Newly Discovered Cause of Insulin Resistance is Not Sugar or Saturated Fat - Dr. Venn Watson

00:56:51
https://www.youtube.com/watch?v=cnTHgRJi0mM

Summary

TLDRThe video discusses a groundbreaking study revealing a nutritional deficiency termed "Cellular Fragility Syndrome" linked to low levels of c-15, a saturated fatty acid important for cell membrane stability. Dr. Stephanie Vin Watson explains how c-15 deficiency leads to weak cell membranes, impacting glucose regulation and causing insulin resistance. When this deficiency affects both the liver and pancreas, it increases the risk of metabolic syndrome and diseases like type 2 diabetes, heart disease, and stroke. The discovery was first noted in dolphins, which showed fatty liver disease and insulin resistance due to low dietary c-15. Similarly, people with low c-15 intake are experiencing accelerated onset of aging-related diseases. Research now indicates that restoring c-15 through diet or supplements can reverse these effects, offering a potential solution to these metabolic problems. The video also highlights how dietary practices in Sardinia, where people consume high levels of grass-fed dairy, result in higher c-15 levels and may contribute to their notable longevity. The methodical approach to understanding c-15 levels and their widespread implications on health is emphasized as an essential step toward combating modern metabolic diseases. The significance of getting comprehensive research and understanding into public awareness is stressed, as these findings could impact how dietary guidelines are shaped to improve global health.

Takeaways

  • 🧠 C-15 plays a crucial role in maintaining healthy cell membranes.
  • 💔 Deficiency in c-15 is linked to metabolic syndrome and cardiovascular diseases.
  • 🐬 Discovery was made through studies on Navy dolphins showing similar diseases.
  • 🍦 Sardinia's high c-15 levels linked to their dairy-rich diet contribute to longevity.
  • 🧬 Ferroptosis is a novel cell death process associated with iron and c-15 deficiency.
  • 🇺🇸 Modern diets reduced c-15 intake, correlating with increased metabolic diseases.
  • 🔬 C-15 deficiency impacts insulin production and glucose regulation.
  • 📊 New research tools are available to measure c-15 levels accurately.
  • 🌍 Global emphasis on dietary adjustments to mitigate c-15 related health issues.
  • 🏥 Health implications stress the need for awareness and potential dietary guidelines adjustments.

Timeline

  • 00:00:00 - 00:05:00

    Dr. Stephanie Vin Watson discusses the onset of insulin resistance and metabolic syndrome resulting from iron deposition in the liver and pancreas, leading to impaired glucose regulation and insulin production. This sets the stage for metabolic syndrome, increasing the risk of heart disease, stroke, and type 2 diabetes.

  • 00:05:00 - 00:10:00

    Dr. Vin Watson introduces a new study on a nutritional deficiency syndrome called cellular fragility syndrome, linked to a lack of C15. This deficiency causes cell membranes to weaken, accelerating aging and contributing to diseases like type 2 diabetes and heart disease.

  • 00:10:00 - 00:15:00

    The discovery of a new cell death pathway, ferroptosis, explains how fragile fatty acids lead to lipid peroxidation, iron accumulation, and reactive oxygen species (ROS) production. This damages mitochondria, furthering the understanding of cellular fragility and its link to aging-related diseases.

  • 00:15:00 - 00:20:00

    Research since 2012 has connected the lack of C15 to the onset and development of 'ferroptosis', a recently discovered cell death mechanism. This process involves lipid peroxidation, iron accumulation, and ROS production, which damage mitochondria and weaken cells.

  • 00:20:00 - 00:25:00

    C15 deficiency is implicated in initiating and progressing ferroptosis. Supplementation with C15 has been shown to reverse this process by stabilizing cell membranes, reducing lipid peroxidation, preventing iron accumulation, and repairing mitochondria.

  • 00:25:00 - 00:30:00

    Research in dolphins revealed iron overload and fatty liver as early signs of C15 deficiency-related diseases. Dolphins with higher C15 levels showed resistance. This has led to understanding and modeling C15's protective effects in human metabolism and disease prevention.

  • 00:30:00 - 00:35:00

    C15 deficiency leads to metabolic syndrome as iron deposits in the liver and pancreas, disrupting glucose regulation and increasing inflammation. Research is exploring the protective role of C15 in maintaining metabolic health and reducing the prevalence of related diseases.

  • 00:35:00 - 00:40:00

    The conversation delves into the historical and prospective understanding of fatty liver disease and its anticipated rise due to lifestyle changes. Studies have linked cellular fragility and early onset of metabolic diseases to C15 deficiency, emphasizing its significance.

  • 00:40:00 - 00:45:00

    Sardinia's unique high C15 levels, due to local dairy-rich diets, offer insights into longevity. Studies show the importance of C15 for metabolic health and its potential role in addressing modern dietary deficiencies to prevent accelerated aging and related diseases.

  • 00:45:00 - 00:50:00

    There's a focus on leveraging C15 supplementation to counteract dietary deficiencies. Comparing global dietary practices with those in Sardinia proposes opportunities to enhance C15 intake through both natural and fortified dietary sources.

  • 00:50:00 - 00:56:51

    Overall, the discussion emphasizes the critical role of C15 in combating accelerated aging and metabolic disorders, underlining its potential benefit when reintroduced adequately into modern diets, either through supplementation or dietary modifications.

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Mind Map

Video Q&A

  • What is cellular fragility syndrome?

    Cellular fragility syndrome is a newly discovered nutritional deficiency linked to low levels of c-15, resulting in weak cell membranes and accelerated aging.

  • How does c-15 deficiency affect insulin resistance?

    C-15 deficiency weakens cell membranes, leading to lipid peroxidation and iron deposition. This causes the liver and pancreas to function improperly, leading to insulin resistance.

  • What role does c-15 play in cell health?

    C-15 helps strengthen cell membranes, reducing lipid peroxidation and iron accumulation, which are crucial for optimal cell functioning and preventing accelerated aging.

  • How was c-15 deficiency discovered?

    C-15 deficiency was discovered through studies on Navy dolphins that showed fatty liver disease and insulin resistance linked to low c-15 in their diet.

  • What health conditions are linked to c-15 deficiency?

    C-15 deficiency is linked to metabolic syndrome, type 2 diabetes, heart disease, and possibly early onset fatty liver disease.

  • Can c-15 levels be measured?

    Yes, c-15 levels can be measured using a fatty acid panel or newer at-home diagnostic tests.

  • Why is Sardinia mentioned in connection with c-15?

    Sardinia is noted for high longevity, partially attributed to diet rich in dairy from grass-fed sheep and goats, leading to higher c-15 levels.

  • How can c-15 deficiency be addressed?

    C-15 deficiency can be addressed through increased dietary intake of c-15 rich foods or supplements like fatty 15.

  • What is ferroptosis, as mentioned in the video?

    Ferroptosis is a process where cell death occurs uniquely via lipid peroxidation and iron, contributing to diseases like those associated with c-15 deficiency.

  • What discoveries were made about c-15 in the past years?

    Since 2012, research has linked c-15 to stable cell membranes and found that its deficiency can drive aging-related diseases.

