soie pour les soins des plaies.

  • Quelles sont les propriétés uniques de la soie en médecine ?

    La soie possède des propriétés hypoallergéniques, antibactériennes et hydrophobes, ce qui en fait un matériau idéal pour les pansements et les fermetures de plaies.

  • Quels sont les défis actuels en matière de soins des plaies ?

    Les défis incluent des taux élevés d’infections chirurgicales, des réactions allergiques aux matériaux traditionnels comme les cyanacrylates, et un manque d'innovation dans les pansements.

  • Quels sont les avantages économiques des technologies à base de soie ?

    Les produits à base de soie sont moins coûteux à fabriquer, tout en offrant de meilleurs résultats cliniques et en réduisant les coûts associés aux infections et complications.

  • Le Dr Mori a-t-il mentionné des applications futures pour la soie ?

    Oui, il estime que la soie peut être utilisée dans des domaines comme les sites donneurs de greffes de peau et les applications hémostatiques.

  • Quelles innovations technologiques ont été discutées pendant l'émission ?

    Outre la soie, on a discuté de l'utilisation de l'holographie pour le diagnostic et l'éducation en médecine.

  • Quels sont les impacts des pansements traditionnels comme les Steri-Strips ?

    Les Steri-Strips présentent des taux d'échecs élevés, provoquent des infections et des réactions cutanées allergiques, et sont surpassés par les nouvelles technologies à base de soie.

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    day Healthcare challenges on our
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    live hey welcome welcome to the medb
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    webcast this Raman Anam Raju I'm the
  • 00:02:22
    host you know with a with the accent you
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    know so I have a very distinguished
  • 00:02:27
    guest today he joining from San
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    right in California right here but um
  • 00:02:33
    before that I just want to mention a
  • 00:02:35
    little bit about um the podcast you know
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    the this is a you know been very
  • 00:02:40
    passionate about this podcast and I I
  • 00:02:42
    interview a lot of doctors on this
  • 00:02:44
    podcast this is for the doctors watching
  • 00:02:46
    other doctors what their journey is from
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    the beginning to the to the to this
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    point you know that is a focus of the
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    podcast but anyway the um let me you
  • 00:02:57
    know the the the I'm into I'm going to
  • 00:03:01
    you know bring Dr Mark Mori is a plastic
  • 00:03:04
    surgeon reconstructive plastic surgeon
  • 00:03:06
    world renowned Sergeant he has he went
  • 00:03:10
    to Harvard then after that John John
  • 00:03:13
    Hopkins then he moved to the you know he
  • 00:03:16
    Now assistant clinical assistant
  • 00:03:18
    professor in the in John Hopkins
  • 00:03:21
    University you know one of the
  • 00:03:23
    prestigious IV League schools so he is
  • 00:03:25
    coming from Santiago actually and then
  • 00:03:27
    he is now became a join in the
  • 00:03:30
    entrepreneur Silicon Valley disease you
  • 00:03:33
    got it now it is a is is
  • 00:03:36
    entrepreneurship he started involved in
  • 00:03:39
    a a new company called Silk you know
  • 00:03:42
    silk has wound care is one of them we
  • 00:03:45
    really obvious in front of us and we
  • 00:03:47
    don't we don't really realize it for
  • 00:03:50
    example silk is used in China in India
  • 00:03:53
    for a long time as a wound dressing so
  • 00:03:56
    wound care is one of these passions
  • 00:03:58
    we're going to talk with him about that
  • 00:04:00
    so like Boron one of the examples is so
  • 00:04:03
    these are obvious things we really not
  • 00:04:05
    realized how much important in wound
  • 00:04:07
    care all these things are let me bring a
  • 00:04:10
    Dr Mark mid to the stage uh Dr mid
  • 00:04:14
    welcome welcome to the med of CER thank
  • 00:04:17
    you very much it's honor to have you
  • 00:04:20
    appreciate the opportunity thank you
  • 00:04:21
    tell us a little bit of your journey
  • 00:04:23
    from east coast to the West Coast all
  • 00:04:25
    the way can you can you tell us a little
  • 00:04:27
    bit where you from originally or sure um
  • 00:04:31
    you know I usually start out um these
  • 00:04:33
    talks I I'm doing uh presentations at
  • 00:04:36
    academic centers really all over the
  • 00:04:38
    United States in fact tomorrow I'm going
  • 00:04:40
    to the University of Pennsylvania and um
  • 00:04:42
    presenting this New Concept about um
  • 00:04:45
    silk and wound care uh to the Department
  • 00:04:48
    of orthopedic surgery at the University
  • 00:04:49
    of
  • 00:04:50
    Pennsylvania um and I usually start out
  • 00:04:52
    these presentations by saying I'm one of
  • 00:04:54
    you you know I'm exactly like you and
  • 00:04:57
    I'm speaking with medical students with
  • 00:04:58
    residents um with people that have been
  • 00:05:00
    practi for a while people academic
  • 00:05:02
    institutions but you know my background
  • 00:05:04
    is um I I grew up in Southern California
  • 00:05:08
    um I uh took courses at California
  • 00:05:11
    Institute of Technology keltech uh for
  • 00:05:14
    many years um really from the time I was
  • 00:05:16
    12 until I was 18 years old every summer
  • 00:05:18
    and every Saturday uh I used to attend
  • 00:05:21
    uh classes in um physics and calculus
  • 00:05:24
    and chemistry and um what have you at
  • 00:05:26
    Caltech and um I did my undergraduate
  • 00:05:29
    degree at Harvard
  • 00:05:30
    and I graduated in 1993 I then started
  • 00:05:33
    medical school um at the Johns Hopkins
  • 00:05:36
    school of medicine I was there for a
  • 00:05:37
    period of 11 years until 2004 I went
  • 00:05:41
    into practice uh in San Diego primarily
  • 00:05:43
    in private practice and Consulting for
  • 00:05:46
    uh medical device companies um
  • 00:05:48
    specifically in the field of biologics
  • 00:05:50
    and also I served as part-time faculty
  • 00:05:53
    um as an associate professor at the
  • 00:05:54
    University of California San Diego for
  • 00:05:56
    about 15 years and then um became very
  • 00:06:00
    interested in um in uh really the uh
  • 00:06:05
    really very creative side of of what can
  • 00:06:07
    be done with um silk science um and have
  • 00:06:11
    been working on this project really for
  • 00:06:13
    about four and a half five years we've
  • 00:06:14
    been commercial for a little over a year
  • 00:06:17
    now but the Genesis of this goes back
  • 00:06:19
    really to
  • 00:06:20
    2013 um and I can tell you a little bit
  • 00:06:22
    about that story um but just the last
  • 00:06:25
    year um the since the commercial launch
  • 00:06:27
    of silk the company it's just really
  • 00:06:30
    been embraced um by many different
  • 00:06:33
    Specialties in surgery um I'm incredibly
  • 00:06:37
    excited to be a part of something that's
  • 00:06:39
    so rapidly growing you know the we we
  • 00:06:42
    were looking at you know since we've
  • 00:06:43
    been in practice since we've been
  • 00:06:44
    commercial now for a year at the growth
  • 00:06:46
    trend of of the sales of the product um
  • 00:06:49
    we're almost at about a 4,000% increase
  • 00:06:52
    from the day that we launched in terms
  • 00:06:54
    of sales we're growing by about 40%
  • 00:06:56
    month over month so I meet with surgeons
  • 00:06:59
    all the time that have problems with
  • 00:07:01
    wound healing it's almost a a little
  • 00:07:04
    discussed topic I'm not sure if there's
  • 00:07:06
    some embarrassment maybe among surgeons
  • 00:07:08
    no one really wants to admit that they
  • 00:07:10
    have problems uh specifically wound
  • 00:07:12
    healing problems it's such a basic thing
  • 00:07:14
    you know you do uh you know a very
  • 00:07:16
    technologically advanced operation you
  • 00:07:19
    know either a robotic procedure or the
  • 00:07:21
    case of orthopedic surgeons let's say an
  • 00:07:23
    arthroplasty you know it's an operation
  • 00:07:25
    that really was never even contemplated
  • 00:07:28
    60 years ago 50 years ago and um at the
  • 00:07:31
    end of it you put on a dressing um that
  • 00:07:34
    is an Antiquated dressing you know in
  • 00:07:35
    the case of stere strips that's a 62y
  • 00:07:38
    old technology terms of cyan acrylate
  • 00:07:41
    technology that's been around since the
  • 00:07:44
    it's at least been FDA approved since
  • 00:07:45
    the late 90s and different forms that's
  • 00:07:47
    been around since the early 80s um and
  • 00:07:51
    despite the fact that there um have have
  • 00:07:53
    been really bad outcomes with those
  • 00:07:55
    Technologies we still use them to this
  • 00:07:57
    day so you you take a very high-tech
  • 00:08:00
    and you put a very low tech product on
