What is cellular fragility syndrome?

Cellular fragility syndrome is a newly discovered nutritional deficiency linked to low levels of c-15, resulting in weak cell membranes and accelerated aging.

How does c-15 deficiency affect insulin resistance?

C-15 deficiency weakens cell membranes, leading to lipid peroxidation and iron deposition. This causes the liver and pancreas to function improperly, leading to insulin resistance.

What role does c-15 play in cell health?

C-15 helps strengthen cell membranes, reducing lipid peroxidation and iron accumulation, which are crucial for optimal cell functioning and preventing accelerated aging.

How was c-15 deficiency discovered?

C-15 deficiency was discovered through studies on Navy dolphins that showed fatty liver disease and insulin resistance linked to low c-15 in their diet.

What health conditions are linked to c-15 deficiency?

C-15 deficiency is linked to metabolic syndrome, type 2 diabetes, heart disease, and possibly early onset fatty liver disease.

Can c-15 levels be measured?

Yes, c-15 levels can be measured using a fatty acid panel or newer at-home diagnostic tests.

Why is Sardinia mentioned in connection with c-15?

Sardinia is noted for high longevity, partially attributed to diet rich in dairy from grass-fed sheep and goats, leading to higher c-15 levels.

How can c-15 deficiency be addressed?

C-15 deficiency can be addressed through increased dietary intake of c-15 rich foods or supplements like fatty 15.

What is ferroptosis, as mentioned in the video?

Ferroptosis is a process where cell death occurs uniquely via lipid peroxidation and iron, contributing to diseases like those associated with c-15 deficiency.

What discoveries were made about c-15 in the past years?

Since 2012, research has linked c-15 to stable cell membranes and found that its deficiency can drive aging-related diseases.

Newly Discovered Cause of Insulin Resistance is Not Sugar or Saturated Fat - Dr. Venn Watson

00:56:51

https://www.youtube.com/watch?v=cnTHgRJi0mM

Resumen

TLDRThe video discusses a groundbreaking study revealing a nutritional deficiency termed "Cellular Fragility Syndrome" linked to low levels of c-15, a saturated fatty acid important for cell membrane stability. Dr. Stephanie Vin Watson explains how c-15 deficiency leads to weak cell membranes, impacting glucose regulation and causing insulin resistance. When this deficiency affects both the liver and pancreas, it increases the risk of metabolic syndrome and diseases like type 2 diabetes, heart disease, and stroke. The discovery was first noted in dolphins, which showed fatty liver disease and insulin resistance due to low dietary c-15. Similarly, people with low c-15 intake are experiencing accelerated onset of aging-related diseases. Research now indicates that restoring c-15 through diet or supplements can reverse these effects, offering a potential solution to these metabolic problems. The video also highlights how dietary practices in Sardinia, where people consume high levels of grass-fed dairy, result in higher c-15 levels and may contribute to their notable longevity. The methodical approach to understanding c-15 levels and their widespread implications on health is emphasized as an essential step toward combating modern metabolic diseases. The significance of getting comprehensive research and understanding into public awareness is stressed, as these findings could impact how dietary guidelines are shaped to improve global health.

Para llevar

🧠 C-15 plays a crucial role in maintaining healthy cell membranes.
💔 Deficiency in c-15 is linked to metabolic syndrome and cardiovascular diseases.
🐬 Discovery was made through studies on Navy dolphins showing similar diseases.
🍦 Sardinia's high c-15 levels linked to their dairy-rich diet contribute to longevity.
🧬 Ferroptosis is a novel cell death process associated with iron and c-15 deficiency.
🇺🇸 Modern diets reduced c-15 intake, correlating with increased metabolic diseases.
🔬 C-15 deficiency impacts insulin production and glucose regulation.
📊 New research tools are available to measure c-15 levels accurately.
🌍 Global emphasis on dietary adjustments to mitigate c-15 related health issues.
🏥 Health implications stress the need for awareness and potential dietary guidelines adjustments.

Cronología

00:00:00 - 00:05:00
Dr. Stephanie Vin Watson discusses the onset of insulin resistance and metabolic syndrome resulting from iron deposition in the liver and pancreas, leading to impaired glucose regulation and insulin production. This sets the stage for metabolic syndrome, increasing the risk of heart disease, stroke, and type 2 diabetes.
00:05:00 - 00:10:00
Dr. Vin Watson introduces a new study on a nutritional deficiency syndrome called cellular fragility syndrome, linked to a lack of C15. This deficiency causes cell membranes to weaken, accelerating aging and contributing to diseases like type 2 diabetes and heart disease.
00:10:00 - 00:15:00
The discovery of a new cell death pathway, ferroptosis, explains how fragile fatty acids lead to lipid peroxidation, iron accumulation, and reactive oxygen species (ROS) production. This damages mitochondria, furthering the understanding of cellular fragility and its link to aging-related diseases.
00:15:00 - 00:20:00
Research since 2012 has connected the lack of C15 to the onset and development of 'ferroptosis', a recently discovered cell death mechanism. This process involves lipid peroxidation, iron accumulation, and ROS production, which damage mitochondria and weaken cells.
00:20:00 - 00:25:00
C15 deficiency is implicated in initiating and progressing ferroptosis. Supplementation with C15 has been shown to reverse this process by stabilizing cell membranes, reducing lipid peroxidation, preventing iron accumulation, and repairing mitochondria.
00:25:00 - 00:30:00
Research in dolphins revealed iron overload and fatty liver as early signs of C15 deficiency-related diseases. Dolphins with higher C15 levels showed resistance. This has led to understanding and modeling C15's protective effects in human metabolism and disease prevention.
00:30:00 - 00:35:00
C15 deficiency leads to metabolic syndrome as iron deposits in the liver and pancreas, disrupting glucose regulation and increasing inflammation. Research is exploring the protective role of C15 in maintaining metabolic health and reducing the prevalence of related diseases.
00:35:00 - 00:40:00
The conversation delves into the historical and prospective understanding of fatty liver disease and its anticipated rise due to lifestyle changes. Studies have linked cellular fragility and early onset of metabolic diseases to C15 deficiency, emphasizing its significance.
00:40:00 - 00:45:00
Sardinia's unique high C15 levels, due to local dairy-rich diets, offer insights into longevity. Studies show the importance of C15 for metabolic health and its potential role in addressing modern dietary deficiencies to prevent accelerated aging and related diseases.
00:45:00 - 00:50:00
There's a focus on leveraging C15 supplementation to counteract dietary deficiencies. Comparing global dietary practices with those in Sardinia proposes opportunities to enhance C15 intake through both natural and fortified dietary sources.
00:50:00 - 00:56:51
Overall, the discussion emphasizes the critical role of C15 in combating accelerated aging and metabolic disorders, underlining its potential benefit when reintroduced adequately into modern diets, either through supplementation or dietary modifications.

Mapa mental

Preguntas frecuentes

What is cellular fragility syndrome?
Cellular fragility syndrome is a newly discovered nutritional deficiency linked to low levels of c-15, resulting in weak cell membranes and accelerated aging.
How does c-15 deficiency affect insulin resistance?
C-15 deficiency weakens cell membranes, leading to lipid peroxidation and iron deposition. This causes the liver and pancreas to function improperly, leading to insulin resistance.
What role does c-15 play in cell health?
C-15 helps strengthen cell membranes, reducing lipid peroxidation and iron accumulation, which are crucial for optimal cell functioning and preventing accelerated aging.
How was c-15 deficiency discovered?
C-15 deficiency was discovered through studies on Navy dolphins that showed fatty liver disease and insulin resistance linked to low c-15 in their diet.
What health conditions are linked to c-15 deficiency?
C-15 deficiency is linked to metabolic syndrome, type 2 diabetes, heart disease, and possibly early onset fatty liver disease.
Can c-15 levels be measured?
Yes, c-15 levels can be measured using a fatty acid panel or newer at-home diagnostic tests.
Why is Sardinia mentioned in connection with c-15?
Sardinia is noted for high longevity, partially attributed to diet rich in dairy from grass-fed sheep and goats, leading to higher c-15 levels.
How can c-15 deficiency be addressed?
C-15 deficiency can be addressed through increased dietary intake of c-15 rich foods or supplements like fatty 15.
What is ferroptosis, as mentioned in the video?
Ferroptosis is a process where cell death occurs uniquely via lipid peroxidation and iron, contributing to diseases like those associated with c-15 deficiency.
What discoveries were made about c-15 in the past years?
Since 2012, research has linked c-15 to stable cell membranes and found that its deficiency can drive aging-related diseases.

