CNS 2025: Keynote Address by Adriana Galván, "Adolescent Brain Development"

00:47:29
https://www.youtube.com/watch?v=XCCQOy4RO9g

Zusammenfassung

TLDRThe 32nd annual meeting of the Cognitive Neuroscience Society, co-chaired by Michael Anderson and Sabina Castner, features a diverse program with contributions from various committees. The keynote address by Adriana Galvan focuses on adolescent brain development, emphasizing the significance of social connections, joy, and strategic risk-taking. Galvan advocates for translating neuroscience research into policies that support adolescents, highlighting their unique developmental needs and the impact of the environment on brain growth. The conference also honors distinguished scientists and encourages engagement with emerging research in cognitive neuroscience.

Mitbringsel

  • 🎉 Welcome to the 32nd annual meeting of the Cognitive Neuroscience Society!
  • 👩‍🔬 Keynote speaker Adriana Galvan focuses on adolescent brain development.
  • 🧠 Adolescence is a critical period for forming new neural pathways.
  • 🤝 Social connections are vital for adolescent development.
  • 🎓 The conference features awards for distinguished scientists.
  • 📚 Research can inform policies that support adolescents.
  • 🌍 The environment significantly impacts brain development.
  • 💡 Adolescents are strategic risk-takers, learning through experiences.
  • ❤️ Embracing joy is important during adolescence.
  • 📈 The Center for the Developing Adolescent aims to translate research into practice.

Zeitleiste

  • 00:00:00 - 00:05:00

    Michael Anderson welcomes attendees to the 32nd annual Cognitive Neuroscience Society meeting, acknowledging the efforts of various committees and individuals who contributed to organizing the event. He highlights the exciting program, including invited sessions on cognitive functions, lesion methods, EEG insights, and the cognitive thalamus, as well as a record number of poster submissions. Anderson encourages attendees to engage with scientists and participate in workshops and social events throughout the conference.

  • 00:05:00 - 00:10:00

    Sabina Castner expresses her happiness to be part of the scientific community and introduces keynote speaker Adriana Galvan, who specializes in adolescent brain development. Galvan's research focuses on the neural mechanisms underlying adolescent behavior and the importance of this developmental stage. She has published extensively and received numerous accolades for her work, including a Fulbright scholarship and a Presidential Early Career Award.

  • 00:10:00 - 00:15:00

    Adriana Galvan begins her keynote address by discussing the unique qualities of adolescents, portraying them as 'superhumans' who excel in learning and social bonding. She aims to shift the negative narrative surrounding adolescence and emphasizes the need for policies that support their development. Galvan shares her personal connection to the topic as both a researcher and a parent of a teenager, highlighting the importance of understanding adolescent brain development.

  • 00:15:00 - 00:20:00

    Galvan explains that adolescence spans from around 10-12 years old to the early 20s, a period often overlooked in terms of funding and research focus. She references a 2018 Nature editorial that calls for more attention to adolescent health, paralleling the focus given to pediatrics and geriatrics. Galvan emphasizes the need for a supportive environment to foster healthy brain development during this critical time.

  • 00:20:00 - 00:25:00

    The National Academy of Sciences report on adolescence highlights the creation of new neural pathways during this developmental stage, influenced by environmental factors. Galvan stresses the importance of celebrating adolescence and recognizing their unique developmental needs, which include exploring the world, building decision-making skills, forming values and identity, and seeking social connections.

  • 00:25:00 - 00:30:00

    Galvan outlines seven developmental needs of adolescents, including the importance of support from caregivers and the need for a nurturing environment to achieve developmental milestones. She emphasizes that adolescents continue to require guidance and support from adults, despite the common perception that they are solely focused on their peers.

  • 00:30:00 - 00:35:00

    Galvan discusses the ongoing brain development during adolescence, characterized by organized and sequential growth, refinement of brain connectivity, and significant plasticity. She explains that the brain's ability to adapt and respond to the environment is crucial for developing cognitive skills and social connections during this period.

  • 00:35:00 - 00:40:00

    The keynote address highlights the importance of joy in adolescence, as their reward systems are highly sensitive, allowing them to learn and adapt quickly. Galvan shares research findings that demonstrate adolescents' heightened sensitivity to rewards and their ability to learn from new experiences, which is essential for navigating the complexities of social interactions and decision-making.

  • 00:40:00 - 00:47:29

    Galvan concludes by discussing the need for scientists to communicate their findings to policymakers and the public, emphasizing the impact of research on adolescent development in various sectors, including education and the justice system. She encourages a collaborative approach to support adolescents and promote their well-being, advocating for policies that recognize their unique developmental needs.

Mehr anzeigen

Mind Map

Video-Fragen und Antworten

  • Who is the keynote speaker at the conference?

    The keynote speaker is Adriana Galvan, a professor of psychology at UCLA.

  • What is the focus of Adriana Galvan's research?

    Her research focuses on adolescent brain development and its implications for behavior and policy.

  • What awards are being presented at the conference?

    Awards include the George Miller award, Distinguished Career Contributions award, and Young Investigator awards.

  • What is the significance of the adolescent brain development period?

    This period is crucial for forming new neural pathways and developing social and cognitive skills.

  • What are some key themes discussed in the keynote address?

    Key themes include the importance of social connections, joy, and strategic risk-taking in adolescence.

  • How can neuroscience research impact policies for adolescents?

    Research can inform policies that better support the developmental needs of adolescents.

  • What is the role of the Cognitive Neuroscience Society?

    The society organizes conferences and promotes research in cognitive neuroscience.

  • What is the importance of the environment in adolescent brain development?

    The environment plays a critical role in shaping brain development and the formation of neural connections.

  • What are some developmental needs of adolescents?

    Developmental needs include exploring the world, building decision-making skills, and forming identity.

  • What is the goal of the Center for the Developing Adolescent?

    The center aims to translate adolescent neuroscience research into practical applications and policies.