  • 00:08:01
    it at the end of it and then you're
  • 00:08:03
    surprised that the low tech product
  • 00:08:04
    doesn't perform so um I think that the
  • 00:08:08
    um General understanding um amongst the
  • 00:08:10
    people at least that we speak with is
  • 00:08:12
    that there's been a real need and we're
  • 00:08:13
    filling it and we're interested in
  • 00:08:15
    continuing to innovate um in the space
  • 00:08:18
    you know that is very surprising I'm
  • 00:08:20
    coming from Silicon Valley the
  • 00:08:22
    Innovations in the own care is not that
  • 00:08:24
    much Advanced I was surprised you know
  • 00:08:26
    when I hear he about that Sil case for
  • 00:08:29
    example is right in front of right in
  • 00:08:32
    front of us everybody knows about silk
  • 00:08:34
    dressing but they don't they never used
  • 00:08:36
    it so what so tell us a little bit about
  • 00:08:39
    silk why you particularly focused on
  • 00:08:41
    silk there's a lot of other areas and
  • 00:08:44
    also among the silk why there is a kind
  • 00:08:47
    of a different kind of silk is there
  • 00:08:49
    different proteins are there so tell us
  • 00:08:51
    a little bit about the the special about
  • 00:08:54
    the silk
  • 00:08:55
    itself well silk has been used basically
  • 00:08:59
    by humankind for about 7,000 years you
  • 00:09:02
    know it was developed as a textile in um
  • 00:09:05
    in eastern Asia in what we believe today
  • 00:09:07
    is China about 7,000 years ago was
  • 00:09:10
    introduced um it's been used for
  • 00:09:12
    medicinal purposes for probably between
  • 00:09:15
    three and 5,000 years the ancient
  • 00:09:17
    Egyptians used it the Romans used it um
  • 00:09:20
    and uh you know it's been continuously
  • 00:09:23
    basically used in medicine in different
  • 00:09:25
    forms um for centuries um if not
  • 00:09:28
    millennia
  • 00:09:30
    um my interest really goes back to I'll
  • 00:09:33
    start with when I started in practice um
  • 00:09:36
    there was a company uh that for which
  • 00:09:38
    Johns Hopkins and the University of
  • 00:09:40
    Maryland was a combined plastic surgery
  • 00:09:42
    training program at the time um where um
  • 00:09:46
    it was a test site for the clinical use
  • 00:09:48
    of a product called alloderm it's an
  • 00:09:50
    acellular dermal matric products product
  • 00:09:53
    it's human cavic skin that's been
  • 00:09:55
    decellularized and used as a graph
  • 00:09:58
    material um the time we were using it
  • 00:10:00
    for abdominal wall reconstruction we
  • 00:10:01
    were using it for breast reconstruction
  • 00:10:03
    we were really almost experimenting with
  • 00:10:05
    it we were on the just The Cutting Edge
  • 00:10:06
    of this very you know interesting
  • 00:10:08
    technology that you could take cavic
  • 00:10:10
    human skin prepare it in a certain way
  • 00:10:12
    and then implant it in the body so I
  • 00:10:14
    started working on different
  • 00:10:16
    applications as a consultant for Life
  • 00:10:18
    Cell in 2004 when I first started in
  • 00:10:20
    practice I wrote some papers on the
  • 00:10:22
    novel use of it for revisionary breast
  • 00:10:24
    surgery to to use it to treat for
  • 00:10:26
    example capsular contracture with breast
  • 00:10:30
    implants and um around 2008 um I began
  • 00:10:34
    working on a different type of product
  • 00:10:36
    um called Veritas it's Bine pericardium
  • 00:10:39
    also a graph material used for abdominal
  • 00:10:41
    wall reconstruction and I worked with
  • 00:10:43
    them until they were acquired covis was
  • 00:10:46
    acquired in 2011 or 2012 by a much
  • 00:10:49
    larger medical device company called
  • 00:10:51
    Baxter continued to work with them for
  • 00:10:53
    about a year um and then in 2013 I
  • 00:10:57
    started working with a company called
  • 00:10:58
    allergen most people know allergen
  • 00:11:00
    because they make breast implants Botox
  • 00:11:02
    fillers like juviderm
  • 00:11:04
    um and uh they're big in the aesthetic
  • 00:11:07
    space specifically in plastic surgery
  • 00:11:09
    and um they had uh acquired a technology
  • 00:11:12
    from a company called caka uh based in
  • 00:11:15
    Massachusetts and it was an implantable
  • 00:11:17
    silk mesh and it was basically a the
  • 00:11:20
    poor man's version of a cellular dermal
  • 00:11:22
    Matrix it was basically an inexpensive
  • 00:11:25
    and easily scalable uh technology that
  • 00:11:28
    could be used as an implant the human
  • 00:11:29
    body and that technology has been around
  • 00:11:32
    for Le at this point about two decades
  • 00:11:35
    what they did is they found a way to
  • 00:11:36
    remove the sasin protein and to leave
  • 00:11:40
    the fibin core intact you know fibin is
  • 00:11:42
    a very interesting protein because
  • 00:11:44
    there's never been um a single human
  • 00:11:47
    being in the history of the world that's
  • 00:11:49
    been known to have an allergic reaction
  • 00:11:51
    to Silk fibroin it's bacteria static
  • 00:11:54
    which means that you can't really grow
  • 00:11:55
    bacteria at least not easily on it and
  • 00:11:58
    it's hydrophobic which means it doesn't
  • 00:12:00
    trap moisture or water and um finally
  • 00:12:04
    it's very strong and so in addition to
  • 00:12:06
    its excellent biocompatible profile it's
  • 00:12:08
    been studied in vitro and it's been
  • 00:12:10
    found to actually be excellent um and to
  • 00:12:12
    have you know many regenerative um
  • 00:12:15
    capabilities you know potentially as
  • 00:12:17
    wound accelerant for example so um
  • 00:12:20
    allergen acquired this technology around
  • 00:12:22
    2013 is when I became involved with them
  • 00:12:25
    right at the time of the product launch
  • 00:12:26
    from 2013 to 2015
  • 00:12:29
    um I was very involved with it there was
  • 00:12:32
    um unfortunately um an offlab promotion
  • 00:12:36
    of it the FDA regulatory program has
  • 00:12:40
    what's called a 510k system and it's
  • 00:12:43
    what allows companies to get um
  • 00:12:44
    authorization from the government to use
  • 00:12:47
    um well to promote that product and to
  • 00:12:49
    make it available for use for an
  • 00:12:51
    intended purpose but it was not um
  • 00:12:53
    promoted for the purpose that um at
  • 00:12:56
    least the FDA was concerned um it was
  • 00:12:58
    appropriate for and so they wound up
  • 00:13:00
    selling that technology to another
  • 00:13:02
    company called sren um I did a little
  • 00:13:05
    bit of work with sren for about a year
  • 00:13:07
    and then for a period of three years I
  • 00:13:08
    started um working on this concept of
  • 00:13:11
    potentially using silk-based um science
  • 00:13:15
    um for wound dressings I had um you know
  • 00:13:18
    just like everyone else every other
  • 00:13:20
    surgeon in the United States uh used uh
  • 00:13:23
    stere strip technology from the early
  • 00:13:25
    1990s when I started in medical school I
  • 00:13:27
    was very familiar with it it's an
  • 00:13:29
    inelastic paper tape technology and um
  • 00:13:32
    there are relatively High rates of
  • 00:13:34
    Detachment blistering it's not
  • 00:13:36
    waterproof for example so I didn't
  • 00:13:38
    really like ster strips and when um when
  • 00:13:41
    dermabond was FDA approved in
  • 00:13:44
    1998 it was interesting to me um as a
  • 00:13:48
    wound closure um product it's a liquid
  • 00:13:50
    obviously it's a polymer um and there
  • 00:13:54
    was a lot of interest in using it not
  • 00:13:55
    just for lacerations and cuts which it
  • 00:13:57
    was FDA approved for but also to cover
  • 00:13:59
    surgical incisions so I was a resident
  • 00:14:01
    at John's Hopkins at the time in 1998
  • 00:14:03
    when cyan acrylate two octal cyan
  • 00:14:05
    acrylate was FDA approved um and but
  • 00:14:08
    cyan acrylate was FDA approved in the
  • 00:14:11
    mid 1980s but it didn't really take off
  • 00:14:13
    because of some side effect profiles um
  • 00:14:16
    that it had and uh and then prio
  • 00:14:19
    dermabond which is a womb closure mesh
  • 00:14:22
    um was introduced uh approximately
  • 00:14:24
    between 2012 and
  • 00:14:26
    2014 um before it was really fully being
  • 00:14:28
    commercial ized and I was an early
  • 00:14:30
    adopter I like the idea I'm a lazy
  • 00:14:32
    surgeon which means that I I don't
  • 00:14:34
    necessarily want to um reapply dressings
  • 00:14:36
    in clinic um It's Time intensive
  • 00:14:39
    patients don't like it it's
  • 00:14:40
    uncomfortable I wanted to be able to put
  • 00:14:42
    a product on a patient let them take
  • 00:14:44
    showers and come back and see me whether
  • 00:14:46
    it's a week later or two weeks later and
  • 00:14:49
    then have it be something that I can
  • 00:14:50
    easily remove so um in Concept in theory
  • 00:14:54
    I liked it it's a mesh product which
  • 00:14:55
    means that you can put it over a joint