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Subtítulos

Desplazamiento automático:

00:00:00
when you have iron plus Ross right and
00:00:02
lipid peroxidation all happening first
00:00:04
in the liver the liver will stop um
00:00:08
producing uh the appropriate amount of
00:00:11
or it won't react appropriately to
00:00:12
glucose so you start getting the onset
00:00:16
of insulin resistance happening at the
00:00:18
liver side basically just because you
00:00:19
have broken liver cells in which the
00:00:22
liver is not responding appropriately to
00:00:24
basically keeping our glucose balanced
00:00:26
at the same time once iron deposition in
00:00:29
this whole process starts happening in
00:00:31
our pancreas our beta cells stop
00:00:34
producing insulin so we've got kind of a
00:00:36
one two hit of both our pancreas and
00:00:39
liver and when you combine those that
00:00:42
then sets you up for metabolic syndrome
00:00:44
right which is this High um insulin or
00:00:47
insulin resistance high glucose you get
00:00:49
this middle um you know at deposity uh a
00:00:53
weight gain and then that all sets you
00:00:55
up for an increased risk of heart
00:00:57
disease stroke um and type two diabetes
00:01:00
Dr Stephanie Vin Watson I had you on
00:01:02
earlier this year but there's this brand
00:01:03
new study that just came out so it was
00:01:05
absolutely worth bringing you right back
00:01:07
on to talk about this so without further
00:01:09
Ado let's just jump right into this
00:01:11
because this is I'm going to let you
00:01:12
explain the science I'll ask some
00:01:13
questions because this is one of the
00:01:14
coolest studies that I've seen this year
00:01:16
great then well thanks Thomas well so we
00:01:19
discovered the first nutritional
00:01:20
deficiency syndrome in over 75 years so
00:01:24
you think about things like vitamin C
00:01:26
and scurvy and vitamin D deficiency in
00:01:28
rickets we have discovered a deficiency
00:01:31
syndrome uh thanks to c-15 deficiencies
00:01:34
and it's called cellular fragility
00:01:36
syndrome and so it's a giant Discovery
00:01:39
and what's so wonderful about
00:01:42
discovering a nutritional deficiency
00:01:44
even though you know it sounds
00:01:46
devastating is that this is something we
00:01:48
can detect Thomas and something we can
00:01:50
fix so so excited to be able to be here
00:01:52
to talk about this discovery and you
00:01:55
know what it means for all of us what
00:01:57
exactly is cellular fragility so yes
00:01:59
when we talk about you know our bodies
00:02:00
are made out of cells so everything
00:02:03
every part of us is made out of cells
00:02:05
and our cells are armored by these cell
00:02:09
membranes and so the cell membranes are
00:02:11
made out of lipids and they can become
00:02:13
weak and what we've learned is that
00:02:16
based upon the type of fatty acids in
00:02:18
the cell membrane dictates how strong or
00:02:21
weak our cells membranes are and why do
00:02:23
we care about that well it's because
00:02:26
when our cells become weak they undergo
00:02:28
faster aging so basically they fall
00:02:31
apart a lot faster they age faster that
00:02:33
translates to us aging faster and so
00:02:36
what's so important about this discovery
00:02:38
is we've learned that over the past 12
00:02:41
years of research not just us but others
00:02:43
around the world that if we don't have a
00:02:46
certain level of C15 in our cell
00:02:48
membrane this sturdy saturated fatty
00:02:51
acid in our cell membrane our cell
00:02:53
membranes become weak we age faster than
00:02:56
we should and we now think it may
00:02:59
explain the onset of these aging
00:03:01
Associated diseases things like type 2
00:03:03
diabetes fatty liver disease heart
00:03:05
disease are increasing in younger and
00:03:08
younger people and now we think that the
00:03:10
c-15 deficiency syndrome cellular
00:03:12
fragility syndrome may be the cause of
00:03:15
why younger and younger people are
00:03:17
getting older diseases is it just
00:03:19
because the the cell becomes more like
00:03:22
penetrable to like all these different
00:03:23
things like how does how does that
00:03:25
really work how does a fragile cell
00:03:28
membrane
00:03:30
impact say like insulin resistance
00:03:32
things like that where's the interplay
00:03:33
there yeah so it's a fascinating story
00:03:36
and it goes back to 2012 so back in 2012
00:03:39
there was a group of scientists at
00:03:41
Columbia University and they published
00:03:44
this paper in which they discovered an
00:03:46
entirely new way that our cells were
00:03:48
dying and it's called ferroptosis or
00:03:51
fosis we just say if you're in England
00:03:53
it's for oposisi
00:03:59
but the key point being that these
00:04:01
researchers discovered entirely new way
00:04:04
our cells were dying prior to this
00:04:05
discovery there were only three known
00:04:07
ways that our cells could die called
00:04:09
apoptosis necrosis and autophagy and
00:04:12
this was just like you go to cell
00:04:13
biology class you know at your
00:04:15
University three ways our cells die
00:04:18
great they discovered a fourth and what
00:04:21
was really interesting about it is that
00:04:23
they discovered that there was a really
00:04:25
unique way that our cells were starting
00:04:27
to die and it started with l literally
00:04:30
the way they explain it is that there's
00:04:31
fragile fatty acids in the cell membrane
00:04:35
that then results in um lipid
00:04:37
peroxidation so lipid peroxidation is
00:04:40
when you have fragile fats they then go
00:04:42
bad so they get um exposed to oxygen
00:04:45
attack by oxygen they get lipid
00:04:47
peroxidation so now you have that and
00:04:50
then for some strange reason iron is
00:04:53
showing up inside of these cells and
00:04:56
when you combine lipid peroxidation with
00:04:58
iron that results in massive production
00:05:02
of these things called reactive oxygen
00:05:04
species or Ross the Ross then go and
00:05:06
kill our mitochondria and as we all know
00:05:09
right from our third grade classes
00:05:10
mitochondria is the PowerHouse of our
00:05:12
cells that knocks out our mitochondria
00:05:15
because I learned that like 10th grade
00:05:18
I'm sorry okay so I'm a nerd so yeah
00:05:21
yeah I know you and Eric just worked out
00:05:24
uh and I stood on the sideline so that
00:05:26
the nerd part was the
00:05:28
mitochondri um so uh yeah so powerhouses
00:05:32
of our cells so basically then knocks
00:05:34
out the batteries the energy producers
00:05:36
of our cells so when these scientists
00:05:38
were looking under the microscope at
00:05:40
Columbia University Thomas they were
00:05:42
seeing intact cells with kind of Strang
00:05:44
looking cell membranes and all the
00:05:47
mitochondria were killed and so they
00:05:48
said this cell is dead what is happening
00:05:52
that was discovered discovered in 2012
00:05:55
since then over
00:05:57
10,000 papers have been published
00:05:59
published on fosis from around the world
00:06:03
nobody has UND despite all that science
00:06:06
nobody has understood what causes froses
00:06:09
why did it show up on our doorstep right
00:06:12
about you know a dozen years ago and um
00:06:16
you know until now so now what we're
00:06:18
finding is that C15 deficiency what this
00:06:21
paper that we just published showed that
00:06:24
C15 deficiency is causing the beginning
00:06:27
the middle and the end of for Tois most
00:06:30
importantly we've been able to show that
00:06:32
putting c-15 back into our bodies fixes
00:06:35
it all so really exciting times so with
00:06:38
this uh study in particular like how was
00:06:40
it laid out what did it uh what exactly
00:06:43
how did you discover this deficiency
00:06:45
specifically with regard to this paper
00:06:47
yeah absolutely so it's really a
00:06:49
culmination of the 12 years of study so
00:06:52
the same year 2012 when fosis was
00:06:55
discovered by Columbia University which
00:06:57
you know to be honest I didn't know
00:06:59
about for many many years at the same
00:07:01
year that paper is published we
00:07:03
published a paper describing the strange
00:07:06
disease that was popping up in the
00:07:08
Navy's dolphins and dolphins in the wild
00:07:10
as well but increasingly there was this
00:07:13
liver disease that was popping up in
00:07:15
Navy dolphins and they had iron overload
00:07:18
in their livers and they were getting
00:07:19
fatty liver disease and insulin
00:07:21
resistance and things that older
00:07:24
Dolphins we get but we were starting to
00:07:26
see it in younger and younger Dolphins
00:07:28
so we were diving in to basically figure
00:07:30
out what was happening with the dolphins
00:07:32
what was causing it that's when we did a
00:07:35
advanced technology called metabolomics
00:07:38
we looked at thousands of small
00:07:40
molecules in their fish diet and in
00:07:42
their bodies to figure out which small
00:07:44
molecules predicted this syndrome that
00:07:47
we were seeing and that's where C15 was
00:07:50
one of the top predictors of dolphins
00:07:52
who weren't getting this disease so that
00:07:55
headed us down this pathway of taking
00:07:57
c-15 into the lab we were then able to
00:08:00
show um in the lab that c-15 helps to
00:08:05
fix all components of fosis it
00:08:08
stabilizes cell membranes by greater
00:08:10
than 80% so it you know stops it right
00:08:12
at the top of the problem it um
00:08:16
decreases lipid peroxidation it stops
00:08:19
iron deposition so we'll talk a little