Weitere Video-Zusammenfassungen anzeigen

Erhalten Sie sofortigen Zugang zu kostenlosen YouTube-Videozusammenfassungen, die von AI unterstützt werden!
Untertitel
en
Automatisches Blättern:
  • 00:00:05
    Good evening. I'd like to welcome you
  • 00:00:06
    all to the 32nd annual uh meeting of the
  • 00:00:09
    Cognitive Neuroscience Society. Uh I'm
  • 00:00:12
    Michael Anderson from the University of
  • 00:00:14
    Cambridge and I am co-program chair this
  • 00:00:16
    year together with Sabina Castner from
  • 00:00:18
    Princeton University. I'm the outgoing
  • 00:00:20
    chair and she is the incoming chair. Um
  • 00:00:24
    I I'd like to say a few words before we
  • 00:00:26
    get started, words of thanks. uh because
  • 00:00:30
    a conference of this magnitude, of this
  • 00:00:32
    size, is no easy feat to put together.
  • 00:00:35
    It's a very complex affair indeed. It
  • 00:00:37
    involves no less than six different
  • 00:00:39
    committees. For for example, can't use
  • 00:00:43
    my classes. uh the the program
  • 00:00:44
    committee, the symposium committee, the
  • 00:00:46
    poster committee, the young investigator
  • 00:00:48
    awards committee, the rising star
  • 00:00:50
    committee, the CNS training trainee
  • 00:00:52
    association, not to mention the members
  • 00:00:55
    of the cognitive neuroscience society
  • 00:00:56
    organization itself like Kate Treway,
  • 00:00:59
    Carrie Miller, and Lisa Munos for
  • 00:01:01
    example. Uh so all of these people have
  • 00:01:04
    invested a significant amount of time in
  • 00:01:07
    evaluating the content that's been
  • 00:01:08
    submitted to our society to ensure that
  • 00:01:11
    you have a high quality cutting edge
  • 00:01:14
    exciting program uh to attend to attend.
  • 00:01:18
    Um just to give you a little bit of a
  • 00:01:21
    flavor I got two microphones here. You
  • 00:01:23
    get a little bit of a flavor of some of
  • 00:01:24
    the content that you're going to be
  • 00:01:25
    hearing about this year. Just in the
  • 00:01:28
    invited sessions, we have a session
  • 00:01:29
    organized by Anna Shapiro on the
  • 00:01:32
    cognitive functions of replay. Uh a
  • 00:01:35
    session organized by Lesie Fellows on
  • 00:01:38
    advances in lesion methods in cognitive
  • 00:01:40
    neuroscience. A session organized by Ben
  • 00:01:43
    Heath uh which is kind of a deep dive
  • 00:01:45
    into what EEG uh has taught us in
  • 00:01:48
    cognitive neuroscience. and a session
  • 00:01:50
    organized by Kai Hang of the University
  • 00:01:52
    of Iowa on uh the the cognitive phalamus
  • 00:01:56
    the the attentional functions of of the
  • 00:01:58
    phalamus and the cognitive functions
  • 00:01:59
    more broadly and that's just the invited
  • 00:02:02
    sessions the membered submitted sessions
  • 00:02:05
    are more numerous and diverse and
  • 00:02:08
    exciting than than even that I think
  • 00:02:11
    you're going to have a hard time
  • 00:02:12
    choosing which things to go to. I I
  • 00:02:14
    certainly you're not going to be able to
  • 00:02:15
    go to everything that you want to go to.
  • 00:02:17
    I certainly won't be able to uh th this
  • 00:02:20
    is not even mentioning the the numerous
  • 00:02:22
    and I think record number of posters
  • 00:02:24
    submitted to our society this year. Uh
  • 00:02:26
    the multiple sessions I I really
  • 00:02:28
    encourage you to try to attend as many
  • 00:02:30
    of these as you can because it gives you
  • 00:02:32
    a chance to talk directly face-toface
  • 00:02:35
    with the scientists producing some of
  • 00:02:37
    the most exciting scientists on the
  • 00:02:39
    horizon of our field. Uh and I think
  • 00:02:41
    they really appreciate it and I think
  • 00:02:43
    you'll really appreciate it as well. We
  • 00:02:45
    have an array of uh lunchtime workshops
  • 00:02:48
    which are easy to miss as you're running
  • 00:02:50
    for your sandwich outside because you're
  • 00:02:53
    so hungry. You may overlook that there's
  • 00:02:55
    a really cool workshop that you could be
  • 00:02:57
    participating in that's directly
  • 00:02:58
    relevant to you. So be sure to to take a
  • 00:03:00
    peek at that in the symposium or in the
  • 00:03:03
    in the in the program. Um we have uh the
  • 00:03:07
    society has chosen to honor a number of
  • 00:03:10
    distinguished scientists this year both
  • 00:03:12
    at the senior level and at the junior
  • 00:03:14
    level. Uh the this year's George Miller
  • 00:03:17
    award recipient is professor Ken Per. Uh
  • 00:03:21
    the distinguished career contributions
  • 00:03:23
    award is uh professor Marie Banich. And
  • 00:03:26
    then we have two young investigators
  • 00:03:28
    early career scientists Emily Finn and
  • 00:03:31
    Andre Bastos. uh each of them will be
  • 00:03:34
    giving uh an award address and I think
  • 00:03:37
    this is going to be really really
  • 00:03:38
    exciting to attend you should check it
  • 00:03:40
    out and see see what all the excitement
  • 00:03:42
    is about and why why they were given the
  • 00:03:44
    their awards.
  • 00:03:47
    Um they on Sunday when you're done
  • 00:03:50
    checking out all the science you can
  • 00:03:51
    handle on Sunday on Sunday night there's
  • 00:03:54
    a performance by Pavlov's dogs at the
  • 00:03:57
    Canab lounge. Uh you should you should
  • 00:03:59
    definitely definitely see they're always
  • 00:04:01
    a good time. uh the CNS traininee uh uh
  • 00:04:07
    committee has organized a panel
  • 00:04:09
    discussion on late Monday night or not
  • 00:04:12
    late Monday night late Monday afternoon
  • 00:04:14
    early evening and it's followed by a CNS
  • 00:04:16
    trainee social immediately after that
  • 00:04:19
    and I think that that this is talking
  • 00:04:20
    about career possibilities uh for for
  • 00:04:23
    young for for early career scientists uh
  • 00:04:27
    immediately after tonight's uh uh
  • 00:04:29
    keynote address uh which Sabina will be
  • 00:04:32
    introducing
  • 00:04:33
    Uh there will be a reception in the
  • 00:04:35
    lobby and I look forward to seeing many
  • 00:04:38
    of you there. Thank you very much.
  • 00:04:42
    [Applause]
  • 00:04:52
    Yeah, good afternoon. These are bright
  • 00:04:54
    lights. Um well, I'm Sabina Castnim. I
  • 00:04:58
    serve together with Mike as a chair of
  • 00:05:00
    the program committee.
  • 00:05:02
    And I just want to say how incredibly
  • 00:05:05
    happy I am to be in this community of
  • 00:05:09
    strong scientists at this point in
  • 00:05:12
    time. Now it is my pleasure and a
  • 00:05:15
    privilege to introduce our keynote
  • 00:05:18
    keynote speaker Adriana
  • 00:05:20
    Galvan. Adriana is a professor of
  • 00:05:23
    psychology and the dean and vice provost
  • 00:05:25
    of undergraduate education at the
  • 00:05:28
    University of California at Los Angeles.
  • 00:05:32
    She's also the co-executive director of
  • 00:05:34
    the UCLA Center for the Developing
  • 00:05:37
    Adolescent. In her science career,
  • 00:05:40
    Eduana has been focused on the
  • 00:05:41
    adolescent brain development and how it
  • 00:05:44
    supports developmental
  • 00:05:46
    milestones during this important period
  • 00:05:49
    of life. Her research expertise focuses
  • 00:05:52
    on characterizing the neurom mechanisms
  • 00:05:55
    underlying under adolescent behavior to
  • 00:05:58
    inform policies that impact young
  • 00:06:03
    people. Adriana has published over 130
  • 00:06:07
    scientific articles on the topic and she
  • 00:06:10
    is the author of a book the neuroscience
  • 00:06:13
    of adolescence.
  • 00:06:16
    She received her BA in neuroscience and
  • 00:06:18
    behavior from Barnard College at
  • 00:06:21
    Columbia
  • 00:06:22
    University and her PhD in neuroscience
  • 00:06:25
    from
  • 00:06:26
    Cornell. She has received multiple
  • 00:06:28
    recognitions for her work including from
  • 00:06:31
    the National Academy of Sciences, the
  • 00:06:33
    American Psychological Association, the
  • 00:06:36
    Cognitive Neuroscience Society, and the
  • 00:06:39
    William T. Grant Foundation. She is also
  • 00:06:42
    the recipient of the UCLA Gold Shield
  • 00:06:46
    Faculty
  • 00:06:47
    Prize. In 2018, Adriana was a Fulbright
  • 00:06:51
    scholar in Barcelona. And in 2019, she
  • 00:06:55
    received the White House Presidential
  • 00:06:58
    Early Career Award for Science and
  • 00:07:00
    Engineers, which is, I think, the
  • 00:07:02
    highest honor for an early career
  • 00:07:06
    researcher. So, we are now looking
  • 00:07:08
    forward to Dr. Gavan's keynote address
  • 00:07:11
    and it's entitled adolescent brain
  • 00:07:14
    development the importance of
  • 00:07:16
    connections. Please help me welcome
  • 00:07:19
    [Applause]
  • 00:07:26
