Iron deficiency in long COVID
Resumo
TLDRThe video explores the connection between blood iron levels and Long COVID, detailing how low iron can exacerbate COVID-19 severity and contribute to persistent symptoms. It discusses the immune system's reliance on iron for proper function and how deficiencies can arise from factors like menstruation and lockdowns. The speaker highlights the importance of maintaining adequate iron levels for vaccine efficacy and overall health, particularly in women. Potential treatments for Long COVID related to iron levels are also mentioned, emphasizing the need for further research in this area.
ConclusΓ΅es
- π©Έ Low iron levels can worsen COVID-19 severity.
- π©ββοΈ Women are more prone to iron deficiency due to menstruation.
- π¬ Iron is crucial for immune function and response.
- π Lockdowns may increase the risk of iron deficiency.
- π Vaccine efficacy can be influenced by iron levels.
- π§ Long COVID symptoms may relate to iron deficiency.
- π½οΈ Dietary sources of iron include meat and spinach.
- β οΈ Reactive oxygen species can be harmful in excess iron.
- π Treatments for Long COVID may involve managing iron levels.
- π Prolonged inflammation and irregular iron usage predict Long COVID risk.
Linha do tempo
- 00:00:00 - 00:05:00
The video discusses the relationship between blood iron levels and Long COVID, summarizing the science behind it and the importance of iron in immune function. It highlights the lack of solutions for Long COVID and the need for further research.
- 00:05:00 - 00:10:00
The speaker explains how low blood iron levels can worsen COVID-19 severity and contribute to Long COVID. They mention the prevalence of iron deficiency in the population and its potential impact on vaccine efficacy.
- 00:10:00 - 00:15:00
The link between iron and the immune system is explored, emphasizing recent discoveries about iron's role in immune responses and how deficiencies can lead to severe COVID-19 symptoms.
- 00:15:00 - 00:20:00
The video outlines the hallmarks of COVID-19, including hyperinflammation and low blood iron levels, and discusses the implications of these findings for patient outcomes and treatment strategies.
- 00:20:00 - 00:25:00
Statistics are provided showing that a significant percentage of hospitalized COVID-19 patients exhibit iron deficiency, correlating low iron levels with increased disease severity.
- 00:25:00 - 00:30:00
The speaker explains the body's natural response to infections, which includes reducing blood iron levels to limit pathogen growth, and how this can lead to complications in severe COVID-19 cases.
- 00:30:00 - 00:35:00
The discussion shifts to Long COVID, noting that prolonged inflammation and irregular iron usage are predictive factors for developing this condition after COVID-19 infection.
- 00:35:00 - 00:40:00
The video highlights the symptoms of Long COVID, such as fatigue and brain fog, and connects these symptoms to iron deficiency and its effects on oxygen delivery in the body.
- 00:40:00 - 00:45:08
The speaker discusses the impact of menstruation on iron levels, particularly in women, and how heavy menstrual bleeding can lead to significant iron loss, contributing to deficiencies and Long COVID.
Mapa mental
VΓdeo de perguntas e respostas
How do blood iron levels affect COVID-19 severity?
Low blood iron levels can lead to anemia, reducing oxygen transport in the body, which may worsen COVID-19 severity.
What is Long COVID?
Long COVID refers to a range of symptoms that persist after the acute phase of a COVID-19 infection, affecting many individuals.
Why are women more affected by Long COVID?
Women may experience more iron deficiency due to menstruation, which can contribute to Long COVID symptoms.
What are the symptoms of iron deficiency?
Symptoms include fatigue, poor performance, hair loss, and cold extremities.
What treatments are suggested for Long COVID related to iron levels?
Potential treatments include hepsin inhibitors and interleukin-6 inhibitors to manage iron levels and inflammation.
How can lockdowns influence iron deficiency?
Lockdowns can lead to changes in diet and physical activity, potentially increasing the risk of iron deficiency.
What dietary sources can help replenish iron?
Iron can be replenished through foods like meat, fish, soybeans, and spinach.
What is the role of transferrin in iron transport?
Transferrin is a protein that carries iron in the blood, facilitating its transport to cells.
How does menstruation affect iron levels in women?
Menstruation can lead to significant iron loss, making women more susceptible to iron deficiency.
What is the significance of reactive oxygen species in relation to iron?
Excess free iron can lead to the production of reactive oxygen species, which can damage tissues.
