Boost Your Brainpower with These 5 Tips from a Neurophysiologist & Elite Human Performance Coach
Summary
TLDRThis episode of the Reena Malik MD podcast features Louisa Nicola, a neurophysiologist and Human Performance Coach, discussing the importance of brain health and how it impacts overall life quality. Alzheimer's and other types of dementia are emphasizing as not being a normal part of aging, with lifestyle habits having a profound effect on whether or not these conditions develop. The conversation delves into how exercise, particularly aerobic and resistance training, along with neurocognitive exercises, are crucial for maintaining cognitive health and improving lifespan. Regular aerobic exercise is highlighted for its ability to remodel the heart and increase hippocampal volume, which is essential for memory. The podcast also discusses the impact of stress on cognitive function, the benefits of maintaining a regular sleep schedule, and the role of nutrition and supplements, such as omega-3s and creatine. Efforts to maintain brain health should begin in one's 20s to prevent diseases like Alzheimer's, which can begin developing early but may not show symptoms until later in life. Overall, the episode offers various strategies for enhancing brain performance, delaying cognitive decline, and achieving a "jacked brain" — a term coined by Louisa Nicola — through consistent, healthy lifestyle practices.
Takeaways
- 🧠 Alzheimer's prevention can start in your 20s.
- 🏋️♂️ Exercise, especially aerobic, significantly boosts brain health.
- 🛌 Regular sleep schedules are crucial for mental fitness.
- 🥦 Nutrition plays a key role in preventing cognitive decline.
- 🧘♀️ Reducing stress helps improve brain function.
- 🔄 Neuroplasticity allows the brain to rewire through experience.
- 💊 Supplements like omega-3s assist in maintaining brain health.
- 🌞 Exposure to natural light aids in setting circadian rhythms.
- 🎯 Setting goals can enhance mental focus and performance.
- 🌿 Plant diversity benefits brain-gut health.
- 🎨 Engaging in new learning activities promotes cognitive strength.
Timeline
- 00:00:00 - 00:05:00
The podcast opens with a focus on the importance of brain health, noting that symptoms of Alzheimer’s might begin in one’s 60s but can start as early as the late 20s. Dr. Reena Malik introduces her guest, Louisa Nica, who discusses ways to prevent Alzheimer’s and enhance brain function. The discussion covers the impact of improving brain quality on life quality, free strategies for boosting brain health, and the benefits of exercise on brain volume and health. The conversation also touches on sleep's role in brain health and potential supplements for brain function.
- 00:05:00 - 00:10:00
Louisa Nica elaborates on brain networks, particularly the prefrontal cortex, responsible for executive functions like decision-making and information processing. She underscores the brain's adaptability, or neuroplasticity, which enables it to form and strengthen networks based on information and experiences. The discussion highlights the influence of one’s environment and relationships on brain health and personal attraction, suggesting that a healthier brain may gravitate toward healthier relationships. Neuroplasticity allows the brain to rewire itself, thus forming new pathways that become habitual over time without needing constant motivation.
- 00:10:00 - 00:15:00
The podcast continues exploring neuroplasticity and its impact on habits, such as addiction. Louisa emphasizes that the brain doesn’t distinguish between right and wrong but processes the information it receives. Long-term bad habits can take significant effort to break because of the neurological and physiological adaptations they create, likened to strong emotional attachments. This underpins the difficulties in overcoming addictions and necessitates building cognitive reserves to resist negative thought patterns as people age, highlighting the challenge of maintaining strong decision-making capabilities.
- 00:15:00 - 00:20:00
Louisa introduces the concept of getting a 'jacked brain' by focusing on three components: functional, structural, and lifestyle adaptations to prevent brain-related disorders. She explains the difference between normal forgetfulness and concerning cognitive decline, emphasizing that while some memory loss is stress-related and not indicative of Alzheimer's, true dementia involves a gradual decline over decades, starting much earlier than symptoms appear. The importance of early lifestyle interventions is underscored in slowing or preventing the onset of such neurodegenerative diseases.
- 00:20:00 - 00:25:00
Alzheimer's disease involves complex brain changes, including the accumulation of amyloid plaques and tau protein tangles, which impair neural communication and eventually lead to neuron death. This neurodegeneration often starts in the hippocampus, leading to early symptoms like memory loss. The conversation elaborates on different types of dementia, such as frontotemporal dementia and vascular dementia, noting the serious, often overlapping symptoms that can severely affect patients and their families emotionally and practically.
- 00:25:00 - 00:30:00
The discussion shifts toward risk factors for Alzheimer's, distinguishing between genetic mutations, which predetermine disease onset, and genetic risk factors, which simply increase susceptibility. The APOE4 gene is highlighted as a significant but non-definitive risk factor; lifestyle choices also critically contribute to disease prevention. The conversation stresses personal responsibility in lifestyle changes to stave off dementia and Alzheimer’s, arguing these conditions are largely preventable with proactive health strategies beginning early in life.
- 00:30:00 - 00:35:00
Stress's effects on brain health are underscored, differentiating between harmful chronic stress and beneficial 'good stress' from activities like exercise or thermal exposure. These positive stresses foster neuroplasticity and support the brain's resilience. Louisa emphasizes managing stress through good sleep, exercise, and proactive mental engagement can enhance brain health and cognitive resilience. Tools like wearable tech can aid in monitoring stress levels, reinforcing the importance of cognitive and physical preparedness to navigate daily stressors.
- 00:35:00 - 00:40:00
Five key actions to boost brain health are discussed: exercise, sleep, social connections, stress management, and nutrition. Exercise, both aerobic and resistance, supports brain health by improving blood flow, enhancing cognitive functions, and promoting growth factors like BDNF. Louisa explains the physiological benefits of exercises, like cardiac remodeling and increased hippocampal volume, contributing to cognitive improvements. Maintaining regular physical activity helps preserve cognitive functions and delays brain aging.
- 00:40:00 - 00:45:00
The podcast highlights the significance of neurocognitive training as a complement to physical exercise. This involves engaging activities like reaction training, balancing, and coordination exercises to enhance brain function. Maintaining a network of quality social connections is also crucial for sustaining cognitive health into old age, as interpersonal interactions contribute to sustained mental engagement and emotional well-being. Regular, quality sleep supports brain repair and cognitive function, emphasizing the importance of sleep regularity over absolute duration.
- 00:45:00 - 00:50:00
The importance of high-quality sleep, particularly its role in removing brain waste through the glymphatic system and its influence on hormones like testosterone and growth hormone, is emphasized. Regular light exposure and consistent sleep schedules support cognitive health by stabilizing circadian rhythms, while measures such as maintaining a cool sleeping environment can enhance sleep quality. The discussion includes strategies for managing jet lag through strategic exposure to light and consideration of dietary and supplement adjustments during travel.
- 00:50:00 - 00:55:00
Dietary approaches to brain health include consuming foods rich in antioxidants, healthy fats, and essential nutrients like Omega-3 fatty acids. Incremental improvements in these areas can contribute to long-term brain health benefits. The role of certain supplements, such as vitamin D and omega-3s, is recognized for their potential to mitigate free radical damage and support brain function. However, the emphasis is placed on maintaining a balanced diet and only using supplements to address specific deficiencies, focusing on a plant-rich diet for overall health benefits.
- 00:55:00 - 01:00:00
Louisa discusses accessories to brain health, such as saunas and red light therapy, while underscoring the primacy of foundational health practices—exercise, sleep, and nutrition. These primary interventions are deemed more impactful than supplementary aids. The practical application of reducing bad stress through simple practices like adequate hydration or consistent exercise is reinforced. A holistic approach to lifestyle choices is advocated to achieve optimal brain health, indicating a preference for balanced, realistic health goals over sporadic or extreme measures.
- 01:00:00 - 01:05:00
The importance of limiting harmful intake, such as certain medications, is discussed in the context of brain health. This includes being aware of the cognitive impact of various over-the-counter and prescription drugs, such as anticholinergics. The collaborative role of health professionals in evaluating current medications and possibly reducing intake to optimize cognitive health is emphasized. The podcast suggests that brain health maintenance is achievable by making informed health decisions and establishing a proactive partnership with healthcare providers.
- 01:05:00 - 01:10:00
Strategies for maintaining high cognitive performance are discussed, highlighting the importance of cultivating healthy habits and establishing a consistent daily routine. Louisa suggests proactive goal setting and structuring daily life to harness neuroplasticity and stay motivated. The conversation underscores the necessity of integrating cognitive exercises and maintaining a balanced lifestyle to manage stress and enhance brain functionality, especially given the cognitive demands of high-performing roles and ambitions.
- 01:10:00 - 01:15:00
Louisa shares insights into the link between the brain and happiness, suggesting that happiness is constructed from various neurochemical processes influenced by daily habits and environmental factors. She advocates for a proactive approach to managing what information the brain receives; proper nutrition and stress management are highlighted as critical factors in sustaining mental well-being. Understanding happiness as a biochemical state encourages a strategic approach to lifestyle choices that enhance mental health.
- 01:15:00 - 01:34:12
The podcast concludes by addressing gender differences in brain health, and the implications of hormones on cognitive function. Louisa mentions the ongoing research on hormonal effects on the brain and the need for gender-specific approaches to brain health. The conversation calls for an understanding of individual differences in hormonal responses and their effects on cognition and behavior, advocating for personalized health strategies to optimize brain health across different life stages.
Mind Map
Video Q&A
When do Alzheimer's symptoms typically start?
Symptoms of Alzheimer's like memory loss can start showing in your 60s, but the damage to the brain may begin in your 20s.
Can Alzheimer's be prevented if it runs in the family?
Leading a healthy lifestyle through diet, exercise, and mental health practices can reduce the risk of Alzheimer's even if you have genetic predispositions.
How does exercise improve brain health?
Exercise distributes nutrients and oxygen throughout the body and brain, improving cognitive functions and increasing hippocampal volume.
What is neuroplasticity?
Neuroplasticity is the brain's ability to rewire itself through experiences and actions, forming and strengthening neural connections.
How do habits impact brain function?
Regular daily habits, such as consistent sleep patterns and exercising, create neural connections that make brains function better over time.
What contributes to cognitive decline?
Stress and poor lifestyle habits can contribute to cognitive decline and increased risks of dementia-related diseases.
Can sauna therapy prevent Alzheimer's?
Emerging studies show that saunas and other methods of inducing heat stress can slow the development of Alzheimer's symptoms.
What's the difference between dementia and Alzheimer's?
Dementia involves a decline in cognitive functions like memory and reasoning, while Alzheimer's is a specific disease causing dementia symptoms due to brain cell death.
How can high-functioning individuals maintain optimal brain health?
High-functioning people can benefit from setting clear goals, maintaining structure in their routines, and managing stress effectively.
Why is sleep so important for brain health?
Sleep repairs brain function by allowing processes like memory formation, hormonal balance, and toxin clearance to occur.
