Fibrosis is excessive scarring that occurs when the body's healing process goes wrong.

How does fibrosis affect the lungs?

It causes stiff scar tissue to build up, making it difficult for oxygen to enter the bloodstream.

What are the consequences of cardiac fibrosis?

It can lead to a stiff heart muscle, reducing its ability to pump blood, resulting in heart failure.

Can fibrosis affect other organs?

Yes, it can also lead to kidney and liver failure.

What treatments are available for fibrotic conditions?

There are very limited safe treatments, and often transplants are the only hope.

What is being done to improve treatments for fibrosis?

Research is ongoing at the Medical Technology Research Centre to find new effective drug treatments.

Fibrosis Explained

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https://www.youtube.com/watch?v=j251C6YIoQ0

Ringkasan

TLDRFibrosis is a pathological condition resulting from excessive scarring after injuries, where fibroblast cells become overactive. This scarring can lead to serious health issues, particularly affecting vital organs such as the lungs and heart. In the lungs, scarring makes it difficult to breathe, and in the heart, it can lead to heart failure. Fibrosis can also affect the kidneys and liver. Current treatment options are limited, usually requiring transplants, but research efforts are underway to develop effective drug therapies.

Takeaways

🧬 Fibrosis accounts for 42% of deaths worldwide.
⚡ Fibrosis is caused by overactive fibroblast cells.
💔 Cardiac fibrosis can lead to heart failure.
🌬️ Lung fibrosis makes breathing difficult.
🔬 Limited treatments are available; transplants are often needed.
🧪 Research is focused on new drug treatments for fibrosis.

Garis waktu

00:00:00 - 00:01:59
Fibrotic diseases account for 42% of global deaths, indicating a significant health threat. Fibrosis occurs when the body’s repair mechanisms malfunction—specifically, fibroblast cells become overactive myofibroblasts, leading to excessive scarring instead of effective wound healing. This unchecked healing process, particularly in vital organs, poses severe health risks and potential fatalities.

Peta Pikiran

Video Tanya Jawab

What is fibrosis?
Fibrosis is excessive scarring that occurs when the body's healing process goes wrong.
How does fibrosis affect the lungs?
It causes stiff scar tissue to build up, making it difficult for oxygen to enter the bloodstream.
What are the consequences of cardiac fibrosis?
It can lead to a stiff heart muscle, reducing its ability to pump blood, resulting in heart failure.
Can fibrosis affect other organs?
Yes, it can also lead to kidney and liver failure.
What treatments are available for fibrotic conditions?
There are very limited safe treatments, and often transplants are the only hope.
What is being done to improve treatments for fibrosis?
Research is ongoing at the Medical Technology Research Centre to find new effective drug treatments.

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Gulir Otomatis:

00:00:00
Worldwide, Fibrotic diseases are responsible for 42% of all deaths
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but what is fibrosis?
00:00:09
Fibrosis happens when our body's natural ability to repair itself goes wrong.
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When an injury occurs, the body sends fibroblast cells to help with repairs
00:00:20
but when they are dispatched to a wound, they transform into myofibroblasts,
00:00:24
which are supercharged fibroblasts.
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Sometimes, instead of closing the wound and dying away
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they start over-healing, resulting in excessive scarring.
00:00:35
This out of control wound healing is fibrosis.
00:00:40
When this scarring happens in a vital organ,
00:00:42
it can cause a lifetime of health problems, and can be fatal.
00:00:47
A major organ commonly affected by fibrosis is the lungs.
00:00:52
The lungs are made up of millions of tiny air sacs.
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If the thin walls of the air sacs become damaged, scar tissue can build up over time
00:01:02
making it difficult for oxygen to get into the bloodstream.
00:01:08
The scar tissue makes the lungs stiff, and they are less able to expand,
00:01:12
making it difficult to breathe
00:01:14
and without a lung transplant it can be fatal.
00:01:19
Cardiac fibrosis can be triggered when the heart muscle is damaged from heart disease
00:01:23
or a heart attack.
00:01:25
The heart muscle becomes stiff and loses its power to pump blood around the body
00:01:30
resulting in heart failure.
00:01:34
Fibrotic conditions can also lead to kidney failure and liver failure.
00:01:38
There is very limited safe treatment to manage fibrotic conditions
00:01:42
and often a transplant is the only hope.
00:01:47
However, research is being done by the Medical Technology Research Centre,
00:01:51
to find new and effective drug
00:01:53
treatments.