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- 00:00:00today I'm going to make a video on how
- 00:00:03your blood iron levels can contribute to
- 00:00:07Long Co this is going to be my last
- 00:00:09video in a long series dedicated to Long
- 00:00:12Co and then I'm going to wrap it all up
- 00:00:14all the science I've been studying on
- 00:00:15that topic including what are the
- 00:00:18recommended tests and treatments for
- 00:00:20oneco remember we still don't have
- 00:00:22actual solution for us to what to do
- 00:00:25when it comes to long coov at all which
- 00:00:27is one of the reasons why I'm pursuing
- 00:00:29the science
- 00:00:31and the iron levels it's very
- 00:00:34fascinating story because we if I
- 00:00:36remember everything correctly then I'm
- 00:00:39going to talk about how how low iron
- 00:00:42blood iron levels can be contributing to
- 00:00:44the severity of the covid-19 disease how
- 00:00:47it contributes to Long Co but also we're
- 00:00:49going to discuss it how prevalent iron
- 00:00:53deficiency is in the population how it
- 00:00:55can also how lockdowns could have
- 00:00:58influenced it as well and even also how
- 00:01:01it could influence vaccine efficiency if
- 00:01:05if one took a covid-19 vaccine and that
- 00:01:08might have had an a factor as to
- 00:01:10basically how well the vaccine worked
- 00:01:12for you versus not and then finally
- 00:01:14we're even going to talk about this
- 00:01:16mystery that I was curious about
- 00:01:18remember I recently did a video on the
- 00:01:20use of the vegus nerve neurom modulation
- 00:01:23so activation of your Vegas nerve to
- 00:01:26treat one of the most common and and
- 00:01:30persistent problems related to Long COV
- 00:01:32which is your brain fog as well as in
- 00:01:34this particular video it was focused on
- 00:01:37anxiety and depression via activation of
- 00:01:40your vus nerve using your ear and
- 00:01:44electrical
- 00:01:46stimulation and I mentioned in that
- 00:01:48video that women are more frequently
- 00:01:51affected than men when it comes to Long
- 00:01:53Co and we're going to
- 00:01:55discuss in relation to iron deficiency
- 00:01:58as to why that might be my name is Dr M
- 00:02:01rashik of marog genomics let's get going
- 00:02:04again arm yourself in patience this is
- 00:02:06not going to be short video I doubt but
- 00:02:09let's see how it works out
- 00:02:12so first we're going to talk about the
- 00:02:16link between iron and your immune system
- 00:02:20and the reason why I want to bring this
- 00:02:21up is because I just want to point out
- 00:02:24how new this information is we are
- 00:02:26literally this is something that we're
- 00:02:28just recently discovering and learning
- 00:02:31and this was discovered in only
- 00:02:332016 so it just goes to show you I keep
- 00:02:37saying this in numerous of my videos
- 00:02:39that we still have enormous gaps of
- 00:02:41knowledge when it comes to understanding
- 00:02:44our immune systems and how our immune
- 00:02:46system will be responding to something
- 00:02:48as complex as
- 00:02:50vaccines and this is one of these gaps
- 00:02:53and this is still one of the gaps of
- 00:02:55knowledge for a lot of Prof Healthcare
- 00:02:57Professionals in terms of that
- 00:02:59relationship between say your IR own
- 00:03:02blood levels and and vaccines and going
- 00:03:05back to the 2016 unusual Discovery there
- 00:03:09was a person who had a mutation this
- 00:03:12specific
- 00:03:13mutation in a protein called transfer
- 00:03:18transfer receptor and this protein
- 00:03:22transfer and receptor its role is to
- 00:03:26take up transfer out of circulation out
- 00:03:28of the blood and stick it inside cells
- 00:03:31if you can say it like that transferin
- 00:03:34is a protein in your blood that
- 00:03:36transfers iron so this is how Iron can
- 00:03:39be moved about in your throughout your
- 00:03:42body via circulation so what was
- 00:03:46expected that such a mutation in this
- 00:03:49transfer receptor protein would achieve
- 00:03:52is that it would re result in basically
- 00:03:55iron deficiency
- 00:03:56anemia and let me just tell you what
- 00:03:59anemia is anemia is basically when you
- 00:04:01don't have enough iron in your body so
- 00:04:03that your bone marrow doesn't have
- 00:04:06enough iron to start producing
- 00:04:09hemoglobin hemoglobin are the molecules
- 00:04:12in your red blood cells that carry
- 00:04:15oxygen so then if you have anemia you
- 00:04:17don't have the proper capacity to move
- 00:04:19around oxygen okay so that would have
- 00:04:22been expected from from that mutation
- 00:04:26but instead something completely
- 00:04:27different was observed and basically Al
- 00:04:30that individual was presenting with
- 00:04:33severe imuno
- 00:04:35deficiency and again remember this is
- 00:04:37only mere not even a decade ago that
- 00:04:40this discovery was made and subsequently
- 00:04:43it was then understood so this was the
- 00:04:45first discovery and then it was
- 00:04:47subsequently understood via further work
- 00:04:49and further analysis that iron is
- 00:04:52absolutely necessary for proper immune
- 00:04:55function and immune responses and that
- 00:04:58deficiencies in your levels will affect
- 00:05:01your ability to properly respond or to
- 00:05:04viral or pathogen infections and your
- 00:05:07vaccine so that has already been very
- 00:05:09well worked out and
- 00:05:12understood let me show you what I'm
- 00:05:15walking on quite a beautiful but
- 00:05:18treacherous uh treacherous environment
- 00:05:21so if I'm very slow this is why all
- 00:05:24right so this that then led to further
- 00:05:27understanding all right iron is needed
- 00:05:29in in proper response to infections and
- 00:05:34therefore it was no longer a surprise
- 00:05:36that iron levels how good a person might
- 00:05:40have iron levels might affect covid-19
- 00:05:43and this indeed has been observed so
- 00:05:46what are the some of the Hallmarks of
- 00:05:48covid-19 especially as you go into the
- 00:05:51more severe situations so number one
- 00:05:55that we probably are now all familiar
- 00:05:57with is hyperinflammation so this High
- 00:06:02inflammatory state right and that's one
- 00:06:04of the major Hallmarks of covid-19 right
- 00:06:07but there's other Hallmarks as well or
