Longevity Experts Have Been Wrong About These Supplements (slow down fat loss)

00:09:34
https://www.youtube.com/watch?v=pt0TxNf6bMc

摘要

TLDRThe video discusses the common misunderstanding in longevity research regarding senescent cells, which are wrongly termed 'zombie cells.' These cells play a crucial role in muscle fiber repair and are essential for muscle regenerative processes. They help satellite cells in muscle growth but become problematic as they accumulate with age. The speaker urges against blocking these cells in younger people as it may hinder muscle repair but suggests it for older adults to prevent muscle wasting. The discussion then shifts to balancing longevity and performance, advocating for a thoughtful approach that includes periods of intense training and recovery. For younger individuals, the emphasis is on building muscle and cardiac strength through fundamental nutrition and exercise. Supplements promising longevity benefits should be reserved for later in life, from around the 40s, to avoid stunting growth. The key takeaway is the importance of balancing growth, repair, and longevity preservation, with different strategies recommended at various life stages to maximize health benefits while avoiding adverse effects on muscle and vitality.

心得

  • 🧬 Senescent cells are crucial for muscle repair, not harmful zombies.
  • 🔄 Balance longevity and performance for optimal health.
  • 🏋️ Younger individuals should focus on muscle and cardiac strength.
  • ➖ Avoid blocking senescent cells when young to assure growth.
  • ⚖️ Alternating between growth and longevity practices is key.
  • 👴 Older adults benefit more from blocking senescent cells.
  • 🥗 Quality nutrition and exercise outweigh supplements for youth.
  • 🕰️ Consider longevity supplements from the 40s onward.
  • 💪 Growth and repair are critical throughout life stages.
  • 🎯 Strategic intent in training can enhance longevity.
  • 📈 Mitochondrial health is tied to longevity practices.
  • 💡 Misunderstanding of senescent cells can hinder effective aging strategies.

时间轴

  • 00:00:00 - 00:09:34

    The speaker addresses the flaws in longevity research concerning muscle preservation and building. They argue that longevity and body composition don't always align and present ways to bridge this gap. They introduce 'senescent cells', often misunderstood as harmful zombie cells, explaining their role in muscle repair and satellite cell function. The speaker criticizes the longevity community for wanting to block these cells, highlighting studies that show blocking them in older adults aids muscle building and prevents sarcopenia, but in younger individuals, it hinders repair. They discuss aging-related increases in these cells and how moderation over a person's lifespan is crucial. They caution against indiscriminate use of longevity treatments like Metformin before 40, advocating for phase-focused workouts and nutrition to blend performance and longevity effectively. Young individuals should focus on foundational health practices like exercise and nutrition without over-relying on supplements for genuine longevity benefits.

思维导图

Mind Map

常见问题

  • What role do senescent cells play in muscle repair?

    Senescent cells aid in fiber repair and are crucial for the regenerative process of muscle.

  • Why are senescent cells often misunderstood in longevity research?

    Senescent cells are labeled as 'zombie cells,' but they actually help in muscle repair and cell regeneration, rather than harming the body.

  • How do senescent cells contribute to satellite cell activity?

    Senescent cells support satellite cells in fusing with muscle to promote growth, which is essential for muscle repair.

  • Should younger people focus on blocking senescent cells?

    No, blocking senescent cells in younger individuals may hinder muscle repair and growth.

  • What impact does blocking senescent cells have on older adults?

    For older adults, blocking senescent cells can help build muscle and prevent age-related muscle wasting.

  • How important is the balance between longevity and performance?

    Finding a balance between longevity and performance is crucial, and chunking time for both can aid in sustainable development.

  • What is the suggested approach to longevity for younger individuals?

    Younger individuals should focus on building muscle and cardiac strength through exercise and nutrition, rather than relying on supplements.

  • When should longevity-focused compounds be considered?

    Longevity-focused compounds should be considered when reaching the 40s, not earlier, to avoid blunting growth.

