Coagulation Cascade Animation - Physiology of Hemostasis

The video explains the process of blood coagulation at the site of vessel injury. Initially, platelets arrive to seal the wound, and then the coagulation cascade is activated involving two pathways: extrinsic and intrinsic. Extrinsic activation is triggered by exposed tissue factors forming a complex with factor 7, leading to the activation of factor 10. At this point, both pathways converge at factor 10a, which plays a crucial role in the coagulation cascade. The intrinsic pathway involves multiple coagulation factors activating each other sequentially, also leading to the activation of factor 10. Factor 10a, combined with factor 5a, initiates thrombin formation, significantly amplifying thrombin levels and consequently enhancing platelet activation and fibrin production. Fibrin creates a mesh that stabilizes the clot by securing platelets and red blood cells. The pivotal role of factor 10a makes it a target for therapeutic interventions in abnormal blood coagulation.