View more video summaries
- 00:00:00how do you get a jacked brain your first
- 00:00:01symptom of Alzheimer's disease May begin
- 00:00:04in your 60s but that has been starting
- 00:00:07in your late 20s early 30s so we can
- 00:00:10essentially prevent ourselves from
- 00:00:13getting Alzheimer's this is the only
- 00:00:15disease that robs you of who you are
- 00:00:18your brain doesn't know the difference
- 00:00:20between you getting hit by a car or you
- 00:00:24going through a divorce or you just
- 00:00:26getting a bad notification from an ex
- 00:00:29improving your V 2ax by 1 Point improves
- 00:00:32your lifespan by 45 days that is correct
- 00:00:36yeah welcome back to the Reena Malik MD
- 00:00:38podcast I'm your host Dr Reena Malik
- 00:00:40urologist and pelvic surgeon today our
- 00:00:43guest is Louisa Nica neurophysiologist
- 00:00:46and Human Performance coach as well as
- 00:00:48director at neuro Athletics where she
- 00:00:50coaches the world's Elite athletes and
- 00:00:53high performing individuals on how to
- 00:00:55optimize their brain for Peak
- 00:00:57Performance not only is she brilliant
- 00:01:00about the brain but she also herself was
- 00:01:02an Olympic Athlete doing triathlons for
- 00:01:05Australia she is a true pleasure to have
- 00:01:07on today we talked about how improving
- 00:01:10the quality of your brain can improve
- 00:01:12the quality of your life what are the
- 00:01:14five things that you can do to improve
- 00:01:18brain health that are free and easily
- 00:01:20accessible and how exercise can not only
- 00:01:24remodel your heart to work more
- 00:01:26effectively but can also increase the
- 00:01:29volume volume of your brain and how
- 00:01:32valuable that is in terms of improving
- 00:01:34your brain health how can you Stave off
- 00:01:37dementia and what exactly is dementia
- 00:01:40and we also talk about the importance of
- 00:01:42sleep how to deal with jet lag and what
- 00:01:44are some things you can do to optimize
- 00:01:47your nighttime routine so that you're
- 00:01:48getting to bed and sleeping at the same
- 00:01:50time every single night and what are the
- 00:01:53two supplements that you should be
- 00:01:54taking for your brain Louisa thank you
- 00:01:56so much for joining us thank you so much
- 00:01:58I'm so excited to be here this is such
- 00:02:00an important topic and I often like
- 00:02:03think about this and I'm like you know
- 00:02:04everyone knows about heart health like
- 00:02:05they've got the best marketing team
- 00:02:07right like everyone knows what's good
- 00:02:09for your heart and you should exercise
- 00:02:11and eat right but no one ever really
- 00:02:13talks about brain health in the same way
- 00:02:16right like I think it's an afterthought
- 00:02:17it's like oh you know my grandpa's
- 00:02:19losing their thoughts or they're they're
- 00:02:22having difficulty remembering things
- 00:02:24it's getting a little Troublesome but
- 00:02:25they don't think about it when they're
- 00:02:26younger I think that's a real issue and
- 00:02:29I've heard you say that you can improve
- 00:02:32the quality of your life by improving
- 00:02:34the quality of your brain correct so
- 00:02:36let's talk about why people should care
- 00:02:38about their brain yeah and that's a
- 00:02:40really you know you've touched on
- 00:02:41something so important most people do
- 00:02:43only care about you know cardiovascular
- 00:02:45disease the number one killer in the
- 00:02:47world so of course we need to be caring
- 00:02:48about it I think this whole world of
- 00:02:51brain health is very elusive because
- 00:02:53even today we still we actually know
- 00:02:55more about space than we do about the
- 00:02:57brain which is quite scary right we hear
- 00:03:00the word dementia but still a lot of
- 00:03:02people are confused as to what it is
- 00:03:05they can't differentiate between
- 00:03:06dementia Alzheimer's disease fronto
- 00:03:08temporal dementia so we can you know we
- 00:03:10can talk about all of that but we really
- 00:03:13need to be caring about the health of
- 00:03:16our brains because when you think about
- 00:03:18it the human brain okay it's about 2 lbs
- 00:03:22I would say it's got the consistency of
- 00:03:23hard jell but it is responsible for
- 00:03:26absolutely everything we do everything
- 00:03:28you are everything you think everything
- 00:03:30you produce from your muscle actions to
- 00:03:33the people that you talk to to the
- 00:03:35person you are married to is ultimately
- 00:03:38determined by the quality of your brain
- 00:03:40and when I think about brain health I
- 00:03:42think about quality of the function of
- 00:03:45the brain that's the neural networks and
- 00:03:48structures which is the gray matter and
- 00:03:50the white matter of the brain so the
- 00:03:52structure structural components and the
- 00:03:54functional components
- 00:03:56and if we are not careful we can end up
- 00:04:01going down this road that 55 million
- 00:04:03people currently go down right now in
- 00:04:05the world and that is Alzheimer's
- 00:04:07disease and that is a very scary State
- 00:04:09and the one thing I do want to point out
- 00:04:12first and foremost is that my hypothesis
- 00:04:15well not if it's not even my hypothesis
- 00:04:17it is my what I believe what I believe
- 00:04:19to be true and that is that dementia is
- 00:04:22not a normal part of aging so we need to
- 00:04:25really redefine what that is because a
- 00:04:28lot of people you just said it oh my
- 00:04:29grandmother's losing like it's not a
- 00:04:32normal part of aging but people think
- 00:04:35that it is and we have the ability to
- 00:04:37change that we have the ability to slow
- 00:04:39the progression of onset of dementia and
- 00:04:42Alzheimer's disease through lifestyle
- 00:04:44habits yeah and we're going to get into
- 00:04:46that but you've said so many important
- 00:04:48things here and I think one thing that
- 00:04:50people don't realize is that the quality
- 00:04:52of your life including the people you
- 00:04:54marry and the people you surround
- 00:04:56yourself are related to your brain
- 00:04:58health let's talk a little bit about
- 00:04:59like does that mean how does that the
- 00:05:01brain change that for you we have these
- 00:05:04networks these specialized NW people
- 00:05:06hear about the prefrontal cortex okay it
- 00:05:08sits in the frontal lobe right at the
- 00:05:10frontal pole of the brain and it's where
- 00:05:13we house our executive functions think
- 00:05:15your information processing speed your
- 00:05:17thinking your decision making these are
- 00:05:19all governed by the prefrontal cortex
- 00:05:21we've also got other networks in our
- 00:05:23brain and they can be molded through
- 00:05:27actions that we produce through the
- 00:05:28people that we talk to through this
- 00:05:30phenomenon called neural plasticity so
- 00:05:33literally everything is information that
- 00:05:36is what you are taking in information
- 00:05:38from your phone information from the
- 00:05:40people that you are talking to
- 00:05:42information from your spouse so when you
- 00:05:45get this information your brain creates
- 00:05:47a network around it and then it becomes
- 00:05:49stronger so that information becomes
- 00:05:51stronger becomes more familiar your
- 00:05:53brain likes familiarity right it loves
- 00:05:55to you know loves regularity and what's
- 00:05:58familiar it doesn't want to be shocked
- 00:06:00so once it sees certain behaviors you
- 00:06:03then mold into that you start to think
- 00:06:05that this is normal that's why I'm
- 00:06:07really careful with the people that I
- 00:06:09talk to it's that old saying like you
- 00:06:11are the the product of the top five
- 00:06:13people that you hang around can your
- 00:06:14brain health affect your attraction to
- 00:06:17people so like if you have a healthier
- 00:06:19brain will you find yourself attracted
- 00:06:21to healthier people I mean I think yes I
- 00:06:24don't know the science behind that but
- 00:06:26you would definitely think so if you are
- 00:06:28on that part and that's also got to do
- 00:06:30with the the endocrine system as well
- 00:06:31the hormones that are produced that are
- 00:06:34signaling different things to your brain
- 00:06:35but I really think it's a a result of
- 00:06:39who and what the information is that
- 00:06:41you're giving your brain it is very
- 00:06:43plastic it doesn't it has to be given
- 00:06:45the information so what is
- 00:06:47neuroplasticity it's the brain's ability
- 00:06:50to rewire itself through actions so
- 00:06:54we've all heard of you know we've got 87
- 00:06:56billion
- 00:06:57neurons average in the human brain they
- 00:06:59are nerve cells they are our chief brain
- 00:07:03cell in the brain and they communicate
- 00:07:05with each other right and they connect
- 00:07:07to one another each neuron has around 15
- 00:07:10to 30,000 connections which if you do
- 00:07:12the math on that it's a lot of it's a
- 00:07:14lot of energy happening in the brain and
- 00:07:17it is thought that if you produce a
- 00:07:19certain action or you think a certain
- 00:07:21thought you create a new connection you
- 00:07:24rewire itself I always try and think of
- 00:07:25have you seen the you take a helicopter
- 00:07:27view you look down on the highway in in
- 00:07:29Dubai there's all these little networks
- 00:07:31these highways it's kind of like
- 00:07:33neuroplasticity and you keep going down
- 00:07:35the one Highway if you keep going down
- 00:07:37it you create and strengthen those
- 00:07:40Pathways when you create and strengthen
- 00:07:42those Pathways it becomes easier like
- 00:07:44Habit to keep going down them without a
- 00:07:46thought so then it becomes more of an
- 00:07:48unconscious part of the default mode
- 00:07:51Network thing that's why you don't want
- 00:07:53to rely on motivation you want to rely
- 00:07:55on habit formation in terms of
- 00:07:57life-changing behaviors absolutely I
- 00:07:59mean because we know that you know
- 00:08:01there's several theories for the brain
- 00:08:03aging process and one of them is we lose
- 00:08:06efficacy to release dopamine so you
- 00:08:09don't want to be relying on dopamine all
- 00:08:12the time and you don't want to be
- 00:08:13relying on motivation all the time you
- 00:08:15want to create these patterns that are
- 00:08:17just like so familiar to you that it
- 00:08:19just feels like second nature yeah
- 00:08:21that's that's sad that we are dopamine
- 00:08:23goes down because it makes things much
- 00:08:25more challenging as you age to find joy
- 00:08:27in the same things that you used to
- 00:08:29previously yeah it is and look apart
- 00:08:31from pathology we know we know certain
- 00:08:33disorders we can't produce the dopamine
- 00:08:36but it's it is scary that we lose that
- 00:08:38as we get older in terms of making bad
- 00:08:40behaviors like say you are an alcoholic
- 00:08:43or say you are even just like eating
- 00:08:46poorly let's say something as simple
- 00:08:47that PE many Americans and and people
- 00:08:49around the world can relate to that also
- 00:08:52is developing a a neural pathway in your
- 00:08:54brain so how do you overcome that yeah I
- 00:08:57always say that your brain doesn't know
- 00:08:59the difference between right or wrong it
- 00:09:00just knows information if you feed it
- 00:09:03alcohol and it it gives you the response
- 00:09:06you got to remember it's also B
- 00:09:08neuroplasticity is also based on how
- 00:09:11strong of an emotion it has this is why
- 00:09:12you know certain breakups are hard to
- 00:09:15get over it's like how emotionally
- 00:09:17attached are you how good did the
- 00:09:18alcohol make you feel if it made you
- 00:09:20feel really good and euphoric and you
- 00:09:22felt you're going to want to seek that
- 00:09:24pleasure again and if you do it again
- 00:09:26you just keep creating these bad habits
- 00:09:29and it takes a lot of strength mentally
- 00:09:33physiologically to overcome certain
- 00:09:36behaviors that's why it's scary right
- 00:09:38this is why drug addiction you know is
- 00:09:40very hard to overcome from a
- 00:09:42physiological standpoint and a
- 00:09:43neurological standpoint so these habits
- 00:09:46it doesn't matter whether you think
- 00:09:47they're bad or good it is just
- 00:09:50information into your brain and it gets
- 00:09:52as as we get older we lose our cognitive
- 00:09:56reserves the builtup reserves that are
- 00:09:58there to help us fight off the negative
- 00:10:01thoughts or fight off the bad habits so
- 00:10:04it just keeps you become weaker in being
- 00:10:06able to say no to these things so how do
- 00:10:08you make yourself stronger how do you
- 00:10:11make your brain Stronger Yeah I actually
- 00:10:13call it how do you get a jacked brain
- 00:10:15yeah it comes down to function which
- 00:10:18we'll talk about function it comes down
- 00:10:20to structural it comes down to living a
- 00:10:23healthy life and just delaying the the
- 00:10:27onset of these brainal Health Related
- 00:10:29Disorders before we get into that let's
- 00:10:31talk about these brain health disorders
- 00:10:33what is the difference right between
- 00:10:35somebody who's a bit forgetful maybe
- 00:10:36forgetting names forgetting where their
- 00:10:38keys are forgetting um simple things
- 00:10:40here and there versus fullon cognitive
- 00:10:44dementia Alzheimer's disease when does
- 00:10:46it become a concern I love that question
- 00:10:49because so many people automatically
- 00:10:51think oh my gosh I've got Alzheimer's
- 00:10:53I've got dementia because I start to
- 00:10:54forget my keys and although some of the
- 00:10:57early signs of cognitive decline is
- 00:11:00short-term memory loss such as where are
- 00:11:02my keys and where do I
- 00:11:04live that can also occur under stress me
- 00:11:09I'm in my mid-30s uh I've have no signs
- 00:11:12of cognitive decline as I know you that
- 00:11:14I know but sometimes I do forget because
- 00:11:15I've got so much going on in my brain so
- 00:11:19we don't want to get too scared I'm sure
- 00:11:21you've come across people who think that
- 00:11:22oh no I've got a bump on my head does
- 00:11:24that mean I have a tumor you know people
- 00:11:25just jump to WebMD and they jump to
- 00:11:27conclusions it's the same thing right
- 00:11:29but let's define globally what dementia
- 00:11:32is it's a set of cognitive decline
- 00:11:36symptoms and dementia is the umbrella
- 00:11:38term that is used to describe all these
- 00:11:40other neurodegenerative diseases
- 00:11:42neurodegenerative so it's a process that
- 00:11:45hope happens over time 20 30 years you
- 00:11:48know your first symptom of Alzheimer's
- 00:11:50disease May begin in your 60s but that
- 00:11:54has been starting in your late 20s early
- 00:11:5630s which is why I'm really advocating
- 00:11:59for people to live a healthy life in
- 00:12:02their 30s where the that's when the the
- 00:12:04real damage occurs because that's when
- 00:12:05the brain begins to atrophy so you've
- 00:12:07got Alzheimer's disease you've got
- 00:12:09Parkinson's dementia you've got fronto
- 00:12:10temporal dementia you've got vascular
- 00:12:13dementia and so they they all sit
- 00:12:17underneath dementia now the reason why
- 00:12:20we know so much about Alzheimer's
- 00:12:21disease is because that's the most
- 00:12:23prevalent currently around 6 million
- 00:12:27people in America have Alzheimer's
- 00:12:28disease
- 00:12:2955 million people worldwide that number
- 00:12:32is said to Triple by the year 2050
- 00:12:34staggering absolutely un because of
- 00:12:37these lifestyle things that people are
- 00:12:39doing well yes and no well let's first
- 00:12:42differentiate the difference between
- 00:12:44you've got many different risk factors
- 00:12:47right we've got genetic mutations and