    Juliana. Um so nice to be here. I really
  • 00:07:30
    enjoy this community and it's wonderful
  • 00:07:32
    to see friends and family. you feel like
  • 00:07:34
    family um from present time and then
  • 00:07:37
    also from all the years I spent training
  • 00:07:40
    in various spaces. As Sabina mentioned,
  • 00:07:42
    I'll be talking about some research
  • 00:07:44
    we've been doing in our lab and labs
  • 00:07:45
    across the world about how adolescence
  • 00:07:48
    develops and how brain development
  • 00:07:50
    during this time is essential for them
  • 00:07:52
    to um develop into
  • 00:07:54
    adults. I really appreciate the the
  • 00:07:58
    opportunity to deliver this keynote
  • 00:08:00
    speech and um and hope you will find it
  • 00:08:02
    informative.
  • 00:08:04
    Imagine if there existed a group of
  • 00:08:06
    people who laugh easily, prioritize
  • 00:08:09
    bonding with others, could learn faster
  • 00:08:11
    than anyone in this room, and embrace
  • 00:08:13
    the uncertainty of life. We might call
  • 00:08:16
    them superhumans. We'd certainly study
  • 00:08:18
    them and love them and want to be them.
  • 00:08:21
    Well, it turns out that this magical
  • 00:08:23
    group of people live among us, and
  • 00:08:25
    they're called teenagers. And that's
  • 00:08:27
    what I'll be talking about today.
  • 00:08:30
    Despite the bad rap that adolescence get
  • 00:08:33
    in the very spaces that can help them
  • 00:08:34
    the most, sometimes in in school
  • 00:08:36
    settings or in legal spaces, um this
  • 00:08:40
    this talk I'm going to give is a
  • 00:08:41
    feel-good story of adolescence and this
  • 00:08:43
    wondrous time of life and what we can
  • 00:08:45
    learn from them and how we as scientists
  • 00:08:47
    can further advance their development by
  • 00:08:50
    translating the science into spaces that
  • 00:08:53
    need adolescence policy and legal
  • 00:08:56
    spaces. How do I know this? Well,
  • 00:08:59
    besides the fact that I um myself was a
  • 00:09:02
    teenager at one point, I'm the second
  • 00:09:03
    from the left there in high school. I am
  • 00:09:06
    now the parent of an adolescent. That's
  • 00:09:08
    my son Gustavo who's 14. Um I've spent
  • 00:09:11
    over 20 years studying the adolescent
  • 00:09:13
    brain. And this is a picture from the
  • 00:09:15
    2003 John Merks Fund summer institute at
  • 00:09:18
    Princeton run by BJ Casey. And some of
  • 00:09:21
    the people you can see here have gone on
  • 00:09:23
    to be some of the most renowned
  • 00:09:24
    developmental scientists in the world.
  • 00:09:26
    And at this time upon reflection we were
  • 00:09:29
    just learning how to use cognitive
  • 00:09:31
    neuroscience skills to inform the
  • 00:09:33
    developing brain or understanding of the
  • 00:09:34
    developing brain. And since then we've
  • 00:09:37
    learned a lot about it. In those early
  • 00:09:39
    years there was a lot of misconceptions
  • 00:09:41
    about adolescence and often framed in
  • 00:09:43
    negative light.
  • 00:09:46
    When I refer to adolescence, I'm talking
  • 00:09:48
    roughly the period of 10 or 11 or 12
  • 00:09:51
    when puberty strikes into the early 20s
  • 00:09:54
    when we adopt social roles that may be
  • 00:09:56
    defined as as adolescent like or
  • 00:09:58
    adult-like or more
  • 00:10:00
    mature. There's vast variation during
  • 00:10:03
    this time in life, but it does span a
  • 00:10:05
    long time. And what's surprising is that
  • 00:10:08
    despite the many years that we spend
  • 00:10:10
    being adolescence, there's much less
  • 00:10:12
    attention paid to it in terms of how
  • 00:10:14
    many dollars we expend, federal dollars
  • 00:10:16
    we expend or how much attention is given
  • 00:10:17
    to adolescence.
  • 00:10:19
    This editorial in the journal Nature in
  • 00:10:22
    2018 characterized it as really nicely
  • 00:10:26
    and they said a modern health care
  • 00:10:27
    system without a focus on the unique
  • 00:10:29
    challenges of pediatrics or geriatrics
  • 00:10:32
    would be unthinkable and yet there's no
  • 00:10:34
    similar effort on behalf of adolescence.
  • 00:10:36
    Luckily that's changing because
  • 00:10:38
    adolescence need us and as I hope I will
  • 00:10:40
    convey in this talk we need adolescence.
  • 00:10:46
    One testament to that is a now
  • 00:10:48
    relatively recent um report consensus
  • 00:10:52
    report by the national academy of
  • 00:10:53
    science of uh and engineering the
  • 00:10:55
    promise of adolescence. And throughout
  • 00:10:57
    this report I highly encourage you to
  • 00:10:59
    read it. They note that the latest brain
  • 00:11:01
    development research shows that the
  • 00:11:03
    developmental period from adolescence
  • 00:11:05
    through emerging adulthood features the
  • 00:11:07
    creation of new neural pathways. And of
  • 00:11:10
    course that doesn't just happen onto
  • 00:11:11
    genetically but it's in response to the
  • 00:11:13
    environment. And so the environment that
  • 00:11:14
    we create for young people is really
  • 00:11:16
    important for how their brains will
  • 00:11:19
    develop. And this has helped this this
  • 00:11:21
    narrative has helped shift how we talk
  • 00:11:23
    about
  • 00:11:24
    adolescence. In that same editorial from
  • 00:11:27
    2018, there was an a note about how
  • 00:11:30
    adolescence research must grow up. We
  • 00:11:32
    need to stop giving adolescence a raw
  • 00:11:34
    deal and start celebrating who they are.
  • 00:11:38
    In part, I think that this this shift
  • 00:11:40
    has um has happened because we've
  • 00:11:42
    learned that our work can have an impact
  • 00:11:44
    on the policies that impact young
  • 00:11:46
    people. Policy makers and legal scholars
  • 00:11:49
    turn to those who study adolescence to
  • 00:11:51
    gain insights into how best to support
  • 00:11:53
    young people. And I'll talk about that a
  • 00:11:55
    little bit in the second part of the
  • 00:11:58
    talk. What can we learn from
  • 00:12:00
    adolescence? We can learn a lot. we can
  • 00:12:02
    help them. But there's a lot that that
  • 00:12:04
    inherently happens during this
  • 00:12:06
    transitional period of life that we as
  • 00:12:08
    adults can learn from them. And I'll
  • 00:12:09
    give a little uh syn synthesis of each
  • 00:12:12
    of these areas of research that support
  • 00:12:14
    these claims. The first is that we can
  • 00:12:17
    embrace joy. Adolescence are really good
  • 00:12:19
    at that and sometimes we don't
  • 00:12:20
    acknowledge it. The second is that
  • 00:12:22
    adolescence are strategic risktakers
  • 00:12:25
    that all the risks that they take are
  • 00:12:27
    are important. um they offered learning
  • 00:12:30
    opportunities that the brain is primed
  • 00:12:32
    to receive during this period of
  • 00:12:34
    life. And finally, adolescence
  • 00:12:37
    prioritize social connections. Perhaps
  • 00:12:39
    now more than ever, social connections
  • 00:12:41
    are paramount to who we are as a
  • 00:12:42
    species. And we are inherently driven to
  • 00:12:45
    connect with other people. And
  • 00:12:46
    adolescence are really good at doing
  • 00:12:48
    this. Whether it's through uh online or
  • 00:12:51
    offline, they they embrace this
  • 00:12:53
    opportunity to meet new people.
  • 00:12:58
    When we are babies, we achieve
  • 00:13:01
    developmental milestones during infancy.
  • 00:13:03
    We learn how to walk and how to talk and
  • 00:13:06
    how to bond with caregivers. And these
  • 00:13:08
    milestones are best achieved when key
  • 00:13:11
    developmental needs are met. Primarily
  • 00:13:13
    when we have support and love and
  • 00:13:15
    attention that we need and deserve. And
  • 00:13:18
    no, no one argues this point that during
  • 00:13:21
    during this time in life, there's an
  • 00:13:23
    optimal rearing environment that
  • 00:13:25
    optimizes achieving these developmental
  • 00:13:27
    milestones. What is less well recognized
  • 00:13:30
    is that adolescence also have
  • 00:13:32
    developmental needs. Obviously, they're
  • 00:13:34
    not learning the basic things like
  • 00:13:36
    learning how to walk or talk or bond
  • 00:13:38
    with caregivers, but they are still
  • 00:13:40
    developing. And so, they too are are are
  • 00:13:44
    learning through trial and error.
  • 00:13:48
    During adolescence, um, we build on what
  • 00:13:51
    was the foundation during early
  • 00:13:53
    childhood and we take these principles
  • 00:13:55
    and the learning opportunities and the
  • 00:13:57
    social connections that we make into
  • 00:14:01
    adulthood. Along with a group of um,
  • 00:14:04
    scientists who formed the National
  • 00:14:06
    Scientific Council of Adolescence, folks
  • 00:14:08