- 00:06:09other other observations can be made so
- 00:06:12another one
- 00:06:14was low blood iron levels that's that's
- 00:06:20referred to as
- 00:06:22hypothermia so notice the difference in
- 00:06:25the two words I apologize if my accent
- 00:06:28doesn't allow you to differ Che but
- 00:06:31hyper as in hyperinflammation means
- 00:06:34something hyper means something too much
- 00:06:36of hypo means something too little of so
- 00:06:40hypo Foria meaning too little iron in
- 00:06:43this case in circulation so that's
- 00:06:45another observation and of course if you
- 00:06:47have that's in other words hypothermia
- 00:06:51means iron deficiency and this is what
- 00:06:53can lead to
- 00:06:55anemia or basically your inability to
- 00:06:57properly build your blood cells that can
- 00:07:01carry oxygen so you'll be starved for
- 00:07:03oxygen with
- 00:07:05anemia
- 00:07:06and such individuals covid-19 they also
- 00:07:10feature low levels of this protein
- 00:07:13called transferin now transferin itself
- 00:07:17is a protein that as I mentioned earlier
- 00:07:19will carry iron in your body circulation
- 00:07:26okay so uh that one basically think of
- 00:07:30like this is in your blood and it moves
- 00:07:32the iron from one part of the body to
- 00:07:34another so transferring is strictly to
- 00:07:37transfer iron levels around your body
- 00:07:39okay so covid-19 patients can present
- 00:07:43with low levels of that
- 00:07:45protein okay so another one
- 00:07:51is sorry one
- 00:07:55moment high levels of another protein
- 00:07:58called fertin now what's that all about
- 00:08:00fertin is yet another Protein that's the
- 00:08:03protein that stores iron inside your
- 00:08:05cells so it's a storage protein so once
- 00:08:08the iron via transfer is brought to a
- 00:08:13specific type of cells this would be say
- 00:08:15either liver spleen bone marrow as
- 00:08:18examples then these cells can take up
- 00:08:21that transfer and Via transfer and
- 00:08:24receptor and it can start storing iron
- 00:08:27inside those cells and uses that protein
- 00:08:30fertin to store iron now what's
- 00:08:33interesting about fertin is that you can
- 00:08:37also have some of it in a circulation
- 00:08:39and it absolutely correlates with your
- 00:08:41iron deficiency so the more fertin you
- 00:08:44have in the circulation in your blood
- 00:08:47floating around the more likely you are
- 00:08:50to exhibit iron deficiency so covid-19
- 00:08:54patients had high levels of
- 00:08:57fertin and that's referred to as hyper
- 00:09:02Feria again that word hyper too much of
- 00:09:06and the reason why I bring that up as
- 00:09:08well is because that's second Hallmark
- 00:09:11of covid-19 that is very frequently
- 00:09:14observed in co9 patients and I'll give
- 00:09:16you some statistics right away and the
- 00:09:18last last measurable marker that um
- 00:09:23clinicians would have observed during
- 00:09:25covid-19 is two high levels of a protein
- 00:09:30called I think it was called heidin now
- 00:09:33what is heidin this is a protein that
- 00:09:36regulates movement of iron levels from
- 00:09:40the storage from the within cells into
- 00:09:43the blood so we talked about how Iron
- 00:09:45can move around blood via transfer how
- 00:09:48it can enter cells and be stored inside
- 00:09:51cells via V via fertin now heidin can
- 00:09:56now regulate how
- 00:09:59how the iron can move from the storage
- 00:10:02into the blood and we'll talk about that
- 00:10:04in a second as well so they also had two
- 00:10:07high levels of this protein called
- 00:10:09heidin
- 00:10:11and again if you have too much of that
- 00:10:14protein in your circulation it will
- 00:10:16clearly demonstrate that you will not
- 00:10:18have enough iron in your circulation all
- 00:10:21right so these are the Hallmarks and how
- 00:10:23frequent is this just to give you some
- 00:10:25of the
- 00:10:27stats basically
- 00:10:30and based on some of the published
- 00:10:32literature 90% of all individuals who
- 00:10:36were hospitalized would
- 00:10:39show hypothermia or basically iron
- 00:10:43deficiency and when it comes to patients
- 00:10:46getting into ICU they mentioned the in
- 00:10:51one of the articles I read mentioned
- 00:10:53that basically within 3 days of getting
- 00:10:55to ICU when if the blood markers were
- 00:10:59measured then we're talking about like
- 00:11:02over 70% of these individuals would show
- 00:11:05low iron levels too much fertin and too
- 00:11:09little transfer so
- 00:11:12clearly the proper regulation of iron in
- 00:11:16these individuals is not there and that
- 00:11:20is a very common feature and what what
- 00:11:23has
- 00:11:25emerged fairly early on is that how
- 00:11:29little iron an individual
- 00:11:32had in the circulation tended to
- 00:11:35correlate with eventual severity of the
- 00:11:39covid-19 disease now we'll talk about
- 00:11:41why this is so important right away is
- 00:11:44because of how how prevalent iron
- 00:11:47deficiency can be in our population so
- 00:11:49we'll touch back on
- 00:11:52that and basically the less iron a per
- 00:11:56person had the more likely they were
- 00:11:58going to be hospit hospitalized and have
- 00:12:00and end up with severe covid-19 there is
- 00:12:03a bit of a trick as well which I'll talk
- 00:12:06about right away that so it might sound
- 00:12:09confusing but basically The Deco message
- 00:12:11here is that what the what one of the
- 00:12:14authors that of multiple papers that I
- 00:12:16studied for this video mentioned
- 00:12:20that what could have determined How
- 00:12:23likely the person were was going to end
- 00:12:26up with severe Co was their existing
- 00:12:30levels of
- 00:12:33iron why is this and it is because of
- 00:12:36the fact
- 00:12:39that we actually have a natural response
- 00:12:43to pathogens that automatically reduces
- 00:12:46our blood iron levels the reason why we
- 00:12:49do this so that iron is purposely
- 00:12:51scavenged out of your blood during
- 00:12:53infection such as say covid-19 in order
- 00:12:55to reduce your blood iron levels
- 00:12:59because pathogens are are basically
- 00:13:03dependent on the iron levels in order to
- 00:13:06replicate and and or duplicate
- 00:13:08themselves and grow so this is our
- 00:13:10natural response this hyper H