- 00:12:50then we've got genetic risk factors and
- 00:12:53I think it's important to differentiate
- 00:12:55these so genetic mutations that's when
- 00:12:58you've got a mutation in your genetic
- 00:13:00code there's something that has happened
- 00:13:02there which will definitely cause you to
- 00:13:05get early onset Alzheimer's disease for
- 00:13:07example if you've got a mutation on
- 00:13:09chromosome 4 we know you're going to get
- 00:13:10Huntington's disease it's just you know
- 00:13:13an error and currently we have three
- 00:13:17genetic errors in that and that is the a
- 00:13:21amalo precursor protein and You' got
- 00:13:23pralon one and pralon two so if we have
- 00:13:25the mutations there we know 100%
- 00:13:27penetrant you will get this
- 00:13:30disease sadly if you look at the
- 00:13:33cases that only represents 2 to 3% of
- 00:13:36the cases really worldwide so why what's
- 00:13:40happening with the rest of them MH why
- 00:13:42are people still getting Alzheimer's
- 00:13:44disease if they don't have the genetic G
- 00:13:47the genetic mutations then we look at
- 00:13:49genetic risk factors and you know I
- 00:13:51really want to talk about this because I
- 00:13:53think we have
- 00:13:56overemphasized this Gene called the AO
- 00:13:59lipoprotein e APO E4 Gene and Chris
- 00:14:03Hemsworth is known to have two so you
- 00:14:06get one gene from Mom you know you get a
- 00:14:08gene one Alo from Mom one from Dad and
- 00:14:12we have the APO lipoprotein e Gene we've
- 00:14:15got Epsilon 2 which is actually quite
- 00:14:18protective so if you have an E2 E2 it's
- 00:14:20a very protective against the disease if
- 00:14:24you have E2 E3 it's protective a very
- 00:14:27average is an E3 E3 I have I an E3 E3 it
- 00:14:32just means it's just it's nullified we
- 00:14:34don't increase the risk it doesn't
- 00:14:35decrease the risk if you have one L of
- 00:14:38E4 raises your risk if you have two
- 00:14:42raises your risk by 10 to 12 times so
- 00:14:45it's quite scary but I want everyone to
- 00:14:48know that if you test positive for the
- 00:14:51these genes I've just said it is a risk
- 00:14:53factor it does not mean that you will
- 00:14:56get Alzheimer's disease in fact 50% of
- 00:14:59people who go on through life with E4 E4
- 00:15:03without even getting Alzheimer's disease
- 00:15:05arguably they are probably living a very
- 00:15:08healthy lifestyle but then you've got
- 00:15:10this other subset of people who are
- 00:15:13getting the disease but they don't have
- 00:15:16the E4 E4 genes they don't have the
- 00:15:18genetic mutations so what could it be it
- 00:15:21turns out that it really does come down
- 00:15:23to the way you're living your life so we
- 00:15:26can essentially prevent ourselves from
- 00:15:30getting Alzheimer's you can prevent
- 00:15:32yourself from getting dementia and
- 00:15:34Alzheimer's disease these are diseases
- 00:15:36that are completely preventable but it's
- 00:15:39up to you and it's up to you to be
- 00:15:41empowered every single day it's an
- 00:15:43individual effort that needs to be
- 00:15:46practiced and it needs to be done every
- 00:15:49day and so what is Alzheimer's dementia
- 00:15:52well Alzheimer's dementia is a is a form
- 00:15:55of neurodegenerative disease that is
- 00:15:58prod L made there's two theories
- 00:16:00currently we actually which is scary
- 00:16:03we've currently got something called the
- 00:16:05amalo hypothesis amalo Cascade
- 00:16:08hypothesis that's what we currently know
- 00:16:10of right now where we get the
- 00:16:12accumulation of this protein and I'm not
- 00:16:14even going to call it a toxic protein
- 00:16:16because we all have it in our brain and
- 00:16:18accumulation of these proteins that end
- 00:16:21up aggregating outside of the neuron so
- 00:16:25remember you've got the neuron the cell
- 00:16:26body you've got the axon that comes off
- 00:16:28of it
- 00:16:29this is outside of the neuron I told you
- 00:16:32earlier that neurons communicate with
- 00:16:34each other 20 to 30,000 maybe 15,000
- 00:16:38connections so if these amalo plaques
- 00:16:42and they Clump together if they are
- 00:16:43building up outside of the neuron they
- 00:16:46are interfering with the way the neurons
- 00:16:49connect and wire together when our
- 00:16:52neurons connect they fire something we
- 00:16:55we have something called a synapse and
- 00:16:56that's how they communicate with each
- 00:16:57other that's how we think that's how we
- 00:17:00produce actions so this ends up getting
- 00:17:03disrupted So currently that is the the
- 00:17:07current hypothesis but then we've also
- 00:17:08got something else that happens within
- 00:17:11the neuron itself and that is the tow
- 00:17:14protein so we've got you know we've got
- 00:17:16these neurofibrillary Tangles and they
- 00:17:19go they basically if you think of the
- 00:17:21analogy I like to use is a roller
- 00:17:23coaster right so you've got these you've
- 00:17:26got these um neurop fiary I would
- 00:17:29say I can't even explain it but they're
- 00:17:32they end up what happening what happens
- 00:17:34is they end up aggregating within the
- 00:17:35cell and they end up killing the neuron
- 00:17:38itself as well so these amalo plaques
- 00:17:41build up create these neurop fiary
- 00:17:43Tangles that basically prevent
- 00:17:45communication between the and
- 00:17:47potentially lead to death of the neuron
- 00:17:48itself and the very early signs of this
- 00:17:51happening is in within an area deep
- 00:17:54within the temporal loads called the
- 00:17:55hippocampus mhm and the temporal loes
- 00:17:58just sit here so so deep within that
- 00:17:59structure is this seahorse shaped
- 00:18:01structure called the hippocampus and
- 00:18:04that's where we have a lot of our memory
- 00:18:05formations a lot of our learning
- 00:18:07occurring there and we get the breakdown
- 00:18:09and degradation of the neurons within
- 00:18:12there which is why the some of the
- 00:18:13earliest signs are memory loss
- 00:18:17forgetfulness and clinically I mean I've
- 00:18:19seen over my career many many patients
- 00:18:21with a variety of different dementias
- 00:18:23ultimately the symptoms tend to be
- 00:18:27overlapping in many of the conditions
- 00:18:29meaning memory loss some have like for
- 00:18:31Parkinson's there's a movement component
- 00:18:33it's really traumatic and I think people
- 00:18:35really need to understand like it's not
- 00:18:37just grandpa or Grandma's getting older
- 00:18:40and they're a little forgetful like it
- 00:18:42can be really tragic to see your family
- 00:18:44go through that and to see them
- 00:18:47literally look at you and maybe not
- 00:18:49recognize you for a moment or a few
- 00:18:52hours or only recognize you for a few
- 00:18:54hours over the course of many weeks and
- 00:18:56so it is really a traumatic experience
- 00:18:59for people to go through and I think if
- 00:19:02people realize that it's in our power to
- 00:19:05hopefully stay that off or prevent that
- 00:19:08for the large majority of people I think
- 00:19:10that's extremely powerful yeah it's you
- 00:19:13know I think to myself you wake up with
- 00:19:16your brain and you wake up with who you
- 00:19:18are every day you go to sleep with who
- 00:19:20you are this is the only disease that
- 00:19:23robs you of who you are and this became
- 00:19:27very apparent to me I've um I've seen a
- 00:19:29patient who has actually looked at me
- 00:19:32and said who am I mhm and it was really
- 00:19:35scary when you really forget who you are
- 00:19:38you forget who your kids are but then it
- 00:19:40can also be scary when you get your
- 00:19:42memory back for a moment and you
- 00:19:43remember what is happening and so it's
- 00:19:47it's actually a very big burden an
- 00:19:50economic burden on and a very big burden
- 00:19:54on the caregiver itself but something we
- 00:19:56should also point out is what I'm also
- 00:19:59advocating for in terms of women's
- 00:20:01rights in science um and research is two
- 00:20:06out of three dementia cases are or
- 00:20:08Alzheimer's disease cases cases are
- 00:20:11women so we know that there is a
- 00:20:13hormonal component with that as well
- 00:20:16what do we think the hormonal component
- 00:20:18is although not not my my field um I am
- 00:20:21going to be interviewing Dr Lisa muscone
- 00:20:23who um you know she's researching this
- 00:20:26field but it does have to do a lot with
- 00:20:28the estrogen yeah so we we're born with
- 00:20:30you know if you are born with a uterus
- 00:20:33and and ovaries we have many estrogen
- 00:20:35receptors in our brain and evidently
- 00:20:38after menopause we we lose that and
- 00:20:42that's one of the reasons another reason
- 00:20:44we believe is just the fact that we are
- 00:20:46living longer yeah I mean I think during
- 00:20:48the during menopause certainly there's
- 00:20:50there's changes because there's less
- 00:20:52estrogen to the brain but also the hot
- 00:20:54flashes have negative impacts because
- 00:20:56that's actually an error in temperature
- 00:20:58regulation in our brain correct and that
- 00:21:00can also disrupt sleep as well which we
- 00:21:02know that sleep is a huge component of
- 00:21:04staving off these disease states are you
- 00:21:06sick of going to the doctor only to have
- 00:21:09them talk at you for 15 minutes and
- 00:21:12leave without knowing exactly why
- 00:21:15they're prescribing you this certain
- 00:21:17medication and what exactly the next
- 00:21:20step is to take to optimize your health
- 00:21:22wouldn't it be great to finally find a
- 00:21:25doctor who actually listens to you
- 00:21:28answer
- 00:21:29your questions and doesn't rush you out
- 00:21:31the door well at my practice Reena Malik
- 00:21:34MD I aim to do just that I specialize in
- 00:21:38taking care of patients who have issues
- 00:21:40with their sex lives issues with their
- 00:21:42bladder with their Hormone Health or are
- 00:21:45having pain in their pelvic region or
- 00:21:48with sex my goal is to give you the time
- 00:21:51and attention you deserve so you can
- 00:21:54leave with a clear understanding of your
- 00:21:58condition as well as our treatment plan
- 00:22:00that's optimized for your goals during
- 00:22:04your visit I'm 100% present with you for
- 00:22:07an entire hour and after you leave you
- 00:22:10can reach me it is super easy to send me
- 00:22:12a message through our secure portal and
- 00:22:14I'll get back to you within 24 to 48
- 00:22:17hours no questions asked no hidden fees
- 00:22:20scheduling is easy just visit our
- 00:22:22website renam Malik md.com slappointment
- 00:22:26we see patients in both Irvine and
- 00:22:29Beverly Hills California and I see
- 00:22:32patients virtually in California Florida
- 00:22:35Illinois Maryland New York New Jersey
- 00:22:38and Virginia oh and don't forget Texas
- 00:22:41if you're outside these states consider
- 00:22:43seeing me for an educational visit I
- 00:22:45look forward to seeing you what are
- 00:22:47early signs so you said short-term
- 00:22:48memory loss what are some other early
- 00:22:50signs that people can pick up maybe even
- 00:22:52younger that they may need to really be
- 00:22:54keeping an eye on this and amping up
- 00:22:56their prevention potentially changes in
- 00:22:59cognition so as as I mentioned earlier
- 00:23:01cognitive performance which we look at
- 00:23:04you've got decision-making information
- 00:23:06processing speed uh your ability to
- 00:23:08think faster these things can start to
- 00:23:12decline we have Global cognition and I
- 00:23:15will tell you that the degree to which
- 00:23:19your cognition lasts is how much that
- 00:23:22you want to to push it right you you go
- 00:23:26to the gym how do we make our muscles
- 00:23:28bigger we have to place it under stress
- 00:23:31your brain is the same if you can place
- 00:23:34your brain under stress stressful
- 00:23:36situations whether albe it through
- 00:23:38learning learning a new task anything
- 00:23:40that is actually going to send hortic
- 00:23:42stress or good stress to your brain to
- 00:23:45push further in a specific area is going
- 00:23:47to be good for it remember our brain is
- 00:23:50it's highly adaptable and every area is
- 00:23:54accounted for every area in the brain is
- 00:23:56accounted for from hearing to to our
- 00:23:58visual cortex to seeing to balancing to
- 00:24:01posture so everything has a purpose in
- 00:24:03the brain it's not just there and the
- 00:24:06Brain kind of takes the theory of use it
- 00:24:08or lose it so if you neglect to use a
- 00:24:11certain area of the brain and this is
- 00:24:13why a lot of cognitive decline actually
- 00:24:15occurs post um you know when somebody
- 00:24:19retires because they're not utilizing
- 00:24:21every aspect of their brain they're not
- 00:24:22learning they're not putting their
- 00:24:24they're not thinking as much they're not
- 00:24:26placing their brain under stress so your
- 00:24:28brain is like okay use it or lose it
- 00:24:30what are good stresses so say let's talk
- 00:24:32about someone who's like got a lot of
- 00:24:33stress in their life how can they you
- 00:24:35know like that's a majority of people
- 00:24:37right people are working full-time
- 00:24:38they're taking care of kids they're
- 00:24:40taking care of Aging parents they're
- 00:24:41taking care of their spouse whatever
- 00:24:43right some people are multiple jobs so
- 00:24:45like how can you differentiate like
- 00:24:47obviously the day-to-day stressors which
- 00:24:49are not necessarily positive all the
- 00:24:51time to those that are good stressors
- 00:24:53that's an important one so when we talk
- 00:24:55about bad stress that is things such as
- 00:24:59putting yourself under chronic stressful
- 00:25:01situations that lasts a long time but
- 00:25:03also I I must admit there's also
- 00:25:05nutrient deficiencies which could signal
- 00:25:07a chronic stress to your brain we don't
- 00:25:09want that good stresses are things like
- 00:25:12exercising thermal regulation such as
- 00:25:14getting into a sauna and releasing these
- 00:25:17heat shock proteins um that is a good
- 00:25:20stress that is something that signals to
- 00:25:22your brain okay I'm under stress like
- 00:25:25for example this morning I posted about
- 00:25:27um mitochondrial bi Genesis the creation
- 00:25:29of new and healthy mitochondria we need
- 00:25:32this we know that mitochondria is a
- 00:25:33Powerhouse of our cell where the the
- 00:25:35site of energy production ATP production
- 00:25:38we can induce more
- 00:25:40mitochondria through getting into cold
- 00:25:44water because when we do we basically
- 00:25:47signal a stressful situation to our body
- 00:25:50and our brain and what happens is your
- 00:25:54body says oh my gosh she's freezing
- 00:25:56she's actually going to die hypothermic
- 00:25:59we have to warm her up how do we warm
- 00:26:01her up well we have to do that through
- 00:26:04mitochondria so the mitochondria get to
- 00:26:06work you start to produce this heat and
- 00:26:09then because it's so stressed it says
- 00:26:10guys we don't have enough mitochondria
- 00:26:12let's produce more so that is a that is
- 00:26:15a positive stressful situation I've
- 00:26:17induced stress to create a positive
- 00:26:21outcome and so that's where I would say
- 00:26:23that is good stress this happens under
- 00:26:25heat stress as well if you go into the
- 00:26:26sauna we do the same we release these
- 00:26:29heat shock proteins which can be a
- 00:26:30really good beneficial thing and in fact
- 00:26:32they've actually done um there was a
- 00:26:34really great study that was done that
- 00:26:36showed that 4 days per week of infrared
- 00:26:39sauna can ameliorate some of the amalo
- 00:26:43beta depositions in a brain like looking