  • 00:14:58
    um at the time I liked this concept or
  • 00:15:00
    this idea that it that it had um a
  • 00:15:02
    certain antimicrobial ability um like a
  • 00:15:05
    like a waterproof cap that would seal
  • 00:15:07
    the incision so these were all things in
  • 00:15:08
    theory that made sense to me but in
  • 00:15:11
    practice I was having again High rates
  • 00:15:13
    of skin allergic reactions wound
  • 00:15:16
    infections wound dehiscences
  • 00:15:19
    and you know that it just some things
  • 00:15:22
    didn't conceptually made make sense you
  • 00:15:24
    know you have for example an incision
  • 00:15:26
    that you close there's a gap in between
  • 00:15:29
    the interface it's not a watertight seal
  • 00:15:31
    you know if you put a liquid it can
  • 00:15:33
    potentially go into the interstices
  • 00:15:35
    between the the healing skid edges and
  • 00:15:38
    it can disrupt wound healing if anything
  • 00:15:40
    else and so I was thinking maybe that's
  • 00:15:42
    it um so I already had this sort of
  • 00:15:46
    background and experience and knowledge
  • 00:15:47
    I'd written some um interesting um
  • 00:15:50
    papers that got published and did some
  • 00:15:52
    clinical trials using uh silk-based
  • 00:15:54
    substrates um as an implant in the body
  • 00:15:56
    I thought let's try it on the exterior
  • 00:15:59
    body so um applied for some at the time
  • 00:16:02
    provisional patents those patents have
  • 00:16:03
    been granted both in the United States
  • 00:16:05
    as well as internationally to use
  • 00:16:07
    silk-based medicine to use silk-based
  • 00:16:09
    meshes um external to the body using
  • 00:16:12
    different adhesives and um then once the
  • 00:16:15
    patents were granted I started working
  • 00:16:17
    on clinical trials which we completed it
  • 00:16:19
    was a collaborative effort between uh
  • 00:16:22
    John's
  • 00:16:23
    Hopkins um where I'm now on faculty in
  • 00:16:25
    UCSC where I used to be on faculty we
  • 00:16:27
    had a number of Surgeons that were
  • 00:16:29
    participants in this clinical trial and
  • 00:16:30
    the the results were really
  • 00:16:32
    overwhelmingly positive so we rapidly
  • 00:16:34
    worked to commercialize this over a
  • 00:16:35
    period of a few years and here we are
  • 00:16:38
    now you know a year since launch and um
  • 00:16:42
    you know I can tell you that um there's
  • 00:16:44
    just a lot of enthusiasm among surgeons
  • 00:16:47
    because we've been plagued with this
  • 00:16:48
    problem no one wants to talk about it
  • 00:16:51
    I'm talking about it now other people
  • 00:16:53
    are you know um being more open I think
  • 00:16:56
    with their own complications and how bad
  • 00:16:58
    um their their outcomes were using cyac
  • 00:17:01
    technology so we consider this to be a
  • 00:17:04
    disruptive and transformative product
  • 00:17:06
    it's not a me2 product there's nothing
  • 00:17:08
    else like it um at least there won't be
  • 00:17:10
    for the next almost two decades um while
  • 00:17:12
    those patents are still in effect and um
  • 00:17:14
    we really hope to supplant the entire s
  • 00:17:17
    AC acate Market um with a skin-friendly
  • 00:17:21
    adhesive with a biologically you know uh
  • 00:17:26
    compatible um and non-immunogenic
  • 00:17:28
    substrate which we believe is silk
  • 00:17:30
    fibroin Dr M you you see a direct
  • 00:17:33
    advantage over copper or Boron or are
  • 00:17:37
    other ones the other areas so you see a
  • 00:17:39
    clear advantage on the silk side of the
  • 00:17:41
    protein you see that that overwhelmingly
  • 00:17:44
    I I tell us a little bit what is a
  • 00:17:47
    special advantage over those those
  • 00:17:49
    traditional other methods than this one
  • 00:17:51
    yeah so first of all it's it's naturally
  • 00:17:54
    sourced um you know I like to think of
  • 00:17:56
    things um in sort of different Cate
  • 00:17:58
    categories for one um it's always better
  • 00:18:02
    to use a biologic and it's always safer
  • 00:18:04
    to use a biologic than to use a
  • 00:18:05
    synthetic I'll I'll talk to you a little
  • 00:18:07
    bit about um cyan acly for example
  • 00:18:10
    because it's probably the most commonly
  • 00:18:12
    used uh wound closure device other than
  • 00:18:14
    ster strips worldwide I mean there's
  • 00:18:16
    probably millions of patients per year
  • 00:18:18
    that actually have procedures done with
  • 00:18:20
    just those two um but as far as um sort
  • 00:18:23
    of safety profile goes a lot of the
  • 00:18:27
    synthetics have problems associated with
  • 00:18:30
    them either the product itself will
  • 00:18:32
    cause an allergic or an irritant contact
  • 00:18:35
    dermatitis or the basically the
  • 00:18:38
    degradation products of those will cause
  • 00:18:41
    an allergic or irritant contact
  • 00:18:43
    dermatitis silk doesn't have that
  • 00:18:44
    problem people have put silk clothing on
  • 00:18:46
    their bodies for 7,000 years and it's
  • 00:18:49
    very rare to find someone who's allergic
  • 00:18:50
    to sarasin you know now that we just
  • 00:18:53
    have purified this product and it's just
  • 00:18:54
    down to the fiban core I don't think
  • 00:18:56
    there's ever been a single report in the
  • 00:18:58
    world medical literature if there has
  • 00:19:00
    been I'm not aware of it and I think I
  • 00:19:02
    probably know that literature as well as
  • 00:19:04
    anyone else um and so there's there's
  • 00:19:06
    never been any reports of anyone that's
  • 00:19:08
    been allergic to it and so that's what I
  • 00:19:10
    was looking for something that had a
  • 00:19:13
    great profile associated with it that
  • 00:19:14
    was waterproof that was meshed so that
  • 00:19:17
    it could Contour over irregular surfaces
  • 00:19:19
    and Joints something that people could
  • 00:19:21
    shower with um that people leave on for
  • 00:19:24
    two weeks three weeks or four weeks
  • 00:19:25
    without problems and something that when
  • 00:19:27
    they removed it wouldn't remove the top
  • 00:19:29
    layer of the skin there's other good
  • 00:19:31
    adhesives on the market but many of them
  • 00:19:32
    are too strong you know they you know
  • 00:19:34
    some of these hydrocol
  • 00:19:36
    dressings you remove them from the body
  • 00:19:38
    and you basically remove the top layer
  • 00:19:40
    of the
  • 00:19:40
    skin this the way I can the way I sort
  • 00:19:43
    of thought about it is I want to be able
  • 00:19:45
    to remove a dressing off the body the
  • 00:19:47
    way I remove a Post-It note off the
  • 00:19:48
    refrigerator the only difference is I
  • 00:19:50
    want it to be stronger and I want it to
  • 00:19:52
    be waterproof and that technology is
  • 00:19:54
    around you know so um I just basically
  • 00:19:57
    utilized existing techn ology to create
  • 00:20:00
    a bigger a better product that fill the
  • 00:20:02
    void you know that that I think we all
  • 00:20:04
    have as surgeons you know you wrote a
  • 00:20:06
    little bit about the adhesive injuries
  • 00:20:09
    medically ined adhesive injuries the
  • 00:20:11
    cost of it the wound care cost can you
  • 00:20:14
    give us a little bit of the numbers on
  • 00:20:15
    that one the the wastage and the cost
  • 00:20:19
    and all those things in the in the the
  • 00:20:21
    ad injuries yeah it's in the billions
  • 00:20:23
    you know is all I can tell you is that
  • 00:20:25
    you know we do between 10 and 12 million
  • 00:20:27
    operations per year in the United States
  • 00:20:29
    huge numbers of operations you know if
  • 00:20:31
    you look at around the world I mean I'll
  • 00:20:33
    just go to Europe for example they
  • 00:20:35
    probably have an equal number of
  • 00:20:36
    surgeries um about one out of every
  • 00:20:39
    eight patients that has surgery will
  • 00:20:41
    have some sort of a skin reaction or a
  • 00:20:44
    problem associated with that dressing or
  • 00:20:46
    wound closure device you know it could
  • 00:20:48
    be a blister it could be an allergic
  • 00:20:49
    skin reaction it could be removing the
  • 00:20:52
    top layer of the skin when you remove
  • 00:20:54
    the dressing um it could be a surgical
  • 00:20:56
    sight infection that's probably related
  • 00:20:58
    to the dressing that was used and um and
  • 00:21:01
    those numbers are big because the
  • 00:21:02
    average hospitalization for a surgical
  • 00:21:05
    sight infection is about a $20,000
  • 00:21:08
    problem there's certain operations that
  • 00:21:09
    we do like arthroplasties you know if
  • 00:21:11
    you have a patient with a total hip
  • 00:21:13
    joint and that gets infected that's like
  • 00:21:16
    a $350,000 cost of the healthc care
  • 00:21:18
    system and you have changed Thea the
  • 00:21:20
    trajectory of that patient's life
  • 00:21:22
    forever you know that patient could die
  • 00:21:24
    they could wind up going to a certain
  • 00:21:26