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  • 00:00:00
    when you have iron plus Ross right and
  • 00:00:02
    lipid peroxidation all happening first
  • 00:00:04
    in the liver the liver will stop um
  • 00:00:08
    producing uh the appropriate amount of
  • 00:00:11
    or it won't react appropriately to
  • 00:00:12
    glucose so you start getting the onset
  • 00:00:16
    of insulin resistance happening at the
  • 00:00:18
    liver side basically just because you
  • 00:00:19
    have broken liver cells in which the
  • 00:00:22
    liver is not responding appropriately to
  • 00:00:24
    basically keeping our glucose balanced
  • 00:00:26
    at the same time once iron deposition in
  • 00:00:29
    this whole process starts happening in
  • 00:00:31
    our pancreas our beta cells stop
  • 00:00:34
    producing insulin so we've got kind of a
  • 00:00:36
    one two hit of both our pancreas and
  • 00:00:39
    liver and when you combine those that
  • 00:00:42
    then sets you up for metabolic syndrome
  • 00:00:44
    right which is this High um insulin or
  • 00:00:47
    insulin resistance high glucose you get
  • 00:00:49
    this middle um you know at deposity uh a
  • 00:00:53
    weight gain and then that all sets you
  • 00:00:55
    up for an increased risk of heart
  • 00:00:57
    disease stroke um and type two diabetes
  • 00:01:00
    Dr Stephanie Vin Watson I had you on
  • 00:01:02
    earlier this year but there's this brand
  • 00:01:03
    new study that just came out so it was
  • 00:01:05
    absolutely worth bringing you right back
  • 00:01:07
    on to talk about this so without further
  • 00:01:09
    Ado let's just jump right into this
  • 00:01:11
    because this is I'm going to let you
  • 00:01:12
    explain the science I'll ask some
  • 00:01:13
    questions because this is one of the
  • 00:01:14
    coolest studies that I've seen this year
  • 00:01:16
    great then well thanks Thomas well so we
  • 00:01:19
    discovered the first nutritional
  • 00:01:20
    deficiency syndrome in over 75 years so
  • 00:01:24
    you think about things like vitamin C
  • 00:01:26
    and scurvy and vitamin D deficiency in
  • 00:01:28
    rickets we have discovered a deficiency
  • 00:01:31
    syndrome uh thanks to c-15 deficiencies
  • 00:01:34
    and it's called cellular fragility
  • 00:01:36
    syndrome and so it's a giant Discovery
  • 00:01:39
    and what's so wonderful about
  • 00:01:42
    discovering a nutritional deficiency
  • 00:01:44
    even though you know it sounds
  • 00:01:46
    devastating is that this is something we
  • 00:01:48
    can detect Thomas and something we can
  • 00:01:50
    fix so so excited to be able to be here
  • 00:01:52
    to talk about this discovery and you
  • 00:01:55
    know what it means for all of us what
  • 00:01:57
    exactly is cellular fragility so yes
  • 00:01:59
    when we talk about you know our bodies
  • 00:02:00
    are made out of cells so everything
  • 00:02:03
    every part of us is made out of cells
  • 00:02:05
    and our cells are armored by these cell
  • 00:02:09
    membranes and so the cell membranes are
  • 00:02:11
    made out of lipids and they can become
  • 00:02:13
    weak and what we've learned is that
  • 00:02:16
    based upon the type of fatty acids in
  • 00:02:18
    the cell membrane dictates how strong or
  • 00:02:21
    weak our cells membranes are and why do
  • 00:02:23
    we care about that well it's because
  • 00:02:26
    when our cells become weak they undergo
  • 00:02:28
    faster aging so basically they fall
  • 00:02:31
    apart a lot faster they age faster that
  • 00:02:33
    translates to us aging faster and so
  • 00:02:36
    what's so important about this discovery
  • 00:02:38
    is we've learned that over the past 12
  • 00:02:41
    years of research not just us but others
  • 00:02:43
    around the world that if we don't have a
  • 00:02:46
    certain level of C15 in our cell
  • 00:02:48
    membrane this sturdy saturated fatty
  • 00:02:51
    acid in our cell membrane our cell
  • 00:02:53
    membranes become weak we age faster than
  • 00:02:56
    we should and we now think it may
  • 00:02:59
    explain the onset of these aging
  • 00:03:01
    Associated diseases things like type 2
  • 00:03:03
    diabetes fatty liver disease heart
  • 00:03:05
    disease are increasing in younger and
  • 00:03:08
    younger people and now we think that the
  • 00:03:10
    c-15 deficiency syndrome cellular
  • 00:03:12
    fragility syndrome may be the cause of
  • 00:03:15
    why younger and younger people are
  • 00:03:17
    getting older diseases is it just
  • 00:03:19
    because the the cell becomes more like
  • 00:03:22
    penetrable to like all these different
  • 00:03:23
    things like how does how does that
  • 00:03:25
    really work how does a fragile cell
  • 00:03:28
    membrane
  • 00:03:30
    impact say like insulin resistance
  • 00:03:32
    things like that where's the interplay
  • 00:03:33
    there yeah so it's a fascinating story
  • 00:03:36
    and it goes back to 2012 so back in 2012
  • 00:03:39
    there was a group of scientists at
  • 00:03:41
    Columbia University and they published
  • 00:03:44
    this paper in which they discovered an
  • 00:03:46
    entirely new way that our cells were
  • 00:03:48
    dying and it's called ferroptosis or
  • 00:03:51
    fosis we just say if you're in England
  • 00:03:53
    it's for oposisi
  • 00:03:59
    but the key point being that these
  • 00:04:01
    researchers discovered entirely new way
  • 00:04:04
    our cells were dying prior to this
  • 00:04:05
    discovery there were only three known
  • 00:04:07
    ways that our cells could die called
  • 00:04:09
    apoptosis necrosis and autophagy and
  • 00:04:12
    this was just like you go to cell
  • 00:04:13
    biology class you know at your
  • 00:04:15
    University three ways our cells die
  • 00:04:18
    great they discovered a fourth and what
  • 00:04:21
    was really interesting about it is that
  • 00:04:23
    they discovered that there was a really
  • 00:04:25
    unique way that our cells were starting
  • 00:04:27
    to die and it started with l literally
  • 00:04:30
    the way they explain it is that there's
  • 00:04:31
    fragile fatty acids in the cell membrane
  • 00:04:35
    that then results in um lipid
  • 00:04:37
    peroxidation so lipid peroxidation is
  • 00:04:40
    when you have fragile fats they then go
  • 00:04:42
    bad so they get um exposed to oxygen
  • 00:04:45
    attack by oxygen they get lipid
  • 00:04:47
    peroxidation so now you have that and
  • 00:04:50
    then for some strange reason iron is
  • 00:04:53
    showing up inside of these cells and
  • 00:04:56
    when you combine lipid peroxidation with
  • 00:04:58
    iron that results in massive production
  • 00:05:02
    of these things called reactive oxygen
  • 00:05:04
    species or Ross the Ross then go and
  • 00:05:06
    kill our mitochondria and as we all know
  • 00:05:09
    right from our third grade classes
  • 00:05:10
    mitochondria is the PowerHouse of our
  • 00:05:12
    cells that knocks out our mitochondria
  • 00:05:15
    because I learned that like 10th grade
  • 00:05:18
    I'm sorry okay so I'm a nerd so yeah
  • 00:05:21
    yeah I know you and Eric just worked out
  • 00:05:24
    uh and I stood on the sideline so that
  • 00:05:26
    the nerd part was the
  • 00:05:28
    mitochondri um so uh yeah so powerhouses
  • 00:05:32
    of our cells so basically then knocks
  • 00:05:34
    out the batteries the energy producers
  • 00:05:36
    of our cells so when these scientists
  • 00:05:38
    were looking under the microscope at
  • 00:05:40
    Columbia University Thomas they were
  • 00:05:42
    seeing intact cells with kind of Strang
  • 00:05:44
    looking cell membranes and all the
  • 00:05:47
    mitochondria were killed and so they
  • 00:05:48
    said this cell is dead what is happening
  • 00:05:52
    that was discovered discovered in 2012
  • 00:05:55
    since then over
  • 00:05:57
    10,000 papers have been published
  • 00:05:59
    published on fosis from around the world
  • 00:06:03
    nobody has UND despite all that science
  • 00:06:06
    nobody has understood what causes froses
  • 00:06:09
    why did it show up on our doorstep right
  • 00:06:12
    about you know a dozen years ago and um
  • 00:06:16
    you know until now so now what we're
  • 00:06:18
    finding is that C15 deficiency what this
  • 00:06:21
    paper that we just published showed that
  • 00:06:24
    C15 deficiency is causing the beginning
  • 00:06:27
    the middle and the end of for Tois most
  • 00:06:30
    importantly we've been able to show that
  • 00:06:32
    putting c-15 back into our bodies fixes
  • 00:06:35
    it all so really exciting times so with
  • 00:06:38
    this uh study in particular like how was
  • 00:06:40
    it laid out what did it uh what exactly
  • 00:06:43
    how did you discover this deficiency
  • 00:06:45
    specifically with regard to this paper
  • 00:06:47
    yeah absolutely so it's really a
  • 00:06:49
    culmination of the 12 years of study so
  • 00:06:52
    the same year 2012 when fosis was
  • 00:06:55
    discovered by Columbia University which
  • 00:06:57
    you know to be honest I didn't know
  • 00:06:59
    about for many many years at the same
  • 00:07:01
    year that paper is published we
  • 00:07:03
    published a paper describing the strange
  • 00:07:06
    disease that was popping up in the
  • 00:07:08
    Navy's dolphins and dolphins in the wild
  • 00:07:10
    as well but increasingly there was this
  • 00:07:13
    liver disease that was popping up in
  • 00:07:15
    Navy dolphins and they had iron overload
  • 00:07:18
    in their livers and they were getting
  • 00:07:19
    fatty liver disease and insulin
  • 00:07:21
    resistance and things that older
  • 00:07:24
    Dolphins we get but we were starting to
  • 00:07:26
    see it in younger and younger Dolphins
  • 00:07:28
    so we were diving in to basically figure
  • 00:07:30
    out what was happening with the dolphins
  • 00:07:32
    what was causing it that's when we did a
  • 00:07:35
    advanced technology called metabolomics
  • 00:07:38
    we looked at thousands of small
  • 00:07:40
    molecules in their fish diet and in
  • 00:07:42
    their bodies to figure out which small
  • 00:07:44
    molecules predicted this syndrome that
  • 00:07:47
    we were seeing and that's where C15 was
  • 00:07:50
    one of the top predictors of dolphins
  • 00:07:52
    who weren't getting this disease so that
  • 00:07:55
    headed us down this pathway of taking
  • 00:07:57
    c-15 into the lab we were then able to
  • 00:08:00
    show um in the lab that c-15 helps to
  • 00:08:05
    fix all components of fosis it
  • 00:08:08
    stabilizes cell membranes by greater
  • 00:08:10
    than 80% so it you know stops it right
  • 00:08:12
    at the top of the problem it um
  • 00:08:16
    decreases lipid peroxidation it stops
  • 00:08:19
    iron deposition so we'll talk a little
  • 00:08:20
