Designer Babies - The Good, the Bad and the Ugly | Hayden Wilkinson | Winner of FameLab Ireland 2019

00:03:19
https://www.youtube.com/watch?v=xUzRZ470zIQ

摘要

TLDRThis story revolves around twins Lulu and Nana, born as the world's first designer babies modified using CRISPR technology for HIV resistance. The narrative delves into the process of CRISPR, how it functions similar to immune responses in bacteria, and discusses ethical implications, public skepticism, and the potential health risks that accompany such genetic modifications. Despite the twins being resistant to HIV, there are concerns about unintended health issues they may face due to poorly executed gene editing. The speaker cautions that humanity is navigating uncharted territory by attempting to alter life’s evolution in such a short time frame, highlighting the need for a more thoughtful approach before diving into genetic engineering.

心得

  • 👶 Lulu and Nana: world’s first designer babies
  • 🔬 CRISPR technology used for gene editing
  • ⚖️ Ethical concerns around genetic modification
  • 🚫 The editing process was illegal
  • 💡 CRISPR functions like a bacterial immune system
  • ⚠️ Potential health risks include cancer
  • 🌎 The need for careful consideration in gene editing
  • ⏳ Evolution took billions of years, we’re rushing change
  • 🤔 Public skepticism and controversy remains
  • 🎭 The world may not be ready for such changes

时间轴

  • 00:00:00 - 00:03:19

    The story follows twins Lulu and Nana, who were born into a challenging world affected by climate change and political issues. They are the first designer babies, genetically modified using CRISPR technology to resist HIV. CRISPR, derived from bacteria's defensive mechanism against viruses, allows precise gene editing. However, the ethics of such genetic alterations are controversial. The scientists behind the process acted in secrecy and performed illegal edits to the twins' genomes. Despite making them HIV-resistant, concerns linger about potential health risks from unintended genetic consequences. The narrative highlights the moral implications of hastily altering life that evolved over billions of years, suggesting that the world may not be prepared for such advancements.

思维导图

视频问答

  • What are Lulu and Nana known for?

    They are the world's first designer babies, genetically modified for HIV resistance.

  • What technology was used to modify their genes?

    CRISPR technology was used to edit their genes.

  • What is CRISPR?

    CRISPR stands for clustered regularly interspaced short palindromic sequences, a genetic engineering technology.

  • Was the genetic editing of the twins legal?

    No, the process was conducted under a cloud of secrecy and is considered illegal.

  • What potential risks come with genetic editing?

    Genetic editing can lead to unforeseen health issues, including the risk of cancer.

  • Why is the editing of genes controversial?

    It raises ethical concerns and questions about the long-term implications of altering human genetics.

  • What could be the long-term effects of such genetic modification?

    The long-term effects are unknown, and there is a risk of unintended consequences.

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  • 00:00:02
    this is a story about twins Lulu and
  • 00:00:05
    Nana born last year into a difficult
  • 00:00:08
    world of climate change Oh plastic
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    oceans oh and Donald Trump oh they were
  • 00:00:16
    born of something very special they not
  • 00:00:22
    one but two of a kind
  • 00:00:24
    they were the world's first designer
  • 00:00:26
    babies now I'm not talking about no
  • 00:00:29
    Louis Vuitton Gucci Prada designer
  • 00:00:31
    babies I'm talking about genetically
  • 00:00:33
    modified babies see when Lulu and Nana
  • 00:00:36
    were just a single-cell old they were
  • 00:00:41
    where we're treated with this CRISPR
  • 00:00:43
    technology which edited their genes
  • 00:00:45
    giving them resistance to HIV now Hayden
  • 00:00:49
    did you just say krispy technology
  • 00:00:52
    no I didn't although that would be
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    delicious no Chris fur or clustered
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    clustered regularly interspaced short
  • 00:00:58
    palindromic sequence technology is the
  • 00:01:01
    genetic engineering technology which
  • 00:01:03
    lets us edit the genes of our choosing
  • 00:01:04
    and it actually comes from a process
  • 00:01:07
    found in bacteria see when bacteria are
  • 00:01:10
    invaded by a virus they scan their
  • 00:01:13
    cellular memory bank for DNA that
  • 00:01:16
    matters viruses DNA when they find it a
  • 00:01:18
    copy is made this copy then binds to
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    cast nine a huge yellow murderous eating
  • 00:01:26
    protein together the DNA and cast nine
  • 00:01:29
    seek out the virus with the similar DNA
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    and well you guessed it
  • 00:01:33
    Wacka Wacka Wacka pass nine eats the
  • 00:01:37
    virus and saves the day but so what
  • 00:01:40
    we're not bacteria and only politicians
  • 00:01:43
    of viruses how does this relate to the
  • 00:01:47
    twins at all well you see by reverse
  • 00:01:49
    engineering our cast known friends here
  • 00:01:51
    to do our bidding we can feed at any
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    sequence of DNA and it will find the
  • 00:01:56
    corresponding DNA within our own genes
  • 00:01:58
    instead of Cassadine eating our DNA it
  • 00:02:00
    will actually edit it so it was the case
  • 00:02:02
    for Lulu and Nana their ccr5 gene was
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    edited with this crispy delicious
  • 00:02:06
    technology so like a droplet of water
  • 00:02:10
    into a vast ocean there was a lot of
  • 00:02:14
    ripple
  • 00:02:15
    into the world of skepticism and ethics
  • 00:02:17
    the scientists responsible for the
  • 00:02:20
    actual process operated under a cloud of
  • 00:02:22
    secrecy during the whole thing what they
  • 00:02:24
    did was and is still to this day
  • 00:02:26
    actually illegal they poorly edited the
  • 00:02:28
    twins genetic code and didn't in fact
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    change anything they were going to be
  • 00:02:32
    born healthy babies anyway what we
  • 00:02:35
    really need to do is take a step back
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    and realize it took earth four billion
  • 00:02:39
    years to evolve life and now we're
  • 00:02:42
    trying to change it in a matter of
  • 00:02:43
    minutes so in the end we've got the good
  • 00:02:47
    Lulu and Nana HIV resistant we've got
  • 00:02:50
    the bad they might not be resistant to
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    many other things now that this genetic
  • 00:02:55
    change could have caused many different
  • 00:02:58
    cancers and we've got the ugly like my
  • 00:03:00
    Eurovision 2020 audition tape the world
  • 00:03:03
    is just not ready yet thank you
  • 00:03:06
    [Applause]
标签
  • twins
  • Lulu and Nana
  • designer babies
  • CRISPR
  • genetic modification
  • HIV resistance
  • ethics
  • health risks
  • biotechnology
  • gene editing