    Skilled Nursing Facility you know they
  • 00:21:28
    may never be able to walk again you know
  • 00:21:30
    so some of these even though the cost of
  • 00:21:32
    the healthare system might only be 350
  • 00:21:34
    or $400,000 the cost of society is
  • 00:21:36
    enormous absolutely and you know two% of
  • 00:21:39
    joints get infected why I just saw a
  • 00:21:42
    study that was published from
  • 00:21:44
    Colombia um it was looking at two
  • 00:21:47
    different cyac acrylate polyester mesh
  • 00:21:49
    adhesives there was something like a
  • 00:21:52
    3.6% um uh infection rate with uh the
  • 00:21:56
    prineo dermabond product and it was over
  • 00:21:58
    7% I think it was like a
  • 00:22:00
    7.6% infection rate associated with the
  • 00:22:03
    metronic um liquid band product I mean
  • 00:22:07
    that's a nightmare I mean it's a
  • 00:22:08
    nightmare for the patient for sure it's
  • 00:22:10
    a nightmare for the surgeon who has to
  • 00:22:12
    care for that patient and it's just not
  • 00:22:14
    a good way for society to spend its
  • 00:22:16
    resources the difference between you
  • 00:22:18
    know an $80 wound dressing and um really
  • 00:22:21
    a catastrophy for that patient you know
  • 00:22:24
    the the the average sales price of our
  • 00:22:26
    product you know for for health Care
  • 00:22:28
    Systems is right around you know I think
  • 00:22:30
    it's like between 80 and
  • 00:22:32
    $120 um that's money well spent you know
  • 00:22:36
    any hospital system that tells you that
  • 00:22:38
    it's not has not had to take care of a
  • 00:22:40
    patient um you know that that's
  • 00:22:42
    experienced one of these really
  • 00:22:43
    catastrophic and avoidable problems the
  • 00:22:45
    cost is under reported and they won't
  • 00:22:47
    care that's definitely true I'll tell
  • 00:22:50
    you this no surgeon wants to publish
  • 00:22:51
    their bad results you know if you're a
  • 00:22:54
    health if you're a Health Care system
  • 00:22:55
    and you have a high infection rate the
  • 00:22:57
    last thing that you want to do is surge
  • 00:22:59
    publish how infection rate is because
  • 00:23:01
    you're going to scare patients away
  • 00:23:02
    you're going to scare referring doctors
  • 00:23:04
    away so it's very it's a very bold thing
  • 00:23:07
    for you know for institutions to publish
  • 00:23:09
    their their bad results but that's how
  • 00:23:10
    we make medicine better and so um I
  • 00:23:13
    think it it like I said it's the you
  • 00:23:16
    know I wasn't necessarily one of those
  • 00:23:17
    surgeons that wanted to tell people
  • 00:23:19
    either how bad my outcomes were with
  • 00:23:20
    cyan acrylate technology um and and you
  • 00:23:24
    know now that we have a better product
  • 00:23:26
    I'm you know I want to tell the world
  • 00:23:28
    about it
  • 00:23:28
    back then I don't think I wanted
  • 00:23:30
    everyone to know that every three
  • 00:23:32
    patients of mine had allergic skin
  • 00:23:34
    reactions or you know one out of every
  • 00:23:35
    two had to either go on which is what we
  • 00:23:38
    found in our clinical trial one out of
  • 00:23:39
    every two patients either had to go on a
  • 00:23:41
    steroid or an antibiotic because of an
  • 00:23:43
    allergic skin reaction using the the AL
  • 00:23:46
    the Johnson and Johnson anacon prineo
  • 00:23:48
    dermabond wound closure system um but
  • 00:23:51
    that's what that's what our data showed
  • 00:23:52
    and there's other now major institutions
  • 00:23:55
    Harvard Medical School Boston Children's
  • 00:23:57
    Hospital publish their data on um in
  • 00:24:00
    pediatric orthopedic surgery showing
  • 00:24:02
    that 25% of kids had allergic skin
  • 00:24:05
    reactions that had been previously
  • 00:24:07
    exposed to dermabond there's a there's a
  • 00:24:09
    paper in the plas and reconstructive
  • 00:24:10
    surgery literature showing that 15% of
  • 00:24:13
    first-time exposed patients for all
  • 00:24:15
    breast procedures had allergic skin
  • 00:24:16
    reactions to dermabond technology so
  • 00:24:19
    anyhow I'm I'm happy to tell you where I
  • 00:24:21
    am now because I wasn't happy with my
  • 00:24:24
    outcomes a decade ago yeah that's the
  • 00:24:26
    industry problem in general you know
  • 00:24:27
    plastic constructive surgery Journal Dr
  • 00:24:30
    Daniel Rani was gave a ringing
  • 00:24:32
    endorsement for the Silk protein because
  • 00:24:35
    he was saying that in the topical you
  • 00:24:37
    know the the the adesu I think um silk
  • 00:24:41
    is going to be randomized trial it
  • 00:24:43
    became very tell us a little bit about
  • 00:24:45
    that Dr well that paper that paper is
  • 00:24:47
    contemporary it's it's actually
  • 00:24:49
    published this month in the prestigious
  • 00:24:51
    plastic constructive surgery Journal I
  • 00:24:53
    think that it's the very first paper
  • 00:24:55
    ever selected by that journal to have an
  • 00:24:57
    Associated video with it hopefully
  • 00:24:59
    that'll be something that's done in
  • 00:25:01
    perpetuity but um uh you know Daniel
  • 00:25:04
    rohan's paper I think is seminal um it's
  • 00:25:08
    it it demonstrates the clear superiority
  • 00:25:10
    of uh of silk-based Technology over um
  • 00:25:15
    stere strip technology which again has
  • 00:25:17
    been around since 1962 I typically tell
  • 00:25:20
    patients um first of all I wasn't born
  • 00:25:22
    in 1962 I was born a little later than
  • 00:25:24
    that not too much later than that but I
  • 00:25:27
    can tell you that there is nothing that
  • 00:25:29
    I do
  • 00:25:30
    today that has not that has not Advanced
  • 00:25:34
    technologically since 1962 from the car
  • 00:25:37
    I drive to the phones that I talk on to
  • 00:25:40
    the instruments that I handle in the
  • 00:25:41
    operating room to the sutures everything
  • 00:25:44
    the computer that I'm on right now
  • 00:25:46
    didn't exist in
  • 00:25:48
    1962 but we still use this
  • 00:25:51
    Antiquated really bad technology today
  • 00:25:54
    and it's the standard of care and
  • 00:25:55
    medicine and no one understands why if
  • 00:25:58
    you were to ask the average surgeon why
  • 00:26:00
    they still use stere strips
  • 00:26:02
    today despite the fact that it has all
  • 00:26:04
    these problems one of the things that
  • 00:26:06
    came out of Daniel rohan's paper was
  • 00:26:07
    that 85% of the time ster strip
  • 00:26:10
    technology fails 10% of the time
  • 00:26:11
    patients get blisters 75% of the time it
  • 00:26:14
    falls off within the first two weeks
  • 00:26:15
    which I think is premature so it's a
  • 00:26:17
    technology that fails 85% of the time
  • 00:26:19
    and it's still the standard of care
  • 00:26:21
    today makes no sense so Vicky fishnick
  • 00:26:24
    she's a friend she educated me on this
  • 00:26:25
    wound care quite a bit she's a nurse she
  • 00:26:28
    is wound care special in nurse in the
  • 00:26:30
    wound care special you know she knows a
  • 00:26:32
    lot more about she educated me quite a
  • 00:26:34
    bit on the wound care I have no idea
  • 00:26:36
    before you know all these obvious things
  • 00:26:38
    and the cost of the wound care it is
  • 00:26:40
    really I learned from quite a bit from
  • 00:26:42
    here so Vicky can you ask any
  • 00:26:46
    questions probably you're in the same
  • 00:26:48
    industry you may know a lot lot more
  • 00:26:51
    than I do so well I mean I agree with uh
  • 00:26:54
    with the doctor on on this maet Dr mofet
  • 00:26:59
    we I mean I still see I'm a nurse
  • 00:27:01
    practitioner but I'm in industry but the
  • 00:27:04
    dress scenes that the
  • 00:27:07
    surgeons historically choose like zeror
  • 00:27:10
    and Neil
  • 00:27:11
    sporen is just like why
  • 00:27:18
    why I I've been asked to submit an
  • 00:27:21
    invited paper um on any topic uh my
  • 00:27:24
    choosing which I'll tell you right now
  • 00:27:26
    I'm working on a paper with some of the
  • 00:27:28
    leaders the thought leaders in the field
  • 00:27:30
    of plastic surgery on specifically how
  • 00:27:34
    to close a surgical wound to standardize
  • 00:27:37
    it how to close a surgical wound and how
  • 00:27:40
    to take care of it after surgery it's a
  • 00:27:41
    very basic thing but it's completely not
  • 00:27:44
    standardized and you might have surgeons
  • 00:27:47
    like you said applying Neosporin for
  • 00:27:49
    which there's absolutely no data you
  • 00:27:52
    have that yeah I mean we we do all sorts
  • 00:27:55
    of things that I would consider to be
  • 00:27:57
    Witchcraft and medicine and half the
  • 00:27:59
    things that we put on patients after
  • 00:28:01
    surgery have really no proven benefit
  • 00:28:04
    and I'll I'll just take this opportunity
  • 00:28:05
    to say say this one thing so the FDA
  • 00:28:08
    approved cyan acrylate technology for
  • 00:28:10
    wound closure in 1998 it's like 27 years
  • 00:28:13