00:08:20
more about that um which is another
00:08:23
obviously key parts of ferroptosis the
00:08:25
Ferro being iron um it stops the
00:08:28
deposition of the iron it decreases the
00:08:31
amount of reactive oxygen species in the
00:08:33
cell and it repaired mitochondria so
00:08:37
that whole series of studies we
00:08:39
published back in
00:08:40
2020 in the paper uh and scientific
00:08:43
reports and so really what's been
00:08:45
happening since 2020 is it's been uh
00:08:49
understanding more and more of what's
00:08:50
been happening in people that has
00:08:53
overlaped with what's happening in
00:08:54
dolphins and US understanding oh my gosh
00:08:58
it's a decrease in c-15 globally that's
00:09:01
happening in the Dolphins it's because
00:09:03
the types of fish they were eating are
00:09:05
have less and less C15 in it as our
00:09:07
waters are getting warmer unfortunately
00:09:10
our fish are getting less fat there's
00:09:12
actually a study that just came out in
00:09:14
science showing that the world's fish
00:09:17
are getting smaller because the waters
00:09:20
are warmer so they have less fat L C5 to
00:09:23
the Dolphins for us we have less C15
00:09:26
globally we've been doing so for over 50
00:09:28
years by taking c-15 out of our diets
00:09:31
because our primary source of C15 is
00:09:33
dairy fat so we had this concurrent uh
00:09:36
you know coincidental decrease in c-15
00:09:39
in diets happening in dolphins and
00:09:40
humans the result however was the same
00:09:43
which was fosis um because of c-15
00:09:46
deficiencies that's so wild so what I do
00:09:49
know about ferroptosis I mean a lot of
00:09:50
it is it's iron deposition in the liver
00:09:52
specifically there's a like one of the
00:09:54
big components of it right that's right
00:09:56
so is that just sending like a Cascade
00:09:59
of high levels of of Ross directly from
00:10:01
the liver epicenter out of the liver and
00:10:03
kind of radiating out from there or is
00:10:05
it just concentrated in the liver or is
00:10:07
ferroptosis occurring independent of the
00:10:09
liver is it not just happening there I
00:10:11
mean and you may or may not know this
00:10:13
but what's actually causing the iron to
00:10:16
just deposit there like why is it
00:10:18
flocking to the liver and why is it just
00:10:19
because it's trying to get metabolized I
00:10:21
don't know I have questions there yeah
00:10:22
it's a it's a those are all great
00:10:24
questions so um and that's what's been
00:10:26
kind of hanging out there it's like what
00:10:28
how is this all happening right and so
00:10:30
it's almost like science has gotten
00:10:31
stuck in the weeds of looking at
00:10:33
specific genes and little triggers
00:10:35
inside the cell meanwhile we had this
00:10:37
like real life patient population that
00:10:39
was getting the syndrome you know the
00:10:41
Dolphins and we were really able to
00:10:43
understand exactly cleanly how this goes
00:10:46
down so um what we Now understand is
00:10:49
What's called the pathophysiology so the
00:10:51
whole thing of how c-15 deficiencies
00:10:54
lead to this entire syndrome and it all
00:10:57
starts with when we have low C15 in our
00:11:00
cells that includes our red blood cells
00:11:03
so let's start with our red blood cells
00:11:05
so then those red blood cells become
00:11:07
weak now our body has a really good way
00:11:09
of detecting weak red blood cells and
00:11:12
saying uh you shouldn't be in the system
00:11:14
anymore we're going to take you out so
00:11:16
you have these cells in the liver called
00:11:18
macroasia and their job is to basically
00:11:22
engulf and eat all the weak red blood
00:11:25
cells that we have in our body which
00:11:27
normally is a good thing
00:11:29
but what happens when we have a lot of
00:11:31
weak red blood cells because we have two
00:11:33
little C15 in those cells the macras
00:11:36
just eat them and the corpses of the red
00:11:39
blood cells that are left behind ah IR
00:11:42
kind iron yep yeah so what happens is
00:11:44
then it accumulates over time our bodies
00:11:47
are still able to make these red blood
00:11:49
cells so they get taken out of the
00:11:50
system we make more so you know when you
00:11:53
don't necessarily have anemia in the
00:11:56
early stages but there is a measurement
00:11:58
called red blood cell distribution width
00:12:01
or RDW and it's one of the first things
00:12:03
we saw in the Dolphins which just means
00:12:05
that your red blood cell sizes are just
00:12:08
there's a lot of variation there's some
00:12:09
big ones some little ones it just means
00:12:11
that your body's working you're losing
00:12:13
red blood cells you're making them and
00:12:14
you just have this mix of sizes so it's
00:12:16
one of the first hints of um something
00:12:20
is going wrong and RDW is actually a
00:12:22
predictor of longevity um in people so
00:12:26
we can get back to the whole longevity
00:12:27
conversation so it's a fascinating
00:12:30
metric that's gained a lot of traction
00:12:32
so again we think it's all tied to this
00:12:34
pH proptosis so the um red blood cells
00:12:37
become weak the iron or the the liver
00:12:40
engulfs them you now have iron
00:12:43
deposition in the liver you now have an
00:12:45
angry liver so now we're talking about a
00:12:47
liver that's getting increased iron and
00:12:51
along with these fragile cells in the
00:12:53
liver as well so you have lipid
00:12:54
peroxidation iron faptos has now kicked
00:12:56
in in the liver so then what happens is
00:12:58
the next um signal and sign are elevated
00:13:01
liver enzymes so the liver is now saying
00:13:04
hey I'm getting a little bit angry here
00:13:06
cuz my cells are getting injured and
00:13:09
that's one of the first signals they
00:13:10
throw off um from there then just like
00:13:13
you were kind of getting to right is
00:13:15
that what happens is when you get enough
00:13:17
iron overload in the liver you get a
00:13:20
spillover effect you have increased Ross
00:13:23
you have increased lipid peroxidation
00:13:25
you have increased iron that iron lipid
00:13:27
peroxidation and reactive oxygen species
00:13:30
spill over into the blood and now they
00:13:33
start seeding our whole bodies so it
00:13:35
goes through these different stages and
00:13:37
that's where now there's tons of papers
00:13:39
talking about iron deposition in the
00:13:41
brain in the heart in the pancreas and
00:13:44
that's those are drivers for Alzheimer's
00:13:48
disease heart disease um type 2 diabetes
00:13:51
in addition to the initial liver disease
00:13:53
so that's how we clearly understand it
00:13:57
all happens we've been able to show that
00:13:58
c 15 reverses this entire process and it
00:14:02
starts at the very beginning we just
00:14:04
need to have stronger cells that stops
00:14:06
this whole process from kicking off it's
00:14:09
like the uh it's like the Roman Empire
00:14:11
like starting in Rome the like the liver
00:14:14
and like creating these little Depot
00:14:15
everywhere else that then from there
00:14:18
like cause problems there you know in
00:14:19
the heart and the brain and whatnot
00:14:21
because it's like it sounds like
00:14:22
everywhere you have a potential iron
00:14:24
deposition you have like another Factory
00:14:26
for Ross right you have another because
00:14:28
it's like the more oxidation that
00:14:30
happens there the more it's going to be
00:14:32
exacerbated in that area that's right
00:14:34
how does that particularly like with the
00:14:36
the Ross and the iron depositions how
00:14:38
does that relate to metabolic disease or
00:14:42
metabolic dysfunction like specifically
00:14:44
with like insulin resistance like how
00:14:45
does high a high level of Ross or a high
00:14:48
level of iron deposited somewhere impact
00:14:51
insulin resistance because I think for
00:14:53
most people that's a that's a hard thing
00:14:55
to bridge right it's like okay we've got
00:14:57
Ross but how does that impact glucose
00:14:59
and my you know that yeah absolutely so
00:15:02
so we now understand we now know that
00:15:05
when you have iron plus Ross right and
00:15:07
lipid peroxidation all happening first
00:15:09
in the liver the liver will stop um
00:15:13
producing uh the appropriate amount of
00:15:16
or it won't react appropriately to
00:15:17
glucose so you start getting the onset
00:15:20
of insulin resistance happening at the
00:15:23
liver side basically just because you
00:15:24
have broken liver cells in which the
00:15:26
liver is not responding appropriately to
00:15:29
basically keeping our glucose balanced
00:15:31
at the same time once iron deposition
00:15:34
and this whole process starts happening
00:15:35
in our pancreas our beta cells stop
00:15:38
producing insulin so we've got kind of a
00:15:41
one two hit of both our pancreas and
00:15:44
liver and when you combine those that
00:15:46
then sets you up for metabolic syndrome
00:15:49
right which is this High um insulin or
00:15:51
insulin resistance high glucose you get
00:15:54
this middle um you know
00:15:56
atopos uh a weight gain and then that
00:15:59
all sets you up for an increased risk of
00:16:01
heart disease stroke um and type 2
00:16:04
diabetes where we caught the Dolphins
00:16:06
was right at that stage of um basically
00:16:09
metabolic syndrome before it had
00:16:12
Advanced to these Advanced um you know
00:16:14
conditions so it was really at the
00:16:16
perfect spot to understand the
00:16:18
pathophysiology leading to that wow so
00:16:20
does a c-15
