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foreign
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[Music]
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I'd like you all to pinch your clothes
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maybe the jumper you're wearing right
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now the jacket maybe the handbag you
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brought with you today
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and to take a second to think about what
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you're holding in your hands
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you'd be right to think that these are
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materials right
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that these materials are made of
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molecules
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but have you ever thought about where
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these molecules come from
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so like mine your clothes are probably a
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mixture of natural and synthetic fibers
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right
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and these synthetic fibers are made of
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molecules that look like this
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and these molecules they're made in
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factories
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they look like this
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and they're made
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from this
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oil
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in fact two-thirds of the clothing
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you're wearing today right now
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are made directly from fossil fuels
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and eighty percent of the clothing that
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you own today
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will likely end up in landfill within
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the next five to ten years
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for these reasons that the clothing
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industry is perhaps one of the most
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polluting Industries worldwide right now
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it emits almost 10 percent of all Global
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carbon dioxide emissions
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so maybe maybe like me you had a bit of
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a hard week at work this week
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and this morning you took a paracetamol
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to ease your headache
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or maybe you've been to the dentist
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and you got an anesthetic
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or maybe you just had too much lunch
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right and you you had an antacid to help
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your heartburn
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have you ever stopped to think about
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where these medicines come from
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they're all made from oil
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in fact 70 of the top 100
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Pharmaceuticals on the market today
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are made directly from fossil fuels
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and this fact has fascinated me
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throughout my career as a chemist
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because it turns out our modern day
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Society has an insatiable thirst
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for fossil fuels
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we need it we need oil to basically
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manufacture everything that we use every
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single day
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and you know it turns out we've been
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going down this one-way Street for the
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best part of a century now
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but we've reached a really critical
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stage in that Journey right now
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and that is because we use 10 billion
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tons of this natural resource every
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single year
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to make few and to make chemicals
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and these industrial activities are
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polluting our planet
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they're driving global climate change
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and fossil fuels are running out
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as an alarming rate
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it's pretty contested in my field right
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now
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but it's accepted that this is going to
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happen in a number of years that has two
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digits and doesn't have three
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and therefore this is going to be
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something that happens in the lifetime
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of our children
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and our grandchildren
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and therefore if we want to do something
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about this we have to start making
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changes now
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solving this problem cannot wait any
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longer
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so my question for you at Ted today is
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do our factories have to look like this
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what happens if they didn't emit any
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carbon emissions
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what if they no longer relied on fossil
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fuels at all
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what if they were living factories
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and talking about microorganisms
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these beautiful invisible living beings
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they live on your skin they live in your
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body
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they live in your homes and in your
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Gardens
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they live in this room right now
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and within all of these environments
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they perform amazing feats of chemistry
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their Nature's chemical factories
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and we've known this for for the best
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part of 2000 years
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because we use this microbial chemistry
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every day
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to make many of the things that we love
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like cheese
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soy sauce
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and the delicious beverages I'm sure
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you're going to partake in very
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responsibly this evening
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none of these would be possible if it
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wasn't for microbial chemistry
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and it turns out saccharomyces is just
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like us it loves sugar
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except when we feed it sugar it gives us
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alcohol and the Beautiful Aromas in your
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beer
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but what if this is not all
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that microbes could do for us
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what if the pen you're holding right now
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could be made using a microbe
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the clothing you're wearing right now
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that paracetamol you took this morning
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what if it could be made using a living
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chemical Factory
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so this is in essence what my lab
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research is at the University of
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Edinburgh in the area of synthetic
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biology
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now synthetic biology is an emerging
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technology that essentially enables us
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to program microbes to do new things
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to do things they've never had to do
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before in nature
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rewiring their metabolism a bit like a
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circuit board
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so that these microbes no longer make
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your cheese
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to make your handbag
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and to do this we have to reorder their
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genes and these genes are made of DNA
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the building blocks of the cell
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and then what we can do is by doing this
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we can change the chemistry of these
