Neuroscientist Reveals How to Repair Gut Health without Probiotics - Dr. Sherr

00:20:42
https://www.youtube.com/watch?v=gJ1UmNBlGp0

Summary

TLDRThe video features a comprehensive discussion on gut health, emphasizing the significance of glutamine as the primary fuel for the small intestine, necessary for maintaining gut wall integrity. Dr. Scot explains that leaky gut, often resulting from nutrient deficiencies, inflammation, and stress, can lead to broader health issues including poor mood and brain function. For athletes and individuals undergoing surgery, glutamine supplementation is highlighted as crucial in preventing gut permeability and muscle loss. Additionally, the conversation explores the impacts of chronic stress on digestion by activating the sympathetic nervous system, which hinders digestion and promotes gut issues. The interview also touches on the relevance of fatty acid supplements, specifically "Fatty 15", in addressing nutritional deficiencies and supporting gut health. Furthermore, misconceptions around glutamine being ineffective in bodybuilding are addressed, clarifying its importance in gut health and neurotransmitter balance involving glutamate and GABA. Suggestions for improving gut health include managing stress, ensuring sufficient intake of glutamine and essential vitamins like B6 and magnesium, and considering supplements for targeted support. Finally, the speaker advocates for a holistic approach to health, emphasizing the interconnectedness of physical and emotional well-being in maintaining optimal gut health.

Takeaways

  • 🦠 Gut integrity relies significantly on glutamine as a primary fuel source for the small intestine.
  • ⚖️ Balancing glutamate and GABA is crucial for mood stability and preventing excitability.
  • 🚴 Athletes suffering from leaky gut can benefit from glutamine supplementation during rigorous training.
  • 🛌 Post-surgery, glutamine helps maintain gut integrity and prevents muscle loss.
  • 🔥 Chronic stress impairs digestion by activating the sympathetic nervous system.
  • 🔍 Leaky gut can lead to broader health issues, including brain permeability and mood disorders.
  • 🥛 Fatty 15 supplements can address deficiencies in saturated fats supporting gut health.
  • 🧠 Poor gut health can increase brain permeability, affecting mental health.
  • 🩹 Gut health issues need a targeted approach involving diet, stress management, and supplementation.
  • 🌿 A holistic approach to health recognizes the connection between physical and emotional well-being.

Timeline

  • 00:00:00 - 00:05:00

    Dr. Scot explains that gut health is crucial because the small intestine requires its fuel, mainly glutamine, while the large intestine is fueled by butyrate. The gut operates as a protective barrier; if it doesn't function well, it leads to issues like leaky gut, which can allow harmful elements from outside to penetrate, causing inflammation and disrupting body systems. Supporting gut health is not just about diet but understanding and possibly supplementing key nutrients.

  • 00:05:00 - 00:10:00

    The discussion highlights how a leaky gut stems from inflammation due to insufficient fuel for gut cells. Glutamine is emphasized as crucial for gut health, not for muscle building, as commonly misconceived. It plays a vital role in athletes' gut integrity who often lack it due to strenuous exercise. Support for the gut often necessitates dietary supplementation with glutamine to prevent leaky gut and maintain overall health, particularly under stress or during recovery.

  • 00:10:00 - 00:15:00

    Dr. Scot elaborates on how stress affects gut health differently than physical stress from exercise. Chronic stress activates the sympathetic nervous system, impeding digestion, while exercise depletes glutamine, both leading to leaky gut. Gut health impacts the brain's health due to the connection between gut permeability and brain inflammation. Proper gut support, including glutamine supplementation and managing stress, is crucial for maintaining health and preventing immune and neurotransmitter issues.

  • 00:15:00 - 00:20:42

    Glutamine’s role in converting to glutamate and its connection to brain function is discussed. Maintaining balance is essential to prevent excessive glutamate and ensuring adequate levels of GABA. Glutamine supplementation is not only crucial for gut health but also influences mental health by aiding GABA production, which affects mood and sleep. Proper nutrition and supplementation, like magnesium and vitamin B6, are recommended to support these bodily systems effectively.

Show more

Mind Map

Video Q&A

  • What is the main fuel for the small intestine?

    Glutamine is the main fuel for the small intestine.

  • How does a lack of proper gut fuel affect health?

    A lack of proper fuel can lead to gut permeability, poor gut health, and mood disturbances.

  • What causes leaky gut?

    Leaky gut is often caused by inflammation, lack of nutrients like glutamine, and stress on the gut cells.

  • Why is glutamine important for athletes?

    Athletes deplete amino acids like glutamine during intense exercise, leading to leaky gut and related symptoms.

  • How can glutamine benefit post-surgery patients?

    Supplementing with glutamine post-surgery can support gut integrity and prevent inflammation and muscle loss.

  • What is the relationship between gut health and mental health?

    Poor gut health can lead to brain permeability and affect neurotransmitter balance, impacting mood and mental health.

  • How can stress affect digestion?

    Chronic stress activates the sympathetic nervous system, impairing digestion and leading to gut issues.

  • What are the benefits of fatty 15 supplements for gut health?

    Fatty 15 supplements provide a concentrated form of saturated fat which can support gut health, especially when diet lacks sufficient C15 levels.

  • How does glutamine help with neurotransmitter balance?