    more about that um which is another
  • 00:08:23
    obviously key parts of ferroptosis the
  • 00:08:25
    Ferro being iron um it stops the
  • 00:08:28
    deposition of the iron it decreases the
  • 00:08:31
    amount of reactive oxygen species in the
  • 00:08:33
    cell and it repaired mitochondria so
  • 00:08:37
    that whole series of studies we
  • 00:08:39
    published back in
  • 00:08:40
    2020 in the paper uh and scientific
  • 00:08:43
    reports and so really what's been
  • 00:08:45
    happening since 2020 is it's been uh
  • 00:08:49
    understanding more and more of what's
  • 00:08:50
    been happening in people that has
  • 00:08:53
    overlaped with what's happening in
  • 00:08:54
    dolphins and US understanding oh my gosh
  • 00:08:58
    it's a decrease in c-15 globally that's
  • 00:09:01
    happening in the Dolphins it's because
  • 00:09:03
    the types of fish they were eating are
  • 00:09:05
    have less and less C15 in it as our
  • 00:09:07
    waters are getting warmer unfortunately
  • 00:09:10
    our fish are getting less fat there's
  • 00:09:12
    actually a study that just came out in
  • 00:09:14
    science showing that the world's fish
  • 00:09:17
    are getting smaller because the waters
  • 00:09:20
    are warmer so they have less fat L C5 to
  • 00:09:23
    the Dolphins for us we have less C15
  • 00:09:26
    globally we've been doing so for over 50
  • 00:09:28
    years by taking c-15 out of our diets
  • 00:09:31
    because our primary source of C15 is
  • 00:09:33
    dairy fat so we had this concurrent uh
  • 00:09:36
    you know coincidental decrease in c-15
  • 00:09:39
    in diets happening in dolphins and
  • 00:09:40
    humans the result however was the same
  • 00:09:43
    which was fosis um because of c-15
  • 00:09:46
    deficiencies that's so wild so what I do
  • 00:09:49
    know about ferroptosis I mean a lot of
  • 00:09:50
    it is it's iron deposition in the liver
  • 00:09:52
    specifically there's a like one of the
  • 00:09:54
    big components of it right that's right
  • 00:09:56
    so is that just sending like a Cascade
  • 00:09:59
    of high levels of of Ross directly from
  • 00:10:01
    the liver epicenter out of the liver and
  • 00:10:03
    kind of radiating out from there or is
  • 00:10:05
    it just concentrated in the liver or is
  • 00:10:07
    ferroptosis occurring independent of the
  • 00:10:09
    liver is it not just happening there I
  • 00:10:11
    mean and you may or may not know this
  • 00:10:13
    but what's actually causing the iron to
  • 00:10:16
    just deposit there like why is it
  • 00:10:18
    flocking to the liver and why is it just
  • 00:10:19
    because it's trying to get metabolized I
  • 00:10:21
    don't know I have questions there yeah
  • 00:10:22
    it's a it's a those are all great
  • 00:10:24
    questions so um and that's what's been
  • 00:10:26
    kind of hanging out there it's like what
  • 00:10:28
    how is this all happening right and so
  • 00:10:30
    it's almost like science has gotten
  • 00:10:31
    stuck in the weeds of looking at
  • 00:10:33
    specific genes and little triggers
  • 00:10:35
    inside the cell meanwhile we had this
  • 00:10:37
    like real life patient population that
  • 00:10:39
    was getting the syndrome you know the
  • 00:10:41
    Dolphins and we were really able to
  • 00:10:43
    understand exactly cleanly how this goes
  • 00:10:46
    down so um what we Now understand is
  • 00:10:49
    What's called the pathophysiology so the
  • 00:10:51
    whole thing of how c-15 deficiencies
  • 00:10:54
    lead to this entire syndrome and it all
  • 00:10:57
    starts with when we have low C15 in our
  • 00:11:00
    cells that includes our red blood cells
  • 00:11:03
    so let's start with our red blood cells
  • 00:11:05
    so then those red blood cells become
  • 00:11:07
    weak now our body has a really good way
  • 00:11:09
    of detecting weak red blood cells and
  • 00:11:12
    saying uh you shouldn't be in the system
  • 00:11:14
    anymore we're going to take you out so
  • 00:11:16
    you have these cells in the liver called
  • 00:11:18
    macroasia and their job is to basically
  • 00:11:22
    engulf and eat all the weak red blood
  • 00:11:25
    cells that we have in our body which
  • 00:11:27
    normally is a good thing
  • 00:11:29
    but what happens when we have a lot of
  • 00:11:31
    weak red blood cells because we have two
  • 00:11:33
    little C15 in those cells the macras
  • 00:11:36
    just eat them and the corpses of the red
  • 00:11:39
    blood cells that are left behind ah IR
  • 00:11:42
    kind iron yep yeah so what happens is
  • 00:11:44
    then it accumulates over time our bodies
  • 00:11:47
    are still able to make these red blood
  • 00:11:49
    cells so they get taken out of the
  • 00:11:50
    system we make more so you know when you
  • 00:11:53
    don't necessarily have anemia in the
  • 00:11:56
    early stages but there is a measurement
  • 00:11:58
    called red blood cell distribution width
  • 00:12:01
    or RDW and it's one of the first things
  • 00:12:03
    we saw in the Dolphins which just means
  • 00:12:05
    that your red blood cell sizes are just
  • 00:12:08
    there's a lot of variation there's some
  • 00:12:09
    big ones some little ones it just means
  • 00:12:11
    that your body's working you're losing
  • 00:12:13
    red blood cells you're making them and
  • 00:12:14
    you just have this mix of sizes so it's
  • 00:12:16
    one of the first hints of um something
  • 00:12:20
    is going wrong and RDW is actually a
  • 00:12:22
    predictor of longevity um in people so
  • 00:12:26
    we can get back to the whole longevity
  • 00:12:27
    conversation so it's a fascinating
  • 00:12:30
    metric that's gained a lot of traction
  • 00:12:32
    so again we think it's all tied to this
  • 00:12:34
    pH proptosis so the um red blood cells
  • 00:12:37
    become weak the iron or the the liver
  • 00:12:40
    engulfs them you now have iron
  • 00:12:43
    deposition in the liver you now have an
  • 00:12:45
    angry liver so now we're talking about a
  • 00:12:47
    liver that's getting increased iron and
  • 00:12:51
    along with these fragile cells in the
  • 00:12:53
    liver as well so you have lipid
  • 00:12:54
    peroxidation iron faptos has now kicked
  • 00:12:56
    in in the liver so then what happens is
  • 00:12:58
    the next um signal and sign are elevated
  • 00:13:01
    liver enzymes so the liver is now saying
  • 00:13:04
    hey I'm getting a little bit angry here
  • 00:13:06
    cuz my cells are getting injured and
  • 00:13:09
    that's one of the first signals they
  • 00:13:10
    throw off um from there then just like
  • 00:13:13
    you were kind of getting to right is
  • 00:13:15
    that what happens is when you get enough
  • 00:13:17
    iron overload in the liver you get a
  • 00:13:20
    spillover effect you have increased Ross
  • 00:13:23
    you have increased lipid peroxidation
  • 00:13:25
    you have increased iron that iron lipid
  • 00:13:27
    peroxidation and reactive oxygen species
  • 00:13:30
    spill over into the blood and now they
  • 00:13:33
    start seeding our whole bodies so it
  • 00:13:35
    goes through these different stages and
  • 00:13:37
    that's where now there's tons of papers
  • 00:13:39
    talking about iron deposition in the
  • 00:13:41
    brain in the heart in the pancreas and
  • 00:13:44
    that's those are drivers for Alzheimer's
  • 00:13:48
    disease heart disease um type 2 diabetes
  • 00:13:51
    in addition to the initial liver disease
  • 00:13:53
    so that's how we clearly understand it
  • 00:13:57
    all happens we've been able to show that
  • 00:13:58
    c 15 reverses this entire process and it
  • 00:14:02
    starts at the very beginning we just
  • 00:14:04
    need to have stronger cells that stops
  • 00:14:06
    this whole process from kicking off it's
  • 00:14:09
    like the uh it's like the Roman Empire
  • 00:14:11
    like starting in Rome the like the liver
  • 00:14:14
    and like creating these little Depot
  • 00:14:15
    everywhere else that then from there
  • 00:14:18
    like cause problems there you know in
  • 00:14:19
    the heart and the brain and whatnot
  • 00:14:21
    because it's like it sounds like
  • 00:14:22
    everywhere you have a potential iron
  • 00:14:24
    deposition you have like another Factory
  • 00:14:26
    for Ross right you have another because
  • 00:14:28
    it's like the more oxidation that
  • 00:14:30
    happens there the more it's going to be
  • 00:14:32
    exacerbated in that area that's right
  • 00:14:34
    how does that particularly like with the
  • 00:14:36
    the Ross and the iron depositions how
  • 00:14:38
    does that relate to metabolic disease or
  • 00:14:42
    metabolic dysfunction like specifically
  • 00:14:44
    with like insulin resistance like how
  • 00:14:45
    does high a high level of Ross or a high
  • 00:14:48
    level of iron deposited somewhere impact
  • 00:14:51
    insulin resistance because I think for
  • 00:14:53
    most people that's a that's a hard thing
  • 00:14:55
    to bridge right it's like okay we've got
  • 00:14:57
    Ross but how does that impact glucose
  • 00:14:59
    and my you know that yeah absolutely so
  • 00:15:02
    so we now understand we now know that
  • 00:15:05
    when you have iron plus Ross right and
  • 00:15:07
    lipid peroxidation all happening first
  • 00:15:09
    in the liver the liver will stop um
  • 00:15:13
    producing uh the appropriate amount of
  • 00:15:16
    or it won't react appropriately to
  • 00:15:17
    glucose so you start getting the onset
  • 00:15:20
    of insulin resistance happening at the
  • 00:15:23
    liver side basically just because you
  • 00:15:24
    have broken liver cells in which the
  • 00:15:26
    liver is not responding appropriately to
  • 00:15:29
    basically keeping our glucose balanced
  • 00:15:31
    at the same time once iron deposition
  • 00:15:34
    and this whole process starts happening
  • 00:15:35
    in our pancreas our beta cells stop
  • 00:15:38
    producing insulin so we've got kind of a
  • 00:15:41
    one two hit of both our pancreas and
  • 00:15:44
    liver and when you combine those that
  • 00:15:46
    then sets you up for metabolic syndrome
  • 00:15:49
    right which is this High um insulin or
  • 00:15:51
    insulin resistance high glucose you get
  • 00:15:54
    this middle um you know
  • 00:15:56
    atopos uh a weight gain and then that
  • 00:15:59
    all sets you up for an increased risk of
  • 00:16:01
    heart disease stroke um and type 2
  • 00:16:04
    diabetes where we caught the Dolphins
  • 00:16:06
    was right at that stage of um basically
  • 00:16:09
    metabolic syndrome before it had
  • 00:16:12
    Advanced to these Advanced um you know
  • 00:16:14
    conditions so it was really at the
  • 00:16:16
    perfect spot to understand the
  • 00:16:18
    pathophysiology leading to that wow so
  • 00:16:20
    does a c-15
  • 00:16:23
    deficiency are you starting to see