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microorganisms
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so that they no longer make your soy
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sauce or your beer
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they make something much better
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like this
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adeptic acids
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now I would forgive you for not knowing
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what atific acid is but
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I guarantee that you're all in contact
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with it right now
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because the adipic acid is used to make
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your clothes it's used to make nylon
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and it's probably one of the most
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prolific chemicals in the world right
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now
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in fact we make over 30 billion tons of
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it every single year exclusively from
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fossil fuels
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via an industrial process that emits
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huge amounts of carbon emissions into
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the into the atmosphere
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in fact it's been estimated that we're
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able to replace this industrial process
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with a microbial living Factory
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it would have the same environmental
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benefits as electrifying every single
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car in the UK twice over
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so this is the question we've been
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asking ourselves for the last couple of
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years
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can we make atypic acid from something a
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little bit more sustainable
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the bar is pretty low right
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something like this
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it turns out in nature there's a polymer
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called lignin
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now lignin is a really sustainable
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material it's a really strong material
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the plants use to strengthen themselves
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as they grow Against Gravity towards the
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Sun
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and lignin is made of this molecule here
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guacal
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and it turns out guaco is the perfect
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chemical to make a dipic acid in a
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microbe
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and even better than that what's not
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good at all it's terrible actually we
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create 17 million tons of this waste
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every single year
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from the paper milling and the
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agricultural Industries
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let's put that in a bit more context
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that's the same as 200 empire state
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buildings worth of waste every single
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year or roughly 400 000 homes
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that's half the size of Vienna today
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every single year
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that we simply sent a landfill or we
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incinerate sending that carbon into the
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atmosphere
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what we've managed to do recently is to
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rewire bacteria so that they now break
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down gwiacol from lignin waste into
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atopic acids
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no longer in a factory like the ones I
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showed you earlier releasing all of
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these toxic chemicals into the
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atmosphere but instead in reactions that
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look like this
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in these living microbial factories in
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water
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at room temperature
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releasing no carbon emissions
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and critically not using any fossil
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fuels at all
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now we're really excited about this
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discovery because it's the first time
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that this molecule this prolific
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industrial chemical has been made from
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this available abundance natural
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resource by a living microbial Factory
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and I think what this does is it paves
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the way for the sustainable manufacture
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of your clothing in the future
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in a way that's not so destructive to
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the planet around us in a way that's far
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more sustainable Greener and cleaner
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and synthetic biology is amazing right
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because we can just rewire the circuit
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boards
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to make a dipic acid from something else
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right
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something like this
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plastic waste
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so therefore imagine being able to take
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the plastic waste that's currently
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polluting the ocean
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and to use that to make your clothing
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using bacteria
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or to take the millions of tons of
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plastic waste that's polluting
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environments World worldwide right now
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maybe to use that as a source of human
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medicine
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using bacteria
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now these are all possibilities that are
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being developed right now in the field
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of synthetic biology
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and the story doesn't even end there
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one of the most densely populated
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microbial habitats on Earth is the human
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body
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we live in close proximity with these
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microorganisms every single day
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in fact you're in contact with almost 40
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trillion of them right now
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so therefore imagine having these living
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factories living inside you
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medicating you only when you need
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treatments
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or perhaps living inside your clothes
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fixing them only when they need repairs
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these are all technologies that are
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possible in the future
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using synthetic biology
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and the amazing chemistry of these
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microscopic living creatures
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so all together I think
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despite what you maybe see in the news
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every day this makes me really
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optimistic about the future
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a future where we no longer exploit
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nature
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traveling down this one-way Street of
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spiraling emissions and mountains of
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waste
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but instead
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I see synthetic biology being able to
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take us to much more virtuous circles
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perhaps the future where there's no such
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thing as waste
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where we use these living factories
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that are cleaner
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they're greener
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and they're powered by processes that
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nature has been evolving for us for
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millions of years
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thank you
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[Applause]