  • How does one balance growth and repair with longevity?

    By alternating between periods of growth and repair while considering longevity supplements and practices after reaching middle age.

  • Why should the focus be on performance in younger years?

    Focusing on performance helps in laying a strong foundation for muscle and health, making longevity practices more effective later.

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  • 00:00:00
    there's some serious flaws in following
  • 00:00:02
    a lot of the longevity research if your
  • 00:00:04
    goal is muscle preservation even
  • 00:00:07
    building muscle and even to a certain
  • 00:00:09
    degree fat loss longevity and
  • 00:00:11
    performance don't always go hand inand
  • 00:00:15
    longevity and body composition don't
  • 00:00:17
    always go hand inand my job has always
  • 00:00:19
    been to sort of bridge that Gap a little
  • 00:00:21
    bit I feel like we can have both as long
  • 00:00:24
    as we understand so I have some ways for
  • 00:00:27
    you to leverage what we know from the
  • 00:00:29
    longevity research with what we know
  • 00:00:31
    from the sort of body composition and
  • 00:00:33
    performance side of things so what I
  • 00:00:35
    want to address today is something
  • 00:00:36
    called a ccent cell which in the world
  • 00:00:39
    of longevity gets overhyped as this
  • 00:00:41
    terrible like zombie cell is literally
  • 00:00:44
    what they call it and it's the most
  • 00:00:45
    frustrating thing because the body does
  • 00:00:47
    not create these cells to hurt us they
  • 00:00:51
    create them to help us but we need to
  • 00:00:55
    understand how to control them okay
  • 00:00:57
    they're not zombies they're more like
  • 00:00:59
    clone and I'll explain how this works
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  • 00:01:58
    underneath this video let's say for
  • 00:02:00
    example you are really busy and you wish
  • 00:02:03
    that you could clone yourself but if you
  • 00:02:05
    cloned yourself that would mean that
  • 00:02:07
    that clone might start running a muck
  • 00:02:09
    with your entire life right like he may
  • 00:02:12
    come home and meet your wife right like
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    something like that he may go and like
  • 00:02:18
    go to the store and start doing weird
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    things and make people think that that's
  • 00:02:22
    you it could really cause a problem but
  • 00:02:24
    if you could take that clone and you
  • 00:02:25
    could say hey clone I'm programming you
  • 00:02:28
    to do this one job then you could send
  • 00:02:30
    that clone to work for you you could
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    send that clone to the gym okay that
  • 00:02:34
    wouldn't really work but anyway you get
  • 00:02:36
    what I'm saying here that's what ccent
  • 00:02:38
    cells do so when people say they're
  • 00:02:40
    zombie cells it's a huge problem because
  • 00:02:44
    they're not zombie cells zombies are
  • 00:02:46
    useless let me explain how this can
  • 00:02:48
    become a problem for your muscle
  • 00:02:50
    building first and then we'll talk about
  • 00:02:51
    how that interplays with fat loss so
  • 00:02:54
    there was a study that was published in
  • 00:02:55
    FAS Journal it's a pretty esteemed
  • 00:02:58
    Journal okay and they found that ccent
  • 00:03:01
    cells actually Aid in fiber repair in
  • 00:03:05
    the regenerative process of muscle so
  • 00:03:08
    when we break down muscle what happens
  • 00:03:11
    is the body says hey let me create a
  • 00:03:15
    proxy of this cell to go and start
  • 00:03:19
    building muscle or start repairing so
  • 00:03:22
    that I can focus on what I need to focus
  • 00:03:23
    on I'm busy with this task so make a
  • 00:03:26
    clone go do my work for me that's the