- 00:13:14hyperopia or reducing of your blood iron
- 00:13:17Revels is also a natural response that
- 00:13:19we have in order to fight infections
- 00:13:23right and the way this is achieved is
- 00:13:25via
- 00:13:26increasing the that heitin protein
- 00:13:29levels the one that regulates transfer
- 00:13:31of iron from Storage into the
- 00:13:33circulation so when you have increased
- 00:13:35levels of
- 00:13:37hepsin heidin then starts to degrade or
- 00:13:41helps to lead to degradation of another
- 00:13:45protein I think was called ferroportin
- 00:13:48so that's a protein that helps to move
- 00:13:51it those iron storage levels from the
- 00:13:53cells that store iron into the
- 00:13:55circulation so when hepsen increases
- 00:13:58that that specific protein that supposed
- 00:14:02to help move the iron from Storage into
- 00:14:05the circulation is degraded and you no
- 00:14:07longer have and you no longer have as
- 00:14:10much blood iron in the circulation and
- 00:14:12this Ferro ptin is found in cells such
- 00:14:16as your liver cells it's found on
- 00:14:19macrofagos your immune cells so why
- 00:14:21because macrofagos can actually destroy
- 00:14:23some of your red blood cells to
- 00:14:25recirculate iron and you can see how
- 00:14:27this all now linked to the immune system
- 00:14:29and and
- 00:14:32um they're also found in in I think I
- 00:14:34believe it was bone marrow cells as well
- 00:14:37so with increased levels of hepsen we
- 00:14:40can dramatic and quickly decrease levels
- 00:14:43of available iron iron levels and this
- 00:14:46way we can fight infection but there is
- 00:14:48a price to pay for that because if this
- 00:14:50goes too far and too much then I have to
- 00:14:54figure out where to
- 00:14:56go then what can happen is is basically
- 00:14:59in essence you might not have done
- 00:15:02enough iron available to you to start
- 00:15:05producing not this way to start
- 00:15:10producing red blood cells because there
- 00:15:13might not be enough iron to produce IM
- 00:15:15globin so there is that that uh that
- 00:15:18danger okay so we have a natural
- 00:15:22defenses defense mechanism and the the
- 00:15:26authors of this publication that I was
- 00:15:27reading mentioned that very likely this
- 00:15:31reduced iron levels we see during Co is
- 00:15:34that natural response it happens to many
- 00:15:37infections so covid-19 is simply one of
- 00:15:40them so uh and this is why they
- 00:15:43suggested that the severity might be
- 00:15:45because of H what was your iron levels
- 00:15:48in the first place prior to being
- 00:15:51infected and then have that natural
- 00:15:53response to reduce your iron levels as
- 00:15:56well but there is a little Kink to all
- 00:15:58of this there's a little complication so
- 00:16:00let me tell you about that so what what
- 00:16:01is going on is I hope I find another
- 00:16:04path I want to go further along the
- 00:16:05beach there is
- 00:16:08um another thing is
- 00:16:11that your iron levels yes predicted how
- 00:16:14low your iron levels yes predicted the
- 00:16:16severity of covid-19 down the road but
- 00:16:20you started with low iron
- 00:16:22levels um if you start with low iron
- 00:16:25levels that resulted in m severity of
- 00:16:30the covid-19 disease once you started
- 00:16:33going
- 00:16:34into severe covid-19 something else
- 00:16:37happened and back again you would have
- 00:16:40high iron levels in your circulation so
- 00:16:43what is going on um basically the
- 00:16:46authors were saying it's like a u-shape
- 00:16:49response you can start with low iron
- 00:16:51levels that leads to a problem and then
- 00:16:54you end up with more iron levels and
- 00:16:56that leads to further problems so it's
- 00:16:58sort of like counterintuitive because
- 00:17:01individuals who had no disease basically
- 00:17:04did not have severe covid-19 at all they
- 00:17:07had normal or high iron levels those who
- 00:17:10ended up with mild severity they had low
- 00:17:13iron levels and those who had very high
- 00:17:15severe covid-19 they had again high iron
- 00:17:18levels but here we're talking about a
- 00:17:20different type of iron here we're
- 00:17:22talking about iron levels that are no
- 00:17:24longer bound and transported via your
- 00:17:27blood in your blood via that protein
- 00:17:29transfering we're talking about in these
- 00:17:32situations these individuals had free
- 00:17:36Iron it's also called catalytic iron
- 00:17:38iron and what's going on is that free
- 00:17:41iron or this catalytic iron if you have
- 00:17:43that in your blood it's dangerous
- 00:17:45because iron when it's free and not
- 00:17:48bound to protein either say transfer or
- 00:17:52or fertin it can now start help produce
- 00:17:56reactive oxygen species and if you've
- 00:17:59been following my channel and watch my
- 00:18:02previous videos you probably would have
- 00:18:04heard me mention reactive oxygen species
- 00:18:08are can be very dangerous why because
- 00:18:11precisely because they're so reactive so
- 00:18:12they can start reacting with your
- 00:18:14biological components and as a
- 00:18:16consequence they can start destroying
- 00:18:18things in your body it can also be used
- 00:18:20as a weapon against for example
- 00:18:23pathogens but if it's disregulated and
- 00:18:25there's too much of it it can start
- 00:18:27destroying
- 00:18:29your own tissues for example right so
- 00:18:31you don't necessarily want to have that
- 00:18:32free free iron in order to start
- 00:18:35contributing to such an
- 00:18:38effect and how do we get there H you
- 00:18:42know I got to admit I was a little bit
- 00:18:44hazy on this I tried to study this and
- 00:18:46understand this in Greater detail but
- 00:18:48basically it has to do with the acidity
- 00:18:51of your blood so I find it quite
- 00:18:54fascinating when this concept of the
- 00:18:56blood acidity I've heard
- 00:18:59about this concept many times remember I
- 00:19:00made a video on one of my veg nerve
- 00:19:04videos I discussed how breathing which
- 00:19:08is regulated bya your vegus nerve can
- 00:19:11influence acidity of your blood this is
- 00:19:14also where masking can be really kind of
- 00:19:16tricky the reason why is
- 00:19:20because when you mask you don't properly