  • 00:16:25
    direct links maybe not like right now
  • 00:16:27
    it's easy to say there's a potential
  • 00:16:28
    indirect direct link because you've got
  • 00:16:29
    the metabolic piece and that could
  • 00:16:31
    affect cardi metabolic and you know
  • 00:16:33
    cardiovascular disease and whatnot are
  • 00:16:35
    there any signs that there's direct
  • 00:16:36
    links with c-15 deficiency and fer
  • 00:16:38
    ferroptosis and cardiovascular disease
  • 00:16:40
    like independent of the metabolic side
  • 00:16:43
    yeah there is so with regard to you know
  • 00:16:45
    the Dolphins were an interesting and
  • 00:16:47
    again a clean model in which because
  • 00:16:49
    they weren't getting enough c-15 in
  • 00:16:51
    their diet because the fish had less C15
  • 00:16:53
    that we were able to see this we were
  • 00:16:55
    able then to repeat this in the lab so
  • 00:16:57
    to be able to show directly that there
  • 00:16:59
    are models of ferroptosis that then we
  • 00:17:02
    could show that c-15 could fix it so
  • 00:17:05
    we've got you know the side that the
  • 00:17:06
    Dolphins are indicating c-15
  • 00:17:08
    deficiencies cause it um able to show in
  • 00:17:11
    a model that c c-15 fixes it so then we
  • 00:17:14
    start moving to the human data right and
  • 00:17:16
    this is where we see um where we explain
  • 00:17:19
    in the paper um which is a beast of a
  • 00:17:22
    paper so if you're trying to
  • 00:17:24
    sleep that could help you sleep just by
  • 00:17:26
    trying to get through this paper so but
  • 00:17:28
    what it Works through this um uh logical
  • 00:17:32
    um arguments with regard to okay what is
  • 00:17:34
    faptos is known to do it is known to um
  • 00:17:37
    increase our risk of heart disease um
  • 00:17:40
    type 2 diabetes and fatty liver disease
  • 00:17:42
    it's really what we focus on not only
  • 00:17:44
    does it increase the risk of it but it
  • 00:17:46
    speeds up the onset of these diseases
  • 00:17:49
    and it makes it more aggressive so if we
  • 00:17:52
    talk about younger people so people with
  • 00:17:55
    um younger kids um people less than 20
  • 00:17:57
    years old getting type 2 diabetes right
  • 00:18:00
    so type two diabetes used to be an adult
  • 00:18:02
    onset disease and we used to call type 1
  • 00:18:04
    diabetes juvenile onset remember that
  • 00:18:08
    okay so at some point in time about when
  • 00:18:10
    all of this started happening children
  • 00:18:13
    started getting type two diabetes and
  • 00:18:15
    not only that but they're more
  • 00:18:17
    aggressive than the type two diabetes
  • 00:18:19
    that we're used to seeing they have a
  • 00:18:21
    higher risk rate and of complications in
  • 00:18:25
    even kids with type one diabetes which
  • 00:18:27
    that in itself is a devastating disease
  • 00:18:30
    so ferroptosis in this process is
  • 00:18:33
    showing up in younger people it's
  • 00:18:35
    explaining how they're getting more
  • 00:18:37
    aggressive diseases faster um people
  • 00:18:40
    between 18 to 44 year old uh 44 years
  • 00:18:43
    old increasingly getting coronary heart
  • 00:18:45
    disease I mean we were on an amazing
  • 00:18:47
    trajectory of decreasing heart disease
  • 00:18:50
    for decades still is the same case for
  • 00:18:52
    people over 50 so like I'm in the clear
  • 00:18:55
    but but for younger people The increased
  • 00:18:58
    risk of of um heart disease is has been
  • 00:19:01
    going way up when I get back to Ty type
  • 00:19:03
    2 diabetes 673 per increase is expected
  • 00:19:07
    in young people um by the year 2030 in
  • 00:19:10
    typ D IB so it's really and then we talk
  • 00:19:12
    about fatty liver disease right this is
  • 00:19:14
    a disease that didn't exist before a
  • 00:19:16
    paper was published by uh the Mayo
  • 00:19:18
    Clinic in 1980 they found the first 20
  • 00:19:21
    patients with fatty liver disease um
  • 00:19:24
    that wasn't associated with alcohol
  • 00:19:26
    right prior you see this disease it was
  • 00:19:28
    always associated with alcohol
  • 00:19:30
    consumption which is why they called it
  • 00:19:33
    non-alcoholic fatty liver disease or
  • 00:19:35
    non-alcoholic stat of hepatitis so Mayo
  • 00:19:37
    Clinic publishes this uh you know first
  • 00:19:40
    20 cases in 1980 today it's now
  • 00:19:43
    impacting one in three people globally
  • 00:19:46
    and one in 10 children so there's this
  • 00:19:49
    been this big mist of how is it
  • 00:19:50
    happening we're all understanding that
  • 00:19:52
    fosis is driving this process and this
  • 00:19:57
    speed up of the of the problem and now
  • 00:20:00
    it's being able to say okay um the
  • 00:20:03
    study's now linking showing people with
  • 00:20:05
    higher c-15 levels lower risk of type 2
  • 00:20:09
    diabetes heart disease and fatty liver
  • 00:20:11
    disease and this isn't just one study or
  • 00:20:13
    two study these are a
  • 00:20:15
    metaanalyses um of you know thousands of
  • 00:20:18
    people over Decades of time consistently
  • 00:20:21
    showing how much basically you know c-15
  • 00:20:25
    we need in order to protect against um
  • 00:20:27
    getting these diseas
  • 00:20:29
    I mean it's almost like we've been
  • 00:20:31
    looking at so many things in isolation
  • 00:20:33
    which we we should but at the same time
  • 00:20:35
    I mean it sounds like it's accelerated
  • 00:20:37
    aging is like really what's happening
  • 00:20:39
    it's like we're just finding that like
  • 00:20:41
    people at a younger age are experiencing
  • 00:20:44
    problems that shouldn't be an issue
  • 00:20:47
    maybe at all but are you know previously
  • 00:20:50
    an issue when they're over 50 60 years
  • 00:20:51
    old and it's like everything's just
  • 00:20:53
    accelerating so it's like okay here we
  • 00:20:54
    are looking at these sole things okay
  • 00:20:57
    like cardiovasculares or Diet diabetes
  • 00:20:58
    but we're not looking at dare I say the
  • 00:21:00
    root I hate when people say the root
  • 00:21:02
    because it sounds kind of cheesy but
  • 00:21:03
    it's like okay like the root really
  • 00:21:05
    seems like okay we're just moving
  • 00:21:06
    through this so fast and I'm kind of
  • 00:21:09
    thinking again like an iron deposition
  • 00:21:11
    and reactive oxygen
  • 00:21:14
    species it's Death By A Thousand Cuts
  • 00:21:16
    it's like you've got an iron deposition
  • 00:21:18
    I know we've talked about this before
  • 00:21:19
    but like you leave you know a bunch of
  • 00:21:21
    anvils or a bunch of dumbbells out in
  • 00:21:22
    the elements right it's like okay if you
  • 00:21:25
    had a little bit of oxygen they would
  • 00:21:28
    rust and they would you know have a
  • 00:21:30
    problem a little bit of the elements
  • 00:21:31
    they would have a problem but as the
  • 00:21:32
    weather gets worse it would just it
  • 00:21:34
    oxidize even more right so it's like
  • 00:21:36
    okay sure the iron deposition as a
  • 00:21:37
    result of this deficiency is problematic
  • 00:21:40
    but then you combine that with the
  • 00:21:42
    crappy lifestyle and it's like almost
  • 00:21:44
    literally throwing gasoline on this fire
  • 00:21:46
    right it's just it's just GNA take off
  • 00:21:48
    from there yeah that's exactly it I mean
  • 00:21:51
    examples include you know as far as you
  • 00:21:52
    know when you talk to pediatricians
  • 00:21:55
    these days and especially like we work
  • 00:21:57
    with Dr Jeff Schwimmer he's one of the
  • 00:21:59
    leaders in pediatric fatty liver disease
  • 00:22:02
    and you know we talked about and we
  • 00:22:04
    brought up this idea of like accelerated
  • 00:22:06
    aging and kids and like I didn't even
  • 00:22:09
    get to finish the sentence he's like oh
  • 00:22:10
    no this is absolutely what's happening
  • 00:22:12
    like kids are getting the diseases of
  • 00:22:14
    their grandparents before their parents
  • 00:22:17
    get them he's like it's unquestionable
  • 00:22:18
    there's accelerated aging happening in
  • 00:22:20
    these kids it's not only impacting their
  • 00:22:23
    kind of like you see them getting high
  • 00:22:25
    blood pressure and high cholesterol I
  • 00:22:27
    mean it's just you know it's and he goes
  • 00:22:29
    and there are you know mental health um
  • 00:22:31
    problems that are coming with it it's
  • 00:22:32
    like you know there's just this giant
  • 00:22:35
    you know ball of twine that is just like
  • 00:22:38
    that they're getting caught up in so
  • 00:22:41
    there isn't C15 is not like oh and
  • 00:22:43
    that's it and that's the only problem
  • 00:22:44
    and that you know it's but a lot of it
  • 00:22:47
    as far as you know when we look back and
  • 00:22:49
    you look back at what is causing this
  • 00:22:51
    why are younger people getting these
  • 00:22:52
    diseases a lot of people fall back on
  • 00:22:54
    Obesity well it's like well you know
  • 00:22:57
    kids are more obese and this is what
  • 00:22:59
    happens with obesity and it's a pretty
  • 00:23:01
    simple problem they also talk about
  • 00:23:03
    trans fats or there's too much ultr
  • 00:23:06
    processed foods and those are all likely
  • 00:23:10
    contributors to the problem but for us
  • 00:23:12
    it's like we go back to the Dolphins
  • 00:23:14
    yeah and the Dolphins aren't obese they
  • 00:23:17
    aren't getting you know Ultra processed
  • 00:23:18
    foods and they're not eating a bunch of
  • 00:23:20
    trans fatty acids so for them they again
  • 00:23:23
    provided this amazingly clean picture of
  • 00:23:26
    they decreased their amount of C5
  • 00:23:29
    we can now quantify how much C15 needs
  • 00:23:32
    to be in those cells it's
  • 00:23:34
    0.2% of fatty acids in our cell membrane
  • 00:23:37
    we need at least that for that cell
  • 00:23:40
    membrane to stay intact you have less
  • 00:23:42
    C15 than that and that is now what we're
  • 00:23:44
    defining as nutritional deficiency
  • 00:23:47
    syndrome or now makes a lot of sense
  • 00:23:48
    cellular fragility syndrome so the good
  • 00:23:51
    thing is we can now measure and detect
  • 00:23:53
    how much is in there and then you know
  • 00:23:56
    detect who has the deficiencies and most
  • 00:23:58
    most importantly how to fix it how can
  • 00:24:00
    we get our world back to where we could
  • 00:24:03
    have these healthy cells um that are
  • 00:24:05
    meant to Keep Us Alive and long and
  • 00:24:08
    healthy for a long long period of time I
  • 00:24:11
    don't know if you know listeners
  • 00:24:13
    understand the the magnitude because it
  • 00:24:16
    took me a long time to like understand
  • 00:24:18