00:16:23
deficiency are you starting to see
00:16:25
direct links maybe not like right now
00:16:27
it's easy to say there's a potential
00:16:28
indirect direct link because you've got
00:16:29
the metabolic piece and that could
00:16:31
affect cardi metabolic and you know
00:16:33
cardiovascular disease and whatnot are
00:16:35
there any signs that there's direct
00:16:36
links with c-15 deficiency and fer
00:16:38
ferroptosis and cardiovascular disease
00:16:40
like independent of the metabolic side
00:16:43
yeah there is so with regard to you know
00:16:45
the Dolphins were an interesting and
00:16:47
again a clean model in which because
00:16:49
they weren't getting enough c-15 in
00:16:51
their diet because the fish had less C15
00:16:53
that we were able to see this we were
00:16:55
able then to repeat this in the lab so
00:16:57
to be able to show directly that there
00:16:59
are models of ferroptosis that then we
00:17:02
could show that c-15 could fix it so
00:17:05
we've got you know the side that the
00:17:06
Dolphins are indicating c-15
00:17:08
deficiencies cause it um able to show in
00:17:11
a model that c c-15 fixes it so then we
00:17:14
start moving to the human data right and
00:17:16
this is where we see um where we explain
00:17:19
in the paper um which is a beast of a
00:17:22
paper so if you're trying to
00:17:24
sleep that could help you sleep just by
00:17:26
trying to get through this paper so but
00:17:28
what it Works through this um uh logical
00:17:32
um arguments with regard to okay what is
00:17:34
faptos is known to do it is known to um
00:17:37
increase our risk of heart disease um
00:17:40
type 2 diabetes and fatty liver disease
00:17:42
it's really what we focus on not only
00:17:44
does it increase the risk of it but it
00:17:46
speeds up the onset of these diseases
00:17:49
and it makes it more aggressive so if we
00:17:52
talk about younger people so people with
00:17:55
um younger kids um people less than 20
00:17:57
years old getting type 2 diabetes right
00:18:00
so type two diabetes used to be an adult
00:18:02
onset disease and we used to call type 1
00:18:04
diabetes juvenile onset remember that
00:18:08
okay so at some point in time about when
00:18:10
all of this started happening children
00:18:13
started getting type two diabetes and
00:18:15
not only that but they're more
00:18:17
aggressive than the type two diabetes
00:18:19
that we're used to seeing they have a
00:18:21
higher risk rate and of complications in
00:18:25
even kids with type one diabetes which
00:18:27
that in itself is a devastating disease
00:18:30
so ferroptosis in this process is
00:18:33
showing up in younger people it's
00:18:35
explaining how they're getting more
00:18:37
aggressive diseases faster um people
00:18:40
between 18 to 44 year old uh 44 years
00:18:43
old increasingly getting coronary heart
00:18:45
disease I mean we were on an amazing
00:18:47
trajectory of decreasing heart disease
00:18:50
for decades still is the same case for
00:18:52
people over 50 so like I'm in the clear
00:18:55
but but for younger people The increased
00:18:58
risk of of um heart disease is has been
00:19:01
going way up when I get back to Ty type
00:19:03
2 diabetes 673 per increase is expected
00:19:07
in young people um by the year 2030 in
00:19:10
typ D IB so it's really and then we talk
00:19:12
about fatty liver disease right this is
00:19:14
a disease that didn't exist before a
00:19:16
paper was published by uh the Mayo
00:19:18
Clinic in 1980 they found the first 20
00:19:21
patients with fatty liver disease um
00:19:24
that wasn't associated with alcohol
00:19:26
right prior you see this disease it was
00:19:28
always associated with alcohol
00:19:30
consumption which is why they called it
00:19:33
non-alcoholic fatty liver disease or
00:19:35
non-alcoholic stat of hepatitis so Mayo
00:19:37
Clinic publishes this uh you know first
00:19:40
20 cases in 1980 today it's now
00:19:43
impacting one in three people globally
00:19:46
and one in 10 children so there's this
00:19:49
been this big mist of how is it
00:19:50
happening we're all understanding that
00:19:52
fosis is driving this process and this
00:19:57
speed up of the of the problem and now
00:20:00
it's being able to say okay um the
00:20:03
study's now linking showing people with
00:20:05
higher c-15 levels lower risk of type 2
00:20:09
diabetes heart disease and fatty liver
00:20:11
disease and this isn't just one study or
00:20:13
two study these are a
00:20:15
metaanalyses um of you know thousands of
00:20:18
people over Decades of time consistently
00:20:21
showing how much basically you know c-15
00:20:25
we need in order to protect against um
00:20:27
getting these diseas
00:20:29
I mean it's almost like we've been
00:20:31
looking at so many things in isolation
00:20:33
which we we should but at the same time
00:20:35
I mean it sounds like it's accelerated
00:20:37
aging is like really what's happening
00:20:39
it's like we're just finding that like
00:20:41
people at a younger age are experiencing
00:20:44
problems that shouldn't be an issue
00:20:47
maybe at all but are you know previously
00:20:50
an issue when they're over 50 60 years
00:20:51
old and it's like everything's just
00:20:53
accelerating so it's like okay here we
00:20:54
are looking at these sole things okay
00:20:57
like cardiovasculares or Diet diabetes
00:20:58
but we're not looking at dare I say the
00:21:00
root I hate when people say the root
00:21:02
because it sounds kind of cheesy but
00:21:03
it's like okay like the root really
00:21:05
seems like okay we're just moving
00:21:06
through this so fast and I'm kind of
00:21:09
thinking again like an iron deposition
00:21:11
and reactive oxygen
00:21:14
species it's Death By A Thousand Cuts
00:21:16
it's like you've got an iron deposition
00:21:18
I know we've talked about this before
00:21:19
but like you leave you know a bunch of
00:21:21
anvils or a bunch of dumbbells out in
00:21:22
the elements right it's like okay if you
00:21:25
had a little bit of oxygen they would
00:21:28
rust and they would you know have a
00:21:30
problem a little bit of the elements
00:21:31
they would have a problem but as the
00:21:32
weather gets worse it would just it
00:21:34
oxidize even more right so it's like
00:21:36
okay sure the iron deposition as a
00:21:37
result of this deficiency is problematic
00:21:40
but then you combine that with the
00:21:42
crappy lifestyle and it's like almost
00:21:44
literally throwing gasoline on this fire
00:21:46
right it's just it's just GNA take off
00:21:48
from there yeah that's exactly it I mean
00:21:51
examples include you know as far as you
00:21:52
know when you talk to pediatricians
00:21:55
these days and especially like we work
00:21:57
with Dr Jeff Schwimmer he's one of the
00:21:59
leaders in pediatric fatty liver disease
00:22:02
and you know we talked about and we
00:22:04
brought up this idea of like accelerated
00:22:06
aging and kids and like I didn't even
00:22:09
get to finish the sentence he's like oh
00:22:10
no this is absolutely what's happening
00:22:12
like kids are getting the diseases of
00:22:14
their grandparents before their parents
00:22:17
get them he's like it's unquestionable
00:22:18
there's accelerated aging happening in
00:22:20
these kids it's not only impacting their
00:22:23
kind of like you see them getting high
00:22:25
blood pressure and high cholesterol I
00:22:27
mean it's just you know it's and he goes
00:22:29
and there are you know mental health um
00:22:31
problems that are coming with it it's
00:22:32
like you know there's just this giant
00:22:35
you know ball of twine that is just like
00:22:38
that they're getting caught up in so
00:22:41
there isn't C15 is not like oh and
00:22:43
that's it and that's the only problem
00:22:44
and that you know it's but a lot of it
00:22:47
as far as you know when we look back and
00:22:49
you look back at what is causing this
00:22:51
why are younger people getting these
00:22:52
diseases a lot of people fall back on
00:22:54
Obesity well it's like well you know
00:22:57
kids are more obese and this is what
00:22:59
happens with obesity and it's a pretty
00:23:01
simple problem they also talk about
00:23:03
trans fats or there's too much ultr
00:23:06
processed foods and those are all likely
00:23:10
contributors to the problem but for us
00:23:12
it's like we go back to the Dolphins
00:23:14
yeah and the Dolphins aren't obese they
00:23:17
aren't getting you know Ultra processed
00:23:18
foods and they're not eating a bunch of
00:23:20
trans fatty acids so for them they again
00:23:23
provided this amazingly clean picture of
00:23:26
they decreased their amount of C5
00:23:29
we can now quantify how much C15 needs
00:23:32
to be in those cells it's
00:23:34
0.2% of fatty acids in our cell membrane
00:23:37
we need at least that for that cell
00:23:40
membrane to stay intact you have less
00:23:42
C15 than that and that is now what we're
00:23:44
defining as nutritional deficiency
00:23:47
syndrome or now makes a lot of sense
00:23:48
cellular fragility syndrome so the good
00:23:51
thing is we can now measure and detect
00:23:53
how much is in there and then you know
00:23:56
detect who has the deficiencies and most
00:23:58
most importantly how to fix it how can
00:24:00
we get our world back to where we could
00:24:03
have these healthy cells um that are
00:24:05
meant to Keep Us Alive and long and
00:24:08
healthy for a long long period of time I
00:24:11
don't know if you know listeners
00:24:13
understand the the magnitude because it
00:24:16
took me a long time to like understand