    Glutamine helps ensure a balance between glutamate and GABA, crucial for mood regulation and preventing excitability.

  • What dietary changes can support gut health?

    Including glutamine-rich foods and supplements, reducing stress, and maintaining necessary vitamin levels like B6 and magnesium can support gut health.

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  • 00:00:00
    Dr Scot sure when it comes down to gut
  • 00:00:03
    health people don't seem to realize that
  • 00:00:06
    the small intestine our gut actually
  • 00:00:09
    needs fuel itself like those cells need
  • 00:00:12
    they need they need fuel it's not
  • 00:00:13
    necessarily coming from just
  • 00:00:15
    carbohydrates or food that we're eating
  • 00:00:17
    they they operate differently yep how
  • 00:00:19
    does that work how does first off like
  • 00:00:21
    how can a lack of proper fuel in the gut
  • 00:00:25
    affect gut permeability gut health
  • 00:00:27
    ultimately uh the mood like how how does
  • 00:00:30
    work yeah so our large intestine is
  • 00:00:34
    fueled by butyrate okay so your main
  • 00:00:36
    source of fuel for your large intestine
  • 00:00:38
    is actually berate so berate is made in
  • 00:00:40
    a lot of different ways but berate is
  • 00:00:41
    the main fuel okay in the small
  • 00:00:44
    intestine the main fuel is actually
  • 00:00:45
    glutamine and what people don't realize
  • 00:00:48
    is that the the fuel which what that
  • 00:00:50
    means is that the the cells in your gut
  • 00:00:52
    in your small intestine require
  • 00:00:54
    glutamine to work to make energy to
  • 00:00:57
    function and those cells are just one
  • 00:01:00
    layer thick so your cellular wall your
  • 00:01:03
    cell wall of your gut is not very thick
  • 00:01:05
    people think it's like this massive you
  • 00:01:07
    know when you look at like a big tube or
  • 00:01:09
    something like that no it's one cell
  • 00:01:10
    thick and there's all these other things
  • 00:01:12
    that are inside the small intestine that
  • 00:01:13
    are like your immune cells and other
  • 00:01:16
    types of cells that are there to help
  • 00:01:17
    protect you the way to think about the
  • 00:01:19
    gut is it's basically outside of your
  • 00:01:21
    body okay our first immune system that
  • 00:01:24
    was developed was inside of our gut the
  • 00:01:27
    first neurons and connections and like
  • 00:01:31
    synapses and things like that like were
  • 00:01:33
    made in your gut because they had to
  • 00:01:34
    understand what was happening from the
  • 00:01:35
    outside world okay so our gut is kind of
  • 00:01:37
    where everything starts and Begins for
  • 00:01:40
    most people and if your gut is not
  • 00:01:42
    working well the whole system starts
  • 00:01:45
    crashing because the gut is protecting
  • 00:01:47
    you from the outside world and if you're
  • 00:01:48
    allowing things to come into the from
  • 00:01:50
    the outside world because you have a
  • 00:01:52
    leaky gut because you're not getting
  • 00:01:53
    enough maybe fuel for those cells or
  • 00:01:56
    there's inflammation or there's
  • 00:01:57
    infection or whatever it might be that
  • 00:01:59
    all kind of go together um you'll find
  • 00:02:01
    that the system starts getting
  • 00:02:03
    disregulated because all those things
  • 00:02:05
    that were supposed to be kept out of
  • 00:02:06
    your body start coming in when the gut
  • 00:02:08
    gets leaky interesting so what are some
  • 00:02:11
    ways like just getting right down to
  • 00:02:12
    Brass tax that you can kind of help
  • 00:02:14
    support that because it's not just about
  • 00:02:16
    the food that you're eating I also put a
  • 00:02:18
    link down below for a company that makes
  • 00:02:20
    a C15 for people that don't eat a lot of
  • 00:02:22
    cheese or people that want to get those
  • 00:02:24
    c-15 levels up a lot of their research
  • 00:02:26
    was funded by the United States Navy
  • 00:02:28
    they have some really interesting stuff
  • 00:02:30
    it's a company called fatty 15 I've
  • 00:02:32
    talked to Dr ven Watson multiple times
  • 00:02:35
    and I've even interviewed her on this
  • 00:02:36
    channel she is who really is one of the
  • 00:02:38
    people that kind of started discovering
  • 00:02:40
    this deficiency in Dolphins but this is
  • 00:02:42
    something that's been talked about
  • 00:02:44
    across the literature for a long time
  • 00:02:47
    but only recently has become sort of
  • 00:02:49
    household information I put a link down
  • 00:02:52
    below for you to try fatty 15 if it's
  • 00:02:54
    something that's of interest to you I
  • 00:02:55
    think it's a very important compound it
  • 00:02:58
    is a form of Satur fat so it's not like
  • 00:03:01
    we're talking anything really weird here
  • 00:03:03
    it's a saturated fat that we would get
  • 00:03:04
    from good quality cheeses but the amount
  • 00:03:07
    of cheese you'd have to eat to get our
  • 00:03:08
    levels back up and again this is a real