    the magnitude of like what a true
  • 00:24:20
    clinical deficiency is like we haven't
  • 00:24:23
    had a clinical deficiency that we could
  • 00:24:26
    say is a legit clinical deficiency
  • 00:24:28
    people say oh I'm deficient in vitamin B
  • 00:24:30
    because I'm you know vegan or whatever
  • 00:24:32
    like it's not a clinical deficiency like
  • 00:24:34
    first of all like a lot of the
  • 00:24:35
    deficiencies we talk about are is
  • 00:24:37
    guesswork it's not we can assume or we
  • 00:24:40
    can get a micronutrient panel and see
  • 00:24:41
    that we're moderately deficient in
  • 00:24:43
    something but a clinical deficiency like
  • 00:24:44
    a real deficiency that's big news and
  • 00:24:47
    that's you know why this paper is is the
  • 00:24:49
    real deal to actually demonstrate that
  • 00:24:51
    we're seeing widespread like this is a
  • 00:24:54
    legit deficiency just like vitamin C
  • 00:24:57
    deficiency causes scurvy just like like
  • 00:24:59
    the real deal yeah I mean it's what was
  • 00:25:01
    critical for this paper was to be able
  • 00:25:03
    to define the pathophysiology of it so
  • 00:25:06
    you can't just say oh this is a normal
  • 00:25:09
    you know bell curve for c-15 levels in
  • 00:25:11
    people and if you have the low level
  • 00:25:13
    you're deficient right it's like no it's
  • 00:25:15
    like it's like it's a nutritional
  • 00:25:18
    deficiency requires one that the thing
  • 00:25:21
    that you're calling deficient that
  • 00:25:23
    nutrient has to be essential so it means
  • 00:25:26
    that we have to get certain amounts our
  • 00:25:28
    body has to have certain amounts of it
  • 00:25:31
    in order to just maintain Baseline
  • 00:25:33
    health and in the absence of it we fall
  • 00:25:36
    apart right and that's very very rare so
  • 00:25:39
    we're talking about our vitamins right
  • 00:25:41
    so vitamin C vitamin D um and then the
  • 00:25:43
    second part is that not only proof that
  • 00:25:47
    if levels are low you develop a disease
  • 00:25:49
    because of those levels but when you
  • 00:25:51
    restore that nutrient back into the
  • 00:25:53
    system that then that specific
  • 00:25:56
    deficiency syndrome is fixed and so
  • 00:25:59
    that's what this paper goes in
  • 00:26:01
    incredible detail has 150 um or 142 uh
  • 00:26:06
    references I've been up for six
  • 00:26:08
    days let get your highlighter out but
  • 00:26:11
    you know so it's um that it goes into
  • 00:26:14
    detail of basically checking off all of
  • 00:26:16
    those boxes um where you know it's it's
  • 00:26:19
    now it's it is well defined it is shown
  • 00:26:22
    that it's caused by um deficiencies in
  • 00:26:24
    C15 it is fixed by C15 it's very
  • 00:26:27
    definable and this all of this showed up
  • 00:26:29
    for oposisi aging all of it showed up at
  • 00:26:33
    the same time we've been taking c-15 out
  • 00:26:36
    of our diets so this you know experiment
  • 00:26:39
    uh that we've done over the last 50
  • 00:26:41
    years um
  • 00:26:43
    unintentionally um for bad reasons um
  • 00:26:46
    you know has by taking C15 out of our
  • 00:26:48
    diets we've basically you know tested
  • 00:26:51
    the hypothesis of is C15 really an
  • 00:26:54
    essential fatty acid um which is what we
  • 00:26:57
    discovered you know back in 20 I want to
  • 00:26:59
    talk about Sardinia for a second because
  • 00:27:01
    like Sardinia is very interesting anyway
  • 00:27:04
    from a longevity perspective I've done
  • 00:27:07
    pretty detailed videos on just multiple
  • 00:27:09
    aspects I mean ranging from like the The
  • 00:27:12
    Grapes grown at high altitude for the
  • 00:27:14
    specific wine the mastic oil um even
  • 00:27:17
    Mastic Gum like other components of
  • 00:27:19
    their diet like a lot of dairy from
  • 00:27:22
    sheep a lot of like very interesting
  • 00:27:25
    diet and in isolation like Sardinia is
  • 00:27:28
    one of the most unique blue zones to
  • 00:27:30
    begin with like it's it has its own
  • 00:27:33
    outlying aspects of it that are
  • 00:27:35
    different from the other blue zones
  • 00:27:37
    independently and I don't want to you
  • 00:27:39
    know go off on my own like high horse
  • 00:27:41
    about it but it's just so interesting
  • 00:27:43
    like you protein consumption is a little
  • 00:27:45
    bit higher in Sardinia than a lot of the
  • 00:27:46
    other ones and um and you mentioned
  • 00:27:50
    something before we were filming about
  • 00:27:51
    Sardinia that I didn't know and that was
  • 00:27:53
    about a specific kind of cheese that
  • 00:27:55
    they eat there and I want to kind of
  • 00:27:56
    double down on that cuz that's really
  • 00:27:58
    interesting can you tell me a little bit
  • 00:28:00
    more about that yeah absolutely so so
  • 00:28:02
    you know Sardinia is FC you're correct
  • 00:28:04
    very fascinating um with regard to uh
  • 00:28:07
    you know it's one of the five longevity
  • 00:28:09
    blue zones as you mentioned Thomas and
  • 00:28:11
    so with Sardinia the other thing that's
  • 00:28:14
    unique about it you know because it's
  • 00:28:15
    called the island of centenarians right
  • 00:28:17
    where people are most likely to live to
  • 00:28:19
    100 years old and specifically men so
  • 00:28:21
    this actually has the largest population
  • 00:28:24
    or relative population of Long lived
  • 00:28:26
    centenarian men of anywhere in the world
  • 00:28:28
    even normally women live longer yeah
  • 00:28:31
    exactly so it's like oh so something
  • 00:28:33
    you're right that something is very
  • 00:28:35
    unique of what's happening in Sardinia
  • 00:28:37
    so as we were going through the papers
  • 00:28:39
    and working through okay what are normal
  • 00:28:41
    levels of c-15 because we what we do in
  • 00:28:44
    the paper is we help Define nutritional
  • 00:28:46
    deficiency you know what's low what's
  • 00:28:49
    normal and now what may be optimal C15
  • 00:28:53
    level so we have the opportunity here to
  • 00:28:55
    maybe not just get back to where we were
  • 00:28:57
    to healthy levels levels where our cells
  • 00:29:00
    keep us healthy the way nature intended
  • 00:29:03
    for maybe most of us but Sardinia is
  • 00:29:05
    providing a clue that there may be a way
  • 00:29:08
    that if we push c-15 levels even higher
  • 00:29:11
    we can actually help support longevity
  • 00:29:14
    and so with Sardinia they have levels so
  • 00:29:17
    on average um the average person today
  • 00:29:20
    has c-15 levels in their cell membranes
  • 00:29:22
    of 0 2% of total fatty acids which is
  • 00:29:26
    right that breaking point it's like you
  • 00:29:28
    may or may not get disease WEA you're
  • 00:29:30
    you know on either side of that 0 2% in
  • 00:29:33
    Sardinia even as you look at the older
  • 00:29:35
    people and our C15 levels naturally
  • 00:29:37
    decline as we get older right so we're
  • 00:29:38
    talking 0 2% in your average aged
  • 00:29:41
    population so in Sardinia they looked at
  • 00:29:44
    60 to 75 year olds and they have C15
  • 00:29:47
    levels of 64 so so more than three times
  • 00:29:51
    higher C5 levels were like what and so
  • 00:29:54
    this paper came out from M at all
  • 00:29:56
    showing and where they called out hey
  • 00:29:58
    people in Sardinia have very high C15
  • 00:30:01
    levels and so when we looked into that
  • 00:30:04
    and then we even when they get to 80 to
  • 00:30:05
    100 it does go down as they age but even
  • 00:30:08
    the 80 to 100 pluss still have 04 per.
  • 00:30:12
    and when they compare that to low
  • 00:30:14
    longevity Zone I shouldn't even put in
  • 00:30:15
    quotes to a low longevity Zone the low
  • 00:30:18
    longevity Zone had 2% so basically the
  • 00:30:20
    world is in a low longevity Zone C15
  • 00:30:24
    level so when we get back to Sardinia
  • 00:30:27
    it's like okay well how are they getting
  • 00:30:29
    C15 level so high there's a whole lot of
  • 00:30:31
    Hope here right so it's like how are
  • 00:30:32
    they doing it so when we looked at
  • 00:30:34
    Sardinia and just basically all the
  • 00:30:36
    papers tons of papers published on
  • 00:30:38
    Sardinia we found that they just like
  • 00:30:41
    you had mentioned they have they first
  • 00:30:45
    all the food that they eat comes from
  • 00:30:47
    what they make so it's local and they're
  • 00:30:51
    they have primarily replaced meat with
  • 00:30:55
    dairy so meat is only eaten maybe once a
  • 00:30:58
    week on Sundays and special occasions
  • 00:31:01
    otherwise they've basically repeat
  • 00:31:02
    replaced where most people eat meat with
  • 00:31:04
    dairy the dairy which is can be up to
  • 00:31:07
    25% of the caloric intake is dairy I'm
  • 00:31:10
    not recommending that for just in
  • 00:31:12
    general but remarkable right
  • 00:31:15
    so where we hit The Sweet Spot is the
  • 00:31:18
    type of dairy they're eating so they are
  • 00:31:20
    goat and sheep herders as you had
  • 00:31:22
    mentioned they it is in a mountainous uh
  • 00:31:25
    region of the island of sardini
  • 00:31:28
    and the goats and the Sheep are grazing
  • 00:31:31
    on mountainous grass now other Studies
  • 00:31:35
    have shown that not only does do
  • 00:31:38
    grass-fed animals produce milk with
  • 00:31:40
    higher c-15 so if you take a cow and you
  • 00:31:42
    feed it grass just any type of grass it
  • 00:31:44
    will have twice as much C15 in its milk
  • 00:31:46
    than a cow that is fed 100% corn so
  • 00:31:49
    there's already right a huge
  • 00:31:50
    differentiate in there so we know that
  • 00:31:52
    eating the grass there are other studies
  • 00:31:54
    show that not only is eating grass going
  • 00:31:57
    to help but the higher the altitude the
  • 00:31:59
    grass the higher the C15 in their milk
  • 00:32:02
    so now you've got gr mountainous grass
  • 00:32:05
    eating local ghosts and sheep um
  • 00:32:09
    creating this um milk that is very high
  • 00:32:13
    in C15 so like double the amount of C15
  • 00:32:16
    as other animals and we know why right
  • 00:32:19
    it's they're eating mountainous grass
  • 00:32:20
    closer to the Sun perhaps maybe like
  • 00:32:22
    something happening in the grass there
  • 00:32:24
    where very well could be I mean the same
  • 00:32:26
    thing was repeated in the Alps so they
  • 00:32:28
    went there was a separate study done in
  • 00:32:29
    the Alps and they showed that uh the Alp
  • 00:32:32
    grass um had led to higher C15 in milk
  • 00:32:35
    and cows that were gracing in Alpine
  • 00:32:38
    grass versus others so you know this is
  • 00:32:41
    actionable right so this is something
  • 00:32:43
    that can be done indust you not
