00:00:00
welcome to hubman Labb Essentials where
00:00:02
we revisit past episodes for the most
00:00:04
potent and actionable science-based
00:00:06
tools for mental health physical health
00:00:09
and
00:00:10
performance I'm Andrew huberman and I'm
00:00:13
a professor of neurobiology and
00:00:14
Opthalmology at Stanford school of
00:00:16
medicine this podcast is separate from
00:00:19
my teaching and research roles at
00:00:20
Stanford it is however part of my desire
00:00:22
and effort to bring zero cost to
00:00:24
Consumer information about science and
00:00:26
science related tools to the general
00:00:28
public today we're going to focus on how
00:00:30
particular hormones influence our energy
00:00:33
levels and our immune system we're going
00:00:36
to talk about the hormones cortisol and
00:00:39
epinephrine also called adrenaline if
00:00:41
you're somebody who has challenges with
00:00:43
sleep or you're somebody who has
00:00:44
challenges getting your energy level up
00:00:46
throughout the day and getting your
00:00:48
energy level down when you want to sleep
00:00:50
today's episode is also for you and we
00:00:52
are going to talk about the immune
00:00:54
system and how to enhance the function
00:00:55
of your immune system I think it's fair
00:00:57
to say that most people would like to
00:00:59
have a lot of energy during the day if
00:01:02
you work during the day and they'd like
00:01:04
their energy to taper off at night and I
00:01:07
think it's fair to say that most people
00:01:09
don't enjoy being sick and it turns out
00:01:11
that the two hormones that dominate
00:01:14
those processes of having enough energy
00:01:16
and having a healthy immune system are
00:01:19
cortisol and epinephrine I just want to
00:01:22
cover a little bit about what cortisol
00:01:24
and epinephrine are where they are
00:01:25
released in the body and brain because
00:01:29
if you can understand understand that
00:01:30
you will understand better how to
00:01:32
control
00:01:34
them first of all cortisol is a steroid
00:01:39
hormone much like estrogen and
00:01:42
testosterone in that it is derived from
00:01:45
cholesterol so understand that
00:01:48
cholesterol is a precursor molecule
00:01:50
meaning it's the substrate from which a
00:01:52
lot of things like testosterone and
00:01:54
estrogen are made please also understand
00:01:57
that cholesterol can be made into
00:01:59
estrogen or testosterone or cortisol and
00:02:02
that cortisol is sort of the competitive
00:02:05
partner to estrogen and testosterone
00:02:08
what this means is no matter how much
00:02:10
cholesterol you're eating or you produce
00:02:12
whether not it's low or it's high if you
00:02:14
are stressed more of that cholesterol is
00:02:18
going to be devoted toward creating
00:02:20
cortisol which is indeed a stress
00:02:23
hormone however the word stress
00:02:26
shouldn't stress you out because you
00:02:27
need cortisol cortisol is vit you don't
00:02:30
want your cortisol levels to be too low
00:02:32
it's very important for immune system
00:02:34
function for memory for not getting
00:02:36
depressed you just don't want your
00:02:38
cortisol levels to be too high and you
00:02:41
don't want them to be elevated even to
00:02:43
normal levels at the wrong time of day
00:02:46
epinephrine or
00:02:48
adrenaline has also been demonized a bit
00:02:51
we think of it as this stress hormone
00:02:53
this thing that makes us anxious fight
00:02:55
or flight the fact of the matter is that
00:02:56
epinephrine is your best friend when it
00:02:59
comes to your immunity when it comes to
00:03:02
protecting you from infection and
00:03:05
epinephrine adrenaline is your best
00:03:07
friend when it comes to remembering
00:03:09
things and learning and activating
00:03:11
neuroplasticity we're going to talk
00:03:13
about that as well once again it's a
00:03:14
question of how much and how long and
00:03:17
the specific timing of release of
00:03:19
cortisol and epinephrine as opposed to
00:03:22
cortisol and adrenaline being good or
00:03:24
bad they're terrific when they're
00:03:26
regulated they are terrible when they're
00:03:28
misregulated and we will give you lots
00:03:30
of tools to regulate them better
00:03:32
cortisol biology 101 in less than 2
00:03:36
minutes your brain makes what we call
00:03:39
releasing hormones and in this case
00:03:41
there's corticotropin releasing hormone
00:03:43
CR is made by neurons in your brain it
00:03:46
causes the pituitary this gland that