  • 00:03:09
    deficiency would be a lot of cheese so
  • 00:03:11
    that link is down below it's a 15% off
  • 00:03:14
    discount link Top Line of the
  • 00:03:15
    description underneath this video I
  • 00:03:17
    highly encourage you to at least go
  • 00:03:19
    there and read some of the literature
  • 00:03:20
    it's fascinating well a lot of this has
  • 00:03:22
    to do with there's so many different
  • 00:03:23
    components to this right so if you have
  • 00:03:26
    a gut that's leaky it's there's so many
  • 00:03:28
    different reasons that why might why
  • 00:03:30
    that why that might be the case right so
  • 00:03:32
    if your gut is not doing a good job
  • 00:03:33
    keeping things out um and and
  • 00:03:35
    maintaining things in the gut and then
  • 00:03:36
    letting them go if they're not supposed
  • 00:03:37
    to be there it's probably because um
  • 00:03:40
    there are a number of factors all kind
  • 00:03:42
    of related to the final issue which is
  • 00:03:45
    inflammation in the gut and when what
  • 00:03:47
    happens if you have a lot of
  • 00:03:48
    inflammation is that those cells that
  • 00:03:50
    are aligning the gut are not getting the
  • 00:03:52
    fuel that they need um and then they
  • 00:03:54
    start opening up and they start to let
  • 00:03:57
    things in and as a result of that you're
  • 00:03:59
    starting get leaky gut and you get all
  • 00:04:01
    these inflammatory things that happen as
  • 00:04:02
    a result of that so and the key fuel
  • 00:04:04
    there for our gut cells is glutamine as
  • 00:04:07
    well and that's you a very important
  • 00:04:08
    amino acid as you know so so okay
  • 00:04:10
    because I know glutamine from sort of
  • 00:04:12
    the bodybuilding world where it doesn't
  • 00:04:14
    really do diddly squat right from a
  • 00:04:15
    muscle building perspective it's not
  • 00:04:17
    essential it's not you know it's uh it's
  • 00:04:19
    created so like why do we really need it
  • 00:04:21
    to build muscle and I think that's been
  • 00:04:24
    demonstrated to largely not do anything
  • 00:04:26
    but there's this other side of glutamine
  • 00:04:29
    that people don't always realize and I
  • 00:04:30
    know there's the endurance side there's
  • 00:04:31
    also just flat out just other sides in
  • 00:04:34
    general like from the endurance
  • 00:04:35
    perspective it's like I don't know if
  • 00:04:37
    people realize and this isn't just for
  • 00:04:39
    endurance athic like it's all relative
  • 00:04:41
    right like if someone is not accustomed
  • 00:04:44
    to doing more cardio and all a sudden
  • 00:04:45
    they do more cardio or they start an
  • 00:04:48
    exercise regime and they start kind of
  • 00:04:50
    depleting these glutamine levels this
  • 00:04:52
    has an impact on their gut health which
  • 00:04:54
    then has an impact on subsequent other
  • 00:04:55
    things yes so many athletes that I've
  • 00:04:57
    worked with over the years have their
  • 00:04:59
    guts are trash and that's because
  • 00:05:01
    they're depleting all of their amino
  • 00:05:03
    acids but the one that's most important
  • 00:05:05
    is going to be the glutamine for their
  • 00:05:06
    gut and so they get leaky gut as a
  • 00:05:07
    result of just being over exercised and
  • 00:05:10
    then they're getting diarrheal symptoms
  • 00:05:12
    they're getting abdominal symptoms so I
  • 00:05:13
    worked with a guy recently at the
  • 00:05:14
    Leadville race which is like the
  • 00:05:16
    ultramarathon in Colorado where I live
  • 00:05:18
    and he was complaining to me like every
  • 00:05:20
    year that he tried it two years before
  • 00:05:21
    at least one year maybe two years where
  • 00:05:23
    you get severe diarrheal symptoms and
  • 00:05:25
    like this is a big problem with people
  • 00:05:26
    doing a lot of these bigger races and
  • 00:05:28
    they get a lot of GI distu
  • 00:05:30
    why is this then there's lots of
  • 00:05:31
    different reasons but one of the reasons
  • 00:05:32
    is that they're depleting all of their
  • 00:05:34
    amino acids because they're doing these
  • 00:05:35
    huge races and the main one that's
  • 00:05:37
    keeping their gut intact is glutamine so
  • 00:05:40
    if you're and so what we did with him
  • 00:05:41
    with him this year was we had him take
  • 00:05:43
    about four to five grams of glutamine
  • 00:05:45
    every four hours and he ran the race in
  • 00:05:48
    three hours less than he did the year
  • 00:05:49
    before and no GI symptoms at all so it's
  • 00:05:53
    underutilized and underappreciated the
  • 00:05:56
    importance of glutamine maybe not from a
  • 00:05:57
    muscle building perspective but from a
  • 00:05:59
    gut Integrity perspective while you're
  • 00:06:01
    trying to build muscle and get stronger
  • 00:06:03
    and do these ultramarathons and things
  • 00:06:04
    like that and I think it makes sense
  • 00:06:06
    like from a you know any kind of
  • 00:06:08
    evolutionary perspective like people
  • 00:06:10
