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i've always been jealous of those people
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that can have that big cup of coffee
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after dinner we all know those people
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right like you go to a restaurant you're
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sitting there with some friends or
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grandparents or something and the waiter
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comes by and like "Can I dessert or
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coffee or anything like that?" And I'm
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thinking like coffee and people just be
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like "Yeah I'll have a cup of coffee or
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I'll have an espresso." And it's 8:00 at
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night and I'm just thinking "How is that
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even possible i would love to be able to
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do that." Heck even decaf seems like it
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would wire me up with that small amount
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of caffeine that's left in decaf point
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is is that there's some ways to get
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caffeine out of your system really
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really really fast particularly this
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compound called rudaarpine which I'm
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going to talk about and I've talked
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about it in other videos uh in other
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ways but this is a way to use it so you
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can still sleep after having caffeine
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let's go ahead and break it down as you
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know on this channel one of the ways
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this channel stays functioning and alive
00:00:57
is through our sponsors and I want to
00:00:59
make a mention that a sponsor that I
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have talked about for a very long time
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on my channel Thrive Market this is why
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I like them okay that's a 30% off
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discount link down below for Thrive
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Market but Thrive Market does not have
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food products that have food coloring
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added to them that have preservatives
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added to them they are as close to
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shopping like you're shopping in Europe
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as you can get they really do vet every
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single product that is on their grocery
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store shelf even though it's online okay
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they even make their own products to
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make sure that the standards are high
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enough that's the point it's not about
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processed food versus not processed food
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it's about how do we up the standard and
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have a place where people can get good
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quality food that they can trust that
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has good quality ingredients that's
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sustainable that's resourceful and can
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also be at a very decent price that's
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competitive with what they would find in
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a grocery store so that link down below
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is for Thrive Market again that's a 30%
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off discount link your entire first
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grocery order so that whole first
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there because you can search by diet
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type point is is that I wish the real
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grocery stores were like Thrive Market
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because Thrive Market has online grocery
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store like shopping in Europe granted
00:02:13
there's still not the same amazing
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things you can get in Europe but it's a
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heck of a lot better so I highly
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recommend you check them out that link
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is down below just beneath this video in
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the top line of the video description so
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there's a study published in
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biomolelecules and therapeutics that
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took a look at this new compound called
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rudocarpine and they found that it
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completely abolished the negative
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effects from caffeine on sleep one of
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the main ways that it does this is when
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we consume caffeine caffeine will make
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it so that we
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are basically inhibiting the effects of
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what is called GABA gaba is a is a
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neurotransmitter and is what is known as
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an inhibitory neurotransmitter okay so
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an inhibitory neurotransmitter means it
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blocks the excitatory actions so if
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something amps you up and gets you like
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over stimulated GABA is what counters
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that it's an inhibitory neurotransmitter
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so essentially what happens is caffeine
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limits the action of GABA so you no
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longer have the inhibitory effects so
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you're extra amped up that's why
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sometimes when you have caffeine you
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feel like you can go and sometimes you
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have caffeine and you feel like you're
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going to spin out and that's exactly why
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if you were to have caffeine you would
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probably have a hard time falling asleep
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because GABA is very important for sleep
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it's why so many sleep aids utilize GABA
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to help us relax interestingly enough
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they also noticed that rudaarpine just
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decreased excitability from caffeine so
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it made it so that caffeine was almost
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just a little bit uplifting but you
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didn't get like the overthe-top
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excitability but really what's going on
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more than anything and this is something
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I've talked about in other topics before
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is that rudaarpine and apagenine both
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they accelerate the metabolism of
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caffeine so they can 3x it 3xes what is
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called cyp1 a2 sip 1 a2 but also cip 21
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which are enzymes these enzymes are in
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our liver and there are a category of
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enzymes called cyp enzymes and if you've
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ever heard about people that are fast
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metabolizers of caffeine versus slow
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metabolizers of caffeine it has to do