  • 00:32:46
    necessarily industrywide but there shows
  • 00:32:48
    that there's hope for us to be able to
  • 00:32:49
    get c-15 hire c-15 back into our Dairy
  • 00:32:52
    so when we look at the cheeses they eat
  • 00:32:55
    um they eat peino cheese which is a hard
  • 00:32:59
    sheep cheese and peoni cheese has C15
  • 00:33:02
    levels that are twice as much as even
  • 00:33:03
    cow's butter which was previously seen
  • 00:33:05
    as like the high C15 one so peino cheese
  • 00:33:09
    great um they have another type of
  • 00:33:11
    cheese that they eat that's like a soft
  • 00:33:13
    goat cheese that they age for 30 days
  • 00:33:17
    and what studies showed is that the c-15
  • 00:33:20
    in those or the fatty acids in that
  • 00:33:22
    cheese are actually free fatty acids so
  • 00:33:24
    it there's over that aging period the
  • 00:33:27
    fatty acids go from these complex lipids
  • 00:33:29
    to these like easy and bioavailable free
  • 00:33:32
    fatty acids so now not only do you have
  • 00:33:34
    C higher c-15 it's now more bioavailable
  • 00:33:37
    because it's a free fatty acid so then
  • 00:33:39
    you add those together and it's like
  • 00:33:41
    that's how they're getting high
  • 00:33:42
    C15 and associated with um lower heart
  • 00:33:46
    disease so people in Sardinia live
  • 00:33:48
    longer because they're less likely to
  • 00:33:50
    die of heart disease which is why men
  • 00:33:52
    are living longer um and now numerous
  • 00:33:56
    studies showing that people with higher
  • 00:33:58
    15 especially between 04 to 0.55% lower
  • 00:34:02
    risk of eing heart disease so you know
  • 00:34:05
    everything starts coming together with
  • 00:34:07
    regard to Sardinia is giving us a lot of
  • 00:34:09
    hope that can we repeat that you know
  • 00:34:11
    model globally it's I know there is some
  • 00:34:15
    literature over a decade ago too on like
  • 00:34:18
    high altitude uh cows in Switzerland and
  • 00:34:21
    the cheese having higher levels of
  • 00:34:23
    conjugated lenic acid as well which is
  • 00:34:25
    again another you know really important
  • 00:34:27
    compound
  • 00:34:28
    when you look at uh so just to clarify
  • 00:34:29
    like c-15 this is an essential fat that
  • 00:34:32
    body can't create it so it has to come
  • 00:34:34
    from the diet that's right yeah so it's
  • 00:34:36
    you know because I know obviously
  • 00:34:37
    there's there's certain compounds in the
  • 00:34:38
    body where well maybe we could dig a
  • 00:34:40
    little deeper and understand why we're
  • 00:34:42
    not producing enough of it yada out of
  • 00:34:43
    it this isn't the case this is purely
  • 00:34:45
    something we would get from the diet
  • 00:34:48
    yeah exactly and so you know there there
  • 00:34:49
    is our body has some production of um
  • 00:34:53
    C15 uh some of it can come from when we
  • 00:34:55
    eat fiber uh that fiber uh contains
  • 00:34:59
    inulin inulin feeds microbes in our gut
  • 00:35:02
    and those microbes can use inulin to
  • 00:35:04
    make c-15 so there's some production
  • 00:35:06
    it's still coming from the diet because
  • 00:35:08
    we're eating the fiber um and that you
  • 00:35:10
    know that can create some C15 the big
  • 00:35:13
    thing with regard to the essential fatty
  • 00:35:14
    acid you know that you're talking about
  • 00:35:16
    um Thomas is that do we make enough C15
  • 00:35:20
    to be able to
  • 00:35:22
    support the you know long-term health
  • 00:35:24
    and what it appears to be is that we can
  • 00:35:26
    get enough
  • 00:35:28
    our bodies can do enough to get to or
  • 00:35:30
    whatever we're eating whatever it is
  • 00:35:32
    that we're eating gets a successful to
  • 00:35:34
    this 0 2% but we need to get above that
  • 00:35:38
    and it's not that much more it's just
  • 00:35:40
    like we just have to get out of this
  • 00:35:42
    danger zone and get into the safe zone
  • 00:35:45
    of having ourselves stable enough it it
  • 00:35:48
    appears to be very clear that we have to
  • 00:35:50
    have some amount of C15 in our diet to
  • 00:35:53
    be able to achieve those levels and
  • 00:35:54
    hence the essentiality yeah I mean it's
  • 00:35:56
    it's not it's not realistic I mean as
  • 00:35:58
    much as I would love to pack up and move
  • 00:36:00
    to Sardinia like I probably wouldn't
  • 00:36:02
    complain like it's not realistic for us
  • 00:36:04
    to get 25% of our our calories from you
  • 00:36:07
    know from dairy that's just unrealistic
  • 00:36:09
    so it's you know when you look at okay
  • 00:36:11
    sure these populations they've got it
  • 00:36:14
    going on like I mean I know from the
  • 00:36:16
    case of Sardinia U like happiness scores
  • 00:36:19
    with men are significantly higher I know
  • 00:36:21
    like they the men have I can't remember
  • 00:36:24
    what they it's a specific term for it
  • 00:36:25
    but the men have more DED at like social
  • 00:36:28
    time whereas like in other regions men
  • 00:36:31
    are a little bit more isolated also
  • 00:36:32
    focused on work and things like that
  • 00:36:34
    there's a like a lifestyle component
  • 00:36:35
    that allows men a little bit more of
  • 00:36:38
    this like social aspect that is seems
  • 00:36:39
    higher than in other regions so there's
  • 00:36:41
    a happiness score with the men um so
  • 00:36:43
    that might add into that I mean the
  • 00:36:44
    whole lifestyle with Sardinia is amazing
  • 00:36:47
    obviously the like the mineral profile
  • 00:36:49
    they get from the shellfish it's you you
  • 00:36:51
    talk about death by a Thousand Cuts in
  • 00:36:52
    this case it's like the other right it's
  • 00:36:54
    like it's like okay they've just got
  • 00:36:55
    it's in isolation so many things going
  • 00:36:58
    for them and then you look at okay well
  • 00:37:01
    if we even tried to engineer that into
  • 00:37:04
    our lives in the United States first of
  • 00:37:07
    all I don't think that it would be the
  • 00:37:10
    same equation with bow Vine Milk you
  • 00:37:12
    know so you go to the US and it's like I
  • 00:37:15
    mean I I don't know the statistic if I
  • 00:37:16
    had to guess it's probably more than 98%
  • 00:37:18
    is consumption of Bine milk versus goat
  • 00:37:20
    milk most people I talked to don't even
  • 00:37:22
    like goat I love goat milk but goat milk
  • 00:37:23
    and goes most people just want so it's
  • 00:37:25
    like okay already you're at a lower
  • 00:37:27
    amount of C15 to begin with not to
  • 00:37:30
    mention I'm going to get in trouble for
  • 00:37:32
    saying this but there's probably less
  • 00:37:33
    pasteurization and stuff occurring like
  • 00:37:35
    in Sardinia like it's probably more raw
  • 00:37:36
    milk consumption and you know that's
  • 00:37:39
    only allowed in eight states in the
  • 00:37:40
    United States to even have raw milk in
  • 00:37:41
    the first place so who knows I you might
  • 00:37:44
    know I mean if if pasteurization breaks
  • 00:37:46
    down some of the C15 I don't know it's
  • 00:37:48
    the bottom line is like it's probably
  • 00:37:50
    unrealistic to get adequate amounts of
  • 00:37:53
    C15 you know from from the diet uh you
  • 00:37:56
    know via dairy in the States yeah I I
  • 00:37:59
    think you know Thomas it's it's a good
  • 00:38:00
    point like we used to I mean because it
  • 00:38:04
    seems like we used to get enough and
  • 00:38:07
    because the point is you know gosh over
  • 00:38:09
    what's been happening this accelerated
  • 00:38:11
    aging the increase in type 2 diabetes
  • 00:38:13
    and heart disease and you know um fatty
  • 00:38:15
    liver disease showing up something is
  • 00:38:18
    worse now than it was before like prior
  • 00:38:21
    1990 and you know
  • 00:38:23
    1990s is when 1977 is when Congress
  • 00:38:27
    released recommendations saying hey um
  • 00:38:31
    saturated all saturated fats are bad for
  • 00:38:33
    you specifically stop drinking whole fat
  • 00:38:35
    milk and stop eating butter and that
  • 00:38:37
    will save your hearts um that ended up
  • 00:38:40
    being partly true and partly devastating
  • 00:38:43
    right so in that whole dairy fat it
  • 00:38:47
    contains that from from cows has one
  • 00:38:51
    less one or less than 1% C15 of all the
  • 00:38:55
    fats it has more than 40%
  • 00:38:57
    pro-inflammatory saturated fats so C15
  • 00:39:01
    you know even in dairy fat especially
  • 00:39:03
    the ones that we're talking about you
  • 00:39:04
    know not in Sardinia are kind of having
  • 00:39:06
    to go an uphill battle with regard to
  • 00:39:10
    C15 be able to do its good job battling
  • 00:39:13
    against you know much higher levels of
  • 00:39:15
    these pro-inflammatory fats other
  • 00:39:17
    Studies have shown that the higher fat
  • 00:39:20
    we eat um with C15 in it the less likely
  • 00:39:24
    our c-15 levels will actually go down
  • 00:39:26
    and that is because when we go to absorb
  • 00:39:28
    all those fats at the same time in the
  • 00:39:30
    food c-15 loses and so we're have a
  • 00:39:33
    higher tendency to absorb these
  • 00:39:35
    pro-inflammatory fats versus C15 so
  • 00:39:38
    there are a lot of things that kind of
  • 00:39:40
    put Dairy at odds There's Hope because
  • 00:39:44
    it's worse than it was so then the
  • 00:39:45
    question is can we get to Sardinian
  • 00:39:47
    level you know which is which is your
  • 00:39:49
    challenge right personally your
  • 00:39:52
    challenge our challenge globally
  • 00:39:55
    challenge accepted all right good deal
  • 00:39:57
    go have some peina um so uh so you know
  • 00:40:02
    can we get to Sardinia even if we were
  • 00:40:05
    at 1950s you know us probably not
  • 00:40:09
    because of all these other challenges
  • 00:40:10
    the last part to put in with regard to
  • 00:40:12
    Dairy is that there was a group of a
  • 00:40:15
    panelists and so these were experts in
  • 00:40:17
    dairy fat and in nutrition uh they met
  • 00:40:20
    in um Europe back in 2017 and they asked
  • 00:40:25
    this question which is okay whole dairy
  • 00:40:27
    fat or individual ingredients within uh
  • 00:40:31
    within dairy fat is there really a
  • 00:40:32
    difference because we're always taught
  • 00:40:34
    that whole food is better and in most
  • 00:40:35
    cases this is absolutely true what they
  • 00:40:38
    concluded is that dairy fat because
  • 00:40:40
    they're over 400 fatty acids there just
  • 00:40:43
    a lot happening in Dairy F we were
  • 00:40:45
    talking about how much variation there
  • 00:40:47
    can be in dairy fat that thousands of
  • 00:40:51
    studies being done on dairy fat conclude
  • 00:40:54