00:03:49
sits about an inch in front of the roof
00:03:51
of your mouth and the base of your brain
00:03:54
to release
00:03:56
act act then goes and causes your
00:03:59
adrenals which sit above your kidneys
00:04:02
and your lower back to release cortisol
00:04:05
a so-called stress hormone but I would
00:04:07
like you to think about cortisol not as
00:04:09
a stress hormone but as a hormone of
00:04:13
energy it produces a situation in the
00:04:15
brain and body whereby you want to move
00:04:19
and whereby you don't want to rest and
00:04:22
whereby you don't want to eat at least
00:04:25
at
00:04:27
first epinephrine or adrenaline 101 in
00:04:31
less than 2
00:04:32
minutes when you sense a stressor with
00:04:35
your mind or your body senses a stress
00:04:37
stressor excuse me from a wound or
00:04:40
something of that
00:04:41
sort a signal is sent to neurons that
00:04:44
are in the middle of your body they
00:04:45
called the sympathetic chain ganglia the
00:04:47
name doesn't necessarily matter they
00:04:49
release norepinephrine very quickly it's
00:04:51
almost like a a sprinkler system that
00:04:53
Just Hoses your body with epinephrine
00:04:57
that will increase heart rate will
00:04:59
increase Brea breathing rate it will
00:05:00
also increase the size of vessels and
00:05:03
arteries that are giving blood flow to
00:05:05
your vital organs you also release
00:05:08
adrenaline from your adrenals again s
00:05:12
riding at top your kidneys and you
00:05:14
release it from an area of your brain
00:05:15
called Locus cerus and that creates
00:05:18
alertness in your brain okay so we have
00:05:21
cortisol and we have epinephrine and
00:05:24
their net effect is to increase energy
00:05:26
so the first tool is to make sure that
00:05:28
your highest levels of cortisol are
00:05:30
first thing in the morning when you wake
00:05:32
up one way or another every 24 hours you
00:05:35
will get an increase in cortisol it's to
00:05:38
stimulate movement from being sleep
00:05:40
presumably horizontal to getting up and
00:05:43
starting to move about your day the best
00:05:45
way to stimulate that increasing
00:05:48
cortisol at the appropriate time is that
00:05:50
very soon after waking within 30 minutes
00:05:53
or so after waking get outside view some
00:05:56
sunlight even if it's overcast get
00:05:58
outside view some some sunlight no
00:06:00
sunglasses do that because in the early
00:06:03
part of the day you have the opportunity
00:06:05
to time that cortisol release to the
00:06:08
early part of the day it will will
00:06:10
improve your focus it will impr improve
00:06:12
your energy levels and it will improve
00:06:14
your learning throughout the day so
00:06:16
here's how it works on a sunny day so no
00:06:19
cloud cover provided that the sun is not
00:06:22
yet overhead it's somewhere low in the
00:06:25
sky could have just crossed the horizon
00:06:27
or if you wake up a little bit later it
00:06:28
could be somewhat low in the
00:06:30
Sky basically the intensity of light the
00:06:33
brightness is somewhere around 100,000
00:06:35
Lux Lux is just a measurement of
00:06:37
brightness on a cloudy day it's about
00:06:40
10,000 luxs okay so tenfold reduction
00:06:44
but bright artificial light very bright
00:06:47
artificial light is somewhere around a
00:06:50
thousand
00:06:51
luxs and ordinary room light is
00:06:55
somewhere around 100 to 200 lucks so
00:06:58
even if you have a very bright bulb
00:06:59
sitting right next to you that's not
00:07:00
going to do the job your phone will not
00:07:02
do the job not early in the day to get
00:07:04
the cortisol released at the appropriate
00:07:07
time you need to get outside so let's
00:07:10
just set a couple General parameters if
00:07:13
it's bright outside and no cloud cover
00:07:16
get outside for 10 minutes if it's a
00:07:18
cloudy day dense overcast you're
00:07:21
probably going to need about 30 minutes
00:07:23
if it's light Cloud broken cloud cover
00:07:24
it's probably going to be somewhere
00:07:26
between 10 and 20 minutes this is why
00:07:28
it's vital to get this light on a
00:07:29
regular basis to get that cortisol
00:07:32
released early in the day that sets you
00:07:34
up for optimal levels of energy now
00:07:37
throughout the day you're going to
00:07:38
experience different things most of you
00:07:40
are not spending your entire day trying
00:07:42
to optimize your health you know some of
00:07:44
you might be but most of you have jobs
00:07:46