    might say like well why I don't want to
  • 00:06:11
    you know I want to do it all with food I
  • 00:06:12
    want to do it it's pretty unnatural to
  • 00:06:14
    go out and run a 100 miles right so me
  • 00:06:17
    the first guy that that did the 26 miles
  • 00:06:19
    the marathon died right so yeah so I
  • 00:06:21
    mean yes maybe we've adapted and we're
  • 00:06:23
    we're better at doing some of these you
  • 00:06:24
    know extreme things what I'm curious is
  • 00:06:26
    how how quickly does gut damage occur
  • 00:06:30
    like I mean if so if someone let's say
  • 00:06:32
    you know I go out and I run 20 mil you
  • 00:06:34
    know let's make it like more relatable
  • 00:06:36
    let's say like someone that's doing a
  • 00:06:39
    couch to 5K goes out and they R they run
  • 00:06:40
    a 5k right they run they're all going to
  • 00:06:42
    need more glutamine man yeah especially
  • 00:06:44
    I mean and you do you need it as well
  • 00:06:45
    when you're doing those 20 MERS and
  • 00:06:46
    things like that we see this even the
  • 00:06:48
    biggest place we see it actually is in
  • 00:06:50
    people that get surgery people that just
  • 00:06:51
    get laid up in the hospital um they need
  • 00:06:54
    a lot more glutamine overall to support
  • 00:06:56
    their gut and in general they don't get
  • 00:06:58
    enough and so we actually we've looked
  • 00:06:59
    at various there's good studies that
  • 00:07:01
    show that if you increase and supplement
  • 00:07:02
    with glutamine they don't lose as much
  • 00:07:03
    muscle mass and their gut doesn't get as
  • 00:07:05
    leaky either and they don't get such
  • 00:07:06
    inflammation issues as a result of that
  • 00:07:08
    so even just a couple days in the
  • 00:07:10
    hospital can be detrimental to your gut
  • 00:07:13
    Integrity because you are inflamed and
  • 00:07:16
    then you're sitting in bed and you're
  • 00:07:17
    like all you're you know you're losing
  • 00:07:19
    lean body mass by just sitting there too
  • 00:07:21
    so opposite extremes apply here so if
  • 00:07:24
    you're doing a lot of energy metabolism
  • 00:07:26
    a lot of work you're going to require a
  • 00:07:27
    lot more glutamine as well not for your
  • 00:07:29
    muscle tissue as much but for your gut
  • 00:07:31
    and that's what people don't think about
  • 00:07:32
    as much so often times we have people
  • 00:07:33
    sipping glutamine
  • 00:07:36
    postoperatively this is not in the in
  • 00:07:37
    the conventional world but in the the
  • 00:07:38
    more alternative side like up to 20
  • 00:07:40
    grams a day in some in some people
  • 00:07:41
    depending on the situation so so with uh
  • 00:07:44
    so it can happen pretty quick so it's
  • 00:07:45
    just like like if someone goes out and
  • 00:07:47
    never run a 5k before they run it then
  • 00:07:48
    it's I mean it's basically depleting
  • 00:07:50
    actively yes um what
  • 00:07:53
    happens the term leaky gut intestinal
  • 00:07:56
    permeability is like thrown around so
  • 00:07:58
    much uh and over I shouldn't say
  • 00:08:01
    overhyped because I I don't think it's
  • 00:08:03
    overhyped I think it's very important
  • 00:08:04
    but it's over marketed right so it's
  • 00:08:06
    like it's talked about in in the wrong
  • 00:08:08
    circles the wrong people where they they
  • 00:08:10
    burnt out that that term yeah but it's a
  • 00:08:13
    very real thing and I think you know you
  • 00:08:15
    and I talked like when I had my Like A
  • 00:08:16
    Parasite last year and like it was
  • 00:08:18
    really messed me up like there was you
  • 00:08:20
    know immune system things that happen
  • 00:08:22
    Downstream of that there's all kinds of
  • 00:08:23
    stuff that happen Downstream that yeah
  • 00:08:25
    um what happens when your gut is
  • 00:08:28
    permeable so when your gut's not doing
  • 00:08:31
    what it's supposed to do it's allowing
  • 00:08:32
    that outside world to come in and that's
  • 00:08:34
    usually going to cause significant
  • 00:08:35
    amounts of immune system activation
  • 00:08:37
    overall and that's usually not going to
  • 00:08:40
    be a good idea also because it's also
  • 00:08:41
    going to cause your brain to get leaky
  • 00:08:43
    as well so once there's a lot of immune
  • 00:08:44
    activation there's a lot of inflammation
  • 00:08:46
    because all these little particles and
  • 00:08:47
    things like that that shouldn't have
  • 00:08:48
    come in from the gut are now in the
  • 00:08:50
    system maybe it's too big of a protein
  • 00:08:52
    maybe it's too big of a carbohydrate
  • 00:08:53
    maybe it's a parasite or maybe it's
  • 00:08:55
    something else that came in because you
  • 00:08:57
    had more of a leaky kind of gut then the
  • 00:08:59
    whole system gets more inflamed and then
  • 00:09:01
    as an inflammatory responses occur you
  • 00:09:03
    have inflammation other or areas of the
  • 00:09:06
    body including your brain which is what
  • 00:09:07
    I've seen the most actually over the
  • 00:09:09