    ago the data that was submitted with the
  • 00:28:17
    510k showed that if you use
  • 00:28:19
    dermabond as opposed to a control where
  • 00:28:22
    no dermabond was used to close a
  • 00:28:24
    laceration that the likelihood that that
  • 00:28:27
    patient was going to get infection and
  • 00:28:28
    this was in I mean the combin was I
  • 00:28:31
    think it was about 450 460
  • 00:28:34
    patients the likelihood of getting an
  • 00:28:36
    infection went up from 0.9% to 3.6%
  • 00:28:39
    which is to say that the FDA knew panel
  • 00:28:42
    of eight judges knew in 1998 that
  • 00:28:45
    applying cyan acrat or Superglue to a to
  • 00:28:48
    a wound increased the risk of infection
  • 00:28:51
    by
  • 00:28:52
    400% yeah and despite that they approved
  • 00:28:56
    it a panel of eight judges approved it
  • 00:28:58
    they they put in language that suggested
  • 00:29:00
    that they completely understood the
  • 00:29:02
    problem they just said that it would be
  • 00:29:03
    figured out in a post market analysis or
  • 00:29:06
    phase four clinical trial which was
  • 00:29:08
    never done and
  • 00:29:10
    somehow other than what's become the
  • 00:29:13
    standard of care something that we've
  • 00:29:14
    known for 27 years increases your risk
  • 00:29:17
    of infection by 400% like why did they
  • 00:29:20
    approve it I have no idea still to this
  • 00:29:23
    day I have no idea and every clinical
  • 00:29:25
    trial that's come out in the last five
  • 00:29:26
    years shows these horrific infection
  • 00:29:29
    rates not to mention you know skin
  • 00:29:32
    allergic reaction rates that in many
  • 00:29:34
    cases have to be treated with steroids
  • 00:29:36
    for long periods of time sometimes in
  • 00:29:38
    some cases oral steroids too like there
  • 00:29:40
    is no benefit and and the other thing
  • 00:29:43
    that's that's been known really for the
  • 00:29:44
    last 40 years is that cyan
  • 00:29:48
    acrylate which is probably the most
  • 00:29:50
    common either the number one or the
  • 00:29:52
    number two most common wound closure
  • 00:29:54
    it's used in the United States today
  • 00:29:56
    that it degrades into form alide so it
  • 00:30:00
    go underes A degradation for degrad
  • 00:30:03
    hydrolysis reaction and it degrades into
  • 00:30:06
    relatively High rates of formaly we've
  • 00:30:09
    actually tested the product and we found
  • 00:30:11
    extremely high rates of form alahh
  • 00:30:13
    that's been released and I think that's
  • 00:30:14
    one of the reasons patients get so sick
  • 00:30:16
    from it the other thing is that if that
  • 00:30:19
    wasn't bad enough the prineo dermabond
  • 00:30:21
    wound closure device which we tested in
  • 00:30:23
    our first study that we published in
  • 00:30:24
    October of
  • 00:30:25
    2023 they put a salt cataly Catalyst in
  • 00:30:28
    it and it's called balconi chloride and
  • 00:30:31
    it it it um it accelerates that
  • 00:30:34
    exothermic
  • 00:30:36
    reaction from two octal acrylate in its
  • 00:30:39
    liquid form into a solid form so that a
  • 00:30:42
    surgeon can get out of the operating
  • 00:30:43
    room in a minute or two as opposed to 10
  • 00:30:46
    minutes and it basically accelerates
  • 00:30:49
    that conversion into very high rates of
  • 00:30:51
    formaly so why that product is on the
  • 00:30:54
    market I don't know and I think part of
  • 00:30:55
    it that that's the reason that it's such
  • 00:30:57
    an easy
  • 00:30:58
    sort of decision for surgeons to make
  • 00:31:00
    and I think for Hospital administrators
  • 00:31:01
    at this point to make is that they don't
  • 00:31:03
    they're trying to move away from that
  • 00:31:04
    technology but it's just something that
  • 00:31:06
    should have never really even come to
  • 00:31:08
    Market I one more question just looking
  • 00:31:12
    at the material of your product I I mean
  • 00:31:16
    I'm there's we we spent some time with a
  • 00:31:19
    major Hospital trying to figure out what
  • 00:31:22
    they could replace zero form for their
  • 00:31:25
    donor
  • 00:31:26
    sites your material just seems like that
  • 00:31:30
    would be ideal you're talking about
  • 00:31:32
    skingraft owner sites yeah yeah I
  • 00:31:34
    completely agree with you and I think
  • 00:31:35
    that really you know I was I was I think
  • 00:31:37
    at the very beginning of the podcast I
  • 00:31:39
    was telling Romana that I think that
  • 00:31:40
    there's a lot of innovation potential
  • 00:31:42
    you know we're just on the cusp of this
  • 00:31:44
    this product that's been around for
  • 00:31:45
    7,000 years that was used in you know
  • 00:31:48
    ancient cultures from the Romans the
  • 00:31:50
    Egyptians the Indians to the Chinese um
  • 00:31:53
    we're just on the you know the the the
  • 00:31:56
    very tip of this iceberg you know I
  • 00:31:58
    think that a fibroin powder can be used
  • 00:32:00
    over skingraft owner sites I think that
  • 00:32:02
    using this product specifically over
  • 00:32:04
    skingraft owner site as opposed to much
  • 00:32:06
    more expensive animal derived um
  • 00:32:09
    biologics you know for example the K's
  • 00:32:12
    product that's um You probably heard of
  • 00:32:15
    you
  • 00:32:16
    know now I put that on my skingraft
  • 00:32:19
    owner sites do you know what the cost of
  • 00:32:20
    that is for
  • 00:32:21
    each
  • 00:32:24
    $4,500 to accelerate wound healing on a
  • 00:32:27
    skingraft owner
  • 00:32:28
    I think that with silk-based technology
  • 00:32:30
    you could do it for maybe a100 to $200
  • 00:32:32
    you know the cost of manufactur would be
  • 00:32:34
    less than $100 and so it doesn't make
  • 00:32:38
    tested just by looking at it almost
  • 00:32:40
    looked silicone I would think that the
  • 00:32:43
    healing for that area would just have a
  • 00:32:47
    finer or just free of the the mesh lines
  • 00:32:51
    and yeah a lot of people don't think of
  • 00:32:53
    insects as animals but they're animals
  • 00:32:55
    so this is an animal derived bioprotein
  • 00:32:57
    and it's used as a wound accelerant you
  • 00:32:59
    know there's other wound accelerants
  • 00:33:00
    that are used for example the Integra
  • 00:33:02
    Asel product um is is I I I use that in
  • 00:33:06
    my own practice it's it's
  • 00:33:09
    $1,600 for a one gram vial to put on
  • 00:33:12
    traumatic you know I use it on traumatic
  • 00:33:14
    upper extremity wounds um I think that a
  • 00:33:17
    similar insect derived animal bioprotein
  • 00:33:20
    for which there's a lot of data now you
  • 00:33:22
    know we haven't done it in human in
  • 00:33:24
    human clinical trials yet but the
  • 00:33:26
    likelihood that that could replace a
  • 00:33:29
    $1,600 um you know animal dered
  • 00:33:32
    bioprotein powder with a $50 powder is
  • 00:33:36
    very good I think that you can replace a
  • 00:33:38
    skingraft donor site that costs
  • 00:33:40
    $4,500 with one maybe costs $100 so I
  • 00:33:44
    think that there's a lot of innovation
  • 00:33:46
    potential here there is I I can tell by
  • 00:33:49
    looking at the material that like this
  • 00:33:51
    could do a lot more I mean some of my
  • 00:33:53
    sites VII was mentioning about CTP sub
  • 00:33:57
    CTP code
  • 00:33:58
    so there's a lot of you know
  • 00:34:00
    reimbursement problems can you tell us a
  • 00:34:02
    little bit about the reimbursement
  • 00:34:03
    challenges you know this is a very great
  • 00:34:06
    opportunity
  • 00:34:07
    now this particular type of product
  • 00:34:10
    because of the ctps you know they have
  • 00:34:14
    been they had a lot of fraud abuse as
  • 00:34:16
    CMS got serious and uh despite the
  • 00:34:19
    alliance of won care stakeholders really
  • 00:34:22
    battling to try that they have weeded it
  • 00:34:24
    down to 177 products on the approved
  • 00:34:27
    list for for February 12th 2025th there
  • 00:34:30
    will only be 17 products there's only so
  • 00:34:32
    many for dfus and only for so many for
  • 00:34:36
    vus of course that's not speaking of the
  • 00:34:39
    surgical you guys in surgery have will
  • 00:34:41
    just you know but if you're looking at
  • 00:34:44
    the CTP skin sub reimbursement for the
  • 00:34:47
    outpatient wound care settings that has
  • 00:34:50
    been drastically reduced and and they're
  • 00:34:52
    done I mean they want all these me tooo
  • 00:34:55
    products out of there is is there any
  • 00:34:58
    abuse um Vicki in that area I'm not sure
  • 00:35:01
    about that yes there's been a lot of
  • 00:35:03
    abuse uh a lot of people arrested about
  • 00:35:06
    uh 203 people that doj announced it uh
  • 00:35:10
    this summer so I mean it's I mean the
  • 00:35:13
    people and CMS is looking and when we
  • 00:35:16
    were in Orlando and CMS came in I mean
  • 00:35:19
    they're basically frustrated and for the
  • 00:35:22
    first time in the history to have all
  • 00:35:24