and you have families and you have
00:07:48
commitments life enters the picture and
00:07:50
provides you stressors those will cause
00:07:53
increases in cortisol and
00:07:56
epinephrine the key is these blips and
00:07:59
cortisol and epinephrine need to be
00:08:01
brief you can't have them so often or
00:08:05
lasting so long that you are in a state
00:08:07
of chronic cortisol elevation or chronic
00:08:11
epinephrine elevation this system of
00:08:13
stress was designed to increase your
00:08:16
alertness and mobilize you towards
00:08:17
things get you frustrated and provide
00:08:20
the opportunity to change Behavior and
00:08:22
the reason it works is that cortisol
00:08:25
when it's released into the bloodstream
00:08:27
it actually can bind to receptors in the
00:08:29
brain it can bind receptors in the
00:08:31
amydala fear centers and threat
00:08:33
detection centers but also areas of the
00:08:35
brain that are involved in learning and
00:08:37
memory and neuroplasticity and this is
00:08:39
why I say that neuroplasticity the
00:08:41
brain's ability to change itself in
00:08:42
response to experience is first
00:08:46
stimulated by attention and focus and
00:08:48
often a low-level state of agitation so
00:08:52
understand that and you won't be quite
00:08:55
so troubled about the little stress
00:08:56
increases that you experience throughout
00:08:58
the day now there are ways to leverage
00:09:02
stress epinephrine and cortisol in ways
00:09:04
that serve you and to do it in a
00:09:06
deliberate way there are also ways to do
00:09:09
that that increase your level of stress
00:09:11
threshold meaning they make it less
00:09:14
likely that epinephrine and cortisol
00:09:17
will be released so I want to talk about
00:09:19
the science of those practices because I
00:09:20
get asked about these practices a lot
00:09:22
things like Wim Hoff breathing which is
00:09:24
also called Tumo breathing things like
00:09:27
ice baths things like high-intensity
00:09:28
interval training
00:09:30
all of those things have
00:09:33
utility the question is how you use them
00:09:36
and how often you use them those tools
00:09:39
just like stress from a life event can
00:09:43
either enhance your immunity or deplete
00:09:44
it that's right those same practices of
00:09:47
ice baths Tumo breathing high-intensity
00:09:50
interval training or training of any
00:09:51
kind can deplete your immune system or
00:09:54
it can improve them excuse me they can
00:09:56
improve it meaning they can improve your
00:09:58
immune system
00:10:00
the key is how often you use them and
00:10:03
when and so I want to review that now in
00:10:05
light of the scientific literature
00:10:07
because in doing that you can build
00:10:09
practices into your daily or maybe every
00:10:11
other day routine that can really help
00:10:13
buffer you against
00:10:15
unhealthy levels of cortisol and
00:10:17
epinephrine meaning cortisol increases
00:10:19
that are much too great or that last
00:10:21
much too long epinephrine increases that
00:10:24
are much too great or that last much too
00:10:26
long let's say somebody tells you
00:10:28
something very troubling or you look at
00:10:30
your phone and you see a text message
00:10:31
that's really upsetting to you that will
00:10:35
cause an immediate increase in
00:10:37
epinephrine adrenaline in your brain and
00:10:39
body and chances are it's going to
00:10:42
increase your levels of cortisol as well
00:10:44
let's say you get into an ice bath or a
00:10:47
cold shower that will cause an
00:10:49
equivalent increase in epinephrine and
00:10:52
cortisol let's say you go out for
00:10:54
high-intensity interval training you
00:10:55
decide you're going to run some Sprints
00:10:57
you do some repeats or you're going to
00:10:59
do some weightlifting in the gym or you
00:11:01
decide that you want to do some hot yoga
00:11:03
you're going to increase your
00:11:04
epinephrine and cortisol levels and
00:11:06
guess what they increase your levels of
00:11:08
energy and alertness so if you're
00:11:10
somebody who struggles with energy and
00:11:12
alertness it can be beneficial provided
00:11:15
you get clearance from your doctor to
00:11:17
have some sort of protocol built into
00:11:19
your day where you deliberately increase
00:11:21
your levels of epinephrine and your
00:11:23
levels of cortisol so it's really
00:11:26
important to understand that the body
00:11:28
doesn't distinguish between a troubling
00:11:30
text message ICE Tumo breathing or
00:11:33