00:24:18
the magnitude of like what a true
00:24:20
clinical deficiency is like we haven't
00:24:23
had a clinical deficiency that we could
00:24:26
say is a legit clinical deficiency
00:24:28
people say oh I'm deficient in vitamin B
00:24:30
because I'm you know vegan or whatever
00:24:32
like it's not a clinical deficiency like
00:24:34
first of all like a lot of the
00:24:35
deficiencies we talk about are is
00:24:37
guesswork it's not we can assume or we
00:24:40
can get a micronutrient panel and see
00:24:41
that we're moderately deficient in
00:24:43
something but a clinical deficiency like
00:24:44
a real deficiency that's big news and
00:24:47
that's you know why this paper is is the
00:24:49
real deal to actually demonstrate that
00:24:51
we're seeing widespread like this is a
00:24:54
legit deficiency just like vitamin C
00:24:57
deficiency causes scurvy just like like
00:24:59
the real deal yeah I mean it's what was
00:25:01
critical for this paper was to be able
00:25:03
to define the pathophysiology of it so
00:25:06
you can't just say oh this is a normal
00:25:09
you know bell curve for c-15 levels in
00:25:11
people and if you have the low level
00:25:13
you're deficient right it's like no it's
00:25:15
like it's like it's a nutritional
00:25:18
deficiency requires one that the thing
00:25:21
that you're calling deficient that
00:25:23
nutrient has to be essential so it means
00:25:26
that we have to get certain amounts our
00:25:28
body has to have certain amounts of it
00:25:31
in order to just maintain Baseline
00:25:33
health and in the absence of it we fall
00:25:36
apart right and that's very very rare so
00:25:39
we're talking about our vitamins right
00:25:41
so vitamin C vitamin D um and then the
00:25:43
second part is that not only proof that
00:25:47
if levels are low you develop a disease
00:25:49
because of those levels but when you
00:25:51
restore that nutrient back into the
00:25:53
system that then that specific
00:25:56
deficiency syndrome is fixed and so
00:25:59
that's what this paper goes in
00:26:01
incredible detail has 150 um or 142 uh
00:26:06
references I've been up for six
00:26:08
days let get your highlighter out but
00:26:11
you know so it's um that it goes into
00:26:14
detail of basically checking off all of
00:26:16
those boxes um where you know it's it's
00:26:19
now it's it is well defined it is shown
00:26:22
that it's caused by um deficiencies in
00:26:24
C15 it is fixed by C15 it's very
00:26:27
definable and this all of this showed up
00:26:29
for oposisi aging all of it showed up at
00:26:33
the same time we've been taking c-15 out
00:26:36
of our diets so this you know experiment
00:26:39
uh that we've done over the last 50
00:26:41
years um
00:26:43
unintentionally um for bad reasons um
00:26:46
you know has by taking C15 out of our
00:26:48
diets we've basically you know tested
00:26:51
the hypothesis of is C15 really an
00:26:54
essential fatty acid um which is what we
00:26:57
discovered you know back in 20 I want to
00:26:59
talk about Sardinia for a second because
00:27:01
like Sardinia is very interesting anyway
00:27:04
from a longevity perspective I've done
00:27:07
pretty detailed videos on just multiple
00:27:09
aspects I mean ranging from like the The
00:27:12
Grapes grown at high altitude for the
00:27:14
specific wine the mastic oil um even
00:27:17
Mastic Gum like other components of
00:27:19
their diet like a lot of dairy from
00:27:22
sheep a lot of like very interesting
00:27:25
diet and in isolation like Sardinia is
00:27:28
one of the most unique blue zones to
00:27:30
begin with like it's it has its own
00:27:33
outlying aspects of it that are
00:27:35
different from the other blue zones
00:27:37
independently and I don't want to you
00:27:39
know go off on my own like high horse
00:27:41
about it but it's just so interesting
00:27:43
like you protein consumption is a little
00:27:45
bit higher in Sardinia than a lot of the
00:27:46
other ones and um and you mentioned
00:27:50
something before we were filming about
00:27:51
Sardinia that I didn't know and that was
00:27:53
about a specific kind of cheese that
00:27:55
they eat there and I want to kind of
00:27:56
double down on that cuz that's really
00:27:58
interesting can you tell me a little bit
00:28:00
more about that yeah absolutely so so
00:28:02
you know Sardinia is FC you're correct
00:28:04
very fascinating um with regard to uh
00:28:07
you know it's one of the five longevity
00:28:09
blue zones as you mentioned Thomas and
00:28:11
so with Sardinia the other thing that's
00:28:14
unique about it you know because it's
00:28:15
called the island of centenarians right
00:28:17
where people are most likely to live to
00:28:19
100 years old and specifically men so
00:28:21
this actually has the largest population
00:28:24
or relative population of Long lived
00:28:26
centenarian men of anywhere in the world
00:28:28
even normally women live longer yeah
00:28:31
exactly so it's like oh so something
00:28:33
you're right that something is very
00:28:35
unique of what's happening in Sardinia
00:28:37
so as we were going through the papers
00:28:39
and working through okay what are normal
00:28:41
levels of c-15 because we what we do in
00:28:44
the paper is we help Define nutritional
00:28:46
deficiency you know what's low what's
00:28:49
normal and now what may be optimal C15
00:28:53
level so we have the opportunity here to
00:28:55
maybe not just get back to where we were
00:28:57
to healthy levels levels where our cells
00:29:00
keep us healthy the way nature intended
00:29:03
for maybe most of us but Sardinia is
00:29:05
providing a clue that there may be a way
00:29:08
that if we push c-15 levels even higher
00:29:11
we can actually help support longevity
00:29:14
and so with Sardinia they have levels so
00:29:17
on average um the average person today
00:29:20
has c-15 levels in their cell membranes
00:29:22
of 0 2% of total fatty acids which is
00:29:26
right that breaking point it's like you
00:29:28
may or may not get disease WEA you're
00:29:30
you know on either side of that 0 2% in
00:29:33
Sardinia even as you look at the older
00:29:35
people and our C15 levels naturally
00:29:37
decline as we get older right so we're
00:29:38
talking 0 2% in your average aged
00:29:41
population so in Sardinia they looked at
00:29:44
60 to 75 year olds and they have C15
00:29:47
levels of 64 so so more than three times
00:29:51
higher C5 levels were like what and so
00:29:54
this paper came out from M at all
00:29:56
showing and where they called out hey
00:29:58
people in Sardinia have very high C15
00:30:01
levels and so when we looked into that
00:30:04
and then we even when they get to 80 to
00:30:05
100 it does go down as they age but even
00:30:08
the 80 to 100 pluss still have 04 per.
00:30:12
and when they compare that to low
00:30:14
longevity Zone I shouldn't even put in
00:30:15
quotes to a low longevity Zone the low
00:30:18
longevity Zone had 2% so basically the
00:30:20
world is in a low longevity Zone C15
00:30:24
level so when we get back to Sardinia
00:30:27
it's like okay well how are they getting
00:30:29
C15 level so high there's a whole lot of
00:30:31
Hope here right so it's like how are
00:30:32
they doing it so when we looked at
00:30:34
Sardinia and just basically all the
00:30:36
papers tons of papers published on
00:30:38
Sardinia we found that they just like
00:30:41
you had mentioned they have they first
00:30:45
all the food that they eat comes from
00:30:47
what they make so it's local and they're
00:30:51
they have primarily replaced meat with
00:30:55
dairy so meat is only eaten maybe once a
00:30:58
week on Sundays and special occasions
00:31:01
otherwise they've basically repeat
00:31:02
replaced where most people eat meat with
00:31:04
dairy the dairy which is can be up to
00:31:07
25% of the caloric intake is dairy I'm
00:31:10
not recommending that for just in
00:31:12
general but remarkable right
00:31:15
so where we hit The Sweet Spot is the
00:31:18
type of dairy they're eating so they are
00:31:20
goat and sheep herders as you had
00:31:22
mentioned they it is in a mountainous uh
00:31:25
region of the island of sardini
00:31:28
and the goats and the Sheep are grazing
00:31:31
on mountainous grass now other Studies
00:31:35
have shown that not only does do
00:31:38
grass-fed animals produce milk with
00:31:40
higher c-15 so if you take a cow and you
00:31:42
feed it grass just any type of grass it
00:31:44
will have twice as much C15 in its milk
00:31:46
than a cow that is fed 100% corn so
00:31:49
there's already right a huge
00:31:50
differentiate in there so we know that
00:31:52
eating the grass there are other studies
00:31:54
show that not only is eating grass going
00:31:57
to help but the higher the altitude the
00:31:59
grass the higher the C15 in their milk
00:32:02
so now you've got gr mountainous grass
00:32:05
eating local ghosts and sheep um
00:32:09
creating this um milk that is very high
00:32:13
in C15 so like double the amount of C15
00:32:16
as other animals and we know why right
00:32:19
it's they're eating mountainous grass
00:32:20
closer to the Sun perhaps maybe like
00:32:22
something happening in the grass there
00:32:24
where very well could be I mean the same
00:32:26
thing was repeated in the Alps so they
00:32:28
went there was a separate study done in
00:32:29
the Alps and they showed that uh the Alp
00:32:32
grass um had led to higher C15 in milk
00:32:35
and cows that were gracing in Alpine
00:32:38
grass versus others so you know this is
00:32:41
actionable right so this is something
00:32:43