  • 00:03:28
    idea they also play a tremendous role in
  • 00:03:32
    Satellite cells satellite cells when you
  • 00:03:35
    tear a muscle like in the gym like or
  • 00:03:36
    not tear it but break it down you have
  • 00:03:38
    these satellite cells and they kind of
  • 00:03:40
    like hover over the muscle I guess it's
  • 00:03:42
    a simple way to put it the regular cell
  • 00:03:45
    okay and then what happens is they fuse
  • 00:03:47
    to the cell and they cause growth so
  • 00:03:48
    these satellite cells hover Like
  • 00:03:51
    Satellites and then fuse and make the
  • 00:03:52
    muscle grow there are less satellite
  • 00:03:55
    cells if there are no ccent cells so if
  • 00:03:59
    you don't have sence then that's a
  • 00:04:02
    problem right so all this talk out there
  • 00:04:04
    in the longevity World about blocking
  • 00:04:06
    ccent cells because they're zombie cells
  • 00:04:10
    I get it when you're older this is super
  • 00:04:13
    super important here's another study
  • 00:04:16
    this study was published in the Journal
  • 00:04:17
    of physiology and it found that when you
  • 00:04:19
    are older blocking ccent cells can
  • 00:04:24
    actually help you build muscle and help
  • 00:04:26
    prevent sarcopenia the age related sort
  • 00:04:29
    of muscle
  • 00:04:30
    wasting huge so if you take that
  • 00:04:32
    literature you're like great this is
  • 00:04:35
    great for me to take all the time
  • 00:04:36
    however in that same study they find
  • 00:04:38
    that younger people it actually blocks
  • 00:04:42
    repair now there's other studies that
  • 00:04:44
    demonstrate that ccent cells promote
  • 00:04:46
    wound healing so ccent cells are
  • 00:04:49
    required for repair what happens is as
  • 00:04:53
    we get older we have so many more ccent
  • 00:04:57
    cells that form because what happens is
  • 00:04:59
    they're formed a lot of times when
  • 00:05:01
    there's DNA damage or just mutations to
  • 00:05:04
    cells so the body creates proxies of
  • 00:05:06
    those cells that cannot procreate that
  • 00:05:08
    cannot replicate in an effort to save
  • 00:05:12
    you from mutated cells growing and
  • 00:05:15
    creating mutated things it's actually
  • 00:05:18
    helping you a ton but eventually you get
  • 00:05:21
    so many ccent cells that it does become
  • 00:05:24
    an encumbrance to things so what happens
  • 00:05:27
    if you focus so much on like calics and
  • 00:05:31
    trying to suppress cell sens well you
  • 00:05:36
    absolutely will hinder your healing you
  • 00:05:38
    will negatively impact things so when do
  • 00:05:41
    you start focusing on it probably in
  • 00:05:45
    your 40s maybe your late 30s now I'm
  • 00:05:48
    talking about you know using these
  • 00:05:49
    compounds that people talk about but
  • 00:05:51
    let's talk about like a bigger longevity
  • 00:05:52
    thing too when I had Peter AA on my
  • 00:05:55
    channel one of the things he said he
  • 00:05:57
    changed his mind on specifically was the
  • 00:05:59
    use of Metformin for longevity you see
  • 00:06:02
    metformin for a long time it's something
  • 00:06:04
    that was increasing amk adenosine
  • 00:06:06
    monophosphate right um this is super
  • 00:06:10
    super important now if you phosphorate
  • 00:06:14
    amk it's essentially like you're in a
  • 00:06:17
    caloric deficit you're activating all
  • 00:06:19
    kinds of longevity Avenues and things
  • 00:06:21
    like that okay but what happens is when
  • 00:06:23
    you activate ampk you also suppress mtor
  • 00:06:26
    and mtor is progrowth and hair but in
  • 00:06:30
    the same breath mtor is also Pro tumor
  • 00:06:34
    growth and also Pro bad growth so if we
  • 00:06:38
    try to block growth we also block
  • 00:06:42
    recovery and repair but if we try to
  • 00:06:46
    provoke it we potentially grow bad
  • 00:06:49
    things so where is the balance well with