high-intensity interval training or any
00:11:35
other kind of exercise it's all
00:11:37
stress cognitively reframing that and
00:11:40
telling yourself I like this I enjoy it
00:11:42
is not going to change the way that that
00:11:45
molecule impacts your body and brain I
00:11:48
sort of chuckle because people would
00:11:50
love to tell you that all you have to do
00:11:52
is say oh this is good for me no what it
00:11:54
does to tell yourself that it's good for
00:11:57
you or that you enjoy it is it that it
00:11:59
liberates other molecules like dopam
00:12:01
dopamine and serotonin that help buffer
00:12:04
the epinephrine response now the way
00:12:07
that it does that I've talked about
00:12:08
previous episode but I'll just mention
00:12:10
that dopamine is the precursor to
00:12:13
epinephrine epinephrine is made from
00:12:15
dopamine and that's why if you tell
00:12:17
yourself you're enjoying something and
00:12:20
because dopamine is so subjective that
00:12:22
you can in some ways as long as you're
00:12:24
not completely lying to yourself you can
00:12:26
get more epinephrine you get more or
00:12:29
more ability to push through something
00:12:32
and you can sort of reframe it but it's
00:12:34
not really cognitive reframing the
00:12:35
cognitive part is the trigger but the
00:12:37
it's a chemical substance that's
00:12:40
actually occurring there it's dopamine
00:12:42
giving you more
00:12:43
epinephrine a bigger amplitude
00:12:45
epinephrine release and it gives you
00:12:48
some sense of control so here's a
00:12:50
protocol that anyone can use if you want
00:12:53
to increase levels of energy if you
00:12:55
suffer from low energy during the
00:12:57
daytime or whenever it is you'd like to
00:12:59
be alert pick a practice that you can do
00:13:03
fairly consistently maybe every day but
00:13:05
maybe every third day or every fourth
00:13:07
day maybe it's an ice bath or a cold
00:13:10
bath maybe it's a cold shower maybe it's
00:13:13
the cyclic in inhale exhale breathing
00:13:16
protocol I described if that wasn't
00:13:17
clear and people always ask for a demo
00:13:19
I'm not going to do the whole thing
00:13:20
right now but I'm willing to do a few
00:13:22
rounds of this or a few Cycles I should
00:13:24
say so it's
00:13:26
inhale I would do that more deeply more
00:13:28
like
00:13:29
like you do that 25 30 times repeatedly
00:13:33
you will start to feel warm people in
00:13:35
the yoga Community they say you're
00:13:37
generating heat you're not generating
00:13:38
heat you're releasing adrenaline inhale
00:13:41
exhale inhale exhale 25 or 30 times you
00:13:43
will feel agitated and stressed that's
00:13:45
because you're releasing adrenaline in
00:13:47
your body and that's because you're
00:13:48
releasing norepinephrine in your brain
00:13:51
and you'll be more alert so if all these
00:13:53
protocols all these activities are just
00:13:56
equivalent they're just stress then how
00:13:58
do we make them good for us how do we
00:14:00
actually benefit from them now of course
00:14:02
the cold itself can have some health
00:14:05
promoting effects it can increase Brown
00:14:07
fat thermogenesis and Metabolism
00:14:09
high-intensity interval training or
00:14:10
other forms of exercise of course has
00:14:13
cardiovascular effects that can be good
00:14:15
for us as does weight training Etc but
00:14:18
what we're talking about here are ways
00:14:20
to increase energy and to teach our
00:14:23
brain and body to teach ourselves how to
00:14:26
regulate the stress response so in
00:14:28
addition to the benefits of the actual
00:14:30
practices what we're talking about is
00:14:33
building a system so that when you
00:14:36
experience increases in epinephrine and
00:14:38
cortisol from Life events you're able to
00:14:41
better buffer those and we are also
00:14:43
talking about ways that you can increase
00:14:45
energy overall because that's what
00:14:47
today's episode is all about energy in
00:14:49
the immune system there's a biological
00:14:52
mechanism that's very important if you
00:14:54
want to do those things increase energy
00:14:57
and your immune system on demand learn
00:14:59
learn to buffer stress on demand in real
00:15:01
time and it means taking these
00:15:05
protocols these practices whether or not
00:15:07
it's cold water or ice bath or exercise
00:15:10
or any of those and making one small but
00:15:15
very powerful adjustment in how you
00:15:16
perform them but in order to make that
00:15:19