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with that family of enzymes and we all
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have a different amount of these enzymes
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but if you increase the availability of
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these particular enzymes it changes how
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quickly you metabolize caffeine
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metabolizing caffeine is as much as like
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hey how long do I have a prolonged
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effect from it compared to like it's in
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and out of my system fast these things
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can upregulate depending on how much
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caffeine you consume and whatnot but
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there's also just a bio-individual
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aspect to it that's why there are people
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that can have caffeine at night and
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metabolize it fast and go to bed in an
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hour if I had caffeine at night I would
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not be able to go to bed for like 6
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hours maybe eight hours right i have
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personally tried ruda cararpine and I
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have noticed that when I take 3 to 400
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milligrams of it I can have a cup of
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coffee about 3 hours before bed and
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sleep like a rock so much so that now I
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have experimented taking rudaarpine even
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independent of caffeine because I've
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noticed that it has a profound effect on
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my sleep and looking at the literature
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there's rodent model literature that
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supports it having an effect on what is
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called a 5HT 5 hydroxy tryptophan
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receptor which has to do with serotonin
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uptake here's what's wild is that
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rudaarpine is technically a cylo
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oxygenase enzyme 2 a COX 2 inhibitor
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which means it acts very similarly to
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like a an ibuprofen or an aspirin on the
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inflammatory system but not so much like
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on our gut right so it can actually
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reduce inflammation in the brain and in
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the body that might help us just sleep
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better in general so quite a fascinating
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compound in that respect but by far the
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most powerful effect is that 3x increase
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in the SIP 1 A2 and SIP 2E1 and the fact
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that there is literature to support that
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it can increase caffeine metabolism get
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rid of literally 75% of the caffeine
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like that like really quick what you
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would want to do is if you knew you were
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going to have caffeine in the afternoon
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or evening it's best to have the
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rutarpine in your system already so if
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you were to take rudocarpine sort of as
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damage control it's going to take a
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little while to build up in your system
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so you'd want to have the root of
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cararpine say two hours or so before 3
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hours or so before because it can build
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up in your system that's going to put
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you at the best situation where it's
00:06:36
already high in your system it's already
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upregulated those CYP enzymes so then
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you have the caffeine and you could
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pretty much go right to sleep and
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there's evidence to suggest that it
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actually is quite restorative sleep so
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you're not just like hey this is damage
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control i could kind of sleep it's like
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no you could have this coffee have this
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caffeine now this could also make it so
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that if you like the taste of energy
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drinks right like I'm not a big energy
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drink guy but let's say you want to have
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an energy drink or if you want to work
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out in the afternoon right like you want
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to have like it's like I want to have a
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pre-workout that has the stuff in it but
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I want to be able to come down from it
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right i want to work out in the evening
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i want to take a pre-workout and get
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that energy or have an energy drink
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maybe you're one of these people if you
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were to take rudaarpine like co-ingest
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it when you take that caffeine you're
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going to be able to have the uplift for
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your workout and then by the time your
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workout's done rudarpine is going to
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start taking an effect and you actually
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come down a lot faster so you can
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shorten the life of the caffeine and
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make it pretty effective and it's a dirt
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cheap compound that I have no fidiciary
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obligation to no relationship with
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rudaarpine i'm not getting paid by
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Chinese tree companies because it does
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come from a Chinese tree one other thing
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that you can also add like I mentioned
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is apagenine apagenine also increases
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the sip 1 A2 so if you combine
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rudocarpine and apagenine apagenine
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seems to work faster but rudocarpine
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seems to be more effective so when you
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combine these two you might put yourself
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in a spot where you get a rapid rapid
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deceleration of that caffeine sort of
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bump up right so overall it's a nice
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little way to play around with it you
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could also take it in the morning just
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so that you can decrease your caffeine
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tolerance you take a little bit each day
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increase a little more so eventually
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you're kind of coming off the caffeine
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without actually cutting out the coffee
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as always keep it locked here my channel
00:08:25
see you tomorrow
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