- 00:26:45at biopsies of the brain correct yeah
- 00:26:48and what about with that's very early
- 00:26:49research what about with cold exposure
- 00:26:51are we seeing have they done that
- 00:26:53investigation no we know that one of the
- 00:26:55most robust um responses to cold
- 00:26:57exposure is the release of neopine which
- 00:27:01is a neurotransmitter neuromodulator
- 00:27:03it's involved in vigilance when released
- 00:27:05from the brain it can be released um
- 00:27:07from the body as well but it's involved
- 00:27:09in vigilance and focus and it's a really
- 00:27:12great neurotransmitter so we know that
- 00:27:15that occurs we also know that we can um
- 00:27:18activate a pathway called the rbm3
- 00:27:20pathway they're now experimenting this
- 00:27:22with postconcussive patients which
- 00:27:24putting you know putting these heads
- 00:27:27into after they've had a concussion like
- 00:27:29dumping dunking their heads into a
- 00:27:31bucket of ice to cool the brain down so
- 00:27:34we know that but that's very it's it's
- 00:27:36still so early yeah yeah so I mean
- 00:27:39interesting stuff I think ultimately
- 00:27:41probably also reducing your bad
- 00:27:43stressors would be beneficial as best as
- 00:27:46possible that's actually one of the risk
- 00:27:47factors so even looking at how can you
- 00:27:52minimize I wouldn't say mitigate because
- 00:27:54it is 2024 how can you minimize the
- 00:27:57amount of stress that you place upon
- 00:27:58your system every day even deep
- 00:28:01breathing is a really great measure and
- 00:28:04you can actually measure your stress I
- 00:28:06wear an aura ring and right now it does
- 00:28:09things like now it picks up on daytime
- 00:28:10stress but we can also see through heart
- 00:28:13rate variability how well or even how
- 00:28:15well we've slept we can increase our
- 00:28:17heart rate variability with deep
- 00:28:19breathing and I'm trying to do
- 00:28:21everything I can to minimize my stress
- 00:28:25and it starts with giving yourself a
- 00:28:27head start start every morning if I'm up
- 00:28:29against a very stressful day I want to
- 00:28:31know that at least I've slept well at
- 00:28:34least I've woken up with some cognitive
- 00:28:36reserve and I've slept well that's the
- 00:28:38first thing that I want to know if I
- 00:28:41exercise I'm armoring my my brain as
- 00:28:44well so that's another thing to kind of
- 00:28:47Shield me against some of the if I've if
- 00:28:49I'm hydrated and I'm eating well and I'm
- 00:28:51eating nutritious food plant-based diets
- 00:28:54are really great as well I'm an omnivore
- 00:28:56I eat everything but really you know
- 00:28:59giving your brain the best outcome it
- 00:29:02can so when it is about to go to war
- 00:29:05because you never know things happen
- 00:29:07every day you want it to be protected
- 00:29:10and be strong enough that's why I call
- 00:29:11it how do you get a jacked brain so
- 00:29:13going to war meaning just dealing with
- 00:29:15stressors absolutely your brain doesn't
- 00:29:17know the difference between you getting
- 00:29:20hit by a car or you going through a
- 00:29:23divorce or you just getting a bad
- 00:29:25notification from an ex on your phone it
- 00:29:28is the degree to which you tell your
- 00:29:31brain that you are affected everyone can
- 00:29:33someone can get hit by a car and have
- 00:29:35the same stress as someone who's just
- 00:29:37gotten a notification on their phone
- 00:29:38yeah or just read the news correct and
- 00:29:40what we actually see in schizophrenic
- 00:29:43patients in depress depressive patients
- 00:29:47we see that they actually have low
- 00:29:48levels of
- 00:29:49neuroplasticity so anything that's going
- 00:29:51to raise the the outcome of
- 00:29:53neuroplasticity as well is going to help
- 00:29:56you so these lifestyle factors that we
- 00:29:58speak about is really yeah yeah so
- 00:30:01you've sort of alluded to them but what
- 00:30:02are the five most important things let's
- 00:30:04say five things I think you've mentioned
- 00:30:06five already five most important things
- 00:30:08we can do to help our brain health and
- 00:30:10maybe in order of importance if you had
- 00:30:12to pick oh okay well I'm biased because
- 00:30:16I'm currently I mentioned to you that
- 00:30:18I'm currently doing my Doctrine it's
- 00:30:20literally in exercise and Mild cognitive
- 00:30:23impairment so I'm looking at many
- 00:30:26different studies um interventions such
- 00:30:28as resistance training aerobic training
- 00:30:30and what these have on global cognition
- 00:30:33and on the structural components of the
- 00:30:36brain so I think at the bottom of the
- 00:30:39pyramid the best thing that you can be
- 00:30:41doing is
- 00:30:43exercising I know that the Sleep people
- 00:30:45and the nutrition people probably have
- 00:30:46something else to say but um let's talk
- 00:30:49about exercise and what that's doing
- 00:30:51yeah so we've got aerobic training and
- 00:30:54that's generally your longdistance
- 00:30:56running that's generally when you're
- 00:30:57getting a lot of blood flow through the
- 00:31:00brain remember you mentioned earlier
- 00:31:02heart health and it's the same thing
- 00:31:05with the brain what's good for the heart
- 00:31:07is good for the brain and good for your
- 00:31:09genitals as you mentioned yes and good
- 00:31:11for your genitals why because the blood
- 00:31:14there's blood vessels to the genitals
- 00:31:15and they're usually smaller than those
- 00:31:17to the heart or the brain so you're
- 00:31:19going to see problems in your genitals
- 00:31:21long before you see them elsewhere
- 00:31:22correct and your brain is the most
- 00:31:24vascular Rich organ in the entire body
- 00:31:27meaning it is infiltrated with blood
- 00:31:30vessels capillaries veins like these are
- 00:31:33important structural components of the
- 00:31:35brain so we let's just actually think
- 00:31:38about the heart for a moment okay you've
- 00:31:40got the aort and branching off the aort
- 00:31:42you've got the corroded arteries and
- 00:31:44then you've got the vertial arteries
- 00:31:45which is the posterior blood supply to
- 00:31:47the brain and everything else is just
- 00:31:49branching off of these two arteries so
- 00:31:51every time your heart pumps you get a
- 00:31:55massive profusion big or small of blood
- 00:31:58to the brain the brain loves that
- 00:31:59because you're getting an influx of
- 00:32:01nutrients and oxygen and we need that
- 00:32:03and it turns out that even even the
- 00:32:07smallest one cell thick capillaries in
- 00:32:10your brain need to be utilized because
- 00:32:12they are essentially providing your
- 00:32:15brain with blood often times during
- 00:32:17cognitive decline they are the first
- 00:32:19things to go they go under stress so the
- 00:32:22first things to go during actually
- 00:32:24hypertension and elevated blood pressure
- 00:32:26is your capillar
- 00:32:28so you every time you kill off a tiny
- 00:32:30little supply of blood to the brain what
- 00:32:32happens that means the neuron is not
- 00:32:34getting fed so it
- 00:32:37dies so we need to maintain our
- 00:32:41vasculature and how do we do that
- 00:32:43through adquate blood flow how do we do
- 00:32:45that through exercise so there's um you
- 00:32:48know aerobic exercise is the most widely
- 00:32:50studied when it comes to cognitive
- 00:32:52impairment and dementia because we
- 00:32:55started off with obviously mice studies
- 00:32:58and you can just get a m a mous to run
- 00:33:00on a wheel the best things that it does
- 00:33:02is when you are exercising you get a
- 00:33:05rapid release of a neurotropic factor or
- 00:33:08a brain derived neurotropic factor bdnf
- 00:33:11and this is a growth factor for the
- 00:33:12brain so what scientists realized early
- 00:33:15on was that when you do as little as 20
- 00:33:18minutes of exercise you release bdnf and
- 00:33:22bdnf when it acts as a growth factor in
- 00:33:25the brain it goes into the hippocampus
- 00:33:28and it is responsible for the growth and
- 00:33:30proliferation of new neurons so it can
- 00:33:33grow new neurons in the hippocampus
- 00:33:36there's also been twoyear follow-up
- 00:33:38studies that have shown an increase in
- 00:33:40hippocampal volume so growing the
- 00:33:43hippocampus now whether that and and the
- 00:33:46the hipocampal sub regions as well
- 00:33:48whether that
- 00:33:50directly relates to um improvements in
- 00:33:53cognition is dependent on the person but
- 00:33:55we know that exercise is is great for
- 00:33:58that what else is aerobic activity doing
- 00:34:02actually there's a really wonderful
- 00:34:03study done out of Ben lavine's group
- 00:34:05he's a he's a cardiologist uh by
- 00:34:08training what he did Reena was he took
- 00:34:1153 50-year-olds sedentary otherwise
- 00:34:14healthy 50-year-olds he subjected them
- 00:34:17to 4 hours of maximal exercise per week
- 00:34:21and when I say maximal I'm talking it
- 00:34:23was around 75% of their maximum heart
- 00:34:26rate mhm for 4 hours a week so it's it
- 00:34:29was pretty a lot he did this um as an
- 00:34:31intervention for 2 years guess what he
- 00:34:34found he reversed the age related
- 00:34:38decline of your heart by 20 years so he
- 00:34:42was looking at the hearts of these 50y
- 00:34:45olds and they were presenting with the
- 00:34:47hearts of 30-year olds and he saw this
- 00:34:50through something called as we age we
- 00:34:52get stiffening of the ventricles
- 00:34:55specifically we get left ventri rric
- 00:34:59stiffness so that you know it
- 00:35:01hypertrophy so it gets bigger so it
- 00:35:03constricts our blood so therefore we
- 00:35:04can't get a lot of blood through stroke
- 00:35:06volume per pump okay so that's scary
- 00:35:09because that means with every heartbeat
- 00:35:11we have less blood flow going to the
- 00:35:14brain he improved that over time and I
- 00:35:18think that that is absolutely incredible
- 00:35:20we called that cardiac remodeling so you
- 00:35:22can literally remodel your cardiac
- 00:35:25system your cardiac system is just like
- 00:35:26your muscular system system so through
- 00:35:29cardiac remodeling through putting your
- 00:35:32your body under these stressful
- 00:35:33situations you can rewire the your
- 00:35:36actual heart so it can be pumping better
- 00:35:39and remember your aort these big blood
- 00:35:42vessels are actually made of muscle so
- 00:35:45the stronger they are the better
- 00:35:48equipped they are at delivering blood to
- 00:35:49the brain so remember blood flow then
- 00:35:52we'll move on and we can talk about um
- 00:35:55you know and we know this I know you've
- 00:35:56done um you've had Dr Andy Galpin on the
- 00:35:59podcast and he spoke tremendously about
- 00:36:01V2 Max which is a measure of your
- 00:36:03cardiorespiratory Fitness we know that
- 00:36:06even just an increase in your V2 Max can
- 00:36:10give you a life ex if you go from below
- 00:36:12average to above average it can give you
- 00:36:15an increased life expectancy of 5 years
- 00:36:17so I think everyone in terms of
- 00:36:20protocols I think everyone should
- 00:36:23understand their Baseline where they sit
- 00:36:26for their Fitness I think everyone
- 00:36:28should get a V2 Max test because it is
- 00:36:31in the pursuit of a higher V2 Max that
- 00:36:34you get the real benefits it's not about
- 00:36:36the number it is about what do I have to
- 00:36:39do to increase my V2 Max and this
- 00:36:44doesn't happen you know you can't just
- 00:36:47you know you can go and get blood work
- 00:36:48done let's just say you've got low
- 00:36:50vitamin vitamin D you can go and just
- 00:36:53take maybe 10,000 IUS of vitamin D per
- 00:36:55day for 2 3 months and you go back and
- 00:36:57get a blood test you'll see a dramatic
- 00:36:59increase it's not the same for v2 Max V2
- 00:37:03Max like to increase your V2 Max you
- 00:37:05really need to be stressing your system
- 00:37:07on a daily basis so in the pursuit of
- 00:37:10that is where you'll get the benefits
- 00:37:12yeah and you posted something very
- 00:37:13recently I think it was on your stories
- 00:37:15maybe about one point of V2 Max increase
- 00:37:19led to uh some really dramatic change
- 00:37:21what was that 45 day increase yeah
- 00:37:24increase in life expectancy so improving
- 00:37:26your V2 Max by 1 Point improves your
- 00:37:28lifespan by 45 days that is correct yeah
- 00:37:31that's really impressive it is and it is
- 00:37:33because of the the changes in the heart
- 00:37:36yeah so we know now based on what you've
- 00:37:38told me is that improving your aerobic
- 00:37:41exercise daily at a at a reasonable V2
- 00:37:44Max around 75% it seems like you'll see
- 00:37:48improvements in cardiac remodeling
- 00:37:50you'll see Improvement in hippocampal
- 00:37:52volume and in terms of sexual function
- 00:37:54you'll see Improvement in erections for
- 00:37:56men and similar improvements in arousal
- 00:38:00for women in terms of clitoral tum
- 00:38:01Essence really great reasons to
- 00:38:04incorporate aerobic exercise
- 00:38:07improvements in global cognition as well
- 00:38:09and glob well I would assume that that
- 00:38:10would be related to your hippocampo
- 00:38:12volume but yeah yes absolutely yeah and
- 00:38:15then we move on to resistance training
- 00:38:18which um again biased to it but I think
- 00:38:20that it offers a tremendous amount of
- 00:38:24positivity to the brain from a
- 00:38:27structureal perspective right and my
- 00:38:30area um of expertise is in an EEG
- 00:38:32Electro andram where you actually
- 00:38:35measure the connectivity of the brain
- 00:38:37the functionality of the brain but then
- 00:38:39when we look at the structural
- 00:38:40components of the brain which you know
- 00:38:41you can see through an MRI for example
- 00:38:44we can see changes in the gray matter
- 00:38:48cortex there was one study that I came
- 00:38:50across and this was back in I think 2016
- 00:38:52which showed that 80% of brain gray
- 00:38:55matter is modifiable by a exercise and
- 00:38:58for the audience what is gray matter so
- 00:39:00we've got both gray matter and white
- 00:39:02matter the gray matter sits on the outer
- 00:39:03cortex of the brain it's generally made
- 00:39:05up of the neuron cell bodies that's why
- 00:39:08if you see it on appearance it can come
- 00:39:10darker and then the white matter is our
- 00:39:13aons it's the myelinated neurons and
- 00:39:16these are the things that you know are
- 00:39:18responsible for conduction and
- 00:39:20conduction speed and velocity this is
- 00:39:22what you'll test if you go and get a
- 00:39:24nerve conduction study or an EMG and
- 00:39:26someone is you know picking up on for
- 00:39:28example Ms multiple sclerosis you'll see
- 00:39:31um complete conduction block or slowing
- 00:39:33of conduction speed and so that's the
- 00:39:36white matter of the brain and that's
- 00:39:38deep within the brain and the outside is
- 00:39:40your gray matter and that thins over
- 00:39:42time we get thinning of the gray matter
- 00:39:45cortex due to age as well however it
- 00:39:48doesn't have to be so we do get the loss
- 00:39:50of neurons as we get older arguably over
- 00:39:53the age of around 25 to 30 we start to
- 00:39:56see an atrophy
- 00:39:58in our brain and are those neurons like
- 00:40:00is that
- 00:40:01reversible it's so it's preventable but
- 00:40:04it's not so adult neurogenesis unfortun
- 00:40:07very controversial as well doesn't exist
- 00:40:09from what I've seen in the literature
- 00:40:11outside of the hippocampus so I mean
- 00:40:13look if that was true we'd all be
- 00:40:15running around growing new brain cells
- 00:40:17which would be amazing yes angiogenesis
- 00:40:20so synaptogenesis exist so gen Genesis
- 00:40:23creation you can create new synapses and
- 00:40:26you connect