    who encompass different areas of
  • 00:14:10
    expertise, we've identified these seven
  • 00:14:13
    developmental needs during adolescence.
  • 00:14:16
    They include exploring the world and
  • 00:14:17
    testing out new ideas and opportunities,
  • 00:14:20
    building decision-making and emotion
  • 00:14:22
    regulation skills. Because although
  • 00:14:24
    there's dramatic growth in areas like
  • 00:14:27
    the prefrontal cortex or emotion
  • 00:14:28
    regulation systems, we need spaces in
  • 00:14:31
    which to practice those skills.
  • 00:14:33
    Adolescence are forming values, goals,
  • 00:14:36
    and identity. It's no coincidence that
  • 00:14:38
    adolescence are often at the forefront
  • 00:14:39
    of new ideas or activism. And at UCLA,
  • 00:14:42
    we certainly saw this last last spring
  • 00:14:44
    and a lot of other places did
  • 00:14:46
    too. Adolescence find meaning and
  • 00:14:48
    purpose through contribution. Contrary
  • 00:14:51
    to the maybe popular narrative that
  • 00:14:53
    adolescence are very inwardly focused,
  • 00:14:55
    it's actually a time in life that when
  • 00:14:57
    they seek out new opportunities to
  • 00:14:59
    contribute to their community and
  • 00:15:01
    contribution has been associated with
  • 00:15:04
    stronger mental
  • 00:15:05
    health. Adolescence continue to need
  • 00:15:08
    support from parents and other caring
  • 00:15:10
    adults. We may assume that adolescence
  • 00:15:12
    start to pay a little bit more attention
  • 00:15:14
    to their friends and their peers, but
  • 00:15:16
    actually they're paying just as much
  • 00:15:17
    attention to those caregivers and adult
  • 00:15:20
    supportive figures who have supported
  • 00:15:22
    them throughout their lives. Adolescence
  • 00:15:25
    are really good at identifying true and
  • 00:15:28
    genuine respect among their peers and
  • 00:15:31
    their adults. And often behaviors that
  • 00:15:33
    we see as risky or ill- advised may be
  • 00:15:38
    enacted because that is one way that
  • 00:15:40
    they find respect among among peers and
  • 00:15:43
    adults. And finally, I won't have much
  • 00:15:46
    opportunity today or time to talk about
  • 00:15:48
    sleep, but that's an area of research
  • 00:15:50
    I've been really interested in in the
  • 00:15:52
    past 10 years or so. And I know that um
  • 00:15:55
    um uh Professor Per will be talking
  • 00:15:57
    about sleep in in his address, so I
  • 00:15:58
    won't talk about it here. And a few
  • 00:16:00
    years ago, the keynote was Matt Walker
  • 00:16:01
    who talked a lot about sleep. But I
  • 00:16:03
    cannot underscore how important sleep is
  • 00:16:05
    for the development of all of these
  • 00:16:07
    milestones and key uh cognitive needs
  • 00:16:10
    that adolescence face during this
  • 00:16:13
    time. Brain development is necessary for
  • 00:16:16
    supporting these specific or adolescent
  • 00:16:19
    specific developmental needs. And when I
  • 00:16:22
    speak to to folks who don't study brain
  • 00:16:24
    development, they often ask,"Well, what
  • 00:16:26
    does it mean that brain development
  • 00:16:27
    keeps happening during adolescence? Does
  • 00:16:30
    it mean that the brain continues to grow
  • 00:16:31
    in size?" And that's not what we mean.
  • 00:16:33
    What we mean is that there's refinement
  • 00:16:35
    of the brain during this time. Sarah
  • 00:16:38
    Jane Blakemore gave a terrific keynote a
  • 00:16:40
    few years ago at this conference, and
  • 00:16:42
    she described the the the particulars of
  • 00:16:45
    what happens in brain development during
  • 00:16:47
    adolescence. So, I'll just briefly
  • 00:16:48
    review it here.
  • 00:16:51
    One is that brain development is
  • 00:16:53
    organized and sequential. And what I
  • 00:16:56
    mean by that and as shown through this
  • 00:16:58
    this video is that the the different
  • 00:17:00
    loes of the brain roughly speaking
  • 00:17:03
    develop from the back to the front. And
  • 00:17:05
    that makes perfect sense. The brain is
  • 00:17:06
    efficient across evolution. The things
  • 00:17:09
    that happen in the back of the brain you
  • 00:17:11
    need right when you're born. the things
  • 00:17:12
    that happen in the front of the brain
  • 00:17:14
    like cognition or future orientation or
  • 00:17:16
    planning for the future perhaps you
  • 00:17:18
    don't need right away when you're born
  • 00:17:20
    because our parents do a really good job
  • 00:17:22
    of scaffolding those cognitive skills
  • 00:17:24
    for us. But during adolescence is when
  • 00:17:26
    we continue to define those higher
  • 00:17:28
    cognitive
  • 00:17:30
    abilities. The second thing that happens
  • 00:17:33
    is that there's refinement of brain
  • 00:17:35
    connectivity. That means that brain
  • 00:17:37
    regions begin are better able to
  • 00:17:39
    communicate with each other and that's
  • 00:17:41
    emblematic of the connections that we're
  • 00:17:43
    making outside of our brain in in our
  • 00:17:45
    community in our schools with our
  • 00:17:47
    families. And this refinement of brain
  • 00:17:50
    connectivity has been the focus of a lot
  • 00:17:51
    of research in um adolescent
  • 00:17:54
    neuroscience because we recognize that
  • 00:17:55
    this affords new cognitive skills,
  • 00:17:58
    faster speed of processing or the
  • 00:18:00
    ability to um to have better connections
  • 00:18:02
    between cognition and emotion.
  • 00:18:07
    There's also significant brain
  • 00:18:09
    plasticity and certainly I don't need to
  • 00:18:11
    share with this group the importance of
  • 00:18:12
    brain plasticity and how our brains are
  • 00:18:15
    reactive to the environment around us
  • 00:18:17
    that our brains unfold in particular
  • 00:18:19
    ways but that doesn't happen in a vacuum
  • 00:18:22
    that the environment and the experiences
  • 00:18:24
    that we have have a huge role in
  • 00:18:27
    scaffolding that sensitivity to the to
  • 00:18:29
    the changing environment.
  • 00:18:31
    This is a image from um a dendrite that
  • 00:18:35
    was provided to me by Linda Wilra at UC
  • 00:18:37
    Berkeley and she studies uh plasticity
  • 00:18:40
    in the adolescent rodent brain and so
  • 00:18:42
    she can provide some insights that of
  • 00:18:44
    course we can't get in in human
  • 00:18:46
    research. But what this video is
  • 00:18:48
    intended to show is that there's very
  • 00:18:50
    dynamic changes in the bhutons that come
  • 00:18:52
    off the the the spine and that happens
  • 00:18:54
    dynamically obviously and in response to
  • 00:18:56
    new
  • 00:18:57
    experiences. Here's a cartoon image that
  • 00:19:01
    um Dr. Wilt has generated showing that
  • 00:19:04
    at any given moment we are both gaining
  • 00:19:06
    connections and losing connections. And
  • 00:19:09
    that's one of the key hallmarks of
  • 00:19:10
    adolescent brain development that in
  • 00:19:12
    response to the environment we may be at
  • 00:19:14
    in one moment pruning away synapses that
  • 00:19:16
    no longer serve us because our the job
  • 00:19:18
    of the of the brain during this time is
  • 00:19:20
    to refine and strengthen those
  • 00:19:22
    connections that are relevant. In
  • 00:19:24
    earlier life that may be strengthening a
  • 00:19:26
    language for a particular lang for the
  • 00:19:29
    language that of of of your parents. Um
  • 00:19:32
    but in adolescence that may mean honing
  • 00:19:34
    a particular skill. We take in a lot of
  • 00:19:36
    skills during adolescence. Social
  • 00:19:38
    skills, driving skills, um abstract
  • 00:19:41
    algebra skills, all of those things are
  • 00:19:43
    new and our brains need to be able to
  • 00:19:45
    respond to it.
  • 00:19:47
    So at the microscopic level, our brain
  • 00:19:49
    cells are literally reaching out for new
  • 00:19:51
    information. And that's why I personally
  • 00:19:53
    find adolescence so fascinating that
  • 00:19:55
    there's no greater time in life or it's
  • 00:19:57
    maybe the last time in life when our
  • 00:19:59
    brains are so dynamic in reaching out
  • 00:20:01
    and seeking out that new
  • 00:20:03
    information. When our spines receive new
  • 00:20:06
    information, they form connections with
  • 00:20:07
    other
  • 00:20:09
    neurons. And this is specific to
  • 00:20:11
    adolescence. Around puberty, our neurons
  • 00:20:14
    can gain and lose about 25% of our
  • 00:20:16
    connections each week. And this drops to
  • 00:20:19
    about 10% by the time we reach
  • 00:20:21
    adulthood. And I only illustrate this
  • 00:20:23
    fact to show that there's a significant
  • 00:20:25
    shift in brain plasticity later in life
  • 00:20:28
    at the microscopic
  • 00:20:31
    level. So back to this question of what
  • 00:20:33
    we can learn from adolescence. I'll