- 00:19:23breathe and you don't properly exhale
- 00:19:25carbon dioxide I made a video on this as
- 00:19:27well and as a consequence you can you
- 00:19:30could inadvertently if you wear a mask
- 00:19:32too long increase concentration of
- 00:19:35carbon dioxide in your blood and that
- 00:19:37can result in changing the acidity of
- 00:19:40your
- 00:19:42blood and the point here is that when
- 00:19:45you change the acidity of your blood and
- 00:19:47we're talking about you don't need to
- 00:19:48change much you don't need to think like
- 00:19:50this is dramatic change the type of pH
- 00:19:54of your blood pH measures the acidity of
- 00:19:56your blood is 7.4 once you start going
- 00:19:59below that level of 7.4 which is the
- 00:20:01normal natural acidity of a blood you
- 00:20:04want you can start
- 00:20:06affecting
- 00:20:08basically I'm giggling because I'm
- 00:20:11walking in such unusual
- 00:20:13path so like you can start
- 00:20:17affecting transference ability to bind
- 00:20:21iron and when your blood acidity drops
- 00:20:24transfer will no longer capture iron
- 00:20:27properly as you would want
- 00:20:30I might have
- 00:20:32uh walked myself into a dead end again
- 00:20:36and you end up with that more of that
- 00:20:39free Iron circulating in the blood you
- 00:20:41can now now that you have more of the
- 00:20:43free Iron circulating in the blood
- 00:20:45remember I just mentioned that free or
- 00:20:47catalytic iron iron can start start
- 00:20:51contributing to producing reactive
- 00:20:54oxygen species and this can start
- 00:20:56destroying the tissues and that's might
- 00:21:00explain some of the observations we
- 00:21:03might see with more severe Co
- 00:21:06covid-19 there's another another element
- 00:21:10to all of this and that
- 00:21:13is and that is there's this natural
- 00:21:17process that we
- 00:21:20have and um it's called I think it's
- 00:21:25called hypoxia or hypoxic
- 00:21:29pulmonary Vasa constriction the name is
- 00:21:32not that important to be honest actually
- 00:21:34but the take message is that this is a
- 00:21:36natural process that basically will
- 00:21:39constrict blood certain BL
- 00:21:42arteries that bring blood to your
- 00:21:45lungs under hypoxic conditions meaning
- 00:21:48there's not enough oxygen in the blood
- 00:21:50and the reason why this happens it's a
- 00:21:52natural natural building phenomena is to
- 00:21:55restrict blood flow to areas of your
- 00:21:58lungs that are not ventilating properly
- 00:22:01meaning they don't properly there's no
- 00:22:03good oxygen exchange there and instead
- 00:22:07when this phenomenon happens this Vasa
- 00:22:09constriction you redirect the blood to
- 00:22:12the areas of your lungs that
- 00:22:14will that will help to get more oxygen
- 00:22:19into into basically your blood so via
- 00:22:24this natural
- 00:22:27process you can basically help yourself
- 00:22:29and this
- 00:22:30process fails in covid-19 as well so it
- 00:22:34doesn't work properly and one of the
- 00:22:36reasons why is because it is also
- 00:22:39dependent on high levels of of uh or
- 00:22:45it's also dependent not on high levels
- 00:22:47it's dependent on on iron as
- 00:22:51well so and basically what we're talking
- 00:22:55about is uh that could also explain why
- 00:22:59you have the severity of the disease as
- 00:23:02well is because the iron
- 00:23:05levels that if they're too high in
- 00:23:08circulation at some point they might
- 00:23:11lead to that failure of that proper
- 00:23:14response and you basically end up you
- 00:23:17can see there's there can be like a a
- 00:23:20domino effect where basically you end up
- 00:23:24as a consequence of less and less oxygen
- 00:23:27available to to an individual and you
- 00:23:30end up with having serious issues
- 00:23:33right all right so that's and that's
- 00:23:37just Co covid-19 now let's talk about
- 00:23:40long Co let's jump into long Co so with
- 00:23:43long Co
- 00:23:44obviously the paper I read when it came
- 00:23:46to iron levels and long Co it talked
- 00:23:49about that basically about onethird see
- 00:23:52this these statistics change a little
- 00:23:54bit from paper to paper that I discussed
- 00:23:57but this particular paper mention that
- 00:23:59approximately
- 00:24:01one3 of uh individuals who end up with
- 00:24:06covid-19 they uh they end up with they
- 00:24:09end up with um on Co
- 00:24:12and and those who are
- 00:24:16hospitalized that statistic is way way
- 00:24:19worse it's about 80% now this is from
- 00:24:21memory I hope I got those numbers
- 00:24:23correct but give or take okay but it's
- 00:24:26serious serious numbers
- 00:24:31so the the authors who investigated what
- 00:24:35could be influencing what are the
- 00:24:36factors that are most likely to
- 00:24:39contribute to Long Co they started over
- 00:24:42200 individuals over multiple months for
- 00:24:46a long period of uh of multiple months
- 00:24:50right and they studied their
- 00:24:53their immune markers they looked at
- 00:24:56their blood markers they they look at
- 00:24:59their clinical data and they looked at
- 00:25:01transcriptomics if you're wondering what
- 00:25:03transcriptomics is it's a fancy schy
- 00:25:05word for investigating what kind of
- 00:25:08mrnas your cells produce and basically
- 00:25:11when you look at what kind of mrnas your
- 00:25:13cell produces it gives you a Clues what
- 00:25:16kind of genes a cell is using because
- 00:25:18remember genes are is a storage of
- 00:25:21information inside your nucleus bya DNA
- 00:25:25and then different cells we will use
- 00:25:27different gen gen
- 00:25:29okay and if different cells use
- 00:25:32different genes basically the way you
- 00:25:33can tell which genes are used is by
- 00:25:35looking at the MRNA because if you use a
- 00:25:38gene then basically you transcribe it
- 00:25:41that's the word for it and you produce
- 00:25:43mRNA and then mRNA is is a blueprint
- 00:25:47that a cell that can then be taken out
- 00:25:49of the
- 00:25:50nucleus and basically it's a blueprint
- 00:25:54that is used within the cell to produce
- 00:25:56a specific protein of Interest and
- 00:25:58proteins are like little robots that do
- 00:26:00all the all the work within your cells
- 00:26:02okay so that's basically when you see
- 00:26:04which mrnas are used that gives you a