that can be done indust you not
00:32:46
necessarily industrywide but there shows
00:32:48
that there's hope for us to be able to
00:32:49
get c-15 hire c-15 back into our Dairy
00:32:52
so when we look at the cheeses they eat
00:32:55
um they eat peino cheese which is a hard
00:32:59
sheep cheese and peoni cheese has C15
00:33:02
levels that are twice as much as even
00:33:03
cow's butter which was previously seen
00:33:05
as like the high C15 one so peino cheese
00:33:09
great um they have another type of
00:33:11
cheese that they eat that's like a soft
00:33:13
goat cheese that they age for 30 days
00:33:17
and what studies showed is that the c-15
00:33:20
in those or the fatty acids in that
00:33:22
cheese are actually free fatty acids so
00:33:24
it there's over that aging period the
00:33:27
fatty acids go from these complex lipids
00:33:29
to these like easy and bioavailable free
00:33:32
fatty acids so now not only do you have
00:33:34
C higher c-15 it's now more bioavailable
00:33:37
because it's a free fatty acid so then
00:33:39
you add those together and it's like
00:33:41
that's how they're getting high
00:33:42
C15 and associated with um lower heart
00:33:46
disease so people in Sardinia live
00:33:48
longer because they're less likely to
00:33:50
die of heart disease which is why men
00:33:52
are living longer um and now numerous
00:33:56
studies showing that people with higher
00:33:58
15 especially between 04 to 0.55% lower
00:34:02
risk of eing heart disease so you know
00:34:05
everything starts coming together with
00:34:07
regard to Sardinia is giving us a lot of
00:34:09
hope that can we repeat that you know
00:34:11
model globally it's I know there is some
00:34:15
literature over a decade ago too on like
00:34:18
high altitude uh cows in Switzerland and
00:34:21
the cheese having higher levels of
00:34:23
conjugated lenic acid as well which is
00:34:25
again another you know really important
00:34:27
compound
00:34:28
when you look at uh so just to clarify
00:34:29
like c-15 this is an essential fat that
00:34:32
body can't create it so it has to come
00:34:34
from the diet that's right yeah so it's
00:34:36
you know because I know obviously
00:34:37
there's there's certain compounds in the
00:34:38
body where well maybe we could dig a
00:34:40
little deeper and understand why we're
00:34:42
not producing enough of it yada out of
00:34:43
it this isn't the case this is purely
00:34:45
something we would get from the diet
00:34:48
yeah exactly and so you know there there
00:34:49
is our body has some production of um
00:34:53
C15 uh some of it can come from when we
00:34:55
eat fiber uh that fiber uh contains
00:34:59
inulin inulin feeds microbes in our gut
00:35:02
and those microbes can use inulin to
00:35:04
make c-15 so there's some production
00:35:06
it's still coming from the diet because
00:35:08
we're eating the fiber um and that you
00:35:10
know that can create some C15 the big
00:35:13
thing with regard to the essential fatty
00:35:14
acid you know that you're talking about
00:35:16
um Thomas is that do we make enough C15
00:35:20
to be able to
00:35:22
support the you know long-term health
00:35:24
and what it appears to be is that we can
00:35:26
get enough
00:35:28
our bodies can do enough to get to or
00:35:30
whatever we're eating whatever it is
00:35:32
that we're eating gets a successful to
00:35:34
this 0 2% but we need to get above that
00:35:38
and it's not that much more it's just
00:35:40
like we just have to get out of this
00:35:42
danger zone and get into the safe zone
00:35:45
of having ourselves stable enough it it
00:35:48
appears to be very clear that we have to
00:35:50
have some amount of C15 in our diet to
00:35:53
be able to achieve those levels and
00:35:54
hence the essentiality yeah I mean it's
00:35:56
it's not it's not realistic I mean as
00:35:58
much as I would love to pack up and move
00:36:00
to Sardinia like I probably wouldn't
00:36:02
complain like it's not realistic for us
00:36:04
to get 25% of our our calories from you
00:36:07
know from dairy that's just unrealistic
00:36:09
so it's you know when you look at okay
00:36:11
sure these populations they've got it
00:36:14
going on like I mean I know from the
00:36:16
case of Sardinia U like happiness scores
00:36:19
with men are significantly higher I know
00:36:21
like they the men have I can't remember
00:36:24
what they it's a specific term for it
00:36:25
but the men have more DED at like social
00:36:28
time whereas like in other regions men
00:36:31
are a little bit more isolated also
00:36:32
focused on work and things like that
00:36:34
there's a like a lifestyle component
00:36:35
that allows men a little bit more of
00:36:38
this like social aspect that is seems
00:36:39
higher than in other regions so there's
00:36:41
a happiness score with the men um so
00:36:43
that might add into that I mean the
00:36:44
whole lifestyle with Sardinia is amazing
00:36:47
obviously the like the mineral profile
00:36:49
they get from the shellfish it's you you
00:36:51
talk about death by a Thousand Cuts in
00:36:52
this case it's like the other right it's
00:36:54
like it's like okay they've just got
00:36:55
it's in isolation so many things going
00:36:58
for them and then you look at okay well
00:37:01
if we even tried to engineer that into
00:37:04
our lives in the United States first of
00:37:07
all I don't think that it would be the
00:37:10
same equation with bow Vine Milk you
00:37:12
know so you go to the US and it's like I
00:37:15
mean I I don't know the statistic if I
00:37:16
had to guess it's probably more than 98%
00:37:18
is consumption of Bine milk versus goat
00:37:20
milk most people I talked to don't even
00:37:22
like goat I love goat milk but goat milk
00:37:23
and goes most people just want so it's
00:37:25
like okay already you're at a lower
00:37:27
amount of C15 to begin with not to
00:37:30
mention I'm going to get in trouble for
00:37:32
saying this but there's probably less
00:37:33
pasteurization and stuff occurring like
00:37:35
in Sardinia like it's probably more raw
00:37:36
milk consumption and you know that's
00:37:39
only allowed in eight states in the
00:37:40
United States to even have raw milk in
00:37:41
the first place so who knows I you might
00:37:44
know I mean if if pasteurization breaks
00:37:46
down some of the C15 I don't know it's
00:37:48
the bottom line is like it's probably
00:37:50
unrealistic to get adequate amounts of
00:37:53
C15 you know from from the diet uh you
00:37:56
know via dairy in the States yeah I I
00:37:59
think you know Thomas it's it's a good
00:38:00
point like we used to I mean because it
00:38:04
seems like we used to get enough and
00:38:07
because the point is you know gosh over
00:38:09
what's been happening this accelerated
00:38:11
aging the increase in type 2 diabetes
00:38:13
and heart disease and you know um fatty
00:38:15
liver disease showing up something is
00:38:18
worse now than it was before like prior
00:38:21
1990 and you know
00:38:23
1990s is when 1977 is when Congress
00:38:27
released recommendations saying hey um
00:38:31
saturated all saturated fats are bad for
00:38:33
you specifically stop drinking whole fat
00:38:35
milk and stop eating butter and that
00:38:37
will save your hearts um that ended up
00:38:40
being partly true and partly devastating
00:38:43
right so in that whole dairy fat it
00:38:47
contains that from from cows has one
00:38:51
less one or less than 1% C15 of all the
00:38:55
fats it has more than 40%
00:38:57
pro-inflammatory saturated fats so C15
00:39:01
you know even in dairy fat especially
00:39:03
the ones that we're talking about you
00:39:04
know not in Sardinia are kind of having
00:39:06
to go an uphill battle with regard to
00:39:10
C15 be able to do its good job battling
00:39:13
against you know much higher levels of
00:39:15
these pro-inflammatory fats other
00:39:17
Studies have shown that the higher fat
00:39:20
we eat um with C15 in it the less likely
00:39:24
our c-15 levels will actually go down
00:39:26
and that is because when we go to absorb
00:39:28
all those fats at the same time in the
00:39:30
food c-15 loses and so we're have a
00:39:33
higher tendency to absorb these
00:39:35
pro-inflammatory fats versus C15 so
00:39:38
there are a lot of things that kind of
00:39:40
put Dairy at odds There's Hope because
00:39:44
it's worse than it was so then the
00:39:45
question is can we get to Sardinian
00:39:47
level you know which is which is your
00:39:49
challenge right personally your
00:39:52
challenge our challenge globally
00:39:55
challenge accepted all right good deal
00:39:57
go have some peina um so uh so you know
00:40:02
can we get to Sardinia even if we were
00:40:05
at 1950s you know us probably not
00:40:09
because of all these other challenges
00:40:10
the last part to put in with regard to
00:40:12
Dairy is that there was a group of a
00:40:15
panelists and so these were experts in
00:40:17
dairy fat and in nutrition uh they met
00:40:20
in um Europe back in 2017 and they asked
00:40:25
this question which is okay whole dairy
00:40:27
fat or individual ingredients within uh
00:40:31
within dairy fat is there really a
00:40:32
difference because we're always taught
00:40:34
that whole food is better and in most
00:40:35
cases this is absolutely true what they
00:40:38
concluded is that dairy fat because
00:40:40
they're over 400 fatty acids there just
00:40:43
a lot happening in Dairy F we were
00:40:45
talking about how much variation there
00:40:47
can be in dairy fat that thousands of
00:40:51
studies being done on dairy fat conclude