  • 00:06:52
    calics I don't think those should be
  • 00:06:55
    added in until you're older but as far
  • 00:06:58
    as longevity is concerned
  • 00:07:00
    very Stark contrasts between periods of
  • 00:07:04
    deprivation and periods where you're
  • 00:07:06
    focusing on Long longevity and then
  • 00:07:08
    periods where you're focused on
  • 00:07:09
    performance if you try to focus on
  • 00:07:11
    performance and Longevity at the same
  • 00:07:13
    time it can be difficult it can be done
  • 00:07:16
    and candidly it's the safest way to do
  • 00:07:18
    it if you start from the get-go because
  • 00:07:20
    it can prevent injury and you can do
  • 00:07:21
    things in a sustainable fashion but I
  • 00:07:24
    personally I like to chunk my time I
  • 00:07:26
    chunk my workouts into high performance
  • 00:07:28
    bouts and then I take longer chunks
  • 00:07:30
    where I focus on more repair and
  • 00:07:32
    Recovery I have much more D Lo weeks
  • 00:07:36
    with my training than I do hard weeks
  • 00:07:38
    and it works that way and if you look at
  • 00:07:40
    some of the competitive athletes these
  • 00:07:41
    days that's how they train what does it
  • 00:07:43
    have to do with longevity because
  • 00:07:45
    longevity is not just how long you live
  • 00:07:47
    it's how long you play the game whether
  • 00:07:50
    that game is professional basketball or
  • 00:07:52
    whether that game is jumping into a
  • 00:07:54
    CrossFit box twice a week for just craps
  • 00:07:56
    and Giggles right or maybe it's just
  • 00:07:58
    being able to play with your kids being
  • 00:08:01
    in the game is really important for
  • 00:08:03
    longevity Your vitality so when we look
  • 00:08:06
    at this what's the best way to structure
  • 00:08:09
    it mitochondrial Health perspective
  • 00:08:12
    longevity there the best thing that you
  • 00:08:15
    can do is focus if you're younger
  • 00:08:17
    because I know people watching this
  • 00:08:18
    video are going to be all ages 20s 30s
  • 00:08:22
    focus on getting the muscle focus on the
  • 00:08:24
    muscle and building the cardiac strength
  • 00:08:26
    so focus on your workouts as much as you
  • 00:08:28
    possibly can focus on your nutrition do
  • 00:08:31
    what you can fundamentally with your
  • 00:08:34
    nutrition and your workouts without all
  • 00:08:36
    the gobbley goop the supplements are not
  • 00:08:38
    going to save your day when you're young
  • 00:08:40
    okay they're not going to help save your
  • 00:08:42
    world what's going to save your world is
  • 00:08:44
    doing the hard work now and Paving the
  • 00:08:47
    road for yourself then when you get into
  • 00:08:49
    your 40s that's when you can start
  • 00:08:51
    playing with the calics that's when you
  • 00:08:52
    start playing with the compounds that
  • 00:08:54
    have longevity aspects in terms of the
  • 00:08:58
    research
  • 00:08:59
    the compounds that have the true
  • 00:09:00
    longevity research behind them are the
  • 00:09:02
    things we already know
  • 00:09:04
    micronutrient-rich Foods protein
  • 00:09:07
    exercise calorie restriction here and
  • 00:09:10
    there those things are all things you
  • 00:09:12
    can do when you're young but if you want
  • 00:09:15
    to start really focusing and getting
  • 00:09:16
    granular the Dave ASP of the world the
  • 00:09:18
    Brian Johnson's of the world I wouldn't
  • 00:09:21
    recommend messing around with that stuff
  • 00:09:23
    until you're at least in your 40s that
  • 00:09:25
    way you get the most and you don't ever
  • 00:09:27
    blunt growth growth and repair is so
  • 00:09:31
    important do not forget it I'll see you
  • 00:09:33
    tomorrow
标签
  • Senescent Cells
  • Longevity
  • Muscle Growth
  • Fat Loss
  • Performance
  • Muscle Repair
  • youger age strategy
  • Older age strategy
  • Balance growth
  • Nutrition