- 00:26:06clue which genes are used to the looked
- 00:26:08at all of this all of this and what was
- 00:26:10really interesting is
- 00:26:12that what the factors that were most
- 00:26:15likely predictive of who's going to end
- 00:26:18up with long Co was prolonged
- 00:26:21inflammation lasting more than two weeks
- 00:26:24as well
- 00:26:26as let me show you this I don't know you
- 00:26:30can see where I just walked so prolonged
- 00:26:33inflammation as well
- 00:26:37as irregular iron usage so basically
- 00:26:40that it's referred to as a normal
- 00:26:43regular iron usage is called homeo iron
- 00:26:46homeostasis and if you don't if it's not
- 00:26:48working normally then that's dis that
- 00:26:51that's disregulated basically we're
- 00:26:52talking about again iron
- 00:26:54deficiency so prolong iron deficiency
- 00:26:57and prolong h inflammation was the most
- 00:27:01likely predictive factors as to who's
- 00:27:03going to end up with lovid more so than
- 00:27:06the level of inflammation that an
- 00:27:10individual could have experienced so
- 00:27:12it's not how much inflammation the
- 00:27:13person had as much as how long that
- 00:27:16inflammation might have had in
- 00:27:18conjunction with inappropriate use of
- 00:27:21iron so that is why that might help
- 00:27:24explain as to why some of the mild Co
- 00:27:28could still result in Long Co
- 00:27:32okay all right so then uh but there's
- 00:27:34one more interesting element in that
- 00:27:36particular study is that besides low
- 00:27:39iron levels in the blood contributing to
- 00:27:42Long CO as well and the circumstance
- 00:27:44some cells ended up have being loaded
- 00:27:48with iron so they had a lot of iron and
- 00:27:52and remember when you have very high
- 00:27:53levels of iron that basically means that
- 00:27:56um that basically means
- 00:27:59that you could be contributing to this
- 00:28:01reactive oxygen species development and
- 00:28:03the cells that
- 00:28:05were that the authors were mentioning
- 00:28:08that were impacted were monocytes so the
- 00:28:11monocytes and I just recently did a
- 00:28:14video on on how monocytes in could be
- 00:28:18contributing to Long CO as well well
- 00:28:20here's an interesting little Connection
- 00:28:22by iron levels that these uh because I
- 00:28:24talked about how this regular function
- 00:28:27of monocytes
- 00:28:28have been proposed as a potential
- 00:28:30contributing factor to long covid and
- 00:28:32how it could be treated by looking at
- 00:28:34that and here we are these Alors are
- 00:28:36also talking about hey look certain
- 00:28:39monocytes including the ones I discussed
- 00:28:41in that previous video have this
- 00:28:43regulated iron levels they have too much
- 00:28:45iron levels and therefore they could run
- 00:28:47the risk of not being normal anymore
- 00:28:50because of that reactive oxygen species
- 00:28:52development via overloading of iron all
- 00:28:56right so that's another inter connection
- 00:28:58there via the long Co all right so
- 00:29:03that's your long Co connection I'll talk
- 00:29:05about treatment at the very end if I
- 00:29:08don't forget I'm very very prone to
- 00:29:11forgetting in general that's basically
- 00:29:13curse of my
- 00:29:15life and
- 00:29:18um what the authors talked about though
- 00:29:20they were ending this particular
- 00:29:22publication based on symptoms look your
- 00:29:25iron levels can uh are long Co is known
- 00:29:29to have known by fatigue brain fog pain
- 00:29:33in the muscles and and technically this
- 00:29:37is also observed during anemia when you
- 00:29:40have low iron deficiency as well so this
- 00:29:42could help explain explain these
- 00:29:44symptoms for example and lack of oxygen
- 00:29:47delivery as a consequence so for example
- 00:29:49pain muscle pain could be explained by
- 00:29:51the fact that if you don't deliver
- 00:29:55enough oxygen into your muscles it's
- 00:29:57like like heavy heavy workout eventually
- 00:30:00you will start building lactic acid just
- 00:30:03like you would do in a in a workout
- 00:30:05because you run out of oxygen during
- 00:30:07heavy duty workout but here if you don't
- 00:30:08have enough oxygen you could easily end
- 00:30:11up with with with pain in a muscle so
- 00:30:13just like one example and the last thing
- 00:30:15that they brought up is
- 00:30:17also the fact
- 00:30:19that premenopausal women are more likely
- 00:30:24to have long Co and this could be due to
- 00:30:28iron deficiencies so that finally brings
- 00:30:31us to to that
- 00:30:34topic of okay so under what
- 00:30:37circumstances do we see iron
- 00:30:39deficiencies in regular
- 00:30:42population and this is one of the most
- 00:30:46common nutritional deficiency in the
- 00:30:48world iron deficiency and basically
- 00:30:51we're talking about you're not getting
- 00:30:53enough iron from how can you get it
- 00:30:56you're not getting a you're not getting
- 00:30:58iron from your food so that's number one
- 00:31:00right number two is for example
- 00:31:03inflammation so persistent inflammation
- 00:31:05so we discussed
- 00:31:08that and uh so that can be say during
- 00:31:11infection but it could be also during
- 00:31:13other under other circumstances such as
- 00:31:17the um examples that were mentioned is
- 00:31:18Imagine hip fracture or colon cancer
- 00:31:22right so then that that's another of the
- 00:31:24ways you can end up with iron deficiency
- 00:31:27in your blood
- 00:31:28but another one that I will admit I was
- 00:31:32completely unaware of this is
- 00:31:33menstruation now this is not a topic of
- 00:31:36expertise for me I obviously I will
- 00:31:41admit that I'm I am full disclosure I am
- 00:31:45a non-menstruating male for any of those
- 00:31:49of you who might have been confused
- 00:31:51otherwise so uh I don't know much about
- 00:31:54the topic I done made I made some videos
- 00:31:57in how
- 00:31:58the menstration has been affected in
- 00:32:01women
- 00:32:02postvaccination so everything I'm going
- 00:32:04to tell you was totally new for me and I
- 00:32:09wonder how many of you guys who might be
- 00:32:12watching this video would know what is
- 00:32:13even the normal volume blood volume loss
- 00:32:17during
- 00:32:18menstruation I now know and it's 80 Ms
- 00:32:22or less now however that's still a lot
