The Key to Living a Longer Life | Breakthrough

00:02:33
https://www.youtube.com/watch?v=pK_1HKRnoe0

概要

TLDRNear Barzeli is researching centenarians to uncover the secrets behind their longevity. He observes that while many in the general population have unhealthy habits, centenarians often possess unique genetic mutations that may protect them from aging. Barzeli's research aims to identify these mutations and develop medications that could help others age more slowly, potentially allowing more people to reach 100 years of age. He emphasizes that while we cannot change our genes, we can create treatments that may intervene in the aging process.

収穫

  • 👵 Centenarians are models for healthy aging.
  • 🧬 Genetic mutations may protect against aging.
  • 🏃‍♂️ Regular exercise contributes to longevity.
  • 🍩 Many in the general population have unhealthy habits.
  • 💊 Medications could help delay aging effects.
  • 🔬 Research focuses on understanding aging at a cellular level.

タイムライン

  • 00:00:00 - 00:02:33

    Barzeli is studying centenarians to understand their healthy aging. He interacts with them, noting their lifestyle choices, such as diet and exercise. While some have unhealthy habits, like smoking and poor diet, they possess protective genes that contribute to their longevity. Barzeli's research focuses on identifying mutations in their cells that may slow aging. He aims to develop medications that can help others age more healthily, emphasizing that while we can't change genes, we can create treatments to delay aging effects.

マインドマップ

ビデオQ&A

  • What is Near Barzeli studying?

    He is studying centenarians to understand their longevity.

  • What do centenarians do differently?

    They have healthier interactions with their environment and some maintain a healthy diet and exercise.

  • What unhealthy habits are common in the general population?

    50% are obese, 50% do not exercise, and many smoke.

  • What genetic factors are being studied?

    Barzeli is looking for mutations in cells that may be associated with longevity.

  • Can we change our genes to live longer?

    No, but medications can be designed to delay aging effects.

  • What is Barzeli's ultimate goal?

    To prove that medications can help us age more like centenarians.

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オートスクロール:
  • 00:00:00
    Near Barzeli has been studying a group
  • 00:00:02
    of exceptionally healthy
  • 00:00:04
    hundredyear-olds or centinarians. Hi
  • 00:00:07
    Milton on the button. So nice meeting
  • 00:00:10
    you. How are you? He believes they're a
  • 00:00:12
    model for how we can all age. Come on in
  • 00:00:14
    fellas. Hello. Hello. Hi. How are you?
  • 00:00:18
    How are you? How are you? One of the
  • 00:00:21
    interesting thing with those
  • 00:00:22
    centinarians is to see how they interact
  • 00:00:24
    with the environment. And we thought,
  • 00:00:26
    hey, maybe they do all the right things.
  • 00:00:29
    Do you eat something special? Do you?
  • 00:00:32
    No, I try to keep a healthy diet. What
  • 00:00:35
    about exercise? Exercise? I walk about a
  • 00:00:38
    quarter of a mile for breakfast. I swam
  • 00:00:40
    every day. So, my body has always been
  • 00:00:44
    activated. And when you look at the
  • 00:00:46
    population, you find almost the
  • 00:00:48
    opposite. I go every just about every
  • 00:00:51
    afternoon to Dunkin' Donut and I have
  • 00:00:54
    coffee there and and a a Boston cream
  • 00:00:56
    that sort of thing. Your eating habits
  • 00:00:59
    are not necessarily healthy. That's
  • 00:01:02
    true. I smoked
  • 00:01:05
    forus so 50 years. 50% of them are
  • 00:01:08
    obese. 50% of them do not exercise. 60%
  • 00:01:12
    of the men and 30% of the women are
  • 00:01:14
    smoking. So it's in spite of all that
  • 00:01:17
    that they have some protection that
  • 00:01:19
    allows them easily to get to age
  • 00:01:22
    100. What we do find that they have is
  • 00:01:26
    genes that are protecting them against
  • 00:01:30
    anything that's thrown their way. Those
  • 00:01:34
    are individual cells that have a
  • 00:01:38
    mutations we think are associated with
  • 00:01:40
    longevity. and we follow what those
  • 00:01:42
    mutations are doing to the cell. What
  • 00:01:45
    happens when you put the cells into a
  • 00:01:47
    hostile environment? The reason we're
  • 00:01:50
    looking for those mutations is that we
  • 00:01:53
    think that those mutation will slow the
  • 00:01:55
    rate of aging. Barzeli believes from a
  • 00:01:58
    biological perspective his centinarians
  • 00:02:01
    are aging slower than the rest of us.
  • 00:02:04
    His plan is to prove that medications
  • 00:02:06
    can make us all age more like them. When
  • 00:02:09
    you do genetic study, the public thinks
  • 00:02:12
    that we need genetic treatment for those
  • 00:02:14
    diseases. But no, we cannot change your
  • 00:02:17
    genes so that you become 100 years old.
  • 00:02:21
    But we can design
  • 00:02:23
    medications based on our knowledge that
  • 00:02:25
    will interfere with this pathway and
  • 00:02:28
    interact, intervene and delay the
  • 00:02:31
    effects of aging.
タグ
  • centenarians
  • longevity
  • aging
  • genetics
  • health
  • exercise
  • diet
  • medications
  • research
  • Barzeli