- 00:40:28we know that to be true through
- 00:40:29neuroplasticity and there's a great
- 00:40:31there's great research coming out now on
- 00:40:33Lion's man and um other adaptogens that
- 00:40:36can really help with that
- 00:40:38process but back to resistance training
- 00:40:41and there was a wonderful study that
- 00:40:43really signified my understanding and
- 00:40:45love for this field and that was by
- 00:40:47Harold atal who basically did a
- 00:40:50systematic review of all of the
- 00:40:51literature on resistance training and
- 00:40:55Mild cognitive impairment
- 00:40:57and he found many things one thing was
- 00:41:01Benta Peterson is a wonderful researcher
- 00:41:04she coined this term called
- 00:41:07myokine and aoine is a muscle based
- 00:41:11protein coming from the P cyto kind
- 00:41:13family and what she found was that under
- 00:41:16contraction of a muscle fiber when you
- 00:41:20contract it and you squeeze it together
- 00:41:23you have the release of these proteins
- 00:41:26that are only released from the muscle
- 00:41:27fiber when they're released they go into
- 00:41:30the bloodstream and they can go into
- 00:41:34they can cross the bloodb brain barrier
- 00:41:36and they can go through and connect in
- 00:41:39on different receptors in the brain and
- 00:41:41have positive effects of the brain so
- 00:41:44for example there is one called Iris MH
- 00:41:47iris is a myoc kind named after the
- 00:41:49Greek god of Iris and because it acts as
- 00:41:51a messenger molecule so when it's
- 00:41:54released from the muscle belly it goes
- 00:41:56up crosses the blood brain barrier and
- 00:41:58it improves the
- 00:42:00proliferation of bdnf so it actually
- 00:42:03helps bdnf Express itself more we've got
- 00:42:08um cathepsin B so all of these wonderful
- 00:42:10myocin that are literally like
- 00:42:12fertilizer for the brain but not just
- 00:42:15that we know that these can go into
- 00:42:17other organs such as prostate we've got
- 00:42:20like receptors on the prostate on the
- 00:42:22ovaries we've got receptors on our on
- 00:42:24our liver and there's a really great
- 00:42:26study now in cell press that showed that
- 00:42:30exercise via lactate which lactate is
- 00:42:33another it's a byproduct of exercise but
- 00:42:35it's also another myokine can
- 00:42:39actually inhibit tumor cell growth
- 00:42:43really yeah doing resistance training is
- 00:42:46improving this myokine release which is
- 00:42:48then going to our brains and having
- 00:42:50improvements in uh basically a multitude
- 00:42:53of ways multitude yeah uh which can be
- 00:42:56you know these one ful growth factors
- 00:42:58that help our brains function better and
- 00:43:00potentially have uh proliferation yes
- 00:43:03absolutely that's a really good sum yeah
- 00:43:05and just to just these myocin are not
- 00:43:07anywhere else they are literally
- 00:43:08released under tension you have to
- 00:43:11really be lifting high this is why you
- 00:43:13when you're going to the gym you should
- 00:43:14be lifting you know you have to be
- 00:43:16lifting hard not these tiny little
- 00:43:18weights because it's you want to put
- 00:43:19your muscles under tension for them to
- 00:43:22release these growth factors but we've
- 00:43:24got circulating tumor cells that can
- 00:43:26actually be downregulated through
- 00:43:29aerobic physical activity and also
- 00:43:30through the myokine release yeah that's
- 00:43:32that's I mean I I love lifting and I
- 00:43:34think it's like addictive like once you
- 00:43:36like oh I can lift more like it's
- 00:43:38actually really sort of fun yeah and
- 00:43:40you've also seen the the studies of the
- 00:43:42age related loss in our strength and
- 00:43:44muscle so even just for the creation of
- 00:43:47like stronger muscles stronger you know
- 00:43:50more strength as we age because one of
- 00:43:52the number one causes of death the CDC
- 00:43:55actually released this over the age of
- 00:43:5680 is Falls mhm and that's really scary
- 00:44:00and then you think if you reverse
- 00:44:01engineer everything right well why do we
- 00:44:04fall okay sometimes cognition you know
- 00:44:08lack of cognition of where to actually
- 00:44:10know where you are in space and time can
- 00:44:12cause that we see balance the you know
- 00:44:15you can get atrophy in the cerebellum
- 00:44:17which is the mini mini brain if you will
- 00:44:20and which is that's responsible for our
- 00:44:23balance and coordination so that can
- 00:44:25also result in it but then we also so
- 00:44:27know that strength obviously and and
- 00:44:30muscle loss psyopia can result in that
- 00:44:33yeah absolutely I mean Falls are some of
- 00:44:34the things I worry about very much so in
- 00:44:36my patients because a lot of them wake
- 00:44:38up at night to urinate and then that
- 00:44:40leads to Falls because they're getting
- 00:44:42up they're you know in the middle of the
- 00:44:43night where they're not fully uh alert
- 00:44:46yet it's dark like there's so many
- 00:44:47things that we talk about with our
- 00:44:49patients But ultimately you know I don't
- 00:44:50think people realize how bad a fall is
- 00:44:52when you're in your 70s and 80s and how
- 00:44:55that can literally increase your
- 00:44:57mortality Risk by 20% you know just from
- 00:44:59having a fall within that first year so
- 00:45:02it is really um important so strength is
- 00:45:04going to help with that as well so okay
- 00:45:06we talked about aerobic exercise
- 00:45:08resistance exercise what's next the
- 00:45:10other one is a sub specialty so my
- 00:45:12company's actually called neuro
- 00:45:13Athletics and I founded this in 2014 and
- 00:45:17that was because there is a third part
- 00:45:19of exercise that we all neglect and
- 00:45:21that's neurocognitive training and it is
- 00:45:24things using things such as your
- 00:45:25reaction training which is actually so
- 00:45:28beneficial for the brain many people say
- 00:45:30to me Louisa can I just do a puzzle or
- 00:45:32Sudoku if it places your brain Under
- 00:45:35Pressure then yes because your brain
- 00:45:38will adapt to it but a really great
- 00:45:41thing that you can do is just get two
- 00:45:42handballs and throw them to the wall and
- 00:45:44that's this part of this neurocognitive
- 00:45:46training reaction training hand eye
- 00:45:48coordination balance these these things
- 00:45:51are actually worthwhile to do as you age
- 00:45:54yeah so let's let's break that down how
- 00:45:56often should you do this and how with
- 00:45:59what regularity in terms of like how
- 00:46:00long should you be spending doing
- 00:46:01something like that you only really need
- 00:46:03to do around 7 to 10 minutes a day
- 00:46:04there's been great studies that have
- 00:46:06done that shows that juggling can
- 00:46:08actually improve the gry matter cortex
- 00:46:11so sadoku is not enough sadoku is not
- 00:46:13enough okay good cuz my mom's obsessed
- 00:46:15but do you know what's actually good
- 00:46:17yeah like anything where you're learning
- 00:46:19learning new language and one thing that
- 00:46:22we do with um some of our clients too is
- 00:46:25we we take into consideration the
- 00:46:28auditory cortex we know that hearing
- 00:46:30loss is another risk factor for dementia
- 00:46:33but um you know doing like hearing tests
- 00:46:36like maybe react to a sound that you can
- 00:46:38hear or we do eye patches at neuro
- 00:46:40Athletics we get all of you know some
- 00:46:42people to wear an eye patch which
- 00:46:43literally closes off half of your brain
- 00:46:45or closes off half of your visual cortex
- 00:46:48so it makes your brain work harder
- 00:46:50because it thinks oh my gosh I've only
- 00:46:51got 50% of my vision I have to work
- 00:46:53harder and it places your brain under
- 00:46:55stress m yeah that's that's a compl
- 00:47:00blindfold yeah yeah but yeah I guess you
- 00:47:02can be Progressive about it right like
- 00:47:04you can do it with both eyes open you
- 00:47:06can do it with one eye patch on with a
- 00:47:08blindfold to to work your way through
- 00:47:10yeah exactly and it's fun anyone can do
- 00:47:13it it's cheap 7 minutes a day just get a
- 00:47:16handball and just throw it to the wall
- 00:47:17and just try and not drop it for a
- 00:47:19minute if you don't do that then go to 2
- 00:47:21minutes and then 3 minutes and it seems
- 00:47:23like it's something you could do with
- 00:47:24your kids like for me like my boys would
- 00:47:26love that yeah yeah absolutely um Okay
- 00:47:28so we've got neuro so we've got aerobic
- 00:47:32exercise resistance exercise
- 00:47:34neurocognitive training what else and
- 00:47:36then one really great study which I'd be
- 00:47:38remiss if I didn't speak about this
- 00:47:40which has nothing to do with exercise
- 00:47:43per se but it's got to do with the
- 00:47:45quality of the connections that you have
- 00:47:47so there was an 80-year study that was
- 00:47:50done out of Harvard which showed that
- 00:47:51the number one thing for a healthy
- 00:47:53performing brain in your in your 80s
- 00:47:56'90s and
- 00:47:57Beyond is the quality of your
- 00:48:00relationships doesn't just mean the
- 00:48:02quality of your like romantic
- 00:48:04relationships it is do you have
- 00:48:06supportive people around you and
- 00:48:08creating a really great social network
- 00:48:10is going to be key to a healthy brain as
- 00:48:13well that is that is so uh important and
- 00:48:16I you know I see a lot of older patients
- 00:48:19and I often ask them like who what are
- 00:48:21you doing like cuz sometimes their their
- 00:48:23Partners have passed away or you know
- 00:48:25the closest people them are getting
- 00:48:27older and the ones that thrive are the
- 00:48:29ones who get involved in their community
- 00:48:31in some way they may have they may go to
- 00:48:33bridge games they may do they may go
- 00:48:36golf with their buddies that they still
- 00:48:37have or make new friends and that is
- 00:48:40really or they'll volunteer even going
- 00:48:42to the library and volunteering or
- 00:48:43something and that's sort of how they
- 00:48:45maintain those social connections
- 00:48:47because I think even there's some day
- 00:48:49that even the the small connections like
- 00:48:51the the connections you have with people
- 00:48:53in passing are also very important to
- 00:48:56Foster because they help us connect with
- 00:48:58people in a different way yeah and and
- 00:49:00then you think about well why is that it
- 00:49:02could be the release of different
- 00:49:03neurochemicals when you're with somebody
- 00:49:05else and your bonding and that could be
- 00:49:06really great it could be the fact that
- 00:49:08you could be learning from somebody else
- 00:49:11because your brain is like oh I'm
- 00:49:12learning from somebody else I'm learning
- 00:49:14new things more connections more growth
- 00:49:16but if you understand the just the
- 00:49:19structural components which I mentioned
- 00:49:21which is we need adequate blood flow to
- 00:49:23feed the neurons what we don't want is
- 00:49:26neuron loss so how do we keep getting
- 00:49:29blood flow to the brain how do we keep
- 00:49:31strengthening the connections between
- 00:49:33the brain and then we'll talk now we can
- 00:49:37shift gears and talk about sleep because
- 00:49:38then that's also probably the next
- 00:49:40pillar of what you can be doing to
- 00:49:42health a healthy performing brain as
- 00:49:44well and so we've done Exercise we've
- 00:49:47done stress uh lower stress we've done
- 00:49:50positive social connections and now
- 00:49:51we'll do the fourth one which is sleep
- 00:49:53sleep is not just this nocturnal thing
- 00:49:56that we we go through it is a it is a
- 00:49:58repair process that is absolutely
- 00:50:01imperative for your brain and sleep we
- 00:50:04can just categorize it as we've got REM
- 00:50:06sleep and we've got deep sleep and your
- 00:50:08brain needs both of them and there's now
- 00:50:11um the latest research is actually
- 00:50:12showing that
- 00:50:14regularity actually is more important
- 00:50:16than quantity and quality really I would
- 00:50:19argue it is all important but regularity
- 00:50:22the time that you go to sleep remember
- 00:50:24Reena what did I say to you at the start
- 00:50:26your brain loves regularity M familiar
- 00:50:30it loves Pat it just wants to do the
- 00:50:32same thing every day don't shock it
- 00:50:34don't scare it right and so we've got a
- 00:50:38really wonderful process and this is
- 00:50:41stage three sleep so we've got stage one
- 00:50:43when we're falling asleep stage two
- 00:50:46we're in light sleep these are non rapid
- 00:50:49eye movement then we going to non Ram
- 00:50:52stage three sleep and on an EEG did you
- 00:50:56ever go into a PSG uh I've actually my
- 00:50:59son had one oh nice okay yeah so yeah
- 00:51:03well what you'd see is you'd see these
- 00:51:05big long waves and and they they're
- 00:51:07called slow delta waves but but slow
- 00:51:10wave sleep which is also PSG is a
- 00:51:12polynom graph for a sleep study for
- 00:51:14those of you listening or watching yeah
- 00:51:15and you know when you go in there you've
- 00:51:16got a lot I want everyone to know like
- 00:51:18because everyone's like well what's the
- 00:51:19difference between that and maybe a
- 00:51:20weareable like there's a lot you know
- 00:51:22we're monitoring a lot of activity
- 00:51:24during that but you see what happens
- 00:51:26during this stage this this Delta wave
- 00:51:29pattern is we know that your brain does
- 00:51:33many things one thing is this is where
- 00:51:34we get the release of testosterone mhm
- 00:51:38it was a 95% of um male testosterone is
- 00:51:41released during deep sleep not 95 but
- 00:51:44but a lot so what happens in
- 00:51:45testosterone is you release the highest
- 00:51:47amount is between 7 and 10: a.m. and
- 00:51:50then it sort of goes through a pulsatile
- 00:51:52but sort of slowly weaning throughout
- 00:51:54the day and then it starts releasing
- 00:51:55again around two to 4: am and goes back
- 00:51:58upwards but it starts in starts in the
- 00:52:00sleep yeah and that would be in deep
- 00:52:02it's probably most important for that
- 00:52:04first first four hours of sleep so like
- 00:52:07going to sleep from 10: to 2 rather than
- 00:52:10like the 2 to 6 or or you know that that
- 00:52:13sort of time frame is more important and
- 00:52:14that's why timing matters right we also
- 00:52:16get the release of growth hormone during
- 00:52:18that stage which is responsible for the
- 00:52:20growth and repair of our muscles so this
- 00:52:22is why when we're in deep Sleep it is a
- 00:52:25repair process for our brain but we also
- 00:52:28know that we activate a system which is
- 00:52:31some similar to a washing machine if you
- 00:52:34will it's called the glymphatic system
- 00:52:36now I mentioned
- 00:52:37neurons what sticks between the neurons
- 00:52:39are these other types of cells it's our
- 00:52:41chief immunity cell in the brain and
- 00:52:43they're called gal cells comes from the
- 00:52:45Greek word glue can you tell I'm Greek
- 00:52:48um and they stick you know they B bind
- 00:52:50together between the two neurons and
- 00:52:53they shrink in size during deep sleep
- 00:52:57and when they shrink it means that we
- 00:52:59can have the we can have our cerebral
- 00:53:02spinal fluid be able to wash away in
- 00:53:05this beautiful synchronous way and it
- 00:53:07gets excreted taking with it toxins
- 00:53:11taking with it the whole marks of
- 00:53:12Alzheimer's disease which is amalo beta
- 00:53:15and it washes it through the brain
- 00:53:17washes it out through the system so you
- 00:53:19wake up you feel good normally if you
- 00:53:21wake up and you've got brain fog which
- 00:53:24is probably quite a big symptom of you