    that you it does not reliably improve
  • 00:40:56
    our metabolic heart and Liver Health
  • 00:40:58
    there are studies that show that it does
  • 00:41:00
    there are just as many studies showing
  • 00:41:02
    that it doesn't so their conclusion was
  • 00:41:05
    you can't just eat more dairy fat um to
  • 00:41:07
    get these individual nutrients to
  • 00:41:09
    support your metabolic heart and Liver
  • 00:41:11
    Health what they did conclude is that
  • 00:41:14
    individual nutrients within dairy fat
  • 00:41:17
    can have a beneficial effect but they
  • 00:41:19
    have to be taken out of that milu what
  • 00:41:23
    they call the Matrix in order to be able
  • 00:41:26
    to have their fact and this sounds like
  • 00:41:28
    a spin but it's you know this is a group
  • 00:41:30
    that has no bias um and what they their
  • 00:41:33
    conclusion is they're just times in
  • 00:41:36
    which you know we can use nature to find
  • 00:41:38
    a nutrient that can really shine when it
  • 00:41:40
    doesn't need to compete especially with
  • 00:41:42
    these changes in agriculture um that we
  • 00:41:46
    have less and less control over so that
  • 00:41:48
    was a really long Answer to No but it's
  • 00:41:50
    I mean it's and part of me thinks too is
  • 00:41:52
    like okay the sardinians also eat in a
  • 00:41:56
    pretty like consistent deficit all the
  • 00:41:59
    time right so it's like you can't deny
  • 00:42:01
    the literature that
  • 00:42:03
    supports heavy saturated fat consumption
  • 00:42:06
    being problematic specifically in a
  • 00:42:09
    surplus right like that's like I haven't
  • 00:42:11
    seen a lot of data to support like I
  • 00:42:13
    just don't think the cohort really
  • 00:42:14
    exists to be like hey like let's look at
  • 00:42:16
    people that consume high amounts of
  • 00:42:17
    saturated fat but they're also in a
  • 00:42:18
    deficit like that pretty much doesn't
  • 00:42:20
    exist in America like if you're eating
  • 00:42:21
    saturated fat you are probably in the
  • 00:42:24
    category like high amounts of saturated
  • 00:42:25
    fat you're you're not doing a carore
  • 00:42:27
    diet you're not doing this you're
  • 00:42:28
    probably in the category of people that
  • 00:42:30
    are getting saturated fat from fried
  • 00:42:31
    foods and things so it's just the cohort
  • 00:42:34
    doesn't exist we can't look at that you
  • 00:42:35
    know so it's like you look at Sardinia
  • 00:42:36
    it's like sure their saturated fat
  • 00:42:38
    consumption as a percentage of their
  • 00:42:39
    diet is probably astronomically high but
  • 00:42:41
    they're also living in a probably
  • 00:42:44
    consistent 10 to 15% deficit and they're
  • 00:42:46
    probably having all these other factors
  • 00:42:49
    that are positively compounding that
  • 00:42:52
    right so it's the saturated fat the
  • 00:42:55
    there's less it's granted a little bit
  • 00:42:56
    of amnesty because it's overridden by
  • 00:42:59
    all this other positive stuff you apply
  • 00:43:00
    that to the us if you were to tell
  • 00:43:02
    people in the US it's almost dangerous
  • 00:43:03
    it would almost be irresponsible to say
  • 00:43:05
    hey United States as a whole people that
  • 00:43:08
    don't have nutrition education you need
  • 00:43:10
    to eat more cheese is the first thing
  • 00:43:12
    they're going to probably do is go to
  • 00:43:15
    does Arby have cheese I don't know but
  • 00:43:17
    like you know they're going to go and
  • 00:43:18
    ask for more queso right like it's it's
  • 00:43:20
    different like it's it's I understand
  • 00:43:23
    the issue there I know that you know C15
  • 00:43:26
    just just like other uh you know some
  • 00:43:28
    other things like you can get in
  • 00:43:30
    supplement form you know you you guys do
  • 00:43:32
    a great job with fatty 15 and C15 there
  • 00:43:34
    and I'll link out to that down below but
  • 00:43:36
    I mean it sounds like that's I mean
  • 00:43:38
    really the way to go for specific C15
  • 00:43:42
    like in isolation yeah I think you know
  • 00:43:44
    there are multiple things we need to do
  • 00:43:46
    right and SOC now that there is really
  • 00:43:50
    is a true nutritional deficiency
  • 00:43:51
    syndrome we need to fix it so if you
  • 00:43:54
    know you find out that scurvy is caused
  • 00:43:56
    by vitamin C icy you don't come up with
  • 00:43:59
    other ways other than like let's start
  • 00:44:02
    with getting vitamin C C back and so
  • 00:44:05
    same thing here and so there are
  • 00:44:06
    multiple ways to be able to bring c-15
  • 00:44:08
    back into our lives you know Eric uh you
  • 00:44:11
    know my Navy physician husband and I
  • 00:44:13
    this was all discovered when we you were
  • 00:44:15
    working at the Navy you know as you know
  • 00:44:18
    myself as a civil servant and um you
  • 00:44:20
    know Eric as active duty
  • 00:44:22
    so um as we were doing the science and
  • 00:44:26
    the studies what became apparent to us
  • 00:44:29
    is that and working in cooperation with
  • 00:44:31
    the Navy is that we had an opportunity
  • 00:44:33
    for a pure C15 ingredient to be able to
  • 00:44:37
    be more potent bioavailable vegan
  • 00:44:40
    friendly to help with this problem so it
  • 00:44:44
    wasn't to create a market right it's
  • 00:44:47
    like unfortunately the Dolphins were
  • 00:44:48
    showing there's a need and you know the
  • 00:44:51
    military way is that if you have a
  • 00:44:53
    problem research is invested on how to
  • 00:44:56
    fix it which is why all of this work how
  • 00:44:58
    about
  • 00:44:58
    that so was like I know this sounds
  • 00:45:01
    crazy but it's like office enval
  • 00:45:03
    research funded this work and it was
  • 00:45:05
    specifically to say hey we've identified
  • 00:45:07
    the syndrome in Dolphins here's the
  • 00:45:10
    money to do the research to figure out
  • 00:45:12
    what the problem is and to fix it and
  • 00:45:14
    you have X number of years it is not
  • 00:45:16
    like you spend your career working on
  • 00:45:18
    little intricacies of it and Publishing
  • 00:45:20
    papers it is a it's a problem that you
  • 00:45:23
    solve go fix it and so which we did and
  • 00:45:26
    we did and you know for the Dolphins we
  • 00:45:28
    did in about four years time because
  • 00:45:30
    that's what you do with the military so
  • 00:45:34
    this really was this whole thing was
  • 00:45:36
    born from saying hey we see a problem it
  • 00:45:40
    started with navy Dolphins right and
  • 00:45:43
    then now that extended to now global
  • 00:45:46
    health and so it's a problem and so one
  • 00:45:50
    way to fix it one part of the solution
  • 00:45:53
    is to have a pure ingredient that
  • 00:45:57
    basically helps take over or puts aside
  • 00:45:59
    these other barriers uh you know having
  • 00:46:02
    to compete with pro-inflammatory
  • 00:46:03
    saturated fats Let It Be vegan friendly
  • 00:46:06
    have it well controlled so that is more
  • 00:46:08
    than
  • 00:46:09
    99.8% pure at the exact amounts we need
  • 00:46:12
    we now know that the average person
  • 00:46:14
    needs between 100 to two milligrams at
  • 00:46:17
    least of pure B available c-15 per day
  • 00:46:20
    um so that is what the dose of fatty 15
  • 00:46:23
    was so this was all driven by a decade
  • 00:46:26
    of science before we even thought of
  • 00:46:28
    bringing you know this ingredient to the
  • 00:46:30
    market so we do feel strongly that this
  • 00:46:33
    ingredient will play an important role
  • 00:46:35
    with regard to for not just as a
  • 00:46:37
    supplement but fortifying Foods how do
  • 00:46:39
    we increase accessibility to c-15
  • 00:46:42
    globally because this problem is not
  • 00:46:44
    just in the US you know it's everywhere
  • 00:46:46
    mostly in developed um countries because
  • 00:46:49
    we've created this problem um and on top
  • 00:46:52
    of that okay what can we learn from
  • 00:46:54
    Sardinia okay so maybe um know cows we
  • 00:46:57
    should be feeding them more grass let's
  • 00:47:00
    put pressure on the industry to be able
  • 00:47:02
    to report for dairy products report how
  • 00:47:04
    much C15 is in your product so that when
  • 00:47:06
    consumers go to the store they can look
  • 00:47:09
    at the different dairy products and say
  • 00:47:10
    if I'm going to choose butter a or
  • 00:47:12
    butter B I'm going to choose the one
  • 00:47:13
    that has higher C15 in it so I think
  • 00:47:16
    there are ways um we can move forward
  • 00:47:18
    another one is with kids you know
  • 00:47:20
    pediatricians in the 1990s really made
  • 00:47:23
    this movement of saying um we went from
  • 00:47:27
    all Americans should avoid eating whole
  • 00:47:30
    fat drinking whole fat Dairy and eating
  • 00:47:33
    butter and that was 1977 through 1990
  • 00:47:36
    then around 1990 1991 the Pediatric
  • 00:47:39
    Community came in um again all with good
  • 00:47:43
    intentions but they then said okay young
  • 00:47:46
    children infants um and toddlers should
  • 00:47:50
    not get whole fat milk and it was pretty
  • 00:47:54
    bold um at the time so we went from
  • 00:47:57
    before 1990 a 12-month-old um child um
  • 00:48:02
    90% of them will have had whole fat milk
  • 00:48:04
    by the time they're one um today it's
  • 00:48:07
    less than 10% of children have been
  • 00:48:09
    exposed to whole fat cow's milk so it's
  • 00:48:13
    been a dramatic so now we're talking
  • 00:48:15
    about the youngest of young not getting
  • 00:48:19
    adequate c-15 levels even from Mom's
  • 00:48:22
    milk because if Mom is C c-15 deficient
  • 00:48:25
    she has less c-15 in her milkk so we're
  • 00:48:27
    talking about deficiencies that are
  • 00:48:29
    starting at Birth which is why we're
  • 00:48:32
    seeing this translating to these are now
  • 00:48:35
    um people turning 30 years old yeah I
  • 00:48:37
    mean we have massive like cell
  • 00:48:40
    differentiation that's occurring at that
  • 00:48:41
    age and it's like who knows even
  • 00:48:43
    epigenetically who knows like what
  • 00:48:45
    that's doing for them how it's setting
  • 00:48:46
    them up for or not setting them up for
  • 00:48:49
    success as they get older right it's
  • 00:48:50
    like when such a pivotal time yeah
  • 00:48:53
    there's a study that just came out in
  • 00:48:54
    fact it's a pre-print right now that
  • 00:48:56
    show in which um it's a big study done
  • 00:48:58
    in France and they follow um moms from
  • 00:49:01
    pregnancy and then um through baby being
  • 00:49:04
    born through the children developing and
  • 00:49:06
    right now they have the kids up to I
  • 00:49:07