    years is that once your gut gets leaky
  • 00:09:12
    um your brain gets leaky and then your
  • 00:09:13
    brain allows things to get across that
  • 00:09:15
    weren't supposed to get there so this is
  • 00:09:17
    when people get you know reactivations
  • 00:09:19
    of things like Epstein bar or lime or
  • 00:09:21
    mold that were never an issue and then
  • 00:09:23
    all of a sudden it could happen where
  • 00:09:25
    you have a massive inflammatory response
  • 00:09:27
    that causes the leaky gut itself or you
  • 00:09:28
    can have issues within the gut itself
  • 00:09:30
    that cause inflammation that maybe the
  • 00:09:32
    food maybe toxins maybe medications
  • 00:09:34
    environmental stuff that cause the gut
  • 00:09:36
    to be leaky on its own that cause an
  • 00:09:37
    inflammatory response in the rest of the
  • 00:09:38
    system so it can go either way if that
  • 00:09:40
    makes sense so U mechanistically if like
  • 00:09:43
    exercise endurance were kind of depletes
  • 00:09:45
    the glutamine yes how does how does
  • 00:09:48
    stress is it working along the same
  • 00:09:49
    pathway I mean is there is there a
  • 00:09:51
    physical change that occurs like through
  • 00:09:53
    exercise that causes this depletion but
  • 00:09:55
    compare that to someone that's like like
  • 00:09:57
    chronically stressed and that's kind of
  • 00:09:59
    contributing to a right so the chronic
  • 00:10:01
    stress is a little bit different right
  • 00:10:02
    but but it's it's similar in this in
  • 00:10:03
    some ways because if you're chronically
  • 00:10:05
    stressed you're activating your
  • 00:10:07
    sympathetic nervous system your
  • 00:10:08
    sympathetic nervous system is like your
  • 00:10:10
    fight ORF flight it's like running from
  • 00:10:11
    a lion kind of nervous system if that's
  • 00:10:13
    not the place that we digest very well
  • 00:10:14
    as you know most of people actually what
  • 00:10:17
    what happens when an animal is in danger
  • 00:10:20
    it shits itself and it runs right so
  • 00:10:22
    that it's like this massive response of
  • 00:10:24
    like just clamping down and then going
  • 00:10:26
    so you don't digest very well if you're
  • 00:10:28
    in simp sympathetic overload so if
  • 00:10:30
    you're massively stressed all the time
  • 00:10:32
    you're not going to be able to have the
  • 00:10:33
    rest and digest and so you're not going
  • 00:10:35
    to able to get enough blood flow to your
  • 00:10:37
    intestines to actually get enough
  • 00:10:39
    digestion to happen so that's when
  • 00:10:41
    people get bloating they don't get
  • 00:10:43
    digestion well they get bacterial
  • 00:10:44
    overgrowth all those kinds of things
  • 00:10:46
    because they're always in sympathetic
  • 00:10:48
    response it's a different response than
  • 00:10:50
    the stress of exercise which is just an
  • 00:10:52
    acute stress that's depleting things
  • 00:10:54
    like glutamine and as a result of that
  • 00:10:56
    you're getting the leak a higher
  • 00:10:58
    incidence of things like a leaky gut um
  • 00:11:00
    but the chronic stress that's happening
  • 00:11:02
    and the sympathetic dominance that
  • 00:11:04
    you're getting you can't digest your
  • 00:11:05
    food that way interesting and there's a
  • 00:11:07
    I mean is that one of the reasons why
  • 00:11:09
    people maybe don't sleep so well like I
  • 00:11:12
    mean is I know there's an interplay
  • 00:11:13
    between glutamine glutamate and Gaba
  • 00:11:16
    right because they kind of work sort of
  • 00:11:17
    Sy or I guess in opposition SL
  • 00:11:20
    synergistically with each other so yeah
  • 00:11:21
    we have glutamine which is your amino
  • 00:11:23
    acid then you have glutamate which is
  • 00:11:24
    also amino acids but glutamine can be
  • 00:11:26
    converted into glutamate glutamate is
  • 00:11:28
    also our primary excitatory
  • 00:11:30
    neurotransmitter in the brain so
  • 00:11:31
    glutamate gets across the blood brain
  • 00:11:33
    barrier very easily and it that's about
  • 00:11:36
    keeping you on it's your energy it's
  • 00:11:38
    your your focus um this is of course dop
  • 00:11:40
    me and norrine are involved but
  • 00:11:42
    glutamate is actually the primary that
  • 00:11:43
    people don't know about but then
  • 00:11:44
    glutamate gets converted into Gaba in
  • 00:11:47
    the brain and then glutamate requires
  • 00:11:49
    vitamin B6 and magnesium to do that so
  • 00:11:52
    you have to have those co-actors to be
  • 00:11:53
    able to convert your glutamate to your
  • 00:11:55
    Gaba in the brain and Gaba is of course
  • 00:11:56
    really important for relaxing and
  • 00:11:58
    calming down and helping you sleep if
  • 00:12:00
    you have too much glutamate compared to
  • 00:12:02
    glut compared to Gaba you're going to
  • 00:12:04
    feel more energy you're not going to be
  • 00:12:05
    able to sleep you're going to be
  • 00:12:06
    irritable insomnia all those kinds of
  • 00:12:08
    things so it's really important that