  • 00:20:35
    synthesize some research u for each of
  • 00:20:37
    these points. Before I do, I I want to
  • 00:20:41
    make the point that although we speak
  • 00:20:43
    about adolescence in generalities and
  • 00:20:45
    certainly we need to do so when speaking
  • 00:20:47
    to
  • 00:20:47
    non-scientists, I recognize the vast
  • 00:20:50
    variation in individual differences in
  • 00:20:52
    young
  • 00:20:53
    people. I often show this slide because
  • 00:20:55
    I think it nicely illustrates how people
  • 00:20:58
    who are the same age and the same grade
  • 00:21:00
    as they are in this image um can look so
  • 00:21:02
    different and in turn receive many
  • 00:21:05
    different inputs from the environment.
  • 00:21:07
    Does anyone want to guess how old these
  • 00:21:09
    kids are? They're all the same
  • 00:21:14
    age.
  • 00:21:16
    13,
  • 00:21:18
    12, 10. Okay. What grade are they
  • 00:21:23
    in? Ninth grade, sixth grade. No one has
  • 00:21:27
    ever gotten this right. It's remarkable.
  • 00:21:29
    Even people who study adolescence, all
  • 00:21:31
    of these kids are 14-year-old eighth
  • 00:21:33
    graders. And I really appreciate that
  • 00:21:36
    because the boys on the far right could
  • 00:21:39
    not look more different. The boy on the
  • 00:21:40
    far right in the blue looks like he's in
  • 00:21:43
    high school and the one next to him
  • 00:21:44
    looks like he's in, you know, six. And
  • 00:21:47
    so this just illustrates that when we do
  • 00:21:51
    our imaging studies or when we talk to
  • 00:21:54
    policy makers, we're we're treating
  • 00:21:55
    everybody all 14y olds the same, but
  • 00:21:57
    obviously they are so different. and
  • 00:21:59
    puberty. And this is where biology can
  • 00:22:01
    really tell us or why we need to keep in
  • 00:22:03
    mind that adolescence is um is not
  • 00:22:08
    devoid of the input of of biology. So I
  • 00:22:12
    say this but and please take all the
  • 00:22:13
    research with a grain of salt when we
  • 00:22:15
    group everybody together for for the
  • 00:22:17
    purposes of comparing adolescence for
  • 00:22:19
    adults to adults for
  • 00:22:21
    example. So what can we learn from
  • 00:22:24
    adolescence? One thing I learned and I
  • 00:22:26
    keep in mind and I probably study
  • 00:22:27
    adolescence because I greatly enjoyed
  • 00:22:29
    being an adolescent was um the
  • 00:22:32
    importance of embracing joy that when ha
  • 00:22:35
    when you have an overactive or
  • 00:22:37
    hyperactive or sensitive reward system
  • 00:22:39
    your brain is paying attention to those
  • 00:22:41
    rewards and in a second I'll talk about
  • 00:22:43
    why that's adaptive and
  • 00:22:45
    important. This is a summary image of a
  • 00:22:47
    lot of research we've done in our lab
  • 00:22:49
    and labs around the world to examine the
  • 00:22:51
    reward system in adolescence. When I was
  • 00:22:54
    a a graduate student at BJ Casece, there
  • 00:22:56
    was actually really very little known
  • 00:22:58
    about the adolescent brain and that
  • 00:23:00
    surprised us when we started to dig into
  • 00:23:02
    the literature. We learned that there
  • 00:23:03
    was a lot of understanding of what
  • 00:23:05
    happens in earlier life or what happens
  • 00:23:07
    in adults or even college students. But
  • 00:23:09
    what makes adolescence so sensitive to
  • 00:23:11
    reward? At least that was our anecdotal
  • 00:23:13
    understanding of adolescence.
  • 00:23:16
    And and indeed when we threw adolescence
  • 00:23:20
    into the sc not threw we put we nicely
  • 00:23:22
    asked them to come into the scanner for
  • 00:23:24
    us and we put them in the scanner and we
  • 00:23:26
    showed them images of money or the
  • 00:23:28
    opportunity to earn money or in a
  • 00:23:30
    subsequent study I I gave them primary
  • 00:23:33
    rewards or we gave them social rewards.
  • 00:23:36
    They all yield activation in in dopamine
  • 00:23:40
    rich regions like the stridum. And this
  • 00:23:41
    is a study or a finding that's been
  • 00:23:43
    consistently shown. And interestingly,
  • 00:23:46
    even when given the same experience in
  • 00:23:48
    the in the scanner, the adolescence show
  • 00:23:50
    an exaggerated response. And so that
  • 00:23:53
    told us a little bit about how what the
  • 00:23:55
    brain is paying attention to during the
  • 00:23:56
    adolescent years. And later led to
  • 00:23:59
    questions about well why would that make
  • 00:24:01
    sense for us to have a time in life when
  • 00:24:03
    we are more sensitive to the rewards in
  • 00:24:05
    our environment.
  • 00:24:07
    Mechanistically, we obviously cannot put
  • 00:24:10
    in um electrodes into the human
  • 00:24:12
    adolescent to to test the hypothesis
  • 00:24:15
    that perhaps they have more dopamine
  • 00:24:17
    sensitivity because that was the obvious
  • 00:24:19
    answer to that and especially there were
  • 00:24:20
    a lot of studies at that time showing
  • 00:24:22
    that dopamine sensitivity led to greater
  • 00:24:25
    reward sensitivity.
  • 00:24:27
    But luckily we have um colleagues who do
  • 00:24:30
    research in in rodent models who can
  • 00:24:32
    shed some light on that and and in um
  • 00:24:35
    and non-human primate models. And the
  • 00:24:38
    basic story is that if you compare um
  • 00:24:40
    dopamine release or the synaptic
  • 00:24:42
    vesicles or the availability of dopamine
  • 00:24:44
    receptors in in human ver and I'm sorry
  • 00:24:47
    in rodent adults versus rodent
  • 00:24:49
    adolescence, there's simply just more
  • 00:24:51
    greater dopamine sensitivity in the
  • 00:24:53
    adolescent brain. I found that
  • 00:24:55
    fascinating because around the same time
  • 00:24:58
    there was a lot of research by Wol from
  • 00:25:00
    Schultz's group showing that dopamine
  • 00:25:03
    did more than code rewards or recognize
  • 00:25:05
    rewards. But in fact, dopamine was
  • 00:25:07
    critical for learning about the
  • 00:25:09
    environment. And that makes perfect
  • 00:25:11
    sense if you have a group of individuals
  • 00:25:13
    who are learning a whole new social
  • 00:25:15
    landscape as they transition into
  • 00:25:16
    adulthood.
  • 00:25:18
    That research was done by Wolram Schultz
  • 00:25:20
    and his colleagues in non-human primates
  • 00:25:23
    whereby they would stick an electrode
  • 00:25:25
    into their brain and were able to
  • 00:25:27
    monitor how dopamine acquire helped
  • 00:25:29
    acquire new learning or helped um with
  • 00:25:32
    the acquisition of how a behavior right
  • 00:25:35
    now would impact an outcome
  • 00:25:37
    later. And those of you who were reading
  • 00:25:40
    this literature at the time in 2003,
  • 00:25:43
    Ferrell and colleagues published this
  • 00:25:45
    very seinal paper showing that dopamine
  • 00:25:47
    was coding learning in the brain. That
  • 00:25:50
    is if you gave a monkey a cue with
  • 00:25:51
    different v um very um varying levels of
  • 00:25:55
    probability that the dopamine would kind
  • 00:25:57
    of stay enga the dopamine neurons would
  • 00:25:59
    stay engaged until they learned about
  • 00:26:01
    that outcome.
  • 00:26:02
    Um, this is really intriguing to me
  • 00:26:04
    because at that point I really had a
  • 00:26:06
    pretty simplified view of the reward
  • 00:26:09
    system in the brain and thought it was
  • 00:26:10
    really simply just coding for for
  • 00:26:12
    reward.
  • 00:26:13
    I shared this at a at a talk and um
  • 00:26:16
    Daphnes Johanni who's a colleague at
  • 00:26:18
    Colombia who who didn't study
  • 00:26:20
    adolescence but she studied the um
  • 00:26:22
    learning systems in the brain and
  • 00:26:24
    dopamine in adults um asked if I would
  • 00:26:27
    want to partner with her and test the
  • 00:26:29
    hypothesis that because the adolescent
  • 00:26:31
    brain is more sensitive in these
  • 00:26:32
    misolyic systems perhaps not only did it
  • 00:26:35
    make adolescence more sensitive to
  • 00:26:36
    reward but also conferred benefits in
  • 00:26:39
    learning behavior and that's exactly
  • 00:26:41
    what we found. I'm not going to go
  • 00:26:43
    through the details of this study, but
  • 00:26:45
    suffice it to say that we asked
  • 00:26:46
    participants, adults and and adolescence
  • 00:26:50
    to perform a very simple probabilistic
  • 00:26:52
    learning task. And over time, what we
  • 00:26:55
    found is that even though the
  • 00:26:57
    adolescence and the adults showed
  • 00:26:58
    similar learning accuracy early in the
  • 00:27:01
    study, by the end of the experiment, the
  • 00:27:03
    adolescence were outperforming the
  • 00:27:05
    adults. And this was work done by Juliet
  • 00:27:07
    Davadau when she did a mini sobatical
