Praktikum Farmakologi - Uji Antipiretik

00:03:54
https://www.youtube.com/watch?v=F464k2J-Puw

概要

TLDRThe video outlines a pharmacological experiment to test the antipyretic effects of paracetamol on mice. The first group of mice receives a dosage of 100 mg of paracetamol per kilogram of body weight, calculated based on their weight of 26 grams, resulting in a dose of 0.26 ml. The normal temperature of the mice is measured before treatment, and after inducing fever with a 10% pepton solution, the temperature is recorded at 39.8 degrees Celsius. Following the administration of paracetamol, the rectal temperature is monitored at specific intervals, and the results are tabulated for further analysis of the drug's efficacy.

収穫

  • 🧪 The experiment tests paracetamol's antipyretic effects.
  • 📏 Dosage is based on the weight of the mice.
  • 🐭 Test mice weigh 26 grams.
  • 🌡️ Normal temperature is checked rectally.
  • 🔥 Induced fever temperature is 39.8°C.
  • 💉 Paracetamol is administered orally.
  • ⏱️ Temperatures are checked at 10, 15, 30, and 120 minutes.
  • 📊 Results are tabulated for analysis.
  • 🔬 Pepton is used to induce fever.
  • 📈 Percentage of protection will be calculated.

タイムライン

  • 00:00:00 - 00:03:54

    In this video, the process of conducting an antipyretic test using paracetamol is outlined, focusing on the preparation stage for the test. The first group is tasked with testing the effects of paracetamol at a dosage of 100 mg per kilogram of body weight. Initially, the weight of the test animal, a mouse weighing 26 grams, needs to be measured, which is critical for calculating the appropriate dose. The calculated dosage for the mouse is 0.26 ml of paracetamol, which will be administered orally. Before treatment, the normal body temperature of the mouse is checked using a thermometer. Subsequently, an induction with 10% pepton is performed, where the amount given is based on the animal's weight, resulting in a 0.26 ml intraperitoneal injection. After a 15-minute waiting period, the temperature is recorded as 39.8 degrees Celsius, indicating fever before the oral administration of paracetamol. The rectal temperature is monitored again at specific intervals following the administration of the medication, after which the percentage protection will be calculated.

マインドマップ

ビデオQ&A

  • What is the purpose of the experiment?

    To test the antipyretic effects of paracetamol on mice.

  • How is the dosage of paracetamol calculated?

    The dosage is calculated based on the weight of the mice, which is 100 mg per kilogram.

  • What is the weight of the test mice?

    The weight of the test mice is 26 grams.

  • How is the normal temperature of the mice checked?

    The normal temperature is checked using a thermometer inserted into the anus.

  • What is the induced fever temperature recorded?

    The induced fever temperature recorded is 39.8 degrees Celsius.

  • What intervals are used to check the rectal temperature after administering paracetamol?

    The rectal temperature is checked at 10, 15, 30, and 120 minutes after administration.

  • What is the role of pepton in the experiment?

    Pepton is used to induce fever in the test mice.

  • How long are the mice left after pepton induction?

    The mice are left for 15 minutes after pepton induction.

  • What is the method of administering paracetamol?

    Paracetamol is administered orally.

  • What is the next step after recording the temperatures?

    The next step is to calculate the percentage of protection based on the results.

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オートスクロール:
  • 00:00:00
    asalamualaikum warahmatullahi
  • 00:00:01
    wabarakatuh
  • 00:00:11
    pada hukum kali ini di mana akan dibagi
  • 00:00:15
    masing-masing kelompok dengan dosis dan
  • 00:00:17
    obatnya masing-masing Nah untuk yang
  • 00:00:20
    pertama kelompok pertama akan melakukan
  • 00:00:23
    uji antipiretik dengan obat parasetamol
  • 00:00:26
    dengan dosis 100 mg/ kilo berat badan
  • 00:00:29
    jadi
  • 00:00:30
    sebelum kita melakukan uji antipiretik
  • 00:00:33
    maka harus dihitung terlebih dahulu
  • 00:00:36
    dosis untuk hewan uji yang akan
  • 00:00:40
    diinduksi selanjutnya sebelum kita
  • 00:00:44
    memberikan obat kepada hewannya maka
  • 00:00:47
    kita harus menimbang berat badan dari
  • 00:00:50
    hewan
  • 00:00:52
    uji
  • 00:00:53
    didapatkan berat badan hewan uji adalah
  • 00:00:56
    26 GR
  • 00:01:01
    setelah ditimbang berat badannya Maka
  • 00:01:03
    selanjutnya kita akan menghir berikut
  • 00:01:05
    adalah perhitungan vao yang akan
  • 00:01:07
    diberikan kepada hewan uji didapatkan
  • 00:01:11
    0,26 mili yang akan kita suntikkan obat
  • 00:01:14
    Paracetamol kepada hewan uji di mana
  • 00:01:17
    untuk pemberiannya itu dilakukan secara
  • 00:01:20
    peroral sebelum diberikan perlakuan
  • 00:01:22
    hewan uji terlebih dahulu diperiksa suhu
  • 00:01:25
    normalnya dengan menggunakan
  • 00:01:28
    termometer yang telah dilapisi faseline
  • 00:01:31
    terlebih dahulu termometer kemudian
  • 00:01:34
    dimasukkan ke
  • 00:01:36
    lubang anus
  • 00:01:39
    [Musik]
  • 00:01:42
    mencit setelah
  • 00:01:45
    berbunyi pertama diberikan induksi eh
  • 00:01:49
    untuk pengujian antipirtik ini yaitu
  • 00:01:51
    pepton dengan konsentrasi
  • 00:01:53
    10% pepton yang digunakan ee adalah
  • 00:01:57
    sebanyak 1% dari berat badan dikarenakan
  • 00:02:00
    mencit yang kita gunakan dalam pengujian
  • 00:02:02
    memiliki berat badan 26 gram berarti
  • 00:02:05
    setelah dilakukan perhitungan pepton
  • 00:02:08
    yang akan diberikan eh secara
  • 00:02:10
    intraperitonial adalah sebanyak 0,26
  • 00:02:13
    mili
  • 00:02:14
    [Musik]
  • 00:02:31
    setelah diinduksi pepton setelah
  • 00:02:32
    diinduksi dengan pepton hewan uji
  • 00:02:34
    kemudian e dibiarkan atau didiamkan
  • 00:02:37
    selama 15 menit
  • 00:02:40
    15 setelah 15 menit kemudian diperiksa
  • 00:02:44
    suhu demam hewan
  • 00:02:47
    [Musik]
  • 00:02:54
    uji dapatlah suhu hewan sebesar
  • 00:03:00
    39,8 derajat Celcius selanjutnya hewan
  • 00:03:04
    uji diberikan obat secara
  • 00:03:13
    peroral
  • 00:03:15
    dahah setelah diberikan obat Paracetamol
  • 00:03:18
    secara oral maka dihitung lagi suhu
  • 00:03:24
    rektumnya pada menit kelim ke-10 15 30
  • 00:03:30
    dan
  • 00:03:32
    120 kemudian tabelkan hasil yang telah
  • 00:03:36
    didapat setelah itu akan dihitung persen
  • 00:03:41
    proteksinya di mana rumus persen
  • 00:03:44
    proteksi dapat dilihat dalam diktat
  • 00:03:47
    halaman 6
タグ
  • paracetamol
  • antipyretic
  • experiment
  • mice
  • dosage
  • fever
  • pepton
  • temperature
  • pharmacology
  • research