- 00:53:26know what maybe you just didn't get a uh
- 00:53:29get enough deep sleep and you didn't
- 00:53:31activate this system this system is
- 00:53:33blocked if you're having marijuana or
- 00:53:36alcohol MH I just want everyone to know
- 00:53:38that it can also be blocked under
- 00:53:39certain medications as well yeah so
- 00:53:42that's you know the deep sleep thing I
- 00:53:43think people don't realize like what
- 00:53:45makes good quality sleep oh yeah I think
- 00:53:47really uh people like well yeah I'm
- 00:53:49sleeping 7 8 hours I'm you know I'm
- 00:53:51getting the right amount of sleep and I
- 00:53:53always you know for me I didn't even
- 00:53:54realize it either I am used to drink I
- 00:53:56mean I'm a physician so we drink coffee
- 00:53:58all the time so I used to drink coffee
- 00:54:00late in the day and I realized when I
- 00:54:02stopped that and I started I could fall
- 00:54:04asleep fine I mean I was chronically
- 00:54:06asleep deprived as a resident I could
- 00:54:07fall asleep anywhere but I would fall
- 00:54:09asleep fine but I'd still feel tired and
- 00:54:11I realized once I limited my caffeine
- 00:54:13intake to prior to noon I actually and
- 00:54:16now I drink decaf a lot of the times um
- 00:54:18my sleep is way better well that's
- 00:54:21because caffeine obviously there's a
- 00:54:23halflife to it so it interrupts sleep
- 00:54:26and caffeine is an adenosine blocker
- 00:54:28which we know um adenosine builds up
- 00:54:30during the day which makes us tired yeah
- 00:54:33and so we want to try and do everything
- 00:54:36we can you know I always say you're
- 00:54:38preparing for sleep the day before or
- 00:54:41the morning that you wake up you are
- 00:54:43setting your circadian rhythm from the
- 00:54:44first time you see sunlight around you
- 00:54:47know 12 hours after that when we're
- 00:54:49going to get tired we really want to be
- 00:54:51in deep sleep and then another thing
- 00:54:53that will kick you out of that stage as
- 00:54:55well is light and you think well I've
- 00:54:58got a dark room but even the smallest
- 00:55:01amount maybe a street light for my
- 00:55:03parents um you know street lights I live
- 00:55:05in New York City I mean there's light
- 00:55:07everywhere but I I wear a mask every
- 00:55:10night so there's one more thing and this
- 00:55:12is new research in the last I would say
- 00:55:146 years we know that in order to fall
- 00:55:16asleep and stay asleep our core body
- 00:55:18temperature needs to drop 2° so keeping
- 00:55:22a cool environment can help you there's
- 00:55:26a difference between ambient temperature
- 00:55:29temperature of the room and your actual
- 00:55:31thermal temperature some people like to
- 00:55:33sleep on a um thermal mattress and then
- 00:55:37but if you don't have that you don't
- 00:55:38need it you can obviously tamper with
- 00:55:40the temperature in your room or even
- 00:55:42sleep with your feet outside of the
- 00:55:44sheets because that's where we you know
- 00:55:46get rid of our isn't wearing socks
- 00:55:48actually reduce your core body
- 00:55:49temperature yeah it does so doing all
- 00:55:52these tiny little oh I hate the word
- 00:55:54hacks but these tiny little
- 00:55:56things can really make an improvement at
- 00:55:58lowering your core body temperature
- 00:56:00throughout the night and enabling you to
- 00:56:02have a deep sleep so sleep regularity
- 00:56:05though is number one so even on the
- 00:56:07weekends sleeping in on the weekends
- 00:56:09probably not ideal no and remember a you
- 00:56:13can't your your sleep isn't like it's
- 00:56:15not like debt that you repay to the bank
- 00:56:17so it's not like I'll sleep 12 hours on
- 00:56:19the weekend I know right and one thing I
- 00:56:21want everyone to know is um the study
- 00:56:24that changed my life there's you know
- 00:56:25there's always there's either always a
- 00:56:27patient a client or a study that changes
- 00:56:30you and the one that changed me for the
- 00:56:32game was a study done on healthy adult
- 00:56:35men and it was um published in pnas
- 00:56:39where they subjected them to sleep
- 00:56:41deprivation of just one week sleep
- 00:56:43deprivation by the way guess what how
- 00:56:45many hours it was six hours yeah you
- 00:56:47know which one I'm talking about it was
- 00:56:48the epigenetic change you've probably
- 00:56:50mentioned it but that changed the game
- 00:56:51for me where they found a um a change in
- 00:56:54711 genes the ones that were upregulated
- 00:56:58were the ones responsible for tumor
- 00:57:00growth the ones that were down regulated
- 00:57:02were the ones responsible for immunity
- 00:57:04yeah it's so interesting I mean I think
- 00:57:05sleep I I love talking about sleep and I
- 00:57:08think that the one we're the only
- 00:57:10species and Matt Walker says this we're
- 00:57:12the only species who intentionally sleep
- 00:57:14deprive ourselves our brains hurt us
- 00:57:16sometimes too right cuz we we let
- 00:57:18ourselves think oh I just want to do
- 00:57:19this one more thing before bed or I just
- 00:57:21want to like I want to Doom scroll or
- 00:57:24watch another episode of TV or whatever
- 00:57:25it is
- 00:57:26that when actually the restorative thing
- 00:57:29would be to go to sleep absolutely and
- 00:57:32unfortunately what happens even when you
- 00:57:34get the you know the buildup of these
- 00:57:36amalo plaques it has this cycle where if
- 00:57:40you don't sleep you know you you raise
- 00:57:43your risk of developing these um this
- 00:57:46disorder but then when you have it it
- 00:57:49also prevents you from sleeping yeah
- 00:57:52it's really really tough I'm not going
- 00:57:54to go back into you know I know we are
- 00:57:56focusing on brain health but and we're
- 00:57:58focusing on sleep right now but I want
- 00:58:00everyone to know that there are only two
- 00:58:02real medications right now um that are
- 00:58:04attacking the amalo but it's very slow
- 00:58:07acting by the time you know they're
- 00:58:10administered through an IV by the time
- 00:58:12they actually get in and you know
- 00:58:14ameliorate these plaes and Tangles it
- 00:58:16takes a very long time and the process
- 00:58:20of building up the amalo is taking place
- 00:58:23so really no drug really is curing we
- 00:58:27have no cure for Alzheimer's disease we
- 00:58:29have no reversal of Alzheimer's disease
- 00:58:33we don't even the the actual FDA
- 00:58:35approved drugs that we have and only
- 00:58:38having a very small amount of an effect
- 00:58:42so banking on the things that actually
- 00:58:45work from a preventative standpoint such
- 00:58:47as sleep is going to just do so many
- 00:58:52more wonders than any drug ever could
- 00:58:54are these things as patients who have
- 00:58:56dementia maybe Alzheimer's a little more
- 00:58:58challenging to get patient Buy in but
- 00:58:59like to get them to sleep better or to
- 00:59:02get them to exercise are they going to
- 00:59:03see improvements in their symptoms at
- 00:59:05all yes and no so if you've already got
- 00:59:08MCI so mild cognitive impairment which
- 00:59:10is a pre-dementia state you can see the
- 00:59:13slowing of that so you can slow the
- 00:59:15progression of the MCI through all the
- 00:59:18mechanisms that we discussed earlier but
- 00:59:20you can never just halt it no yeah I
- 00:59:22mean I think it can it can help their
- 00:59:24other health conditions too because very
- 00:59:26often because it's a very often a
- 00:59:28vascular issue they also have high blood
- 00:59:30pressure they also have U maybe have had
- 00:59:33a stroke they you know these other
- 00:59:35horrible things that have happened and
- 00:59:36so like they can help with those
- 00:59:38conditions as well yeah absolutely and
- 00:59:40improve their quality of life quick
- 00:59:41break from this episode to let you know
- 00:59:43I am so grateful that you're spending
- 00:59:45part of your day with me I started
- 00:59:47creating content online to empower
- 00:59:49people to learn more about their bodies
- 00:59:51without needing to go see a doctor pay a
- 00:59:53co-pay wait in a waiting room or find
- 00:59:56parking and it has been one of the most
- 00:59:59rewarding experiences of my life if you
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- 01:00:24support the show and join today at renam
- 01:00:27malik. supercast docomo to see you there
- 01:00:30in terms of travel so you said melatonin
- 01:00:32what do you do when you're traveling
- 01:00:33like how do you to because of course
- 01:00:35you're going to get jet lagged of course
- 01:00:37your time zones are off when I do a
- 01:00:38short trip I try to stay on the same
- 01:00:40time zone that I was when I go home um
- 01:00:43if possible but I think if you're on a
- 01:00:45longer trip you know what do you tend to
- 01:00:47do so I tend to try and set my so Rhythm
- 01:00:50based on where I'm going to land and I
- 01:00:52do this through a number of ways a one
- 01:00:54of the biggest things for traveling is I
- 01:00:56try and minimize the amount of food that
- 01:00:58I'm eating on a plane that's the first
- 01:01:00thing the second thing is I do like to
- 01:01:03sleep as much as possible banking on
- 01:01:05sleep even though I mentioned earlier
- 01:01:07that it's not like a debt that you can
- 01:01:09repay to the bank but you can you can
- 01:01:11Bank on sleep so you can put as much
- 01:01:14sleep in your tank as humanly possible
- 01:01:17prior to going just to cater for the jet
- 01:01:20lag I'm also using light exposure I'm
- 01:01:24doing this through natural sunlight
- 01:01:26light but also through a 10,000 Lux
- 01:01:28light box that I car carry around with
- 01:01:30me you can get these on Amazon for about
- 01:01:3140 bucks so I'm doing that to help set
- 01:01:34my set my circadian rhythm to the time
- 01:01:36zone that I'm going into so like for
- 01:01:39example if you are going from New York
- 01:01:41to LA and LA's uh your normal Circ
- 01:01:45rhythm is to wake up at let's say 7:00
- 01:01:47a.m. right but here 7:00 a.m. is 4:00
- 01:01:49a.m. right so what are you doing to
- 01:01:51prepare for that and then when you're
- 01:01:52going back let's like give some some
- 01:01:54concrete examples yeah so I would set I
- 01:01:57only do it for 72 hours I will put my
- 01:02:00body into a a state where I'm getting
- 01:02:02into waking up at 4:00 a.m. and
- 01:02:05hopefully going to sleep at 1 p.m. PST
- 01:02:09which will be 700 p.m. I will do this
- 01:02:11through the use of melatonin through the
- 01:02:14use of magnesium L3 and8 and through the
- 01:02:16use of Pharma Gaba and Gaba is our chief
- 01:02:20inhibitory neurotransmitter and this is
- 01:02:23just to help me calm my mind down and
- 01:02:25Rel relax me so I can induce sleep
- 01:02:27better often times it won't work out
- 01:02:30that way I'll probably get to bed at
- 01:02:31maybe fall asleep at 8:00 p.m. but then
- 01:02:33wake up at 5: so it helps so you you'll
- 01:02:37like so you maybe for the 3 days before
- 01:02:39you'll wake up at so say you wake up at
- 01:02:407:00 you wake up at 600 and then you
- 01:02:42wake up at 5 you wake up at 4 and what
- 01:02:44time are you taking these supplements
- 01:02:46like how often before so say you want to
- 01:02:48sleep at 700 you're taking at 600 you're
- 01:02:49taking my five no 20 minutes prior to
- 01:02:52bedtime 20 minutes yeah that's when I
- 01:02:54I've seen the most effect for me me and
- 01:02:56you know from the and then when you're
- 01:02:58on vacation you reverse it to go back
- 01:03:01that's correct and it's all for me I
- 01:03:03don't have um jet lag when I go to
- 01:03:05Australia it's when I'm coming back that
- 01:03:07I'm it's a punish for me so I do
- 01:03:09everything I can even I even use
- 01:03:11caffeine to help stimulate me during um
- 01:03:14the the moment when I need to wake up as
- 01:03:16well and why don't you eat on a plane
- 01:03:19because you've already got lowered
- 01:03:21digestion you're already up in the air
- 01:03:23you've got first of all the worst thing
- 01:03:24about being up in the air is you've got
- 01:03:26less oxygen mhm right and now um I was
- 01:03:29actually I went and bought I haven't
- 01:03:31used it yet I bought this drink bottle
- 01:03:33that can actually you know help with the
- 01:03:36oxygenation as well on flight I I mean I
- 01:03:38don't know if it's completely you know
- 01:03:41efficacious but I'm I'm going to try
- 01:03:43that but yeah but pretty much when it
- 01:03:45comes to food on the plane you are not
- 01:03:48moving around you don't have aot lot of
- 01:03:49blood flow so digestion is just not
- 01:03:51going to be at its peak so you want to
- 01:03:52just be able to minimize the amount of
- 01:03:54food that you have to digest at such a
- 01:03:56high altitude got it got it so don't be
- 01:03:58snacking the whole FL because that's
- 01:04:00probably one of the reasons why you also
- 01:04:01feel horrible when you get off a plane
- 01:04:03yeah yeah or drinking or whatever oh my
- 01:04:06gosh people who drink on a plane um I
- 01:04:08don't understand well someone who used
- 01:04:10to drink I don't drink anymore but I
- 01:04:12think um it used to be like part of the
- 01:04:13vacation experience right like I'm going
- 01:04:15to have a cocktail on the plane and I'm
- 01:04:17going to relax I'm going to maybe go to
- 01:04:18sleep and it'll help me relax and maybe
- 01:04:21should just take some melatonin before
- 01:04:22the plane do you ever do that like take
- 01:04:24just to like make the plane ride faster
- 01:04:26do you like try to sleep on a plane if
- 01:04:28it's an overnight so tomorrow night I
- 01:04:30fly out at like 10: p.m. so it'll be an
- 01:04:33overnight flight so for me I will take
- 01:04:35melatonin just to try and like settle me
- 01:04:37down so I'm not up wired for 14 hours
- 01:04:39the entire trip got it got it we didn't
- 01:04:42touch on REM sleep and I will because
- 01:04:43that's the last stage of sleep that is
- 01:04:45also very crucial for the brain so rapid
- 01:04:49ey movement sleep we know that on a uh
- 01:04:52on a PSG you'll see these horizontal eye
- 01:04:54movements of the brain and what we know
- 01:04:56is that you are completely paralyzed
- 01:04:58from the neck down but your brain if you
- 01:05:01look at these brain waves it mimics an
- 01:05:03awake patient so it's a lot of chaos is
- 01:05:06happening and this is generally where we
- 01:05:08get our memory formation vivid dreams
- 01:05:10occur which is why um and we get also
- 01:05:14the process of learning and the
- 01:05:16penetration of learning and skill
- 01:05:18acquisition you know if you've got kids
- 01:05:20and they're out there learning a skill
- 01:05:22it's also going to get penetrated during
- 01:05:24sleep you know skill takes the form of
- 01:05:27actual happening in real time learning
- 01:05:29of the skill but also the penetration of
- 01:05:31the skill yeah I think one I remember
- 01:05:34the first time I learned that we're
- 01:05:35paralyzed in our sleep I was like how
- 01:05:37does that even work evolutionarily like
- 01:05:38what if you get you like you know
- 01:05:41sometimes you wake up and you're like
- 01:05:42you feel like you can't move for a
- 01:05:44second and um it doesn't happen often
- 01:05:46but like you know you wake up at the
- 01:05:47wrong moment or whatever and um it's
- 01:05:50it's sort of scary but two the the
- 01:05:51learning acquisition thing is is really
- 01:05:54um important and that's one thing I
- 01:05:55learned from Matt Walker when I was Lear
- 01:05:57reading his book and stuff was like
- 01:05:59these these teenagers right their circu
- 01:06:01Rhythm is a bit later yeah and they're
- 01:06:03high school at least when I was I think
- 01:06:05they've gotten better when I was in high
- 01:06:07school you had to wake up at 7:00 a.m.
