Paget’s Disease of Bone: Key points in 105 seconds!

00:01:47
https://www.youtube.com/watch?v=VYBgYc8KjPw

概要

TLDRPaget's disease of the bone involves increased bone turnover due to accelerated resorption and rapid bone formation, resulting in weaker and less organized new bone. Symptoms often include bone and joint pain, potential deformities like bowed legs, and complications such as cranial nerve compression leading to deafness. Diagnosis can be made via blood tests, particularly noting high alkaline phosphatase levels, and through X-ray imaging that reveals characteristic findings like 'blade of grass' lesions. Treatment focuses on pain management, reducing bone turnover with medications like bisphosphonates, and in some cases, surgical intervention may be required.

収穫

  • 🦴 Paget's disease leads to increased bone turnover.
  • ⚠️ New bone is weaker and less organized.
  • 💉 High alkaline phosphatase levels are key for diagnosis.
  • 🩻 X-ray findings include classic lesions.
  • 🦵 Common symptoms are bone and joint pain.
  • 🔍 Diagnosis can be made with blood tests and imaging.
  • 💊 Treatment includes analgesics and bisphosphonates.
  • 🛠️ Surgery may be necessary in some cases.
  • 👂 Cranial nerve compression can result in deafness.
  • ❤️ Cardiac hypertrophy may occur due to increased blood flow.

タイムライン

  • 00:00:00 - 00:01:47

    Paget's disease is characterized by increased bone turnover due to heightened resorption, resulting in rapid bone formation that leads to weaker and less organized new bone. This condition can increase the risk of fractures and deformities, although many patients may show no symptoms, and it can be detected through blood tests indicating elevated alkaline phosphatase levels while calcium and other bone markers remain normal. Diagnostic imaging can reveal classic findings such as osteolytic lesions and characteristic patterns like 'blade of grass' lesions in the skull. Common presentations of Paget's disease include bone and joint pain, possible cranial nerve compression leading to deafness, bowed legs, and cardiac hypertrophy due to increased blood flow. Treatment typically includes analgesics, NSAIDs, and bisphosphonates to lower bone turnover, along with calcitonin in some cases, and potentially surgery for severe situations.

マインドマップ

ビデオQ&A

  • What is Paget's disease?

    Paget's disease is a condition characterized by increased bone turnover, leading to weaker and less organized new bone.

  • What are the symptoms of Paget's disease?

    Common symptoms include bone pain, joint pain, fractures, bowed legs, cranial nerve compression, and possible cardiac hypertrophy.

  • How is Paget's disease diagnosed?

    It can be diagnosed through blood tests showing elevated alkaline phosphatase levels and imaging studies like X-rays.

  • What are typical X-ray findings in Paget's disease?

    X-rays may show bone lucency, osteolytic lesions, and patterns like 'blade of grass' or 'cotton wool' in the skull.

  • What treatments are available for Paget's disease?

    Treatment options include analgesics, non-steroidal anti-inflammatories, bisphosphonates, calcitonin, and sometimes surgery.

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  • 00:00:00
    hi guys a quick video on Paget's disease
  • 00:00:02
    of the bone in case this comes up in
  • 00:00:04
    medical questions or scenarios what is
  • 00:00:05
    Paget's disease it's basically when you
  • 00:00:07
    have increased bone turnover due to
  • 00:00:10
    basically increase resorption and
  • 00:00:12
    therefore you're trying to build bone
  • 00:00:13
    quickly and because you're building it
  • 00:00:15
    quickly the newer bone is weaker and
  • 00:00:16
    it's less organized which can lead to an
  • 00:00:19
    increased ring-a-ding risk of things
  • 00:00:20
    like fractures and deformities as well
  • 00:00:22
    I'm the most patient you've presented
  • 00:00:24
    are any symptoms whatsoever you may pick
  • 00:00:26
    it up simply on blood tests so the key
  • 00:00:28
    thing to remember is a very high out
  • 00:00:29
    foss alkaline phosphatase is high but
  • 00:00:32
    the other bone type gloves are generally
  • 00:00:34
    normal about calcium PTH phosphate
  • 00:00:37
    they're normal that are raised out of
  • 00:00:38
    course it may be picked up on x-ray you
  • 00:00:40
    may get classic things like bone lucency
  • 00:00:43
    osteo lytic lesions the bone size may be
  • 00:00:45
    increased classic things like blade of
  • 00:00:47
    grass lesions or cotton wool patterns in
  • 00:00:50
    the skull a variety of ways that it may
  • 00:00:52
    come up on x-ray however if people do
  • 00:00:54
    present with problems bone pain is the
  • 00:00:56
    commonest way that it presents joint
  • 00:00:58
    pain as well if the disease happening
  • 00:00:59
    near a joint but bone pain generally you
  • 00:01:02
    can preserve with the fractures of
  • 00:01:03
    course bowed legs is a key thing to
  • 00:01:05
    remember
  • 00:01:05
    cranial nerve compression things like
  • 00:01:07
    deafness can happen because of Paget
  • 00:01:09
    disease and also things like cardiac
  • 00:01:10
    hypertrophy with increased bone blood
  • 00:01:13
    flow how are you treated generally
  • 00:01:15
    analgesia things like non-steroidal
  • 00:01:17
    anti-inflammatories I use
  • 00:01:19
    bisphosphonates can reduce that bone
  • 00:01:22
    turnover this could be oral generally
  • 00:01:24
    but it could be IV bisphosphonates as
  • 00:01:26
    well
  • 00:01:26
    calcitonin sometimes just use and
  • 00:01:28
    ultimately things like surgery may be
  • 00:01:30
    needed as well so Paget's disease
  • 00:01:32
    increased bone turnover worth looking at
  • 00:01:34
    some of these things are just getting a
  • 00:01:35
    grind and your mind much more lights on
  • 00:01:37
    our webinars are online training our
  • 00:01:38
    courses and our audiobooks hashtag
  • 00:01:41
    campus well past hashtag I went with
  • 00:01:43
    Aurora
タグ
  • Paget's disease
  • bone turnover
  • resorption
  • fractures
  • deformities
  • alkaline phosphatase
  • X-ray
  • bisphosphonates
  • treatment
  • symptoms