adjustment I can't just tell you the
00:15:20
adjustment I have to tell you the
00:15:22
mechanism so that you know if you're
00:15:24
doing it correctly or not this is really
00:15:26
a case where if you can understand a
00:15:28
little bit of mechanis M you will be far
00:15:31
better off than just adopting
00:15:34
protocols cortisol as I mentioned is
00:15:37
released from the adrenals it can have
00:15:39
action both in the body and in the brain
00:15:42
cortisol can cross the blood brain
00:15:43
barrier epinephrine cannot that's one of
00:15:46
the reasons why it's released both from
00:15:48
the adrenals in your body and released
00:15:50
from this brain stem area the locus
00:15:52
culus in your brain that's a powerful
00:15:55
thing because what it means is that the
00:15:59
body can enter states of Readiness and
00:16:02
alertness while the Mind remains calm so
00:16:06
I'm presuming at this point that you're
00:16:08
getting your morning light to time your
00:16:09
cortisol increase I'm presuming that you
00:16:13
want more energy or that you want to
00:16:15
increase your immune system's function
00:16:17
and its ability to combat infections of
00:16:19
various kinds now the simplest way to
00:16:23
describe how to do that would be in the
00:16:24
context of cold water or a breathing
00:16:26
protocol let's presume cold water so
00:16:29
let's say you decide you're going to
00:16:30
take a cold shower you get into the cold
00:16:32
shower and if it's cold enough that will
00:16:34
be stressful you will experience an
00:16:36
increase in epinephrine it will increase
00:16:39
your alertness now you're using this as
00:16:41
a practice as a tool to build you could
00:16:45
call it resilience but the ability to
00:16:46
stay calm in the mind while being
00:16:48
stressed in the body epinephrine in the
00:16:50
body and you do that by subjectively
00:16:53
trying to calm yourself now you can do
00:16:55
that by telling yourself it's good for
00:16:56
you by emphasizing your exhales anything
00:17:00
that you can do to try and stay calm
00:17:02
despite the fact that you are in a
00:17:03
heightened state of alertness you do
00:17:06
this with exercise you could do this
00:17:07
with music pretty much anything that
00:17:09
will give you a really heightened state
00:17:11
of
00:17:11
alertness offers you the opportunity to
00:17:14
try and stay calm in the mind what
00:17:15
you're trying to do at a mechanistic
00:17:17
level is to have adrenaline released
00:17:21
from the adrenals but not have
00:17:24
adrenaline epinephrine released from the
00:17:25
brain stem to the same degree so you're
00:17:28
not just trying to buffer this you're
00:17:29
not trying to say oh this is good for me
00:17:30
this is good for me I'm going to grind
00:17:32
this out you're not trying to grind it
00:17:33
out you're trying to move through this
00:17:36
calmly while maintaining alertness in
00:17:38
the immediate period following that
00:17:41
practice your system your entire brain
00:17:44
and body are different your body is
00:17:47
actually primed to resist infection when
00:17:51
you have high levels of epinephrine in
00:17:53
it for short periods of time so the
00:17:55
scientific study that explored how
00:17:57
increasing adrenaline in the body can
00:18:00
improve immune resistance is grounded in
00:18:02
a well-known phenomenon that increases
00:18:06
in stress actually protect you against
00:18:09
infection in the short term so I want to
00:18:12
look at the classic data first describe
00:18:15
what was done and then I want to talk
00:18:16
about the more recent study which is
00:18:18
immediately actionable there are a
00:18:20
classic set of studies that are really
00:18:22
based mainly on the work of somebody
00:18:24
named Bruce mckuin who was at the
00:18:25
Rockefeller University in New York I'm
00:18:28
not going to go through all the details
00:18:29
of the study but essentially what they
00:18:30
were doing was exposing subjects to some
00:18:34
sort of infection either bacterial or
00:18:37
viral infection and inducing stress
00:18:40
sounds like a double whammy right you'd
00:18:42
think that maybe getting a little
00:18:43
electric foot shock or cold water
00:18:45
exposure or something to increase your
00:18:48
levels of stress and adrenaline would
00:18:50
just make the effects of the infection
00:18:52
worse but no quite the
00:18:54
opposite brief bouts of stress which now
00:18:58
you should be thinking about in terms of
00:18:59
cortisol and epinephrine release we