00:40:54
that you it does not reliably improve
00:40:56
our metabolic heart and Liver Health
00:40:58
there are studies that show that it does
00:41:00
there are just as many studies showing
00:41:02
that it doesn't so their conclusion was
00:41:05
you can't just eat more dairy fat um to
00:41:07
get these individual nutrients to
00:41:09
support your metabolic heart and Liver
00:41:11
Health what they did conclude is that
00:41:14
individual nutrients within dairy fat
00:41:17
can have a beneficial effect but they
00:41:19
have to be taken out of that milu what
00:41:23
they call the Matrix in order to be able
00:41:26
to have their fact and this sounds like
00:41:28
a spin but it's you know this is a group
00:41:30
that has no bias um and what they their
00:41:33
conclusion is they're just times in
00:41:36
which you know we can use nature to find
00:41:38
a nutrient that can really shine when it
00:41:40
doesn't need to compete especially with
00:41:42
these changes in agriculture um that we
00:41:46
have less and less control over so that
00:41:48
was a really long Answer to No but it's
00:41:50
I mean it's and part of me thinks too is
00:41:52
like okay the sardinians also eat in a
00:41:56
pretty like consistent deficit all the
00:41:59
time right so it's like you can't deny
00:42:01
the literature that
00:42:03
supports heavy saturated fat consumption
00:42:06
being problematic specifically in a
00:42:09
surplus right like that's like I haven't
00:42:11
seen a lot of data to support like I
00:42:13
just don't think the cohort really
00:42:14
exists to be like hey like let's look at
00:42:16
people that consume high amounts of
00:42:17
saturated fat but they're also in a
00:42:18
deficit like that pretty much doesn't
00:42:20
exist in America like if you're eating
00:42:21
saturated fat you are probably in the
00:42:24
category like high amounts of saturated
00:42:25
fat you're you're not doing a carore
00:42:27
diet you're not doing this you're
00:42:28
probably in the category of people that
00:42:30
are getting saturated fat from fried
00:42:31
foods and things so it's just the cohort
00:42:34
doesn't exist we can't look at that you
00:42:35
know so it's like you look at Sardinia
00:42:36
it's like sure their saturated fat
00:42:38
consumption as a percentage of their
00:42:39
diet is probably astronomically high but
00:42:41
they're also living in a probably
00:42:44
consistent 10 to 15% deficit and they're
00:42:46
probably having all these other factors
00:42:49
that are positively compounding that
00:42:52
right so it's the saturated fat the
00:42:55
there's less it's granted a little bit
00:42:56
of amnesty because it's overridden by
00:42:59
all this other positive stuff you apply
00:43:00
that to the us if you were to tell
00:43:02
people in the US it's almost dangerous
00:43:03
it would almost be irresponsible to say
00:43:05
hey United States as a whole people that
00:43:08
don't have nutrition education you need
00:43:10
to eat more cheese is the first thing
00:43:12
they're going to probably do is go to
00:43:15
does Arby have cheese I don't know but
00:43:17
like you know they're going to go and
00:43:18
ask for more queso right like it's it's
00:43:20
different like it's it's I understand
00:43:23
the issue there I know that you know C15
00:43:26
just just like other uh you know some
00:43:28
other things like you can get in
00:43:30
supplement form you know you you guys do
00:43:32
a great job with fatty 15 and C15 there
00:43:34
and I'll link out to that down below but
00:43:36
I mean it sounds like that's I mean
00:43:38
really the way to go for specific C15
00:43:42
like in isolation yeah I think you know
00:43:44
there are multiple things we need to do
00:43:46
right and SOC now that there is really
00:43:50
is a true nutritional deficiency
00:43:51
syndrome we need to fix it so if you
00:43:54
know you find out that scurvy is caused
00:43:56
by vitamin C icy you don't come up with
00:43:59
other ways other than like let's start
00:44:02
with getting vitamin C C back and so
00:44:05
same thing here and so there are
00:44:06
multiple ways to be able to bring c-15
00:44:08
back into our lives you know Eric uh you
00:44:11
know my Navy physician husband and I
00:44:13
this was all discovered when we you were
00:44:15
working at the Navy you know as you know
00:44:18
myself as a civil servant and um you
00:44:20
know Eric as active duty
00:44:22
so um as we were doing the science and
00:44:26
the studies what became apparent to us
00:44:29
is that and working in cooperation with
00:44:31
the Navy is that we had an opportunity
00:44:33
for a pure C15 ingredient to be able to
00:44:37
be more potent bioavailable vegan
00:44:40
friendly to help with this problem so it
00:44:44
wasn't to create a market right it's
00:44:47
like unfortunately the Dolphins were
00:44:48
showing there's a need and you know the
00:44:51
military way is that if you have a
00:44:53
problem research is invested on how to
00:44:56
fix it which is why all of this work how
00:44:58
about
00:44:58
that so was like I know this sounds
00:45:01
crazy but it's like office enval
00:45:03
research funded this work and it was
00:45:05
specifically to say hey we've identified
00:45:07
the syndrome in Dolphins here's the
00:45:10
money to do the research to figure out
00:45:12
what the problem is and to fix it and
00:45:14
you have X number of years it is not
00:45:16
like you spend your career working on
00:45:18
little intricacies of it and Publishing
00:45:20
papers it is a it's a problem that you
00:45:23
solve go fix it and so which we did and
00:45:26
we did and you know for the Dolphins we
00:45:28
did in about four years time because
00:45:30
that's what you do with the military so
00:45:34
this really was this whole thing was
00:45:36
born from saying hey we see a problem it
00:45:40
started with navy Dolphins right and
00:45:43
then now that extended to now global
00:45:46
health and so it's a problem and so one
00:45:50
way to fix it one part of the solution
00:45:53
is to have a pure ingredient that
00:45:57
basically helps take over or puts aside
00:45:59
these other barriers uh you know having
00:46:02
to compete with pro-inflammatory
00:46:03
saturated fats Let It Be vegan friendly
00:46:06
have it well controlled so that is more
00:46:08
than
00:46:09
99.8% pure at the exact amounts we need
00:46:12
we now know that the average person
00:46:14
needs between 100 to two milligrams at
00:46:17
least of pure B available c-15 per day
00:46:20
um so that is what the dose of fatty 15
00:46:23
was so this was all driven by a decade
00:46:26
of science before we even thought of
00:46:28
bringing you know this ingredient to the
00:46:30
market so we do feel strongly that this
00:46:33
ingredient will play an important role
00:46:35
with regard to for not just as a
00:46:37
supplement but fortifying Foods how do
00:46:39
we increase accessibility to c-15
00:46:42
globally because this problem is not
00:46:44
just in the US you know it's everywhere
00:46:46
mostly in developed um countries because
00:46:49
we've created this problem um and on top
00:46:52
of that okay what can we learn from
00:46:54
Sardinia okay so maybe um know cows we
00:46:57
should be feeding them more grass let's
00:47:00
put pressure on the industry to be able
00:47:02
to report for dairy products report how
00:47:04
much C15 is in your product so that when
00:47:06
consumers go to the store they can look
00:47:09
at the different dairy products and say
00:47:10
if I'm going to choose butter a or
00:47:12
butter B I'm going to choose the one
00:47:13
that has higher C15 in it so I think
00:47:16
there are ways um we can move forward
00:47:18
another one is with kids you know
00:47:20
pediatricians in the 1990s really made
00:47:23
this movement of saying um we went from
00:47:27
all Americans should avoid eating whole
00:47:30
fat drinking whole fat Dairy and eating
00:47:33
butter and that was 1977 through 1990
00:47:36
then around 1990 1991 the Pediatric
00:47:39
Community came in um again all with good
00:47:43
intentions but they then said okay young
00:47:46
children infants um and toddlers should
00:47:50
not get whole fat milk and it was pretty
00:47:54
bold um at the time so we went from
00:47:57
before 1990 a 12-month-old um child um
00:48:02
90% of them will have had whole fat milk
00:48:04
by the time they're one um today it's
00:48:07
less than 10% of children have been
00:48:09
exposed to whole fat cow's milk so it's
00:48:13
been a dramatic so now we're talking
00:48:15
about the youngest of young not getting
00:48:19
adequate c-15 levels even from Mom's
00:48:22
milk because if Mom is C c-15 deficient
00:48:25
she has less c-15 in her milkk so we're
00:48:27
talking about deficiencies that are
00:48:29
starting at Birth which is why we're
00:48:32
seeing this translating to these are now
00:48:35
um people turning 30 years old yeah I
00:48:37
mean we have massive like cell
00:48:40
differentiation that's occurring at that
00:48:41
age and it's like who knows even
00:48:43
epigenetically who knows like what
00:48:45
that's doing for them how it's setting
00:48:46
them up for or not setting them up for
00:48:49
success as they get older right it's
00:48:50
like when such a pivotal time yeah
00:48:53
there's a study that just came out in
00:48:54
fact it's a pre-print right now that
00:48:56
show in which um it's a big study done
00:48:58
in France and they follow um moms from
00:49:01
pregnancy and then um through baby being
00:49:04
born through the children developing and
00:49:06
right now they have the kids up to I
00:49:07