    think about 11 years old and some of the
  • 00:49:09
    oldest ones in the cohort and what the
  • 00:49:11
    pre-print shows is that moms who had
  • 00:49:14
    less C15 in their red blood cell
  • 00:49:16
    membrane during pregnancy and in the in
  • 00:49:20
    their milk um resulted in kids uh if
  • 00:49:24
    they had lower C15 the kids don't
  • 00:49:27
    perform as well as 2year olds threeyear
  • 00:49:30
    olds and five and six year olds
  • 00:49:32
    cognitively um so it's just you know
  • 00:49:34
    like you're saying what does this mean
  • 00:49:36
    from a developmental level and so that
  • 00:49:39
    it's not like oh therefore all infants
  • 00:49:41
    should get fatty 15 right this is like
  • 00:49:44
    how about why don't we start by getting
  • 00:49:46
    whole fat milk safely you know back into
  • 00:49:49
    um you know into our youngest of young
  • 00:49:52
    and you know things like um infant
  • 00:49:54
    formulas have no c-15 in them no and so
  • 00:49:57
    separate papers you know made a call to
  • 00:50:00
    action saying we should be putting C15
  • 00:50:02
    fortifying C15 in infant formulas
  • 00:50:04
    because it's becoming clear and clear
  • 00:50:06
    this is an essential nutrient we we need
  • 00:50:08
    so there's a lot of things um to be done
  • 00:50:12
    we think you know fat5 and supplements
  • 00:50:15
    part of the solution but we're really
  • 00:50:17
    working with the whole Community Global
  • 00:50:18
    Community to fix you know a big problem
  • 00:50:21
    the upside is there's so much hope
  • 00:50:23
    because there's a solution yeah there I
  • 00:50:27
    and I have mixed feelings on like
  • 00:50:29
    fortification of foods but at the same
  • 00:50:31
    time it's like this is something where I
  • 00:50:33
    mean is that in your crosshairs at all
  • 00:50:35
    like just being like okay we've got like
  • 00:50:37
    good you know dairy product like okay we
  • 00:50:40
    fortify with vitamin D because we saw
  • 00:50:42
    that as an issue yeah like is there is
  • 00:50:44
    it in your crosshairs to see like hey
  • 00:50:46
    like we can or where's your stance on
  • 00:50:47
    fortification with C15 yeah I think in
  • 00:50:49
    this case it's you know c-15s it's it's
  • 00:50:51
    the next natural biggest impact step so
  • 00:50:55
    you know supplements are great great
  • 00:50:56
    because people could choose and we have
  • 00:50:58
    super Savvy you customers who do the
  • 00:51:01
    Deep dive on the science who listen to
  • 00:51:02
    you know your podcast and you know are
  • 00:51:05
    ready to learn are diving in they have a
  • 00:51:07
    lot of knowledge they come back with
  • 00:51:08
    really smart questions which we greatly
  • 00:51:11
    appreciate um and they're ready to come
  • 00:51:13
    in and be like the early adopters right
  • 00:51:16
    and um and so supplementation is a great
  • 00:51:18
    place to start where really the global
  • 00:51:21
    impact can be is going to be
  • 00:51:22
    fortification of of foods and the nice
  • 00:51:24
    thing about C15 as an ingredient is it's
  • 00:51:27
    really stable so a lot of times we think
  • 00:51:29
    about fats and fatty acids like omega-3
  • 00:51:31
    and Omega 6es those are oils those are
  • 00:51:33
    just tough T to like they get attacked
  • 00:51:36
    by oxygen so they go bad really fast we
  • 00:51:39
    happen to be gifted with c-15 in which
  • 00:51:41
    its whole role is a stabilizer so it
  • 00:51:44
    stabilizes our cells a big part of that
  • 00:51:46
    is because it's not an oil right it's a
  • 00:51:48
    it's a um a stable powder at room
  • 00:51:52
    temperature so that means it doesn't go
  • 00:51:54
    bad so this means it's just Prime to be
  • 00:51:57
    able to fortify Foods in anywhere in the
  • 00:52:01
    world and be a stable way to you know
  • 00:52:03
    get this nutrient you know back into
  • 00:52:05
    people's lives affordably uh so that's
  • 00:52:07
    really our next stop um is how do we use
  • 00:52:11
    this as part of uh you know a broad
  • 00:52:14
    solution is there a way for people to um
  • 00:52:18
    like see where their c-15 levels are at
  • 00:52:20
    or I mean is that is that even possible
  • 00:52:22
    now or is it really just right now it
  • 00:52:23
    takes pretty extensive work um so so it
  • 00:52:26
    used to be where you needed to get a
  • 00:52:28
    fatty acid panel um which isn't the end
  • 00:52:30
    of the world but it's not like you any
  • 00:52:32
    of us go to our doctors and they're like
  • 00:52:34
    oh here your here's your fatty acid pan
  • 00:52:36
    then uh I don't know if you not
  • 00:52:38
    everyone's uh you know I don't know if
  • 00:52:40
    anyone saw the South Park episode on the
  • 00:52:42
    uh it was the OIC episode but like n
  • 00:52:45
    quote the song The navigating the
  • 00:52:46
    American Healthcare System song that
  • 00:52:49
    Butters was singing I just it's amazing
  • 00:52:51
    and it just just so I'm just saying like
  • 00:52:53
    Okay here here's me going to go get an
  • 00:52:55
    essential fatty acid pan
  • 00:52:57
    uh it's going to take me two weeks of
  • 00:52:58
    going to four different doctors and
  • 00:53:00
    calling yeah so yeah fits right along
  • 00:53:03
    Butters and the fact that's butter is
  • 00:53:05
    kind of Butters Butters um so uh so now
  • 00:53:10
    uh so there are a lot of functional um
  • 00:53:13
    Physicians and Healthcare practitioners
  • 00:53:15
    that have been using a fatty acid panel
  • 00:53:16
    for maybe at least the F last five years
  • 00:53:19
    that has included C15 so we've talked to
  • 00:53:22
    a lot of as we've been working with a
  • 00:53:24
    lot of functional medicine practitioners
  • 00:53:26
    they're like oh my gosh wait we've
  • 00:53:28
    actually been collecting c-15 we didn't
  • 00:53:29
    know whether we should care about and as
  • 00:53:31
    they're going back Thomas they're like
  • 00:53:34
    writing us back and they're like oh my
  • 00:53:36
    gosh we see like 12% of the people that
  • 00:53:39
    you know of our you know patients that
  • 00:53:41
    we've been looking at over the past five
  • 00:53:43
    years 12% are unquestionable like we're
  • 00:53:46
    talking like 0.002% or 0.04 versus 0.2
  • 00:53:50
    right and uh and then another 12 to 14%
  • 00:53:53
    being in this like less than 0.2 to you
  • 00:53:56
    know 0.1% and so they're like no this is
  • 00:53:58
    real we're like well yeah you know it's
  • 00:54:01
    definitely real so the test has been
  • 00:54:04
    available um what we're now doing is
  • 00:54:06
    we've um partnered with gova Diagnostics
  • 00:54:09
    to be able to have an atome spot test um
  • 00:54:12
    for c-15 so that people can get their
  • 00:54:14
    c-15 levels measured um uh via uh goova
  • 00:54:19
    so this is theirs um independent but as
  • 00:54:22
    we were um making these discoveries
  • 00:54:24
    obviously the next next natural question
  • 00:54:26
    is well that's great but how do I know
  • 00:54:29
    what my C15 levels are so um now there's
  • 00:54:32
    a way to be able to do that i''d be
  • 00:54:34
    curious to test mine now I was just in
  • 00:54:35
    Europe for a month and I think I like
  • 00:54:37
    pretty much only the only thing I ate
  • 00:54:39
    was like drinking like six lattes a day
  • 00:54:42
    and eating cheese and the occasional
  • 00:54:44
    Pudo and that was like my diet for a
  • 00:54:46
    month so yeah I think you're probably be
  • 00:54:48
    in that
  • 00:54:50
    3.44 not quite Sardinian but get close
  • 00:54:53
    do you actually see is it something that
  • 00:54:54
    builds up over time or uh you see a
  • 00:54:56
    pretty rapid increase upon like
  • 00:54:59
    increasing not only diet but also
  • 00:55:00
    supplementation form of it yeah so in
  • 00:55:02
    general it takes I mean to to safely get
  • 00:55:05
    to understand where you're at the nice
  • 00:55:07
    thing that uh this test measures it it
  • 00:55:09
    actually measures the amount of C15 in
  • 00:55:11
    your red blood cell membranes so other
  • 00:55:13
    tests might measure serum and plasma
  • 00:55:15
    which kind of gets to what your you
  • 00:55:16
    might have the spike that goes up and
  • 00:55:18
    down it's less reliable like when you
  • 00:55:20
    talk about glucose versus hba1c this
  • 00:55:22
    would be your the red blood cell
  • 00:55:24
    membrane is like your HB A1C so it's a
  • 00:55:25
    more stable measurement and it's
  • 00:55:28
    stabilizing your cell membranes so to
  • 00:55:30
    actually get that measurement of your
  • 00:55:31
    cell membranes is the most directly
  • 00:55:33
    important um so it measures um those
  • 00:55:36
    levels um that you're then able to um
  • 00:55:40
    work off of from there interesting well
  • 00:55:43
    I will most importantly link out to the
  • 00:55:45
    study down because I I do know that and
  • 00:55:48
    I hope the viewers know that you know
  • 00:55:50
    the more eyeballs that get on a study
  • 00:55:52
    the better like it's algorithmic just
  • 00:55:55
    like everything else in the world now so
  • 00:55:57
    you know get eyeballs on the study
  • 00:55:58
    because this is one of those things
  • 00:55:59
    where it's like people say why isn't
  • 00:56:00
    this front page news it's like we focus
  • 00:56:01
    on so many other things and this is this
  • 00:56:03
    is clear legit science this is not
  • 00:56:05
    Fringe Weird Science cherry-picking
  • 00:56:07
    connect the dots BS like this is real
  • 00:56:10
    stuff and it needs the eyeballs on it
  • 00:56:12
    and that's why I brought you here and I
  • 00:56:14
    know yes you have a supplement company
  • 00:56:17
    with C15 and I'll link out to that down
  • 00:56:18
    below but that was not the purpose of
  • 00:56:20
    this video the purpose is like let's get
  • 00:56:22
    eyeballs on this study because people
  • 00:56:24
    legitimately need to know this yeah
  • 00:56:26
    thanks Thomas I mean we call oursel a
  • 00:56:28
    team of nerdy do Cutters and our whole
  • 00:56:30
    purpose is really to help improve Global
  • 00:56:33
    Health that was our job as a military
  • 00:56:35
    family it's our job you know with this
  • 00:56:37
    company so thank you for helping to get
  • 00:56:39
    the word out yeah awesome thank you for
  • 00:56:40
    coming and thanks Eric for the workout
  • 00:56:43
    this
  • 00:56:44
    morning all right so uh as always keep
  • 00:56:46
    it locked in the channel I'll link out
  • 00:56:48
    to everything down below and thank you
  • 00:56:49
    great thank you
Tags
  • c-15
  • cellular fragility
  • insulin resistance
  • metabolic syndrome
  • dairy fat
  • Sardinia
  • ferroptosis
  • aging
  • nutritional deficiency