00:19:02
actually able to increase immune system
00:19:05
function the duration here is really
00:19:07
important because if stress stayed too
00:19:10
high for too long then yes indeed stress
00:19:13
can hinder the immune response but for a
00:19:17
period of about 1 to 4 days it actually
00:19:19
can protect you by way of increasing the
00:19:22
immune response there's a human study
00:19:24
that I definitely want to point out to
00:19:26
you because it it was published more
00:19:29
recently than the mchan work the title
00:19:31
of the paper is voluntary activation of
00:19:33
the sympathetic nervous system that's
00:19:34
the system that causes figh ORF flight
00:19:36
and AKA stress this is Cox Kox at all PN
00:19:41
proceedings of the National Academy of
00:19:42
Sciences 2014 and they incorporate the
00:19:45
ever famous Wim Hoff breathing here's
00:19:47
what they
00:19:48
did they injected people with
00:19:53
eoli and they had groups that either did
00:19:57
the sorts of breathing I've been
00:19:58
described ring that increase adrenaline
00:20:00
release although I should say I don't
00:20:02
think you need that breathing to get
00:20:05
adrenaline release you could do it with
00:20:06
cold exposure you could do it with other
00:20:08
things high-intensity interval training
00:20:10
as well and what they found was that
00:20:15
the response to the ecoli was quite
00:20:18
different in the people that had a
00:20:20
protocol in this case breathing to
00:20:22
increase adrenaline so this is a
00:20:26
remarkable study because what they found
00:20:27
was that The Fever The vomiting all the
00:20:30
negative effects of eoli many of them
00:20:34
and some cases all of them were greatly
00:20:36
attenuated by way of engaging the
00:20:39
adrenaline system the point is you can
00:20:42
control your immune system by finding a
00:20:44
way that you can increase adrenaline and
00:20:47
this runs counter to what we always hear
00:20:50
which is don't get too stressed or you
00:20:51
will get sick learn to control
00:20:54
adrenaline turn it on and turn it off
00:20:56
learn to control cortisol turn it on
00:20:59
with light in the morning try and turn
00:21:00
it off and then when it spikes because
00:21:02
of Life events learn to turn it off
00:21:06
learning to turn on and off
00:21:08
adrenaline AKA epinephrine and learning
00:21:12
to turn on and off
00:21:14
cortisol affords you the ability to turn
00:21:16
on energy and focus and your immune
00:21:19
system that's the most important point
00:21:21
from today's podcast and understanding
00:21:24
that it doesn't matter what protocol you
00:21:26
use maybe it's a cup of coffee and
00:21:28
running up a Hill five or six times that
00:21:29
will improve your immune system function
00:21:31
if you get adrenaline in your system you
00:21:33
can use a ice bath you can use a cold
00:21:35
bath it really doesn't matter so up
00:21:37
until now we've been talking about
00:21:39
increasing energy and increasing the
00:21:41
immune system by way of cortisol and
00:21:44
epinephrine but I'd be totally remiss if
00:21:47
I didn't cover how cortisol and
00:21:50
epinephrine if chronically elevated or
00:21:53
if elevated too high can have a lot of
00:21:56
detrimental effects your immune system
00:21:58
over time will get battered and you
00:22:00
won't be able to fight infection off as
00:22:01
well right you can start laying down the
00:22:05
sort of classic pattern of cortisol
00:22:07
induced body fat why do we seek high fat
00:22:11
Andor high sugar foods when we are
00:22:14
stressed for a while why would that be
00:22:17
and the reason is that the so-call
00:22:19
glucocorticoids of which cortisol is a
00:22:24
glucocorticoid it's caused as we've
00:22:26
mentioned before by releasing hormones
00:22:27
from the brain and AC th from the
00:22:29
pituitary Etc but normally high levels
00:22:32
of glucocorticoid shut off the releasing
00:22:36
hormones in the brain and in the
00:22:37
pituitary they shut down in a so-called
00:22:40
negative feedback loop chronic stress
00:22:43
however stress that lasts more than four
00:22:46
to seven days causes changes in the
00:22:50
feedback loop between the adrenals and
00:22:54
the brain and the pituitary such that
00:22:57
now the brain and the tary respond to
00:22:59
high levels of glucocorticoids cortisol
00:23:01
by releasing more of them it becomes a
00:23:03
positive feedback loop and that's bad
00:23:06
it's a Cascade of stress equals more
00:23:09