- 01:06:08to go to school and you're you're that's
- 01:06:10like 4 hours earlier than your circadian
- 01:06:12rhythm is really allowing and so they're
- 01:06:15losing all that skill acquisition
- 01:06:17correct they're losing the skill
- 01:06:18acquisition they're as well what about
- 01:06:20the amount of dopamine that gets
- 01:06:22released as well that you know that
- 01:06:23molecule that motivates us and drives us
- 01:06:26and you know puts Forward Motion in
- 01:06:29place that's also getting that's not
- 01:06:30also getting released you know at the
- 01:06:32right time so that's scary as well yeah
- 01:06:35for people who wake up in the middle of
- 01:06:36the night uh and have trouble falling
- 01:06:39asleep what do you suggest for them do
- 01:06:40not look at light and I know many of
- 01:06:42your viewers are going to be like well
- 01:06:43that's great Louisa I'm going to trip
- 01:06:45going to the bathroom I would suggest
- 01:06:47getting Lighting on the floor yeah I
- 01:06:50tell them to get track lighting so like
- 01:06:51when you're walking it just like it it
- 01:06:53activates to your footstep but
- 01:06:56it's motion censored and usually like
- 01:06:57just track lighting on the on the bottom
- 01:06:59like hallway floor yeah don't open the
- 01:07:03fridge that's going to be like a a lot
- 01:07:04of people think okay I'm hungry I'll go
- 01:07:06to the fridge I also say that leave the
- 01:07:08bed for sleeping if you're doing other
- 01:07:11things in there like you know watching
- 01:07:12TV maybe doing homework for young kids
- 01:07:15or whatever that may be you're you're
- 01:07:18also taking away from that sleep
- 01:07:19pressure so you really want to minimize
- 01:07:21the bedroom and just leave it for sleep
- 01:07:24and that's it yeah I've always been so
- 01:07:26curious why people get these huge Master
- 01:07:28Suite bedrooms because I don't even go
- 01:07:30in my bedroom except to sleep like I
- 01:07:31don't spend time in there hanging out
- 01:07:33like reading a book in the in the um you
- 01:07:36know in a chair or something like that's
- 01:07:38in my living space and so I've always
- 01:07:40been like very curious as to why people
- 01:07:43uh develop these huge ginormous like
- 01:07:46bedrooms like they're going to be
- 01:07:47spending all this time like you know
- 01:07:49doing stuff in their bedroom but maybe
- 01:07:50other things that's okay leave it for
- 01:07:53sex and sleep yes yeah absolutely um in
- 01:07:56terms of reading before bed so obviously
- 01:07:58want to avoid looking at a screen so try
- 01:08:01not to look at a phone or or something
- 01:08:03but what about using a Kindle versus
- 01:08:05reading a real book with some sort of
- 01:08:07light obviously you need some light to
- 01:08:08read what do you think about that it
- 01:08:10depends on whether it's actually going
- 01:08:11to keep you some people get EX so for me
- 01:08:15like I'm better off watching a TV show
- 01:08:17because that just requires nothing from
- 01:08:19me mentally when I read I get stimulated
- 01:08:21and excited so that's going to stimulate
- 01:08:24me so I I choose not to read but in
- 01:08:26terms of lighting it look it's better
- 01:08:28than looking at a screen I know that you
- 01:08:30can like lower the lighting on the the
- 01:08:33Kindle so that's going to be great too
- 01:08:35but generally you really want to just
- 01:08:37get into bed I say so lights out at
- 01:08:38neuro Athletics is 10: p.m. if I want
- 01:08:41you in bed at 10:00 I want you asleep by
- 01:08:4210:00 I want you to get actually in bed
- 01:08:44by around
- 01:08:46940 and give yourself the 20 minutes of
- 01:08:48you know just relax sleep latency and
- 01:08:52sleep onset yeah yeah okay so we got
- 01:08:55four things right five what's the fifth
- 01:08:56thing well the fifth thing is um I would
- 01:08:58say it it falls under the bandwagon of
- 01:09:01nutrition we know that one of the best
- 01:09:02things that you can have for your brain
- 01:09:04now I never get involved in nutrition on
- 01:09:06Instagram these wars are just absolutely
- 01:09:08insane I am an omnivore I maintain a
- 01:09:11really great lipid profile even though I
- 01:09:13have red meat I really I really take
- 01:09:16that into consideration we know the
- 01:09:18brain loves antioxidants we know that it
- 01:09:21loves selenium okay we know that it
- 01:09:24loves vitamin A vitamin E so we want to
- 01:09:27be getting antioxidants from
- 01:09:29blackberries blueberries oranges we know
- 01:09:31that it loves vitamin C these can help
- 01:09:34protect you against free radicals these
- 01:09:36free radicals that occur in our
- 01:09:39environment in our just in our daily
- 01:09:42thoughts in our stress and in fact which
- 01:09:44recently um I've just done an episode
- 01:09:47dedicated to water and I just um I
- 01:09:50didn't even know I'm currently drinking
- 01:09:52um essential no I'm drinking out of a
- 01:09:55I'm drinking smart water out of a a
- 01:09:57plastic bottle these bottles release
- 01:09:59these tiny microplastics and apparently
- 01:10:01um on average we're all having a credit
- 01:10:04card worth of microplastics per week
- 01:10:07yeah each bottle is like 15
- 01:10:08microplastics and then just think of
- 01:10:10that over the I just did a video on this
- 01:10:11that's why oh so you've done the same
- 01:10:13thing okay great so yeah I mean I think
- 01:10:15it's fine I think like once in a while
- 01:10:17as long as you're not always drinking
- 01:10:18like you're a traveling you're not home
- 01:10:20right but like I think if you're
- 01:10:21drinking from a water bottle once in a
- 01:10:22while that's cold and not in a hot
- 01:10:24environment it's fine and it's all about
- 01:10:27the dose right so if you are constantly
- 01:10:30drinking from plastic water Botts that
- 01:10:32stored in your hot garage that's
- 01:10:33probably not as safe or if you're
- 01:10:35warming up your food in plastic
- 01:10:37containers that's not as safe as using a
- 01:10:39glass and that's really pretty simple
- 01:10:41and easy to do but I don't like to
- 01:10:42stress people out and be like oh you
- 01:10:44know you got to get rid of every plastic
- 01:10:46thing in your house and spend a ton of
- 01:10:48money to buy more because it's again
- 01:10:49it's the dose absolutely so so we know
- 01:10:52that that can help with free radical
- 01:10:54damage that is something that's really
- 01:10:55going to mitigate it and protect it
- 01:10:57against it so we want to increase our
- 01:10:59antioxidant profiles we sitting under
- 01:11:02that as well is really there's so much
- 01:11:05great research now on Creatine we used
- 01:11:06to think that creatine was just good for
- 01:11:08the body we know that it is really good
- 01:11:10for the brain from a
- 01:11:12neuroprotective standpoint we've seen
- 01:11:15that postmenopausal women we've seen
- 01:11:17them um you know in a a 2-year really
- 01:11:20great study I think this was um done by
- 01:11:22Dr Darren kandal he dosed them with uh
- 01:11:24around 10 G of creatine per day they had
- 01:11:27improvements in muscle mass and bone
- 01:11:29density and I know people are going to
- 01:11:32say but Louisa doesn't this ruin your
- 01:11:33kidneys and it doesn't so creatine is
- 01:11:35absolutely fantastic for that we're now
- 01:11:37seeing the association of creatine and
- 01:11:42Parkinson's disease so I know that the
- 01:11:43Alzheimer's research is going to come I
- 01:11:45think it's going to come from a
- 01:11:47neuroprotective standpoint so it helps
- 01:11:50with ATP generation so Cell Energy
- 01:11:53metabolism we need it we want it the
- 01:11:57next thing is our brain is made of fats
- 01:12:02and water and around
- 01:12:0520% of our lipids in our brain is made
- 01:12:08from
- 01:12:09DHA and omega-3 fatty acids is another
- 01:12:13thing that I would definitely recommend
- 01:12:16anybody it doesn't matter outside of go
- 01:12:18and do your blood work but really having
- 01:12:21high dose omega-3 fatty acids EPA and
- 01:12:24DHA specifically Al is going to do
- 01:12:26wonders for your brain it's going to do
- 01:12:28wonders for actually downregulating
- 01:12:30inflammation it's got a huge safety
- 01:12:33profile and it can really really help
- 01:12:36with these inflammatory biomarkers but
- 01:12:38it can also help with cell membrane
- 01:12:40fluidity yeah so there's pretty good
- 01:12:42evidence on Omega-3s and it's it's very
- 01:12:44difficult to get enough from our diet I
- 01:12:47think I mean I think you can do it but I
- 01:12:49think it's challenging unless you're
- 01:12:50eating fish every day or um but this
- 01:12:53even depends on the type of fish m MH
- 01:12:55yeah yeah so it's very tough um so yeah
- 01:12:58I think that's a good one are you
- 01:12:59feeling in a rut in the bedroom wishing
- 01:13:01you had the kind of sex life you could
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- 01:13:39what other things in terms of diet you
- 01:13:41know I think Whole Foods generally
- 01:13:43speaking lots of plants and plant
- 01:13:46forward meaning lots of vegetables lots
- 01:13:48of fruits as antioxidant with with high
- 01:13:50antioxidants are very beneficial other
- 01:13:52things that you recommend the things
- 01:13:53that I don't it's it's like okay just we
- 01:13:57know that there is this you know people
- 01:14:00argue well saturated fat is bad because
- 01:14:02it clogs the AR arteries and it's like
- 01:14:04okay that's great as long as you
- 01:14:06maintain a good um lipid profile like I
- 01:14:09mentioned you keep your apob B down your
- 01:14:11um LDL down it's it's it's fine and I
- 01:14:14want to reiterate like one of the I
- 01:14:16think one of the worst things that has
- 01:14:18ever happened in brain health is the
- 01:14:20fact that people think the brain is made
- 01:14:22of cholesterol and cholesterol past
- 01:14:25dietary cholesterol can pass through the
- 01:14:26blood brain barrier I want to make a
- 01:14:28note that dietary cholesterol cannot
- 01:14:31pass through to the brain unless you
- 01:14:33have a compromised bloodb brain barrier
- 01:14:35so don't even think about like oh
- 01:14:38avocados are good for your brain it's
- 01:14:39not doesn't work that way yeah the blood
- 01:14:42brain barrier does get weaker though as
- 01:14:44we age yeah we do get permeability in
- 01:14:46the bloodb brain barrier and actually
- 01:14:48one of the best things um to do for that
- 01:14:51is exercise as well it really does help
- 01:14:53with the Integrity of the bloodb brain
- 01:14:55barrier via these little capillaries
- 01:14:59yeah yeah that's great um in terms of
- 01:15:01things that cross the bloodb brain
- 01:15:03barrier medications so I do a lot of
- 01:15:06overactive bladder management and one of
- 01:15:07the medications we use unfortunately for
- 01:15:10overactive bladder that often insurance
- 01:15:12covers because it's cheaper is
- 01:15:14anticholinergics yes and these have very
- 01:15:18you know challenging side effects
- 01:15:20including dry mouth dry eyes
- 01:15:21constipation but there's more and more
- 01:15:23data suggesting that that there is a
- 01:15:25link there is an association between
- 01:15:27these medications and dementia and I
- 01:15:30can't tell you the number of patients I
- 01:15:31have who come to me and they're on 16
- 01:15:34medications okay 16 yeah like 16 I mean
- 01:15:38like high blood pressure diabetes high
- 01:15:40cholesterol um they may be depressed
- 01:15:43they may have uh overactive bladder and
- 01:15:45so they're on all these medications and
- 01:15:47I'm always like wait wait are you even
- 01:15:48seeing a benefit let's let's peel it
- 01:15:50back cuz if you're not seeing a benefit
- 01:15:52let's stop these medications because
- 01:15:54they're not doing any favors if they're
- 01:15:56not helping you so is there anything
- 01:15:58else that we should be doing to improve
- 01:16:00brain health that we haven't talked
- 01:16:01about you also should be hydrating and
- 01:16:04then look everything else is an
- 01:16:05accessory item when it comes to brain
- 01:16:07health as long as you're getting the
- 01:16:09like I always say the cake is exercise
- 01:16:13sleep proper nutrition and the two
- 01:16:15nutrients you know the two supplements
- 01:16:17that we discussed everything else is an
- 01:16:19accessory ice baths I have one in my
- 01:16:21living room because I love it I think
- 01:16:23it's great for me
- 01:16:25it's an accessory your your saers that
- 01:16:28is an accessory red light therapy which
- 01:16:30is something that I'm really getting
- 01:16:32into now we know that like near infrared
- 01:16:34light and red light can penetrate uh the
- 01:16:36skin and go into the superficial organs
- 01:16:38we're seeing great efficacy for that
- 01:16:41actually being going going into the nose
- 01:16:43and shooting up to the brain we're
- 01:16:44seeing that for stroke
- 01:16:46patients helping with healing and trauma
- 01:16:49but again it's just an accessory it's
- 01:16:51not going to have the biggest bang for
- 01:16:52The Bu yeah what are things that people
- 01:16:54people think are helping and you
- 01:16:56mentioned like avocados and things but
- 01:16:58what are things that people think help
- 01:16:59their brain but they don't oh you know
- 01:17:01there is a lot of research on like early
- 01:17:04research on medicinal mushrooms and I
- 01:17:06get asked often do you think that this
- 01:17:07is going to be good that people are
- 01:17:08taking Lion's man and it's like it's
- 01:17:11very it's very nuanced it's very in
- 01:17:14small doses it might help with
- 01:17:16synaptogenesis as I mentioned but
- 01:17:18there's just a lot of the supplements
- 01:17:20that you're taking should only be taken
- 01:17:23if clinically relevant like if you get a
- 01:17:26low if you got like if you're vitamin D
- 01:17:28deficient vitamin is wonderful for the
- 01:17:30brain and if you're vitamin D deficient
- 01:17:32yes but if you're you know if you're
- 01:17:34over 60 that's fine like you're you're
- 01:17:36fine you don't need to be supplementing
- 01:17:37with absolutely everything yeah yeah I
- 01:17:39think that's important is there
- 01:17:41something that you used to think was
- 01:17:43important about for brain health that no
- 01:17:45longer is or something you've changed
- 01:17:46your mind on I did change my mind on
- 01:17:49plant diversity I would say that I was
- 01:17:52never carnivore no but I'm now trying to
- 01:17:55do more because I'm seeing a lot of
- 01:17:58research in the way the gut communicates
- 01:18:02we've got you know it's a bir
- 01:18:03directional access between the the brain
- 01:18:06and the gut you've got this one fiber
- 01:18:08the you know you've got the vagus nerve
- 01:18:10which goes down to from the brain down
- 01:18:13into the gut but then you've got around
- 01:18:1410 fibers that go from the gut to the
- 01:18:17brain which can help you know signal
- 01:18:20things such as depression anxiety
- 01:18:23schizophrenia so I'm changing my mind
- 01:18:26about how important plant diversity is
- 01:18:31in maintaining a healthy gut to maintain
- 01:18:33a healthy brain and I'm sure you're
- 01:18:36aware of Dr Chris Palmer who is
- 01:18:38completely on the ketogenic side where
- 01:18:40he is you know advocating for a
- 01:18:42ketogenic Rich diet due to you know
- 01:18:46mitochondrial dysfunction which is a
- 01:18:48Hallmark of a lot of these um diseases
- 01:18:50in mental Mental Illness but I I I'm
- 01:18:53seeing just so much strong evidence cuz
- 01:18:55I'm in the Alzheimer's disease space on
- 01:18:58having plant rich foods for the brain so
- 01:19:01yeah I think there's a lot of data on
- 01:19:03fiber and which is what you're getting
- 01:19:05from plant rich foods like the
- 01:19:06cruciferous vegetables and how that
- 01:19:08affects brain health right because
- 01:19:11you're affecting you're getting uh buic
- 01:19:13acid which is then affecting brain
- 01:19:15health so that's one thing I've changed
- 01:19:16my mind on and one thing that I've it's
- 01:19:19not changed my mind but something that
- 01:19:20I'm now really really pushing for is sex
- 01:19:24differences we know that there is a
- 01:19:27difference okay in our brains in terms
- 01:19:29of if you are born and I I want to be
- 01:19:31very careful with you know in terms of
- 01:19:33gender but if you are born with ovaries
- 01:19:36and a UR you've got a different brain to
- 01:19:38that of a a male in terms of the
- 01:19:41neuroendocrine system so I think the way
- 01:19:44that we use Precision medicine when it
- 01:19:47comes to patient advocacy I think it's
- 01:19:50shouldn't be a onesize fits all approach
- 01:19:55it upsets me that even you know the
- 01:19:57first studies that were done on the the
- 01:19:59sex differences in brains was done in