  • 00:12:10
    your gut's working so that your gut is
  • 00:12:12
    getting you glutamine and it's and it's
  • 00:12:14
    doing what it needs to do so you don't
  • 00:12:15
    get leaky gut and inflammation this
  • 00:12:16
    inflammation is going to screw up your
  • 00:12:17
    neurotransmitters as well in various
  • 00:12:19
    ways including Gaba and then but it's
  • 00:12:21
    also important you're getting enough
  • 00:12:22
    glutamine for the rest of the body as
  • 00:12:23
    well not just your gut so if you have a
  • 00:12:25
    leaky gut you need more glutamine not
  • 00:12:27
    only for your for your small intestine
  • 00:12:29
    but for the rest of your body especially
  • 00:12:31
    for your conversion over to Gaba so you
  • 00:12:33
    can actually sleep and so if you're
  • 00:12:35
    depleted in your gut you need more
  • 00:12:36
    glutamine and if you have a leaky gut
  • 00:12:38
    you need more glutamine and then if you
  • 00:12:40
    have if you need that much more you're
  • 00:12:41
    also going to need more so you can get
  • 00:12:42
    into the system so you can actually
  • 00:12:44
    convert it over to Gaba as well and this
  • 00:12:46
    is the irbil that you have with a lot of
  • 00:12:48
    people that have a leaky gut or that are
  • 00:12:50
    depleted overall in Gaba is that they
  • 00:12:52
    just don't have enough to maintain and
  • 00:12:54
    and help with them with their mood along
  • 00:12:56
    with their sleep interesting yeah cuz
  • 00:12:57
    you I mean on the surface you would
  • 00:12:58
    think okay glutamine would be the
  • 00:13:00
    opposite of what you would need if it's
  • 00:13:01
    going to feed glutamate that's going to
  • 00:13:03
    make you moreable so it's actually you
  • 00:13:05
    need more glutamate to make enough Gaba
  • 00:13:06
    right so it's a thing where you need
  • 00:13:08
    enough of the precursor it's a balance
  • 00:13:09
    between those two things right so if you
  • 00:13:11
    don't have that balance you're going to
  • 00:13:12
    have an overabundance of glutamate
  • 00:13:13
    you're going to be screwed because
  • 00:13:14
    you're not going to be able to sleep
  • 00:13:15
    you're going to have tremors so you have
  • 00:13:17
    to not only make sure that you're
  • 00:13:18
    getting enough glutamine but also the
  • 00:13:20
    co-actors that are responsible for the
  • 00:13:22
    conversion which is your vitamin B6 and
  • 00:13:24
    your magnesium so that's also very
  • 00:13:26
    important for people of course and then
  • 00:13:28
    you know most of
  • 00:13:29
    the foods that we eat now are depleted
  • 00:13:31
    in a lot of those kinds of minerals
  • 00:13:32
    especially magnesium many of us are
  • 00:13:34
    magnesium deficient as you know as well
  • 00:13:36
    and so I often have my patients taking
  • 00:13:37
    magnesium at night uh along with maybe
  • 00:13:40
    vitamin B6 but usually I'm doing I'm
  • 00:13:41
    checking levels for that kind of thing
  • 00:13:43
    because you can take too much B6 as well
  • 00:13:44
    which is not always a good thing so yeah
  • 00:13:46
    so if you're trying to uh sort of if you
  • 00:13:50
    have too much glutamate and actually
  • 00:13:53
    let's back up for a second I think
  • 00:13:54
    people can understand a little bit more
  • 00:13:56
    like what glutamate is when they think
  • 00:13:57
    of like MSG that's a great great example
  • 00:14:00
    and I don't want to put MSG on the spot
  • 00:14:02
    cuz I know that people get sensitive
  • 00:14:03
    about their MSG but I can honestly say
  • 00:14:05
    in my personal experience like I don't
  • 00:14:07
    sleep when I have MSG I am very wired
  • 00:14:10
    and I know I'm not alone in that and I
  • 00:14:11
    know that it's difficult to talk people
  • 00:14:13
    do get very sensitive when you talk
  • 00:14:14
    about their MSG and I'm not bashing MSG
  • 00:14:16
    but it's just I didn't think it was that
  • 00:14:18
    controversial I think I thought
  • 00:14:19
    everybody had one guy one time put me on
  • 00:14:21
    he was a very well-known very well-known
  • 00:14:24
    uh food star uh from that uh what is
  • 00:14:28
    that uh ugly delicious that show he I
  • 00:14:31
    mean massive following on Twitter I did
  • 00:14:33
    a video that was talking about it wasn't
  • 00:14:34
    even negative about MSG it was really
  • 00:14:36
    just talking about uh a couple of the
  • 00:14:38
    studies there's one particular study
  • 00:14:40
    that was was literally called Chinese
  • 00:14:41
    food syndrome like because and talked
  • 00:14:44
    about the effects of MSG on on the brain
  • 00:14:46
    and he just like I mean the things he
  • 00:14:48
    called me I mean I don't even want to
  • 00:14:50
    say them on YouTube right it was just
  • 00:14:51
    like because just shock value because
  • 00:14:53
    there was a a perceived attack on a
  • 00:14:55
    particular like the Umami flavor right
  • 00:14:57
    yeah I understand yeah that wasn't but
  • 00:15:00
    the bottom line is that if you look at