stress equals more stress so this is why
00:23:11
it's very important to learn to turn off
00:23:13
the stress response so there's one study
00:23:15
that doin her colleagues did where they
00:23:17
stimulate chronic stress by increasing
00:23:19
corticosterone but
00:23:21
cortisol and they found that subjects
00:23:24
would in increase their consumption of
00:23:26
sugar and fat in fact they would even
00:23:29
eat lard and that led to all sorts of
00:23:30
things like type 2 diabetes um that led
00:23:34
to dysfunction in the adrenal output Etc
00:23:38
and so the real key is to learn to shut
00:23:40
off the stress response and you should
00:23:42
uh watch yourself next time you
00:23:44
experience stress if it's a short-term
00:23:45
bow of stress typically it blocks hunger
00:23:49
if it's a longer bow of stress typically
00:23:52
it triggers hunger in particular for
00:23:53
these so-called Comfort Foods sugary and
00:23:55
fatty foods other bad effects of stress
00:23:58
is that yes indeed stress can make you
00:24:01
go gray pigmentation of hair just like
00:24:04
pigmentation of skin is controlled by
00:24:07
melanocytes well it turns out that
00:24:10
activation of the so-called sympathetic
00:24:13
nervous system which is really just
00:24:14
another name for the system that
00:24:16
liberates adrenaline from the adrenals
00:24:19
and epinephrine in the brain drives
00:24:22
depletion of melanocytes in hair stem
00:24:25
cells so indeed there's a rate of age
00:24:28
that we will undergo based on our
00:24:30
genetics but stress will make us go
00:24:32
great how do I know the difference
00:24:34
between chronic and AC acute stress and
00:24:36
how do I keep chronic stress at Bay once
00:24:40
again getting your light and your
00:24:43
feeding and your exercise and your sleep
00:24:47
on a consistent schedule or consistent
00:24:50
is is going to be the most powerful
00:24:52
thing you can do in order to buffer
00:24:54
yourself against negative effects on
00:24:57
Mental Health and phys physical health
00:24:58
for that matter there are things that
00:25:01
one can take supplements prescription
00:25:03
drugs Etc all supplements of course have
00:25:06
to be checked out for their safety
00:25:07
margins for you because it's going to
00:25:09
differ from person to person you're
00:25:10
responsible for making sure they're safe
00:25:12
for you if you decide to use them one of
00:25:14
the most common ones is
00:25:17
ashwagandha it has a very strong effect
00:25:20
on cortisol itself how strong the
00:25:23
decrease in cortisol noted in humans is
00:25:26
14.5 to 27.9 9% reduction in otherwise
00:25:30
healthy but stressed humans the other
00:25:33
compound that I think deserves attention
00:25:35
is appenine a p i GE n i n appenine
00:25:40
which is what's found in chamomile I
00:25:45
take it before bedtime 50 milligrams the
00:25:47
major source of action is to calm the
00:25:50
nervous system and it does that
00:25:52
primarily by adjusting things like Gaba
00:25:55
and chloride channels but also has a
00:25:56
mild effect in reducing cortisol so
00:25:59
asoag gandha and Aenon together sort of
00:26:02
uh I would consider the most
00:26:05
potent commercial compounds that are in
00:26:07
supplement non-prescription form that
00:26:10
one could use if they were interested in
00:26:12
reducing chronic stress especially late
00:26:15
in the day by way of reducing cortisol
00:26:17
late in the day so you're probably
00:26:18
getting the impression that cortisol and
00:26:20
epinephrine are a bit of a double-edged
00:26:21
sword you want them elevated but not for
00:26:24
too long or too much you don't want them
00:26:27
up for days and days and days but you do
00:26:29
want to have a practice in order to
00:26:31
increase them in the short term
00:26:35
so we should talk about protocols that
00:26:38
can set a foundation of of cortisol and
00:26:42
epinephrine that is headed towards
00:26:44
optimal optimization is always going to
00:26:46
be a series of regular practices that
00:26:48
you do every day so sleeping at certain
00:26:50
times light at specific times food at
00:26:52
specific times certain foods Etc and
00:26:54
that's highly individual but there are
00:26:55
some universals and we've covered a
00:26:57
number of those in the discussion today
00:27:00
meal timing meal schedules has a
00:27:03
profound effect on energy levels and as
00:27:06
I mentioned before the energy I'm
00:27:08
referring to is not glucose energy so
00:27:11
what I'm talking about is neural energy