  • 00:27:09
    from graduate school at Columbia and
  • 00:27:10
    came to UCLA and collected these
  • 00:27:13
    data. Juliet also found that this
  • 00:27:16
    greater outperformance of adolescence
  • 00:27:19
    compared to adults in learning was
  • 00:27:21
    accompanied by greater prediction error
  • 00:27:23
    related activation in these learning
  • 00:27:25
    systems both in the hippocampus and in
  • 00:27:29
    the stratum. And furthermore that
  • 00:27:32
    connectivity among these stridal and um
  • 00:27:36
    hypocample systems or regions in the
  • 00:27:38
    brain conferred greater uh memory
  • 00:27:42
    positivity bias in the adolescence
  • 00:27:44
    whereby this stronger connectivity in
  • 00:27:46
    the hippocampus and the stridum was
  • 00:27:48
    associated with a a greater memory bias
  • 00:27:50
    in the adolescence if they had been
  • 00:27:52
    positively rewarded. So here's where
  • 00:27:54
    that reward sensitivity comes in and it
  • 00:27:57
    supports and and and amplifies the
  • 00:27:59
    learning that adolescence do compared to
  • 00:28:01
    adults. And again coming back to the e
  • 00:28:03
    ecological validity of that it makes
  • 00:28:06
    perfect sense because as adolescence
  • 00:28:08
    we're faced with a lot of new
  • 00:28:09
    situations, a lot of new social
  • 00:28:10
    interactions, new skills that we're
  • 00:28:12
    learning. And so it makes sense that we
  • 00:28:14
    have a system that supports learning
  • 00:28:16
    those new bits of information.
  • 00:28:20
    This was supported also by research in
  • 00:28:22
    Holland by Eveina Cone who's done a lot
  • 00:28:25
    of this research also showing that
  • 00:28:27
    increased rial sensitivity in
  • 00:28:28
    adolescence benefits learning and um Dr.
  • 00:28:32
    Cronhn's work has and has shown this in
  • 00:28:34
    all types of learning, cognitive
  • 00:28:35
    learning, social learning um in ways
  • 00:28:37
    that that support this notion that it's
  • 00:28:40
    not a coincidence that adolescence has
  • 00:28:43
    this period in life when we have greater
  • 00:28:44
    sensitivity in the very systems that
  • 00:28:47
    help us identify rewards that we should
  • 00:28:49
    orient towards and also support
  • 00:28:52
    learning. And by the way, humans are not
  • 00:28:55
    the only ones who show this these
  • 00:28:56
    changes during adolescence. Most species
  • 00:28:59
    on Earth have an adolescent period of
  • 00:29:01
    life when individuals take greater risks
  • 00:29:04
    when they're seeking out new social
  • 00:29:06
    structures. And all animals do what
  • 00:29:09
    adolescence or human humans do during
  • 00:29:11
    adolescence. They spend more time
  • 00:29:13
    socializing with their peers. They
  • 00:29:16
    squabble with adults. They eat more
  • 00:29:18
    food. And they fumble through a new
  • 00:29:20
    social landscape. Because becoming an
  • 00:29:22
    adult doesn't happen overnight. It
  • 00:29:25
    requires learning. It requires
  • 00:29:26
    mimicking. And whether you're a kitten
  • 00:29:28
    or a puppy or human adolescent, becoming
  • 00:29:31
    an adult takes time, experience, and
  • 00:29:33
    learning. And it's for this very reason
  • 00:29:36
    that the adolescent brain is so special
  • 00:29:38
    because it's literally the bridge that
  • 00:29:40
    helps kids enter into the next dimension
  • 00:29:42
    of life. And when we do that, we're not
  • 00:29:46
    always smooth when we're transitioning
  • 00:29:48
    into adulthood. And we're often
  • 00:29:50
    mimicking the social behaviors of of
  • 00:29:52
    adults. um similar to the ways in which
  • 00:29:55
    babies make the the the behaviors of of
  • 00:29:58
    those around them. I'm going to show you
  • 00:30:00
    a video from released when the book
  • 00:30:03
    Wildthood was released uh a few years
  • 00:30:05
    ago and it kind of illustrates the
  • 00:30:08
    social mimickry that that needs to
  • 00:30:09
    happen during adolescence and I find it
  • 00:30:11
    really
  • 00:30:16
    charming. Look at these albatross.
  • 00:30:18
    They're masters of this courtship dance.
  • 00:30:21
    They're in sync. They're looking at each
  • 00:30:25
    other.
  • 00:30:28
    Okay? So, they're using it to assess
  • 00:30:30
    each other's suitability as partners.
  • 00:30:32
    Okay? They're beautiful when they're
  • 00:30:33
    doing it. Now, you're going to see the
  • 00:30:34
    teenagers doing
  • 00:30:38
    it. They're not looking at each other.
  • 00:30:40
    They're going in each different
  • 00:30:42
    direction. They're doing it by the side
  • 00:30:44
    of the road. Like,
  • 00:30:48
    and I love this so much because we do
  • 00:30:52
    the same thing as humans, right? We see
  • 00:30:54
    in here they learn these moves by
  • 00:30:57
    watching the more mature adults. Our
  • 00:30:59
    behaviors are mimicked by adolescence.
  • 00:31:02
    I'm often asked about how bad is social
  • 00:31:04
    media for young people. Maybe they
  • 00:31:06
    shouldn't be doing it. Well, then maybe
  • 00:31:07
    we shouldn't be doing it because that's
  • 00:31:09
    what young people are doing is mimicking
  • 00:31:11
    their parents. And this is the the book
  • 00:31:12
    is this wonderful book by Barbara Nat
  • 00:31:15
    Heroets if you're interested about um
  • 00:31:18
    the journey that adolescence make into
  • 00:31:23
    adulthood. The second thing we can learn
  • 00:31:26
    from adolescence is how to prioritize
  • 00:31:28
    social connections. Um they're really
  • 00:31:31
    good at it and sometimes they we kind of
  • 00:31:34
    get them in trouble for doing it. the
  • 00:31:36
    the social connections that they are
  • 00:31:38
    doing during this time are um or the
  • 00:31:42
    maturing connections in their brain are
  • 00:31:44
    reflective of the ongoing connections
  • 00:31:46
    they're making with their peers, with
  • 00:31:47
    their families, and with their
  • 00:31:49
    communities. We've recently done some
  • 00:31:51
    research to examine the the attributes
  • 00:31:53
    or the benefits of of pro-social
  • 00:31:55
    behavior.
  • 00:31:57
    What you're seeing here are data from a
  • 00:31:59
    study in which we collected um
  • 00:32:01
    information from about 270 adolescent
  • 00:32:03
    270 adolescents ages 9 to 15 and a group
  • 00:32:07
    of of young adults and they did a simple
  • 00:32:10
    decision-making task where they were
  • 00:32:12
    trying to earn money for either
  • 00:32:13
    themselves or someone in their family, a
  • 00:32:16
    friend or a stranger. So for example,
  • 00:32:19
    they would choose whether or not to lose
  • 00:32:22
    a $1.50 50 in favor of their mom earn
  • 00:32:25
    ear earning $3. These are very common
  • 00:32:28
    pro-social tasks that are used to assess
  • 00:32:30
    how people make decisions when it's
  • 00:32:31
    going to benefit them versus benefit
  • 00:32:32
    someone else. And what we found
  • 00:32:35
    unsurprisingly is that costly giving
  • 00:32:38
    that is giving up money for yourself in
  • 00:32:40
    for someone else um varied as a function
  • 00:32:43
    of age and that uh it different it was
  • 00:32:47
    differentiated based on who the target
  • 00:32:49
    was whether it was a family member, a
  • 00:32:50
    friend or a stranger.
  • 00:32:53
    What a little bit surprised us is that
  • 00:32:55
    the family the person the family person
  • 00:32:58
    received um the most costly given
  • 00:33:00
    behavior by the ad by the adolescent
  • 00:33:02
    regardless of age and this actually
  • 00:33:04
    increased as young people became
  • 00:33:05
    adolescence and increased into the early
  • 00:33:07
    adulthood
  • 00:33:09
    age. There was significant activation in
  • 00:33:12
    regions that as Sarah Jane Blakemore
  • 00:33:14
    described are considered the social
  • 00:33:15
    brain that help us identify the feelings
  • 00:33:18
    of others or take the perspective of
  • 00:33:19
    other people. In this case, we found um
  • 00:33:22
    significant uh age related differences
  • 00:33:24
    in the dorsal prefrontal cortex when
  • 00:33:27
    giving by age where there was an
  • 00:33:29
    increase during the late adolescent
  • 00:33:30
    years that that tapered off. So the
  • 00:33:34
    systems that are ongoing maturation
  • 00:33:36
    during adolescence are showing that or
  • 00:33:38
    paying the most attention to who they
  • 00:33:40
    are giving to and um and engaging these
  • 00:33:43
    systems the most. And again, this is um
  • 00:33:46
    consistent with research on um neural
  • 00:33:50
    systems that that um became more engaged
  • 00:33:52
    during their adolescent
  • 00:33:56
    years. Um the last thing I'll say is
  • 00:34:00
    about what we can learn from adolescence
  • 00:34:01
    is how they make strategic risks. When
  • 00:34:05