- 00:32:25of blood loss and basically
- 00:32:29when a woman menstruates this volume
- 00:32:31this normal volume that equates to
- 00:32:33roughly 2 milligrams of iron loss per
- 00:32:37day compared to a man or or a non-
- 00:32:42menring woman which would be similar is
- 00:32:44about 1.5 milligrams per day So
- 00:32:47eventually what it means is that a
- 00:32:50menstruating
- 00:32:51woman will lose more iron because of
- 00:32:54that than a man would or a woman who no
- 00:32:58longer menstruates but menstruations can
- 00:33:01also they can vary in in volume and they
- 00:33:04can vary dramatically now what are we
- 00:33:07talking about dramatically we're talking
- 00:33:09about some women can menstruate up to
- 00:33:11400 Mills of blood that's a lot and what
- 00:33:15does that mean when it comes to
- 00:33:18understanding iron loss basically in
- 00:33:20other words this means that such a woman
- 00:33:24when she menstruates this much she could
- 00:33:26be losing up to 200 100 milligrams of
- 00:33:29iron in a month and all right these
- 00:33:32numbers are potentially meaningless to
- 00:33:34you but your average woman has
- 00:33:38approximately 300 milligrams of that
- 00:33:42iron available in the storage so you can
- 00:33:45see that a woman with very heavy
- 00:33:47menstruation could easily deplete
- 00:33:51majority of her available iron and it's
- 00:33:54not that it's easy to necessarily
- 00:33:57replenish
- 00:33:58so by the way what are the symptoms of
- 00:34:00iron deficiency that's also very
- 00:34:01interesting in case because I don't even
- 00:34:03know how many women know this I would
- 00:34:06assume that women would know this but
- 00:34:08you know what I gotta I gotta admit to
- 00:34:10you it's not like I ever have a
- 00:34:12conversation about this uh with my
- 00:34:15female friends so by the way what do you
- 00:34:17do to replenish your iron levels due to
- 00:34:19your menstruation yeah I know it just
- 00:34:21doesn't come up in a conversation so so
- 00:34:24what are the symptoms so the symptoms is
- 00:34:26something like fatigue
- 00:34:28you uh poor performance right overall
- 00:34:31because you just don't have enough you
- 00:34:33don't have enough iron you don't have
- 00:34:34enough
- 00:34:36oxygen and uh and and another one that I
- 00:34:40remember of the top of my head was for
- 00:34:42example hair loss that was interesting
- 00:34:44as well so so there's multiple symptoms
- 00:34:46that and I think also maybe like I hope
- 00:34:49I'm right about this like your hands and
- 00:34:51feet getting cold but either way there's
- 00:34:53like number of symptoms of um when you
- 00:34:56have iron deficiency and how are you
- 00:34:58supposed to then what are you supposed
- 00:34:59to do in order to to help your situation
- 00:35:02well you're supposed to ideally you
- 00:35:04would want to take it have appropriate
- 00:35:07dietary intake of iron but that ain't
- 00:35:11easy and I didn't know this either there
- 00:35:13so look we're all learning here and to
- 00:35:17replenish those two milligrams of iron
- 00:35:20loss that are menstruating woman
- 00:35:23experiences the Alors mentioned you
- 00:35:25would have to eat something like either
- 00:35:27for a single day you would have to eat
- 00:35:30either something like 200 or 300 grams
- 00:35:34of fish meat or eat a kilogram of
- 00:35:38soybeans or eat 5 kilogram of spinach so
- 00:35:44H not necessarily easy so for those who
- 00:35:47might not be able to properly replenish
- 00:35:49the iron levels you can take
- 00:35:51supplements and uh however apparently it
- 00:35:55is not recommended at all to take
- 00:35:57supplements if you don't have symptoms
- 00:35:59if you have a if uh your iron levels are
- 00:36:02low but you don't exhibit symptoms it is
- 00:36:05not apparently recommended to take
- 00:36:07supplements so I just thought I would
- 00:36:09share that what I'm basically studying
- 00:36:11and reading about this okay so
- 00:36:15then this is so interesting where I'm
- 00:36:17walking around it's like B millions of
- 00:36:19tiny little shelves and steps just got
- 00:36:22to make sure I don't fall
- 00:36:24anywhere and this is even further
- 00:36:27exasperated especially if you're a woman
- 00:36:29under additional conditions such as and
- 00:36:32this is um at first I was like oh what
- 00:36:34an interesting fact or this is
- 00:36:36surprising such as number one was if you
- 00:36:39are an athlete and now that I think
- 00:36:42about it okay that makes sense remember
- 00:36:43I made this video on beta glucans
- 00:36:46helping athletes recover their immune
- 00:36:49system so perhaps this basically means
- 00:36:52that your immune system is required for
- 00:36:56your proper respon
- 00:36:58proper
- 00:37:00function or recovery process
- 00:37:03post uh strenuous workouts okay and
- 00:37:06perhaps this could explain why athletic
- 00:37:10women might be an even further
- 00:37:14additional
- 00:37:15additional situation where they might
- 00:37:18consider iron supplementation or or have
- 00:37:21a propriatary appropriate dietary intake
- 00:37:24of that and the other one is vegetarian
- 00:37:27Ian because uh as I just told you a
- 00:37:31moment ago it's not necessarily easy to
- 00:37:34replenish your iron levels
- 00:37:37via VIA vegetarian diet and that's
- 00:37:42another and especially for menstruating
- 00:37:44women so I thought I would share all of
- 00:37:46this with you
- 00:37:49and why is that apart so this can
- 00:37:52obviously explain why women are more
- 00:37:56likely are more frequently observed to
- 00:37:59have long Co and this is potentially
- 00:38:01could be linked to something as simple
- 00:38:04and potentially so easily controlled as
- 00:38:09your iron level regulation all
- 00:38:13right so and that brings me will bring
- 00:38:16me now to the last few aspects of this
- 00:38:20sorry I apologize long video is
- 00:38:22lockdowns vaccines and treatments forong
- 00:38:26Co so uh for
- 00:38:29example I hope you can hear this uh for
- 00:38:32example when it comes to lockdowns there
- 00:38:34was a paper I read that showed how how
- 00:38:38lockdowns resulted in iron deficiency in
- 00:38:41some individuals and the reason why is
- 00:38:43because lockdowns resulted in dramatic
- 00:38:46changes in people's dietary patterns and