00:27:12
epinephrine and
00:27:14
cortisol fasting and timing ones eating
00:27:18
are two sides of the same coin when our
00:27:20
blood glucose is low cortisol and
00:27:22
epinephrine are going to go up anytime
00:27:24
we hav't eaten for 4 to 6 hours levels
00:27:27
of epinephrine and cortisol are going to
00:27:28
go up pretty substantially one thing
00:27:30
that many people do to great benefit is
00:27:33
they follow a so-called circadian eating
00:27:35
schedule they eat only when the Sun is
00:27:38
up they stop when the sun is down more
00:27:40
or less the other way to think about
00:27:43
this is they stop eating a couple hours
00:27:44
before sleep and they eat more or less
00:27:46
upon waking assuming that they're waking
00:27:48
up more or less around the time the sun
00:27:50
rises maybe plus or minus 2 hours now
00:27:53
let's say you decide to do what I do
00:27:56
which is I skip breakfast I drink water
00:27:58
I delay my caffeine for 90 minutes to 2
00:28:00
hours and then I drink my caffeine and
00:28:02
then my first meal is typically around
00:28:04
lunchtime 11:30 or 12 so I've got a
00:28:06
cortisol increase I've got my sunlight
00:28:08
in the morning so I'm getting a big
00:28:10
pulse in energy early in the day and yes
00:28:12
there's a little bit of agitation I am
00:28:13
hungry sometimes early in the day
00:28:15
sometimes no but my grillin system is
00:28:17
used to kicking in right around noon at
00:28:21
the point where I eat as long as I don't
00:28:23
eat
00:28:24
carbohydrate in my case I know that my
00:28:26
epinephrine levels are going to stay
00:28:28
stay pretty high so for me it's usually
00:28:30
meat and salad or something of that sort
00:28:32
or fish and salad so fasting is a tool
00:28:36
for many reasons can increase growth
00:28:38
hormone Etc but today I'm talking about
00:28:41
fasting as a tool to bias your system
00:28:44
toward more epinephrine adrenaline
00:28:46
release and toward more cortisol release
00:28:48
but still low enough that it's not
00:28:50
chronic stress that it's not causing
00:28:52
negative health effects one has to learn
00:28:54
how to regulate these hormones with
00:28:56
behavior with nutrition perhaps with
00:28:58
supplementation I also want to mention
00:29:00
again that I think there's great benefit
00:29:01
to having a practice that perhaps you do
00:29:03
every other day but if you can't maybe
00:29:05
every third day or every other day of
00:29:08
deliberately increasing your adrenaline
00:29:10
in your body while learning to stay calm
00:29:12
in the mind so that you learn to
00:29:14
separate the brain body experience the
00:29:16
idea is to stay calm in your mind so
00:29:18
that then you can regulate your action
00:29:20
so once again we've covered a ton of
00:29:23
material I hope right now you're
00:29:25
thinking okay am I in a state of chronic
00:29:28
stress am I under activated or could I
00:29:30
afford to increase my levels of
00:29:32
adrenaline cortisol to improve my
00:29:34
relationship to my immune system and to
00:29:37
energy neural energy and I hope that
00:29:40
you'll think about some of the ways in
00:29:42
which cortisol and adrenaline are not
00:29:46
good or bad that stress isn't good or
00:29:48
bad but short-term stress is healthy
00:29:50
alertness and energy is healthy even if
00:29:51
it puts you at the edge of agitation
00:29:54
that's an opportunity to learn how to
00:29:55
control these hormones better and I hope
00:29:58
hope that if you're in a state of
00:29:59
chronic stress that you'll do things to
00:30:01
start tamping down some of that stress
00:30:04
and that you realize that your nervous
00:30:06
system and your hormone system are
00:30:07
linked but they're linked in ways that
00:30:09
you can control that we don't have to be
00:30:11
slaves to our hormones and certainly not
00:30:13
the hormones that cause us stress we can
00:30:14
learn to control those both to the
00:30:16
benefit of our body and benefit of mind
00:30:19
thank you for joining me for what I hope
00:30:21
was an informative discussion and an
00:30:23
actionable discussion about how to
00:30:25
increase energy and the immune system by
00:30:28
way of cortisol and adrenaline
00:30:30
epinephrine I really appreciate your
00:30:33
willingness to learn new topics as well
00:30:35
as to embrace and think about new tools
00:30:37
and whether or not they're right for you
00:30:39
and as always thank you for your
00:30:41
interest in science
00:30:44
[Music]