    we talk about adolescence or the the
  • 00:34:07
    media speaks about risk takingaking in
  • 00:34:08
    adolescence, they're often thinking
  • 00:34:10
    about this kind of risk- takingaking.
  • 00:34:12
    Maybe risk takingaking that is ill ill-
  • 00:34:14
    advised or may cause harm to the self or
  • 00:34:16
    other. But when I think about
  • 00:34:18
    risk-taking, I think about or during
  • 00:34:20
    adolescence, I think about how adaptive
  • 00:34:22
    it is for the adolescent that if they're
  • 00:34:24
    engaging in a risk, it may be adaptive
  • 00:34:27
    for that person to gate social status to
  • 00:34:30
    uh form a social bond or to leave the
  • 00:34:32
    nest so to speak. And so often
  • 00:34:35
    adolescence, as I mentioned before, are
  • 00:34:37
    trying out new things. Maybe they're
  • 00:34:39
    speaking on behalf of a cause they
  • 00:34:41
    believe in or trying out for new sports
  • 00:34:43
    or engaging in volunteer experiences. As
  • 00:34:46
    adults, we may not see this as
  • 00:34:47
    risk-taking, but all of those are
  • 00:34:49
    formative experiences that help shape
  • 00:34:51
    who they are and are supported by
  • 00:34:54
    enhancement of the misolyic system that
  • 00:34:57
    is oriented towards
  • 00:34:59
    risk-taking. We did a study a few years
  • 00:35:02
    ago. It was a graduate student Emily
  • 00:35:04
    Barkley Levenson who was interested in
  • 00:35:06
    understanding whether or not adolescence
  • 00:35:08
    are good at identify advantageous versus
  • 00:35:11
    disadvantageous risks. And so she used
  • 00:35:14
    um a task that had previously been
  • 00:35:17
    published by Russ PDRA called the mixed
  • 00:35:19
    gambles task in which adolescence are
  • 00:35:22
    given a simple pie chart and asked is
  • 00:35:24
    this a risk you would be willing to
  • 00:35:25
    take? And based on the expected value of
  • 00:35:28
    each of those combinations of of the
  • 00:35:30
    offers they were given, some some um
  • 00:35:34
    risks were advantageous to take, some
  • 00:35:36
    were disadvantageous, and some were
  • 00:35:38
    neutral. So it looked a little bit like
  • 00:35:41
    this, not a little bit. This is exactly
  • 00:35:42
    what it looked like. So um they were
  • 00:35:45
    either made in this case in the upper
  • 00:35:46
    left, this was a disadvantageous risk
  • 00:35:49
    because you were gambling on winning
  • 00:35:50
    eight dollars or $6 versus losing losing
  • 00:35:53
    18. an advantageous risk might offer
  • 00:35:57
    gaining $17 versus losing five and a
  • 00:36:00
    neutral risk was was um had
  • 00:36:02
    parody. And what we found behaviorally
  • 00:36:06
    is that when we plotted out the expected
  • 00:36:08
    value of each of these gamles and
  • 00:36:11
    compared adolescence and adults who were
  • 00:36:13
    receiving an fMRI scan, there was no
  • 00:36:15
    difference in the choices they made when
  • 00:36:17
    the risks were at
  • 00:36:18
    disadvantageous. So that told us a few
  • 00:36:20
    things. Um one, the task was working.
  • 00:36:23
    the ad the all the participants were
  • 00:36:25
    able to identify the distinction among
  • 00:36:27
    these different gamles they were offered
  • 00:36:29
    that contrary to maybe popular belief
  • 00:36:32
    adolescence were not more willing to
  • 00:36:33
    take this advantageous
  • 00:36:36
    risks. There was no difference in the
  • 00:36:38
    neutral behavior but differences emerged
  • 00:36:40
    when participants were presented with an
  • 00:36:43
    advantageous risk and in this case the
  • 00:36:45
    adolescence were better able at
  • 00:36:47
    endorsing taking an advantageous risk as
  • 00:36:49
    compared to the adults. Obviously, these
  • 00:36:52
    are very different types of risks than
  • 00:36:53
    they face in the real world. But to us,
  • 00:36:55
    it gave us some insight into how the
  • 00:36:57
    brain is responding to um risks that are
  • 00:37:00
    presented to them. And also that
  • 00:37:02
    adolescence were were in at least in
  • 00:37:04
    this house better able than adults to
  • 00:37:06
    identify them.
  • 00:37:08
    when they were taking these advantageous
  • 00:37:10
    risks, the adolescence showed greater
  • 00:37:12
    engagement of these same systems that
  • 00:37:14
    I've previously mentioned as engaging
  • 00:37:16
    during social rewards or or um other
  • 00:37:19
    types of of monetary rewards.
  • 00:37:23
    So we can learn a few things from
  • 00:37:25
    adolescence and I find this work
  • 00:37:28
    continue to find this work really
  • 00:37:29
    interesting but also have started to
  • 00:37:32
    think how we can use the science to
  • 00:37:34
    inform policies and programs that impact
  • 00:37:36
    adolescence because we've let science
  • 00:37:38
    sit on the shelf then then maybe it
  • 00:37:42
    wasn't as impactful as we as we think it
  • 00:37:44
    it was. Um at the center for the
  • 00:37:47
    developing adolescent which I run with
  • 00:37:48
    my colleague Andrew Fellini we've
  • 00:37:51
    learned a lot. We're not policy makers.
  • 00:37:53
    We're not legal scholars. But we've
  • 00:37:55
    learned that communication to these
  • 00:37:56
    spaces are really important for us to
  • 00:37:58
    translate what we think is the most
  • 00:38:00
    important aspects of of the science we
  • 00:38:02
    do, which is on adolescence. And so we
  • 00:38:05
    work hard to build this this um
  • 00:38:09
    birectional communication among among um
  • 00:38:13
    communicators, among policy makers, and
  • 00:38:15
    of course among
  • 00:38:17
    scientists. And this has led to some
  • 00:38:20
    research to some to some work that has
  • 00:38:22
    impacted um spaces that are not just in
  • 00:38:25
    the laboratory. This is an amicus brief
  • 00:38:27
    that a few of us signed on to um a few
  • 00:38:30
    years ago in in Miller v. Alabama. Um
  • 00:38:33
    and developmental science provides
  • 00:38:35
    concrete evidence to support the
  • 00:38:37
    argument that juveniles warrant
  • 00:38:39
    different treatment in the justice
  • 00:38:40
    system than do adults.
  • 00:38:42
    Many other um adolescent neuroscientists
  • 00:38:44
    have have um been in communication with
  • 00:38:47
    legal scholars about this. But it really
  • 00:38:50
    is remarkable how much of an impact
  • 00:38:52
    science can have when we are open to the
  • 00:38:55
    communication with folks who who have
  • 00:38:57
    not been coming to conferences like we
  • 00:38:59
    are um and understanding the the
  • 00:39:01
    benefits and the ramifications of of the
  • 00:39:04
    methods that we use.
  • 00:39:08
    Um this kind of work in neuroscience and
  • 00:39:11
    developmental psychology has led to
  • 00:39:12
    several different Supreme Court rulings
  • 00:39:15
    and ration um a lot of them have been
  • 00:39:17
    centered on the understanding that the
  • 00:39:20
    brain continues to develop during
  • 00:39:21
    adolescence that it is plastic that
  • 00:39:24
    there's a differences in peer influence
  • 00:39:27
    during the adolescent per during the
  • 00:39:29
    adolescent period um and it has led to
  • 00:39:32
    some significant changes in how we treat
  • 00:39:34
    young people in the justice system and
  • 00:39:35
    this I just highlight this as one
  • 00:39:36
    example because obviously ly many
  • 00:39:38
    different spaces educational system
  • 00:39:40
    impacted um can have an impact but the
  • 00:39:43
    justice system is one that has stood
  • 00:39:44
    out.
  • 00:39:47
    um uh colleagues of ours uh BJ Casey, uh
  • 00:39:50
    S Leah Somerville, Ariel Baskin Robbins
  • 00:39:54
    nicely synthesized this research a few
  • 00:39:56
    years ago and the the studies I or the
  • 00:40:00
    Supreme Court rulings listed in this
  • 00:40:01
    table are all for young people under the
  • 00:40:04
    age of 18, but we know that the brain
  • 00:40:06
    continues to mature beyond 18. And so in
  • 00:40:09
    this review they made the case that
  • 00:40:11
    psychological and neuroscientific
  • 00:40:13
    evidence for expanding the age of
  • 00:40:15
    youthful
  • 00:40:17
    offenders. They relied on terrific work
  • 00:40:19
    by um Alli Cohen published in 2016. And
  • 00:40:24
    this study was really important because
  • 00:40:26
    it it addressed an issue that is often
  • 00:40:28
    asked of those of us who testify before
  • 00:40:31
    different judges or in criminal cases
  • 00:40:33
    where they ask a simple question. When
  • 00:40:36
    is an adolescent an adult? And we may
  • 00:40:39
    take for granted, right, as scientists,
  • 00:40:40
    we kind of have these age age bins. Um,
  • 00:40:45
    in adolescent research, it's often based
  • 00:40:46
    on the age of majority, which is age 18
  • 00:40:48
    in this country. But the study examined