- 00:38:49their physical activities
- 00:38:52and the authors of that publication
- 00:38:54mentioned listen we should have never
- 00:38:56have lockdowns with without proper
- 00:38:58education of the public on the
- 00:39:00importance of of proper diet that can
- 00:39:05then properly supplement your iron
- 00:39:07levels because subsequently you could it
- 00:39:11runs the risk of leading to iron
- 00:39:13deficiency so that's one now let's talk
- 00:39:15about vaccines
- 00:39:17so one of the agencies what was it the I
- 00:39:20think it was called the
- 00:39:23European hematology Association
- 00:39:26hematologic Association basically M
- 00:39:29published an expert opinion mentioning
- 00:39:32that anyone who was taking covid-19
- 00:39:36vaccine should have had made sure that
- 00:39:40their iron levels are at appropriate
- 00:39:42normal levels prior to taking the
- 00:39:44vaccine and this actually points out the
- 00:39:46as I mentioned at the beginning of the
- 00:39:48video the standard knowledge Gap when it
- 00:39:51comes to vaccine use and iron levels
- 00:39:54this is something that is missing
- 00:39:55amongst in the Collective knowledge of
- 00:39:58many of our experts and that basically
- 00:40:02in essence your iron levels should be
- 00:40:05made sure to be good and normal anytime
- 00:40:08you vaccinate now there's a lot of
- 00:40:10missing information still
- 00:40:13because the your vaccine efficacy can
- 00:40:17depend on your iron levels but not every
- 00:40:21vaccine is dependent on that so only
- 00:40:23some vaccines will Pro will have their
- 00:40:27efficacy of response affected by your
- 00:40:29iron levels but not necessarily every
- 00:40:31single one and this also might explain
- 00:40:34how why different populations throughout
- 00:40:37the world might have had exhibited
- 00:40:39different efficacy to vaccines and that
- 00:40:41could have been explained simply by how
- 00:40:44what were their iron levels
- 00:40:47okay in in in their blood so something
- 00:40:50as simple as that but another thing we
- 00:40:52still don't know is what is the level of
- 00:40:55iron deficiency required in order for
- 00:40:57the vaccine efficacy to be affected
- 00:41:00which vaccines truly are
- 00:41:03affected and but the authors of that
- 00:41:06publication mention listen we should be
- 00:41:08really really paying attention to this
- 00:41:10because even slightly increasing vaccine
- 00:41:13efficacy for some of the vaccines
- 00:41:15especially especially say say childhood
- 00:41:18vaccines could dramatically influence
- 00:41:20global mortality and uh so that's
- 00:41:23something you well do you remember
- 00:41:26anyone mentioning this uh when Mass
- 00:41:29vaccination was starting cuz I don't may
- 00:41:31maybe there were some clever people
- 00:41:33warning us but I don't remember any any
- 00:41:37of this at all all right and then
- 00:41:38finally what about what about in terms
- 00:41:42of proposed treatments for long Co and
- 00:41:46we're going to wrap it up here and wow I
- 00:41:48made it to yet another bag which is very
- 00:41:51cool and the authors who who basically
- 00:41:57with that paper on long covid and iron
- 00:42:00deficiency proposed couple potential
- 00:42:02treatments so well first of all they
- 00:42:04mention
- 00:42:05look making sure
- 00:42:08that that you don't succumb
- 00:42:11to the severe depletion of your iron
- 00:42:15iron levels due to due to say
- 00:42:18covid-19 or basically your SARS c 2
- 00:42:21Virus Infection could have been easily
- 00:42:24influenced by something like having
- 00:42:26vaccines available okay they were not so
- 00:42:28let's skip that but also proper use of
- 00:42:31something like
- 00:42:32antivirus right and this might explain
- 00:42:35for example why such countries as India
- 00:42:39or Peru and I made a video on this who
- 00:42:44heavily promoted use of certain
- 00:42:47antivirals
- 00:42:49that I will shall not be
- 00:42:52named um might have had such spectacular
- 00:42:56results the reason why is because then
- 00:43:00the individuals who were subsequently
- 00:43:02infected might not have had such severe
- 00:43:05such
- 00:43:07severe iron deficiency loss
- 00:43:11that as without use of those antivirals
- 00:43:15so that's an interesting connection that
- 00:43:17I didn't think about and
- 00:43:20uh but apart from that obviously now
- 00:43:23it's too late like that this is done and
- 00:43:25over with they're talking about like
- 00:43:27what would have been a smart thing to do
- 00:43:29prior to infection now what about those
- 00:43:32who have long Co and they're talking
- 00:43:34about couple things number one is to use
- 00:43:37those heidin Inhibitors so Inhibitors
- 00:43:40that will prevent that will
- 00:43:43prevent that elevated levels of hepsin
- 00:43:46in the blood and remember I I was
- 00:43:47telling you that once you have high
- 00:43:49levels of heidin in your blood this will
- 00:43:51result in uh in basically
- 00:43:57reduce iron levels in your blood right
- 00:43:59so not something we don't want so we
- 00:44:00trying to avoid that so that's number
- 00:44:02one and the other one they mentioned is
- 00:44:05interlan six Inhibitors why that
- 00:44:09specific Inhibitors is because
- 00:44:10apparently elevated interlan six can
- 00:44:14lead to elevated hpin levels as well so
- 00:44:16that those are the potential treatments
- 00:44:18for lung Co that are mentioned here and
- 00:44:20this brings us to the end of this rather
- 00:44:23long video but I you know me i' like to
- 00:44:26wrap up the topics uh in one go and just
- 00:44:29complete them and uh so Hey listen uh if
- 00:44:33you like this topic please give me a
- 00:44:35like please share the video This Is How
- 00:44:37We Grow uh leave a comment and uh if you
- 00:44:41are an expert in in iron levels as well
- 00:44:44let us teach us some more on that as
- 00:44:46well in the comments below and uh the
- 00:44:49last thing I'll mention is uh thanks for
- 00:44:51your support and including supporting
- 00:44:52the P my patreon channel where we
- 00:44:55publish additional topics as well and
- 00:44:57I'll see you next time bye everyone
- 00:45:03[Music]
- Long COVID
- Iron levels
- COVID-19
- Iron deficiency
- Immune system
- Vaccine efficacy
- Menstruation
- Health
- Treatment
- Nutrition