think about 11 years old and some of the
00:49:09
oldest ones in the cohort and what the
00:49:11
pre-print shows is that moms who had
00:49:14
less C15 in their red blood cell
00:49:16
membrane during pregnancy and in the in
00:49:20
their milk um resulted in kids uh if
00:49:24
they had lower C15 the kids don't
00:49:27
perform as well as 2year olds threeyear
00:49:30
olds and five and six year olds
00:49:32
cognitively um so it's just you know
00:49:34
like you're saying what does this mean
00:49:36
from a developmental level and so that
00:49:39
it's not like oh therefore all infants
00:49:41
should get fatty 15 right this is like
00:49:44
how about why don't we start by getting
00:49:46
whole fat milk safely you know back into
00:49:49
um you know into our youngest of young
00:49:52
and you know things like um infant
00:49:54
formulas have no c-15 in them no and so
00:49:57
separate papers you know made a call to
00:50:00
action saying we should be putting C15
00:50:02
fortifying C15 in infant formulas
00:50:04
because it's becoming clear and clear
00:50:06
this is an essential nutrient we we need
00:50:08
so there's a lot of things um to be done
00:50:12
we think you know fat5 and supplements
00:50:15
part of the solution but we're really
00:50:17
working with the whole Community Global
00:50:18
Community to fix you know a big problem
00:50:21
the upside is there's so much hope
00:50:23
because there's a solution yeah there I
00:50:27
and I have mixed feelings on like
00:50:29
fortification of foods but at the same
00:50:31
time it's like this is something where I
00:50:33
mean is that in your crosshairs at all
00:50:35
like just being like okay we've got like
00:50:37
good you know dairy product like okay we
00:50:40
fortify with vitamin D because we saw
00:50:42
that as an issue yeah like is there is
00:50:44
it in your crosshairs to see like hey
00:50:46
like we can or where's your stance on
00:50:47
fortification with C15 yeah I think in
00:50:49
this case it's you know c-15s it's it's
00:50:51
the next natural biggest impact step so
00:50:55
you know supplements are great great
00:50:56
because people could choose and we have
00:50:58
super Savvy you customers who do the
00:51:01
Deep dive on the science who listen to
00:51:02
you know your podcast and you know are
00:51:05
ready to learn are diving in they have a
00:51:07
lot of knowledge they come back with
00:51:08
really smart questions which we greatly
00:51:11
appreciate um and they're ready to come
00:51:13
in and be like the early adopters right
00:51:16
and um and so supplementation is a great
00:51:18
place to start where really the global
00:51:21
impact can be is going to be
00:51:22
fortification of of foods and the nice
00:51:24
thing about C15 as an ingredient is it's
00:51:27
really stable so a lot of times we think
00:51:29
about fats and fatty acids like omega-3
00:51:31
and Omega 6es those are oils those are
00:51:33
just tough T to like they get attacked
00:51:36
by oxygen so they go bad really fast we
00:51:39
happen to be gifted with c-15 in which
00:51:41
its whole role is a stabilizer so it
00:51:44
stabilizes our cells a big part of that
00:51:46
is because it's not an oil right it's a
00:51:48
it's a um a stable powder at room
00:51:52
temperature so that means it doesn't go
00:51:54
bad so this means it's just Prime to be
00:51:57
able to fortify Foods in anywhere in the
00:52:01
world and be a stable way to you know
00:52:03
get this nutrient you know back into
00:52:05
people's lives affordably uh so that's
00:52:07
really our next stop um is how do we use
00:52:11
this as part of uh you know a broad
00:52:14
solution is there a way for people to um
00:52:18
like see where their c-15 levels are at
00:52:20
or I mean is that is that even possible
00:52:22
now or is it really just right now it
00:52:23
takes pretty extensive work um so so it
00:52:26
used to be where you needed to get a
00:52:28
fatty acid panel um which isn't the end
00:52:30
of the world but it's not like you any
00:52:32
of us go to our doctors and they're like
00:52:34
oh here your here's your fatty acid pan
00:52:36
then uh I don't know if you not
00:52:38
everyone's uh you know I don't know if
00:52:40
anyone saw the South Park episode on the
00:52:42
uh it was the OIC episode but like n
00:52:45
quote the song The navigating the
00:52:46
American Healthcare System song that
00:52:49
Butters was singing I just it's amazing
00:52:51
and it just just so I'm just saying like
00:52:53
Okay here here's me going to go get an
00:52:55
essential fatty acid pan
00:52:57
uh it's going to take me two weeks of
00:52:58
going to four different doctors and
00:53:00
calling yeah so yeah fits right along
00:53:03
Butters and the fact that's butter is
00:53:05
kind of Butters Butters um so uh so now
00:53:10
uh so there are a lot of functional um
00:53:13
Physicians and Healthcare practitioners
00:53:15
that have been using a fatty acid panel
00:53:16
for maybe at least the F last five years
00:53:19
that has included C15 so we've talked to
00:53:22
a lot of as we've been working with a
00:53:24
lot of functional medicine practitioners
00:53:26
they're like oh my gosh wait we've
00:53:28
actually been collecting c-15 we didn't
00:53:29
know whether we should care about and as
00:53:31
they're going back Thomas they're like
00:53:34
writing us back and they're like oh my
00:53:36
gosh we see like 12% of the people that
00:53:39
you know of our you know patients that
00:53:41
we've been looking at over the past five
00:53:43
years 12% are unquestionable like we're
00:53:46
talking like 0.002% or 0.04 versus 0.2
00:53:50
right and uh and then another 12 to 14%
00:53:53
being in this like less than 0.2 to you
00:53:56
know 0.1% and so they're like no this is
00:53:58
real we're like well yeah you know it's
00:54:01
definitely real so the test has been
00:54:04
available um what we're now doing is
00:54:06
we've um partnered with gova Diagnostics
00:54:09
to be able to have an atome spot test um
00:54:12
for c-15 so that people can get their
00:54:14
c-15 levels measured um uh via uh goova
00:54:19
so this is theirs um independent but as
00:54:22
we were um making these discoveries
00:54:24
obviously the next next natural question
00:54:26
is well that's great but how do I know
00:54:29
what my C15 levels are so um now there's
00:54:32
a way to be able to do that i''d be
00:54:34
curious to test mine now I was just in
00:54:35
Europe for a month and I think I like
00:54:37
pretty much only the only thing I ate
00:54:39
was like drinking like six lattes a day
00:54:42
and eating cheese and the occasional
00:54:44
Pudo and that was like my diet for a
00:54:46
month so yeah I think you're probably be
00:54:48
in that
00:54:50
3.44 not quite Sardinian but get close
00:54:53
do you actually see is it something that
00:54:54
builds up over time or uh you see a
00:54:56
pretty rapid increase upon like
00:54:59
increasing not only diet but also
00:55:00
supplementation form of it yeah so in
00:55:02
general it takes I mean to to safely get
00:55:05
to understand where you're at the nice
00:55:07
thing that uh this test measures it it
00:55:09
actually measures the amount of C15 in
00:55:11
your red blood cell membranes so other
00:55:13
tests might measure serum and plasma
00:55:15
which kind of gets to what your you
00:55:16
might have the spike that goes up and
00:55:18
down it's less reliable like when you
00:55:20
talk about glucose versus hba1c this
00:55:22
would be your the red blood cell
00:55:24
membrane is like your HB A1C so it's a
00:55:25
more stable measurement and it's
00:55:28
stabilizing your cell membranes so to
00:55:30
actually get that measurement of your
00:55:31
cell membranes is the most directly
00:55:33
important um so it measures um those
00:55:36
levels um that you're then able to um
00:55:40
work off of from there interesting well
00:55:43
I will most importantly link out to the
00:55:45
study down because I I do know that and
00:55:48
I hope the viewers know that you know
00:55:50
the more eyeballs that get on a study
00:55:52
the better like it's algorithmic just
00:55:55
like everything else in the world now so
00:55:57
you know get eyeballs on the study
00:55:58
because this is one of those things
00:55:59
where it's like people say why isn't
00:56:00
this front page news it's like we focus
00:56:01
on so many other things and this is this
00:56:03
is clear legit science this is not
00:56:05
Fringe Weird Science cherry-picking
00:56:07
connect the dots BS like this is real
00:56:10
stuff and it needs the eyeballs on it
00:56:12
and that's why I brought you here and I
00:56:14
know yes you have a supplement company
00:56:17
with C15 and I'll link out to that down
00:56:18
below but that was not the purpose of
00:56:20
this video the purpose is like let's get
00:56:22
eyeballs on this study because people
00:56:24
legitimately need to know this yeah
00:56:26
thanks Thomas I mean we call oursel a
00:56:28
team of nerdy do Cutters and our whole
00:56:30
purpose is really to help improve Global
00:56:33
Health that was our job as a military
00:56:35
family it's our job you know with this
00:56:37
company so thank you for helping to get
00:56:39
the word out yeah awesome thank you for
00:56:40
coming and thanks Eric for the workout
00:56:43
this
00:56:44
morning all right so uh as always keep
00:56:46
it locked in the channel I'll link out
00:56:48
to everything down below and thank you
00:56:49
great thank you

Etiquetas

c-15
cellular fragility
insulin resistance
metabolic syndrome
dairy fat
Sardinia
ferroptosis
aging
nutritional deficiency