  • 00:40:51
    whether there are differences in
  • 00:40:53
    cognitive ability or performance in
  • 00:40:56
    emotional versus non-emotional context.
  • 00:40:58
    This was funded by the MacArthur
  • 00:40:59
    Foundation um in a in some efforts that
  • 00:41:03
    aimed to to to merge neuroscience with
  • 00:41:06
    um with re with um policy um
  • 00:41:11
    initiatives. And what Ally and her
  • 00:41:13
    colleagues found is that under um
  • 00:41:17
    non-threatening environments and very
  • 00:41:18
    cold cognitive environments, there were
  • 00:41:21
    distinctions in cognitive performance
  • 00:41:23
    among adolesccents ages 13 to 17, young
  • 00:41:27
    adults ages 18 to 21 and um individuals
  • 00:41:31
    between the ages of 22 to 25. There was
  • 00:41:34
    a linear increase in their cognitive
  • 00:41:35
    performance.
  • 00:41:37
    However, they included a manipulation in
  • 00:41:40
    the task whereby these individuals were
  • 00:41:42
    making cognitive um choices under
  • 00:41:45
    emotional um context or or threat. And
  • 00:41:49
    here you start to see a difference in
  • 00:41:51
    the ways in which people make cognitive
  • 00:41:53
    choices. And now the young adult group
  • 00:41:56
    looked more similar to the adolescent
  • 00:41:58
    group as compared to the 22 to 25 year
  • 00:42:01
    olds. This is really important research
  • 00:42:03
    because sometimes I think we take for
  • 00:42:05
    granted um the distinct nuance in
  • 00:42:08
    developmental um maturation that again
  • 00:42:11
    we as scientists may take for granted
  • 00:42:13
    but is very important in in decisions
  • 00:42:16
    related to policies related to young
  • 00:42:18
    people.
  • 00:42:20
    This research was really important for
  • 00:42:23
    um a recent and it's nice that we're in
  • 00:42:25
    Massachusetts um last year showing that
  • 00:42:28
    the m Massachusetts Supreme Court ruled
  • 00:42:30
    against life without parole parole for
  • 00:42:32
    emerging
  • 00:42:33
    adults. The court's decision was
  • 00:42:35
    influenced in part by a comprehensive
  • 00:42:37
    review of scientific research on brain
  • 00:42:39
    development. And this is the collective
  • 00:42:42
    work of so many people who have taken
  • 00:42:44
    their cognitive neuroscience research
  • 00:42:46
    and and amplified it and communicated it
  • 00:42:48
    to to folks outside of the of the lab. I
  • 00:42:51
    testified in this court and I have to
  • 00:42:53
    say one of the most gratifying things
  • 00:42:55
    I've ever experienced in my career was
  • 00:42:57
    this text message. Um this is from the
  • 00:42:59
    lawyer with whom I worked on this case
  • 00:43:01
    and he said we won. Yay. No life without
  • 00:43:04
    pearl for 18 19 20 year olds in
  • 00:43:06
    Massachusetts. Over 200 people have you
  • 00:43:08
    to thank for a chance of freedom. Ryan
  • 00:43:10
    and I are going to the prison blah blah
  • 00:43:11
    blah to tell our client. But it's um
  • 00:43:14
    it's just a reminder to me sometimes we
  • 00:43:16
    get stuck in our in our research uh labs
  • 00:43:20
    and the details of an experiment or how
  • 00:43:23
    we're going to submit a grant or write a
  • 00:43:25
    paper. Um but people are paying
  • 00:43:27
    attention. What we write in our
  • 00:43:28
    discussion sections makes a lot of has a
  • 00:43:31
    big impact in the ways in which those
  • 00:43:33
    data are interpreted.
  • 00:43:36
    Um so I mentioned earlier that at the
  • 00:43:38
    center for the developing adolescent we
  • 00:43:40
    aim to translate the science of
  • 00:43:42
    adolescence into um spaces that are not
  • 00:43:46
    for people who are not as versed in
  • 00:43:47
    science. We do this a few ways. We've
  • 00:43:50
    recently launched what's called steps
  • 00:43:52
    for youth. It's an initiative that
  • 00:43:55
    translates science to enhance policy
  • 00:43:57
    success. We also provide um briefs for
  • 00:44:01
    folks who are interested in various
  • 00:44:03
    topics about how for example um
  • 00:44:06
    anti-black race racism impacts
  • 00:44:09
    development, social media impacts
  • 00:44:11
    development, the importance of
  • 00:44:13
    contribution during
  • 00:44:14
    adolescence and we also um speak to
  • 00:44:17
    various groups. We partner with TED to
  • 00:44:20
    describe the science of adolescence. And
  • 00:44:22
    I only display all this because when I
  • 00:44:25
    was a graduate student, I never felt
  • 00:44:27
    like it would be I honestly thought it
  • 00:44:29
    was important or I could have something
  • 00:44:30
    to say. But realizing how important this
  • 00:44:33
    is has been uh a really important part
  • 00:44:35
    of of the research I've I've been
  • 00:44:39
    doing in all of these spaces. We also
  • 00:44:41
    remind folks that the impact of lived
  • 00:44:44
    experience, the the impact that lived
  • 00:44:46
    experience has on adolescent brain
  • 00:44:47
    development. We know that social
  • 00:44:49
    structures and systems can support or
  • 00:44:51
    challenge positive development. That
  • 00:44:54
    communities and cultural practices
  • 00:44:55
    support development. Um and finally that
  • 00:44:59
    early life adversity can have a
  • 00:45:00
    significant impact on young people even
  • 00:45:02
    if it happens early in life that
  • 00:45:04
    ramifications can be observed in
  • 00:45:06
    adolescence. But again the beauty of
  • 00:45:08
    adolescence is that the plasticity can
  • 00:45:10
    help redirect those impacts of early
  • 00:45:11
    life adversity.
  • 00:45:14
    So I'll just end by giving or offering
  • 00:45:17
    some thoughts about how we can support
  • 00:45:19
    and continue to support the developing
  • 00:45:20
    brain. And the first is that we can
  • 00:45:22
    celebrate adolescence that we can move
  • 00:45:24
    away from a narrative that pathologizes
  • 00:45:26
    period of life that is so normative that
  • 00:45:28
    is not only unique to to humans and that
  • 00:45:31
    is necessary for our transition to
  • 00:45:33
    adulthood. We can invest in frameworks
  • 00:45:35
    that recognize the whole person. We
  • 00:45:37
    obviously do not develop in a vacuum.
  • 00:45:40
    And so all of the the spaces in which
  • 00:45:42
    adolescence are reared matter for who
  • 00:45:44
    they
  • 00:45:45
    are. That we can provide adolescence
  • 00:45:48
    with opportunities to contribute and to
  • 00:45:50
    develop their identities because that
  • 00:45:52
    often they they may be changing during
  • 00:45:54
    this time, but that is all part of the
  • 00:45:56
    the trial and error learning that
  • 00:45:57
    happens during this period of
  • 00:45:59
    life. We can support the inherent
  • 00:46:02
    adolescent need to collaborate and to
  • 00:46:05
    learn through social means. Um it's no
  • 00:46:08
    coincidence that they like to spend time
  • 00:46:09
    with their peers offline and and online.
  • 00:46:12
    Um and that's because they are also
  • 00:46:13
    learning the social rules that will help
  • 00:46:15
    them transition into
  • 00:46:17
    adulthood. And we can amplify their
  • 00:46:19
    positive experiences and promote their
  • 00:46:21
    health. There there's a lot of
  • 00:46:23
    discussion, rightfully so, about mental
  • 00:46:25
    health during adolescence, particularly
  • 00:46:27
    after the pandemic. But adolescence are
  • 00:46:29
    not only their mental health. Um, Andrew
  • 00:46:31
    and I wrote a a recent article, a
  • 00:46:34
    relatively recent article, um, calling
  • 00:46:36
    for the need for young people to
  • 00:46:38
    experience to have experiences that
  • 00:46:40
    boost their their mental health that
  • 00:46:42
    rather than reacting to to mental health
  • 00:46:44
    challenges, perhaps we can support them
  • 00:46:46
    before then because we know that there
  • 00:46:48
    are a lot of things we can put in place
  • 00:46:49
    to support that. that is volunteering
  • 00:46:52
    experiences, good sleep as I mentioned,
  • 00:46:54
    um supportive environments or
  • 00:46:56
    relationships with with caregivers, all
  • 00:46:59
    of those things support mental health
  • 00:47:01
    before it becomes a
  • 00:47:02
    challenge. And with that, I will end. Um
  • 00:47:05
    thank my lab members, current and
  • 00:47:08
    former, my collaborators, my funding
  • 00:47:10
    source, um and also those uh who support
  • 00:47:13
    our work at the center for the
  • 00:47:14
    developing adolescent. And thank you
  • 00:47:17
    [Applause]
  • 00:47:27
    Do it. Do it.
Tags
  • Cognitive Neuroscience Society
  • Adolescent Brain Development
  • Keynote Address
  • Michael Anderson
  • Sabina Castner
  • Adriana Galvan
  • Neuroscience Research
  • Social Connections
  • Developmental Needs
  • Policy Impact