    seven Maxs get together and put the same
  • 00:35:28
    LCD tells you the frustration level and
  • 00:35:31
    the of the abuse uh of this
  • 00:35:33
    reimbursement so a product like this I
  • 00:35:37
    mean I can tell you a lot of potential I
  • 00:35:40
    believe that that silk-based
  • 00:35:43
    Technologies and other similar
  • 00:35:45
    Technologies again less expensive animal
  • 00:35:47
    deriv
  • 00:35:48
    bioprotein are going to save the Health
  • 00:35:50
    Care System tremendous amounts of money
  • 00:35:52
    and and give you improved outcomes which
  • 00:35:54
    is what you want you know one thing that
  • 00:35:55
    I haven't really mentioned yet is that
  • 00:35:58
    um you look at the typical patient with
  • 00:36:00
    a sub2 cimeter laceration that goes to
  • 00:36:02
    the emergency department the vast
  • 00:36:03
    majority of patients that go to an
  • 00:36:04
    emergency department with a cut for
  • 00:36:06
    example they'll wait in an ER for four
  • 00:36:09
    hours they'll um either meet with a
  • 00:36:11
    physician or a mid-level practitioner
  • 00:36:13
    who's going to suture them up the
  • 00:36:15
    laceration tray is going to be several
  • 00:36:16
    hundred dollars they're going to have a
  • 00:36:18
    painful injection of a local anesthetic
  • 00:36:20
    then they're going to be sutured up much
  • 00:36:21
    in the same way people were sutured up a
  • 00:36:23
    thousand years ago um that concept of of
  • 00:36:26
    suturing patient close I'm a surgeon
  • 00:36:28
    that's what I do for a living but the
  • 00:36:30
    concept of furing a patient close um is
  • 00:36:33
    is something that I think is is I don't
  • 00:36:35
    know if I want to use the word barbaric
  • 00:36:36
    but it's Antiquated um instead you could
  • 00:36:39
    merely you know cleanse it with ceiling
  • 00:36:42
    and or you know an irrigation solution
  • 00:36:44
    that has some sort of antimicrobial
  • 00:36:46
    activity and then you could strap the
  • 00:36:47
    laceration closed and that strapping of
  • 00:36:50
    laceration closed takes 5 Seconds you
  • 00:36:52
    know suturing aeration Clos can take 20
  • 00:36:54
    minutes and then that same patient that
  • 00:36:56
    gets sutured has to go back for a wound
  • 00:36:59
    check back to the ER then they have to
  • 00:37:00
    go back to their primary medical doctor
  • 00:37:03
    to have the sutures removed and then
  • 00:37:04
    once the sutures are removed you're
  • 00:37:05
    basically removing a foreign body that's
  • 00:37:07
    now transited through the skin and it's
  • 00:37:09
    basically an open wound again now that
  • 00:37:11
    patient is at risk of infection and I
  • 00:37:13
    think that all of that can be
  • 00:37:16
    circumvented merely by strapping a
  • 00:37:18
    laceration closed with a product that
  • 00:37:20
    can cost less than $100 so and so I
  • 00:37:23
    think there's tremendous cost savings um
  • 00:37:26
    that we're capable of and you know I've
  • 00:37:27
    been in this field long enough to know
  • 00:37:29
    that um a lot of the spending in
  • 00:37:31
    medicine is frankly wasteful um doesn't
  • 00:37:33
    improve outcomes for patients um you
  • 00:37:36
    know some of the technology we have is
  • 00:37:38
    you know again like cyac it's more
  • 00:37:40
    expensive and it's worse for you um than
  • 00:37:42
    using nothing at all for example I think
  • 00:37:44
    there's a lot of examples of that that I
  • 00:37:45
    can think of you know the I wear silk
  • 00:37:48
    tie that's why I like Silk you know silk
  • 00:37:51
    is a as a natural product as a
  • 00:37:53
    biological product biologic product as
  • 00:37:56
    you said you know I want to ask you why
  • 00:37:59
    there is a resistance in the wound care
  • 00:38:01
    area with the people in resistance or
  • 00:38:03
    ignorance or why that is not developed
  • 00:38:06
    that much as as expected that is that is
  • 00:38:08
    a puzzle to puzzling to me both you can
  • 00:38:11
    answer about that I I wouldn't say
  • 00:38:13
    there's any resistance at all we've been
  • 00:38:15
    embraced I just got off the I did a zoom
  • 00:38:17
    earlier this afternoon with one of the
  • 00:38:19
    largest Health Systems in the United
  • 00:38:21
    States and um all their stakeholders
  • 00:38:23
    were on the zoom and they want to
  • 00:38:25
    convert their entire hospital system
  • 00:38:27
    system to silk-based technology it's
  • 00:38:31
    like I said it's one of the largest
  • 00:38:32
    Hospital Systems in the United States um
  • 00:38:34
    I I you know I'm comfortable saying
  • 00:38:36
    because I there's no reason not to say
  • 00:38:38
    it but many of the top Healthcare
  • 00:38:40
    Systems in the United States have
  • 00:38:41
    converted now to Sil based technology so
  • 00:38:43
    the Mayo Clinic Johns Hopkins Cleveland
  • 00:38:46
    Clinic UCLA um if you go to Emory if you
  • 00:38:50
    go to one of the top healthare systems
  • 00:38:52
    in the United States they're familiar
  • 00:38:53
    with silk-based technology now Dr m
  • 00:38:57
    distinguisher doctor if you can suggest
  • 00:38:59
    like that you know that I think the
  • 00:39:01
    world has to follow not only United
  • 00:39:03
    States the whole world has to follow I
  • 00:39:06
    think they need to take a look at this
  • 00:39:08
    new Innovations in the in the wound care
  • 00:39:11
    you know that is one thing is Big Time
  • 00:39:12
    missing and Vicki always educates me in
  • 00:39:16
    this kind of area but I very surprising
  • 00:39:19
    for me he a very surprise for Outsiders
  • 00:39:22
    uh from living in Silicon Valley how
  • 00:39:24
    behind this wound care industry in The
  • 00:39:27
    Innovation side you know it is really so
  • 00:39:29
    people like you we need them and we need
  • 00:39:31
    more people like Vicky and you and then
  • 00:39:34
    to promote this kind of products and
  • 00:39:36
    both of you can work together off of of
  • 00:39:38
    the of the podcast but but but I think
  • 00:39:42
    um Dr Mar I'm going to present a topic
  • 00:39:44
    on something different is I'm a I'm an
  • 00:39:46
    innovator I like to bring a lot of
  • 00:39:50
    interdisciplinary Fields physics
  • 00:39:51
    mathematics you said that you loved
  • 00:39:53
    physics when you were in calch so that's
  • 00:39:56
    a good idea so I'm going to present a
  • 00:39:58
    hologram holography is the how they use
  • 00:40:00
    in medicine that's what I'm going to
  • 00:40:02
    talk about if you don't mind for a few
  • 00:40:04
    few minutes thank you Romana thank you
  • 00:40:06
    Victor quite an honor so when you come
  • 00:40:09
    back we can give you the website and all
  • 00:40:11
    those things then then I will be very
  • 00:40:14
    happy to right yeah let
  • 00:40:17
    me me the let's
  • 00:40:22
    the let me bring this
  • 00:40:26
    um yeah that is a Dr Mark morphed you
  • 00:40:29
    know he's from John Hopkins you know
  • 00:40:31
    very distinguished professor and and he
  • 00:40:34
    a he a really true innovator in the
  • 00:40:37
    wound care industry you know we need to
  • 00:40:39
    really pay attention to what he's doing
  • 00:40:41
    you know so I think the world has to
  • 00:40:43
    follow you know that hologram I'm going
  • 00:40:44
    to talk about little the Holograms you
  • 00:40:46
    know star treack you know the all three
  • 00:40:48
    of us watching this star treack there is
  • 00:40:51
    a called the doctor the emergency
  • 00:40:53
    medical program in 1995 there was a AI
  • 00:40:56
    Program start in in in in thech
  • 00:40:59
    introduced AI you know they didn't call
  • 00:41:01
    AI but artificial intelligence but it's
  • 00:41:04
    called the doctor the emergency medical
  • 00:41:06
    program that is called hologram Richard
  • 00:41:09
    picardo is a you know he was the he was
  • 00:41:12
    the actor there in the Hologram is a is
  • 00:41:15
    a holographic doctor hologram doctor so
  • 00:41:18
    actually there is a there is a gentleman
  • 00:41:20
    Gan do doov he is a physicist he
  • 00:41:24
    engineer and then he was he was he was
  • 00:41:27
    watching the star track inspired a lot
  • 00:41:29
    of people like me and him and everybody
  • 00:41:31
    fix people so you saw the transportation
  • 00:41:34
    transporting the the human beings to
  • 00:41:37
    other planets other galaxies so you
  • 00:41:40
    thought about it how can can we
  • 00:41:42
    transport the energy to that way so he
  • 00:41:46
    he call he called that is um you know
  • 00:41:49
    that holographic energy teleportation
  • 00:41:51
    you call it's a wild imagination what he
  • 00:41:54
    wants to do is he wants to take the you
  • 00:41:56
    know when you when you do cancer
  • 00:41:58
    treatment or any other treatment in the
  • 00:42:00
    the radiation it is always there is a
  • 00:42:02
    good self you know that there's a
  • 00:42:04
    doctors their nurses there I don't have
  • 00:42:06
    to tell them that really damage the
  • 00:42:08