  • 00:15:02
    how MSG works in the body like it's it's
  • 00:15:04
    I'm not even saying it's good bad or
  • 00:15:05
    ugly it's just what it is right yeah and
  • 00:15:07
    your your experience is very very common
  • 00:15:09
    because if you flood the system with MSG
  • 00:15:12
    or glutamate sources it doesn't have to
  • 00:15:13
    be MSG like a good one that's very high
  • 00:15:16
    brow is caviar caviar has lots of MSG so
  • 00:15:18
    if you have any High glutamate
  • 00:15:20
    containing foods like some of the harder
  • 00:15:21
    cheeses as well headaches are common and
  • 00:15:23
    headach is a very common sign that
  • 00:15:25
    you're overabundant in that glutamate
  • 00:15:27
    you know versus your glutamine so versus
  • 00:15:29
    your Gaba excuse me so you have your
  • 00:15:30
    glutamate that's high and it's having a
  • 00:15:32
    hard time converting itself over to Gaba
  • 00:15:35
    and as a result of that you get those
  • 00:15:36
    symptoms that you were describing right
  • 00:15:38
    so it's it's always a fine balance our
  • 00:15:40
    body is always in this balance right and
  • 00:15:41
    and it's trying to rebalance itself when
  • 00:15:43
    we have these stresses and that can be
  • 00:15:45
    good and but sometimes it requires you
  • 00:15:47
    to be thinking about well maybe I can't
  • 00:15:48
    get all of this from food I really have
  • 00:15:50
    to think about how I can support my
  • 00:15:51
    glutamine system with higher levels of
  • 00:15:53
    glutamine if I have more symptomatic
  • 00:15:55
    leaky gut you small intestinal bacterial
  • 00:15:57
    overgrowth those kinds of things and
  • 00:15:59
    then also maybe have to support your
  • 00:16:00
    Gaba system too not only by working on
  • 00:16:02
    the glutamine sources but how are you
  • 00:16:04
    increasing the Gaba as well in various
  • 00:16:06
    ways and you can do that you know
  • 00:16:07
    primarily by improving how the Gaba
  • 00:16:10
    receptor is working and supporting it
  • 00:16:12
    you know while you're working on the
  • 00:16:13
    dietary changes and working on the leaky
  • 00:16:14
    gut but you know often times you want to
  • 00:16:16
    help people right now because they're
  • 00:16:18
    having symptoms and so you can often
  • 00:16:19
    support the Gaba system by giving things
  • 00:16:21
    that support Gaba at the same time as
  • 00:16:23
    working on their leaky gut and working
  • 00:16:24
    on their glutamine and their conversion
  • 00:16:26
    from glutamate into Gaba as well so with
  • 00:16:28
    your vitamin B6 and magnesium yeah and I
  • 00:16:30
    know uh you know separately I'll put a
  • 00:16:32
    link down below to you know you guys'
  • 00:16:34
    project and transcriptions and what you
  • 00:16:36
    guys do with that cuz there's some
  • 00:16:36
    interesting stuff that I've talked about
  • 00:16:38
    on this channel before like trro calm
  • 00:16:40
    and ways to improve kind of increase
  • 00:16:42
    gabble levels which is really
  • 00:16:43
    interesting something that I've been a
  • 00:16:44
    big fan of for a long time yeah we're a
  • 00:16:45
    big fan of looking at the Gaba receptor
  • 00:16:47
    in a very novel way not just what's
  • 00:16:50
    going to be binding the receptor in some
  • 00:16:53
    alisic way which is like around the
  • 00:16:55
    receptor but what are you actually doing
  • 00:16:56
    to make sure that Gaba doesn't get
  • 00:16:58
    efficient or depleted and most of my
  • 00:17:00
    patients are Gaba deficient but no
  • 00:17:02
    doctor ever ask them about it and
  • 00:17:04
    because nobody thinks that if somebody's
  • 00:17:06
    depressed or anxious or can't sleep that
  • 00:17:07
    it could be a Gaba deficiency but it
  • 00:17:09
    could and so if you can support the Gaba
  • 00:17:10
    system in this holistic way right
  • 00:17:12
    looking at supporting the Gaba receptor
  • 00:17:15
    by enhancing not only just what's
  • 00:17:17
    binding to it on these other sites but
  • 00:17:18
    also Gaba itself along with you know
  • 00:17:21
    magnesium and B6 and that conversion
  • 00:17:23
    over the glutamate to Gaba like that's a
  • 00:17:25
    bit of a longer process for people but
  • 00:17:27
    if you do them together like you can get
  • 00:17:28
    people sleeping and feeling better like
  • 00:17:30
    their mood regulated their uh their
  • 00:17:32
    overall just feeling of just comfort in
  • 00:17:36
    themselves just go up so much because if
  • 00:17:38
    you're over if you're overabundant in
  • 00:17:40
    glutamate especially like you're just
  • 00:17:42
    jittery you're edgy all the time like
  • 00:17:43
    you're not a fun person to be around
  • 00:17:45
    right so like that's not what we want to
  • 00:17:47
    be and you show up for our our spouses
  • 00:17:48
    and our kids and and things and just
  • 00:17:51
    supporting that Gaba system can go so
  • 00:17:53
    far in helping them and so yeah troom is
  • 00:17:55
    is a big one for that but in general my
  • 00:17:58