    other parts of the good cells so what he
  • 00:42:11
    wants to do is as a physicist he's
  • 00:42:13
    thinking there is a way can we do a way
  • 00:42:16
    to skip that all those good good cells
  • 00:42:18
    and go to the bad cell and kill that
  • 00:42:21
    cell cancered cell that's a wild
  • 00:42:23
    imagination it's not easy practically
  • 00:42:26
    everybody was laugh in at the time but
  • 00:42:29
    let me tell you something about it
  • 00:42:30
    that's what is hologram does that's
  • 00:42:33
    holographic technique is using is is
  • 00:42:35
    talking about hologram has a three you
  • 00:42:37
    know in the the actually 19 2020 Britney
  • 00:42:41
    Houston tour holographic tour started in
  • 00:42:43
    in Europe she she went on she in the
  • 00:42:46
    Europe she went on a special Tour on the
  • 00:42:48
    holographic after she died you know then
  • 00:42:51
    in Koso you know where Dr morid is close
  • 00:42:54
    by that you know
  • 00:42:57
    God of rap toak Shakur is he was on
  • 00:43:01
    hologram appear so holograph photo if
  • 00:43:04
    you see it if you see them it is
  • 00:43:06
    actually in the middle looks like this
  • 00:43:08
    interference pattern that's all you
  • 00:43:10
    don't see any images you see dark spots
  • 00:43:12
    and white spots that's all you see that
  • 00:43:15
    is the holographic image so what is
  • 00:43:18
    there are three very distinct properties
  • 00:43:20
    of the Hologram is a very bizarre
  • 00:43:22
    properties you know one is that a
  • 00:43:24
    computer you store one and zeros in the
  • 00:43:27
    holog the one and zeros are stored in
  • 00:43:29
    the computer in the Hologram is a spots
  • 00:43:32
    do interference pattern basically dark
  • 00:43:35
    spots and the bright spots they do that
  • 00:43:38
    that is a holographic picture
  • 00:43:40
    actually so there is second property of
  • 00:43:42
    the Hologram is you take you you you
  • 00:43:45
    take that you project that 2D image then
  • 00:43:48
    it becomes a 3D image you know it
  • 00:43:51
    becomes a 3D image 2D image you project
  • 00:43:53
    into 3D image two dimensional lower
  • 00:43:56
    Dimension go to the higher dimension in
  • 00:43:58
    that sense but the third property is
  • 00:44:00
    much more very counterintuitive you can
  • 00:44:04
    Shine the Light on any parts of the
  • 00:44:06
    parts of that picture photo holographic
  • 00:44:10
    plate it becomes the entire image you
  • 00:44:12
    don't have to do show the you don't have
  • 00:44:14
    to shed the light on the entire plate
  • 00:44:17
    you just any part so the partt contains
  • 00:44:20
    the W every part contains the W is a
  • 00:44:22
    very counterintuitive idea in this in
  • 00:44:24
    this u in the in the holography so
  • 00:44:27
    holograph is a very special is actually
  • 00:44:30
    the holograph the creation is a little
  • 00:44:32
    bit of complex kind of thing it's not
  • 00:44:35
    that but it's a reference beam and you
  • 00:44:37
    you do it's like a wave pattern CEST and
  • 00:44:40
    trous when the CER meet there's a bright
  • 00:44:43
    spot and the TR meet where the the cust
  • 00:44:45
    and T meat that the two waves interfere
  • 00:44:48
    each other in the dark spot and the and
  • 00:44:50
    the bright spots are created that is the
  • 00:44:53
    that is the reason you see H hologram on
  • 00:44:55
    the right side that is is the if you
  • 00:44:57
    want to see an apple hologram you have
  • 00:44:59
    to take a one reference beam one you
  • 00:45:01
    send it through different way then it
  • 00:45:04
    becomes a hologram so I can go through
  • 00:45:06
    the but if you want to do a traditional
  • 00:45:09
    2D to 3D reconstruction hot ultrasound
  • 00:45:11
    for example uh you do volume renting
  • 00:45:13
    algorithm you know Nvidia sells that
  • 00:45:15
    clock Vis sorry clar Vis there's a you
  • 00:45:19
    know I don't know Dr mfit could be using
  • 00:45:21
    in his practice some of the plastic
  • 00:45:23
    surgery things I didn't know but some of
  • 00:45:26
    the volume rendering algorithms 2D
  • 00:45:28
    images it takes a bunch of 2D images and
  • 00:45:31
    then reconstruct into 3D but you know
  • 00:45:33
    hologram is different hologram is 2D to
  • 00:45:37
    3D direct it is actually stereo
  • 00:45:39
    ultrasound it can you know I saw this
  • 00:45:41
    one is an amazing inside you know I was
  • 00:45:44
    teaching them uh you know how to operate
  • 00:45:46
    the kids you know kids came down and and
  • 00:45:48
    they're playing with the heart itself it
  • 00:45:50
    is a improved spatial perception
  • 00:45:52
    enhanced diagnostic accuracy is an
  • 00:45:55
    amazing year there is a the company here
  • 00:45:57
    in Silicon Valley does this is called G
  • 00:45:59
    scale G scalar that's called they do
  • 00:46:02
    that this one Jan doof they just
  • 00:46:05
    recently got the US pay in 2022 he got
  • 00:46:08
    approval for this strange T Energy
  • 00:46:12
    transportation of he call it hemia hemia
  • 00:46:17
    protocol basically it is it doesn't the
  • 00:46:20
    way he did it that is a very ingenious
  • 00:46:23
    method he's a phist you know he got the
  • 00:46:25
    he got the 16 DARPA defense uh in the
  • 00:46:28
    defense Department of Defense gave him
  • 00:46:30
    contact in the funded this project
  • 00:46:33
    holographic ring creates what he does is
  • 00:46:36
    US using the interference pattern and
  • 00:46:40
    avoiding all the all the darkg spots in
  • 00:46:44
    the good cells you put the darkg spots
  • 00:46:46
    and only the bright spot is concentrated
  • 00:46:48
    on the cancer cell the cell that you
  • 00:46:51
    know using metal nanop particles to
  • 00:46:54
    identify the the cancer C and then shoot
  • 00:46:58
    them into the heat you know Heat Wave he
  • 00:47:00
    send a heat wave and kill them so got
  • 00:47:02
    approval actually us P got the US PID on
  • 00:47:05
    it and Jin doov is still alive is a 80
  • 00:47:09
    years old you know the Department of
  • 00:47:12
    Defense the Dara director said that it's
  • 00:47:14
    going to change the game of the
  • 00:47:16
    holography treatment of cancer treatment
  • 00:47:18
    of diseases plaque and all those things
  • 00:47:20
    is going to change but we is still in
  • 00:47:23
    the in the process but it is going to be
  • 00:47:25
    very interesting in the in the universe
  • 00:47:28
    and brain there is a you know 1982 I'm a
  • 00:47:31
    physicist and I read book on holographic
  • 00:47:33
    Universe Michael talber is from San
  • 00:47:35
    Francisco um he wrote a book called
  • 00:47:38
    called very interesting book if you get
  • 00:47:40
    a chance read this book it is an amazing
  • 00:47:42
    he died very young age but uh Michael
  • 00:47:46
    Talbert wrot in that image he said that
  • 00:47:49
    this if you that's he explained about
  • 00:47:52
    the holographic images if you cut the
  • 00:47:54
    holographic image into two parts Parts
  • 00:47:57
    is not cut into the half and half it
  • 00:47:59
    becomes two small parts if you cut it
  • 00:48:01
    into small small parts it becomes a
  • 00:48:03
    smaller and smaller so every partt
  • 00:48:05
    contains the whole only retrieval is the
  • 00:48:08
    challenge but every partt contains when
  • 00:48:10
    you make it smaller smaller that means
  • 00:48:13
    then you can do a new kind of medicine
  • 00:48:15
    is coming up EO biology embryo
  • 00:48:18
    containing information of the whole
  • 00:48:19
    organism that is one of the Chinese very
  • 00:48:22
    interested in this one every cell and
  • 00:48:25
    every every cell contains all the
  • 00:48:26
    information of the entire body that's
  • 00:48:28
    what the acupuncture is actually it is a
  • 00:48:32
    peer reviewed study in fact they found
  • 00:48:34
    out University San Francisco per in the
  • 00:48:36
    year that they did the pain and anxiety
  • 00:48:39
    that they can be reduced the year the
  • 00:48:41
    Year represents entire body you know
  • 00:48:44
    that's very strange that's what they
  • 00:48:45
    what they did in the in the in the
  • 00:48:47
    acupuncture actually so they kind of
  • 00:48:49
    holograph hologram they use in the in
  • 00:48:52
    the acupuncture imagination wise so the
  • 00:48:55
    brain is hologram one of the thinks is
  • 00:48:57
    my my favorite physicist David bomb on
  • 00:49:01
    the right side the coral pram is the
  • 00:49:04
    neurosurgeon from the from Stanford year
  • 00:49:06
    he di both of them passed away but they
  • 00:49:09
    they were suggesting the brain as a
  • 00:49:12
    hologram the the amount of information
  • 00:49:15
    that is stor it has to be hologram
  • 00:49:17
    because that's what they say the amount
  • 00:49:19
    of hologram that you the amount of the
  • 00:49:21
    storage that you do require Holograms
  • 00:49:23
    can accommodate not any other way but in
  • 00:49:26
    there's a you know Observer reality that
  • 00:49:28
    is another one but one of the things is
  • 00:49:31
    the pram problem was in the trauma
  • 00:49:34
    patients that that people don't remember
  • 00:49:38
    when they the part of the brain is taken
  • 00:49:39
    out they don't remember part of the
  • 00:49:41
    ABCDs either they remember everything or
  • 00:49:44
    they don't remember at all that is so
  • 00:49:47
    what he his argument is that every cell
  • 00:49:49
    every neuron has all the information of
  • 00:49:51
    the entire entire memory so is a is a
  • 00:49:54
    classical I don't know that that was a
  • 00:49:57
    that is an argument from called pram and
  • 00:50:00
    then they agreed by the David bomb says
  • 00:50:02
    that that what is physics he says that
  • 00:50:04
    one mind you know that one mind is is
  • 00:50:07
    theory of one mind all the one universal
  • 00:50:09
    Consciousness is the is the key for all
  • 00:50:11
    of them there's only one Consciousness
  • 00:50:13
    that does a manifest into different ones
  • 00:50:16
    but you know the now Alzheimer's they're
  • 00:50:18
    using for because certain way our brain
  • 00:50:21
    works with Holograms very strange now
  • 00:50:23
    they're using the rose one of the things
  • 00:50:26
    to cognitive you know functions improve
  • 00:50:28
    the cognitive functions using Holograms
  • 00:50:31
    that's uh you know that's a very now
  • 00:50:34
    surgery that probably Dr morid May doing
  • 00:50:36
    that soon in the radical Improvement in
  • 00:50:39
    the diagnosing and treatment and
  • 00:50:40
    educating other other doctors effective
  • 00:50:43
    learning capacity and all those things
  • 00:50:45
    holography can be a great tool in
  • 00:50:47
    teaching that's thank you for watching
  • 00:50:49
    there these are the companies they do
  • 00:50:51
    they do medical holography that's they
  • 00:50:54
    do deep perception real view is really
  • 00:50:56
    good one one one my friend shaa Pia
  • 00:50:58
    she's a you know she's a space doctor
  • 00:51:02
    she she was working with the one company
  • 00:51:03
    in the holography company there so
  • 00:51:06
    Universe maybe hologram that's what the
  • 00:51:08
    the Michael Talbert said that we are in
  • 00:51:10
    the Hologram we may be part of the
  • 00:51:12
    simulation so that's uh that is thank
  • 00:51:14
    you for watching let me bring uh you
  • 00:51:16
    know that's Universe maybe hologram
  • 00:51:18
    where all the projections of the hram
  • 00:51:21
    that's the end of the St so that's
  • 00:51:23
    somehow strangely we're all connected to
  • 00:51:25
    that let me bring to the guest that my
  • 00:51:28
    physics presentation is over let me
  • 00:51:34
    bring Dr Dr M you know something that I
  • 00:51:38
    want to present every time we come down
  • 00:51:40
    the physics I'm a physics guy I want to
  • 00:51:42
    give you Innovations come through
  • 00:51:43
    interdisciplinary field what do you
  • 00:51:46
    think it's all interdisiplinary I mean
  • 00:51:49
    you know we adopt plastic surgery as a
  • 00:51:51
    field for example um owes its Origins
  • 00:51:55
    really to all other specialties in
  • 00:51:56
    medicine um you know the very first
  • 00:51:58
    rhinoplasty that was done was done by an
  • 00:52:00
    orthopedic surgeon um jacqu Joseph prior
  • 00:52:04
    to him it was an uh there was someone
  • 00:52:06
    else who uh also pioneered the field and
  • 00:52:08
    he was an ENT doctor um the penectomy or
  • 00:52:11
    abdominoplasty that we do came from uh
  • 00:52:14
    Johns Hopkins actually from an
  • 00:52:17
    OBGYN um so we borrow from one another
  • 00:52:19
    all the time you know the very first uh
  • 00:52:21
    kidney transplant that was done in the
  • 00:52:23
    world wasn't done by a transplant
  • 00:52:24
    surgeon it was done by um Dr Murray at
  • 00:52:27
    Harvard um who won the N prize for it it
  • 00:52:29
    was done by a plastic surgeon so there's
  • 00:52:32
    you know there's a there's a lot of um
  • 00:52:34
    cross-pollination that I think goes on
  • 00:52:36
    in medicine um I see that you know now
  • 00:52:38
    that we're commercial for example the
  • 00:52:40
    orthopedic surgeons are talking to you
  • 00:52:43
    know the other Specialists the gyns are
  • 00:52:45
    learning from the plastic surgeons or
  • 00:52:47
    the plastic surgeons are learning from
  • 00:52:49
    the cardiac surgeons we all talk to one
  • 00:52:51
    another and that's kind of what makes
  • 00:52:52
    this an interesting field yeah that's a
  • 00:52:54
    that that's that's only way to bring
  • 00:52:57
    really Innovations to the Forefront
  • 00:52:59
    Vicki what do you think of that what is
  • 00:53:01
    what is what is the future of the W care
  • 00:53:03
    you think Dr M what is the you know one
  • 00:53:07
    of the ad we are talking about but is
  • 00:53:08
    there any other areas of the plastic
  • 00:53:11
    surgery you can talk about surgery also
  • 00:53:13
    plastic surgery are there any new
  • 00:53:15
    Innovations coming up there in the in
  • 00:53:16
    the Plastic Surgery side and the or the
  • 00:53:19
    wound car you were talking about any any
  • 00:53:21
    new there's a lot of uh I work with a
  • 00:53:24
    lot of startups and getting them through
  • 00:53:26
    through foundations and and finding the
  • 00:53:30
    the uh the med like foundations that
  • 00:53:33
    will provide money that is undiluted
  • 00:53:37
    which is always great because we can run
  • 00:53:39
    them through CRPS so getting products
  • 00:53:42
    such as yours uh through foundations
  • 00:53:45
    like this opens up the door for CRP or
  • 00:53:49
    DOD uh options and they look at that and
  • 00:53:53
    they invest in it uh and as a as a you
  • 00:53:57
    know because it's for them and it's uh I
  • 00:54:00
    mean it's very interesting what you have
  • 00:54:02
    here because I'm almost I'm working with
  • 00:54:05
    a startup where we're bringing some
  • 00:54:06
    products with hemostatics for uh combat
  • 00:54:11
    so your platform here is very
  • 00:54:15
    interesting I I think you have a lot
  • 00:54:18
    more growth with this silk than just
  • 00:54:21
    where you're currently using it here's
  • 00:54:23
    something else that's interesting is
  • 00:54:24
    that fibro one is a natural h static
  • 00:54:27
    agent using it in the same way that you
  • 00:54:30
    might use Arista or one of the other
  • 00:54:32
    hematic agents that you're using and
  • 00:54:33
    again the key about it is that you can
  • 00:54:35
    manufacture it for you know maybe not
  • 00:54:37
    pennies but dollars you know the cost of
  • 00:54:40
    manufacturer is tremendously less and
  • 00:54:42
    you and that also means that you can
  • 00:54:43
    scale it in a way that you can't scale
  • 00:54:45
    other Technologies you're probably
  • 00:54:47
    pretty familiar with negative pressure
  • 00:54:49
    wound wound yeah it's an unscalable
  • 00:54:52
    technology it works but it's unscalable
  • 00:54:55
    you can't put a $500 W closure device on
  • 00:54:59
    every cesarian section there's 1.2
  • 00:55:01
    million C-sections done per year in US
  • 00:55:03
    you simply can't do it no it's not
  • 00:55:05
    affordable no you can put silk on every
  • 00:55:07
    one of those patients you know that adds
  • 00:55:10
    either nothing it's either less
  • 00:55:12
    expensive or essentially the same price
  • 00:55:14
    as the other wound closure devices but
  • 00:55:16
    instead of having a 6% infection rate in
  • 00:55:18
    in C-sections around the country you
  • 00:55:21
    know I'm hopeful that we'll see what we
  • 00:55:22
    see with class one operations in
  • 00:55:24
    orthopedic and plastic surgery it'll go
  • 00:55:25
    down to either 0% or 1% so that's where
  • 00:55:28
    I think the real value at is it's not
  • 00:55:30
    necessarily to innovate in a way that it
  • 00:55:32
    becomes untenable technology not just in
  • 00:55:34
    the United States but all around the
  • 00:55:36
    world but to inovate a way that it it's
  • 00:55:38
    something you can duplicate in
  • 00:55:40
    developing countries just as easily as
  • 00:55:42
    you can in you know the you know the the
  • 00:55:46
    wealthiest cities in America Dr Dr Mor
  • 00:55:50
    not only you're a great surgeon and then
  • 00:55:52
    you you're are bringing the very cost
  • 00:55:54
    effective solution for the care you're
  • 00:55:57
    true innovator thank you for joining
  • 00:55:59
    thank you Vicki for joining and if you
  • 00:56:00
    want to stay there outside of the
  • 00:56:02
    broadcast you can talk together if we
  • 00:56:03
    stay but but it is a truly an honor and
  • 00:56:06
    privilege sir appreciate it you very
  • 00:56:09
    much thank you all thank you thank you
  • 00:56:10
    all for
  • 00:56:12
    joining we are retelling their stories
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Tag
  • soins des plaies
  • soie
  • innovation médicale
  • chirurgie plastique
  • infection
  • technologie biologique
  • holographie