    perspectives as you know Tom is like is
  • 00:17:59
    that I really want to support the system
  • 00:18:01
    as much as possible so like looking and
  • 00:18:03
    testing vitamins and minerals and
  • 00:18:04
    nutrients looking at their like their
  • 00:18:06
    copper and their their zinc level is
  • 00:18:08
    really important as well to make sure
  • 00:18:09
    the receptor is working magnesium B6 is
  • 00:18:12
    as well really really important as well
  • 00:18:13
    as the glutamine levels so yeah it's I
  • 00:18:15
    mean even if it's one of those things
  • 00:18:16
    that's just a a pattern interrupt for
  • 00:18:18
    someone to be able to get off that ledge
  • 00:18:20
    and be able to do the inner work that
  • 00:18:21
    they need to do you know it's like
  • 00:18:22
    that's kind of what it is for me it's
  • 00:18:24
    like I don't like to rely on things but
  • 00:18:27
    I do also know that there's
  • 00:18:29
    part of that internal sort of wisdom
  • 00:18:32
    that you have to listen to sometimes is
  • 00:18:33
    that hey yes there is a time and a place
  • 00:18:35
    where I need to intervene or need an
  • 00:18:37
    intervention and that's where you can
  • 00:18:39
    have something else step in whether it's
  • 00:18:41
    glutamine whether it's transcriptions
  • 00:18:42
    whether it's you know whatever the
  • 00:18:44
    intervention is to get you to that place
  • 00:18:46
    where you're in the head space where you
  • 00:18:47
    can do the work to get yourself right
  • 00:18:49
    because I think people don't realize how
  • 00:18:51
    important the mental and emotional side
  • 00:18:54
    of this is with the gut too 100% And
  • 00:18:57
    that's always my perspective too and in
  • 00:18:58
    fact we have a nonprofit organization
  • 00:19:00
    it's called Health optimization medicine
  • 00:19:02
    and practice it was formed in 2017 Dr
  • 00:19:05
    Ted aoso is the founder he's also the
  • 00:19:07
    founder of transcriptions and the key
  • 00:19:09
    was optimizing Health instead of
  • 00:19:11
    treating disease okay most people out
  • 00:19:14
    there are looking at treating disease
  • 00:19:15
    looking at the root cause of illness and
  • 00:19:16
    that's okay but if you're not focused on
  • 00:19:18
    how to keep people healthy how to keep
  • 00:19:19
    those cells healthy that's the
  • 00:19:21
    foundation that's the ground of it all
  • 00:19:23
    but while you're doing that while you're
  • 00:19:24
    looking at optimizing vitamins minerals
  • 00:19:26
    nutrients circadian rhythms exposure es
  • 00:19:29
    relationships you name all these things
  • 00:19:31
    these are really important it could take
  • 00:19:32
    a long time to feel better it can take
  • 00:19:34
    if you've the common scenario is that
  • 00:19:36
    somebody wants to feel better tomorrow
  • 00:19:38
    but it took them 40 years to feel the
  • 00:19:39
    way they do right so they can't expect
  • 00:19:41
    that tomorrow they're going to feel
  • 00:19:42
    better but that's why transcriptions was
  • 00:19:43
    developed as a way to help people you
  • 00:19:45
    know right now while they're on that
  • 00:19:47
    longer path to optimizing their health
  • 00:19:49
    which takes a while like I want to
  • 00:19:50
    optimize my B6 and magnesium levels in
  • 00:19:53
    my patients I want to optimize their gut
  • 00:19:54
    but I've had it take years to optimize
  • 00:19:57
    people's guts in some cases if you deal
  • 00:19:58
    with parasites and you have to deal with
  • 00:20:00
    bacterial overgrowth and then you have
  • 00:20:01
    to do various kinds of things and then
  • 00:20:03
    you have to have of course compliance as
  • 00:20:05
    well and people are doing the things but
  • 00:20:06
    it can take a lot of time so what are
  • 00:20:08
    you going to do in the in in the in the
  • 00:20:09
    inter term like you said like the
  • 00:20:11
    glutamine or maybe a transcriptions
  • 00:20:12
    product could help you or lots of
  • 00:20:14
    different things can help overall maybe
  • 00:20:15
    going on a Meditation Retreat like just
  • 00:20:17
    becoming more parasympathetic just
  • 00:20:18
    relaxing a little bit can really really
  • 00:20:20
    help as well and you just like we say
  • 00:20:22
    you know calming down is usually the
  • 00:20:23
    answer to most problems so yeah agreed
  • 00:20:25
    man well I'll link out to everything
  • 00:20:26
    down below and then otherwise where can
  • 00:20:28
    people find
  • 00:20:29
    so transcriptions is a good place so
  • 00:20:30
    transcription. comom is where we have
  • 00:20:31
    some of our products um I'm personally
  • 00:20:33
    on Instagram at Dr Scott Shar D RS ttsh
  • 00:20:36
    h e RR that's probably where I do most
  • 00:20:38
    of my work overall so perfect thanks man
  • 00:20:40
    all right thank you
Tags
  • gut health
  • glutamine
  • leaky gut
  • gut permeability
  • neurotransmitter balance
  • exercise and gut health
  • chronic stress
  • digestive health
  • diet and supplements
  • mental health