- 01:20:01like 1850 and we still hold true those
- 01:20:05notion like we we're going to space okay
- 01:20:08and we still can't understand the
- 01:20:10difference between male and female
- 01:20:11brains I think that that is something
- 01:20:14that I would love after I get this done
- 01:20:16maybe I'll go through and and start
- 01:20:18researching the sex differences in male
- 01:20:20and females because male and female are
- 01:20:23inherently different in that aspect so
- 01:20:25that's another thing I've changed my
- 01:20:26mind on yeah no I think that's really
- 01:20:28interesting I I do think that um there's
- 01:20:31a lot of work to be done in so many
- 01:20:33areas but absolutely there there are
- 01:20:35differences I think in genders and we'll
- 01:20:37see how that plays out over time I mean
- 01:20:39you'll interview Dr mcone and I think
- 01:20:40that'll be really useful but there's a
- 01:20:42lot of data in terms of like how
- 01:20:44hormones affect our brains and obviously
- 01:20:47we have different levels of hormones but
- 01:20:49every hormone in terms of male and
- 01:20:50female but those hormones are very
- 01:20:52valuable for both so for men estrogen is
- 01:20:54important and for women testosterone is
- 01:20:56important and people don't really
- 01:20:57realize how valuable that is and people
- 01:20:59don't realize that everything is
- 01:21:01everything meaning that it's not just
- 01:21:03about these structural components these
- 01:21:05receptors in the brain of estrogen and
- 01:21:06testosterone it is what are they what is
- 01:21:09estrogen doing or what is the lack of
- 01:21:11estrogen doing and what is it doing on
- 01:21:13your mood and your cognition and then
- 01:21:16what is that then doing on the choices
- 01:21:18that you make every day to either go to
- 01:21:20the gym or not go to the gym um you know
- 01:21:22for me you know during the menstrual
- 01:21:25cycle sometimes I I just can't go to the
- 01:21:27gym and so that then it's not just oh
- 01:21:31estrogen and and it is like what happens
- 01:21:33after that what very individual right
- 01:21:35like there's some people who don't
- 01:21:37notice a difference with their cycle and
- 01:21:38there's some people who do and there's
- 01:21:40you know it's like how hormone sensitive
- 01:21:41are you we're not looking at The
- 01:21:42receptors right you're not looking at
- 01:21:44how many receptors are getting activated
- 01:21:46and how sensitive those receptors are I
- 01:21:47mean it goes down to a very deep level
- 01:21:50so I always tell my patients like it
- 01:21:51doesn't matter what your numbers are I
- 01:21:53mean we look at them we monitor them
- 01:21:54because they're important to see that
- 01:21:56we're headed in the right direction but
- 01:21:58what matters to me is how you feel
- 01:22:00because I can't test receptors you have
- 01:22:02I can't test how sensitive they are to
- 01:22:04the amount of testosterone or the amount
- 01:22:05of hormones you're getting and so I
- 01:22:07think it's really important to realize
- 01:22:09that that every person is individual
- 01:22:11yeah and and and just as a closing out
- 01:22:13on that it's all also about when you
- 01:22:16advocate for women's rights it's
- 01:22:17advocating for women to come forward and
- 01:22:20be able to trust their physician and
- 01:22:22have a really good doctor patient
- 01:22:23relationship where they can can be
- 01:22:24completely honest with how they're
- 01:22:27feeling um I lost my my grandmother and
- 01:22:30my auntie both in the matter of like two
- 01:22:32weeks from um from cancer and my mom and
- 01:22:36I talk about it often you two women who
- 01:22:38just never told us how they were feeling
- 01:22:40I'm so sorry yeah and that's it's it's
- 01:22:43devastating like you never you never
- 01:22:44knew and I I remember asking I said why
- 01:22:46didn't you tell me I didn't want to
- 01:22:47bother anyone MH that's a very yeah it's
- 01:22:50a very I would never hear a male well I
- 01:22:52haven't no sorry I shouldn't say that I
- 01:22:53haven't heard um any of my my
- 01:22:55grandfather ever say that I think it's
- 01:22:57different I mean I think men tend to
- 01:22:59bottle up a lot of things I mean I work
- 01:23:01with a lot of male patients they don't
- 01:23:02share necessarily always but it's just I
- 01:23:04think it's it's in human nature to
- 01:23:06sometimes not want to burden others but
- 01:23:08certainly I think in terms of women we
- 01:23:10so busy taking care of others that we
- 01:23:12often don't take care of ourselves
- 01:23:15whereas for men I think it's that they
- 01:23:16feel like they need to be masculine and
- 01:23:18they don't share things and so it
- 01:23:20happens for different reasons
- 01:23:21potentially that are cultural uh but uh
- 01:23:24I think it's still in both genders it
- 01:23:26does it does happen yeah I know your
- 01:23:29your company works with Elite athletes
- 01:23:30and high- Performing individuals so
- 01:23:32let's talk about either you want your
- 01:23:35kid to train to become an athlete or you
- 01:23:37yourself are a high performing maer Like
- 01:23:39a Surgeon like for me I need to go to
- 01:23:41work and I need to operate on people and
- 01:23:42I need to be at the top of my game so
- 01:23:44what are additional things that someone
- 01:23:46who is like really high performing or
- 01:23:48you're trying to at a young age get your
- 01:23:50kids to sort of become High performing
- 01:23:53um what do you do
- 01:23:55set goals and routines if you have a
- 01:23:58goal that you're working towards it can
- 01:24:01and you really and you really pinpoint
- 01:24:02on that goal and you work towards it and
- 01:24:04you've reversed engineered it you need
- 01:24:06you you can put structure around that
- 01:24:08goal to achieve it that's what I see a
- 01:24:10lot of um a lot of these athletes doing
- 01:24:12they know exactly what they want and
- 01:24:14they get about doing it absolutely every
- 01:24:17single day so that's that's one
- 01:24:19behavioral aspect to it the second one
- 01:24:21is
- 01:24:22physiological if you do want to be high
- 01:24:25performing you have to get your
- 01:24:27physiology in order physiology first I
- 01:24:30believe it's physiology before Behavior
- 01:24:33meaning you have to be sleeping you have
- 01:24:36to be eating well you have to be
- 01:24:38performing every single day so looking
- 01:24:42at behavioral characteristics of what
- 01:24:45makes a high performer it's the habits
- 01:24:47it's the rituals it's the structure and
- 01:24:51it's not veering off path from that as
- 01:24:55hot as that sounds in terms of goal
- 01:24:56setting I mean that's kind of part of
- 01:24:58neuroplasticity too right you're setting
- 01:25:00a goal and you're setting out to achieve
- 01:25:03that goal and making a map with which to
- 01:25:05achieve that goal essentially correct
- 01:25:07and you're opening that dopamine Loop
- 01:25:10the circuit opens and if you set that
- 01:25:12goal and you achieve little Milestones
- 01:25:16towards that goal that dopamine is going
- 01:25:17to keep feeding you and you're going to
- 01:25:19keep going and going this is why I was a
- 01:25:21triathlete which fed into my entire
- 01:25:23career I raced you know internationally
- 01:25:26for Australia and I had a really good
- 01:25:28coach and he was the one that set I
- 01:25:30didn't have the ability back then I was
- 01:25:32young I was a teenager I didn't have the
- 01:25:34ability to set my own goals so he set
- 01:25:36them for me and he benchmarked me and I
- 01:25:39used to want to be I I wanted to go
- 01:25:41faster and he said no he never spoke to
- 01:25:44me about dopamine he probably even
- 01:25:45didn't know what that was but if I had
- 01:25:48gone out and tried to achieve my own
- 01:25:50goals I probably would have just failed
- 01:25:53and not done it so it's about how do you
- 01:25:56goal set how do you achieve those small
- 01:25:58Milestones how do you reward yourself
- 01:26:00with dopamine that keeps telling you to
- 01:26:02keep going and you just keep going on
- 01:26:04that path and try as hard as you can no
- 01:26:07matter what age you are but I'm speaking
- 01:26:09more so for adolescent
- 01:26:12teenagers try to limit the amount of
- 01:26:14social media you have I see it changing
- 01:26:16brains and they're their brains aren't
- 01:26:18developed yet yeah so that's yeah yeah
- 01:26:22so I think with kids set their goals
- 01:26:24help them set their goals their goals I
- 01:26:27think that's I mean I'm raising two kids
- 01:26:28so I often think about you know how can
- 01:26:31I get them to find that ambition but
- 01:26:34also I think setting like smaller goals
- 01:26:36is really helpful because if you say hey
- 01:26:37I want you to get a scholarship let's
- 01:26:39say for example I me know parents want
- 01:26:41these things for their kids right I want
- 01:26:42you to get a scholarship that's like
- 01:26:43such a lofty goal and it's like 10 years
- 01:26:45away right so it's like how do you get
- 01:26:47there like what what is how do you got
- 01:26:49to as you mentioned reverse engineer
- 01:26:51like what do I need to do right now to
- 01:26:53get there and that can be even again for
- 01:26:54your brain health what can I do right
- 01:26:56now to prevent Alzheimer's or to prevent
- 01:26:59dementia later on I'm reverse
- 01:27:01engineering the brain I want to have
- 01:27:03right yeah and and remember the best
- 01:27:05form of exercise is the one that you
- 01:27:07stick to so if you do love you know this
- 01:27:10is for for kids as well get them just
- 01:27:12what do you love first and foremost you
- 01:27:14can beat anything these days just due to
- 01:27:16social media so there's got to be a
- 01:27:18passion in there because that passion is
- 01:27:20going to drive you every day to keep
- 01:27:22wanting to do it so once you find that
- 01:27:23passion even like with your exercise
- 01:27:26with your sleep gamify it if you have to
- 01:27:29and that's what's going to make you
- 01:27:31stick to it yeah I think finding the
- 01:27:32passion is key you can't force your kid
- 01:27:34to do something and I I've sort of let
- 01:27:36my children figure that out for
- 01:27:38themselves and when they start showing
- 01:27:40me signs that they are really into
- 01:27:42something we lean into that but we try
- 01:27:45not to like put our own desires like you
- 01:27:47know I would love it if they were like
- 01:27:49you know professional North Indian
- 01:27:51dancers but like that's not going to
- 01:27:52happen so U that's okay you know yeah I
- 01:27:55wanted to talk just briefly before we uh
- 01:27:57close out is like happiness so in terms
- 01:28:00of how your brain and happiness are
- 01:28:03connected from a neurophysiologic
- 01:28:05perspective yeah that's such a that's
- 01:28:08such a good question because I was
- 01:28:10actually speaking about this yesterday
- 01:28:11in terms of sleep right there's really
- 01:28:14great studies that show that um you know
- 01:28:16people with even mild depression have
- 01:28:17trouble sleeping and that's because
- 01:28:20generally when you think about sleep we
- 01:28:22know that serotonin helps us fall asleep
- 01:28:25and melatonin helps us stay asleep so
- 01:28:27there's a strong component there of um
- 01:28:29happiness but happiness really is if you
- 01:28:33think about you know when I think about
- 01:28:35food food is not food food is
- 01:28:37information right so if you feed your so
- 01:28:41I think about happiness not as like
- 01:28:42let's walk outside like happiness is
- 01:28:45what your brain is telling you and
- 01:28:47that's being projected in your
- 01:28:48physiology so what are you feeding your
- 01:28:52brain to help it release certain
- 01:28:55neurochemicals to tell you that we are
- 01:28:57happy happy is just a word to describe a
- 01:29:00set of neurochemicals that are released
- 01:29:02so are we eating a Dietrich food that is
- 01:29:05you know full of tryptophan you know
- 01:29:08precursor to serotonin which ends up
- 01:29:10coming from a turkey for example are we
- 01:29:13do we have any stresses in our life from
- 01:29:15a micronutrient perspective that is
- 01:29:18signaling to the brain I am a bit under
- 01:29:20stress right now so I'm going to lower
- 01:29:23everything that doesn't need to be there
- 01:29:25such as happiness does does my brain see
- 01:29:27a perceived threat I'm evidently not
- 01:29:30going to be happy about that so in a
- 01:29:32lower happiness so I see it that way and
- 01:29:34I also see that you know this is from
- 01:29:37Chris Palmer's book if you are in a an
- 01:29:40energy crisis in your brain low energy
- 01:29:44levels you cannot think in any way that
- 01:29:49you are going to just wake up and be
- 01:29:51happy happiness is something that is
- 01:29:54deliberate you cannot and this is s I've
- 01:29:58seen this in in studies but I've also
- 01:30:00this is also my opinion you cannot just
- 01:30:03wake up and be happy you have to put the
- 01:30:06work in every day to make yourself happy
- 01:30:09because your brain is just there you are
- 01:30:12feeding your brain information and it is
- 01:30:14feeding it back to you and so you have
- 01:30:17to feed it information that is going to
- 01:30:20give you the happiness that you want
- 01:30:23yeah that's really powerful yeah it's in
- 01:30:25our control it's in our control so we
- 01:30:27end our uh podcast with a few questions
- 01:30:29and these can be about about you
- 01:30:31individually or about your work well the
- 01:30:32first question can't be about your work
- 01:30:34so the first question is if tomorrow you
- 01:30:36lost all your abilities to coach or to
- 01:30:39do all your training and you couldn't be
- 01:30:41an athlete either cuz that was something
- 01:30:42you've done in the past what would you
- 01:30:44do o I always say that if I wasn't doing
- 01:30:48what I was doing I would actually go to
- 01:30:50space yeah yeah I don't Co I don't know
- 01:30:53why um I I had this very big fear of
- 01:30:57planes and I fly a lot so to overcome
- 01:31:00that I started to learn about Aviation
- 01:31:02um I was a math major by my M's in
- 01:31:05mathematics so I do love math and
- 01:31:07Engineering um and then I thought
- 01:31:09imagine how amazing it would be to go to
- 01:31:11space and so I started like
- 01:31:12investigating I was like okay I would I
- 01:31:15I would go out of my way and do that I
- 01:31:16think that's cool yeah maybe someday you
- 01:31:18will we'll see what's a life hack or
- 01:31:21health hack that you haven't shared yet
- 01:31:22that you would share oh God gosh one
- 01:31:24thing that I'm trying to do now is
- 01:31:26Implement um a walk for 1 hour a day
- 01:31:30without any Electronics that's a good
- 01:31:33one oh have you ever tried it I I not an
- 01:31:36hour I've done like 10 15 20 minutes 30
- 01:31:39minutes maybe but not an hour yeah I
- 01:31:41leave my house now with nothing not even
- 01:31:43my I've got my watch I at home and I
- 01:31:46just I go I guess it's safe in New York
- 01:31:48to do that I know right there's a lot of
- 01:31:50people around I mean it's safe here too
- 01:31:52but I think if you live in like a small
- 01:31:54maybe depending what's a non-negotiable
- 01:31:56something like that you you do every day
- 01:31:59no matter whether you're traveling
- 01:32:01whether you're um you know wherever you
- 01:32:03are in the world exercise I mentioned to
- 01:32:06you um today is so bad for me I've had a
- 01:32:09I've had minimal 4 hours I still went to
- 01:32:12the gym because I know that the sheer
- 01:32:14forcing of blood to my brain is going to
- 01:32:17actually outweigh the effects of sleep
- 01:32:20deprivation so when you're tired when
- 01:32:22you're sleep deprived what do you what
- 01:32:23do you focus on how do you like what do
- 01:32:25you do do you do both aerobic and um
- 01:32:28resistance or do you focus on something
- 01:32:29in particular I go high intensity
- 01:32:31because I'm trying to get as much
- 01:32:33blood oxygen rich just to my brain as I
- 01:32:36can and I focus on breathing okay yeah
- 01:32:39and what's something you know now that
- 01:32:41you wish you knew earlier
- 01:32:43o that the power of the people that you
- 01:32:50get your advice from I used to take
- 01:32:52advice from anyone really anyone who was
- 01:32:55going to give it to me you know in your
- 01:32:5720s and I was so hungry I always wanted
- 01:32:59to be you know amazing and really great
- 01:33:03at every so I just took advice from
- 01:33:04anyone even relationship advice from you
- 01:33:06know my single
- 01:33:08friends we've all done that
- 01:33:10unfortunately um even to this day I've
- 01:33:13got friends who um who are not married
- 01:33:16or don't run a business who you know who
- 01:33:19give me advice and I I I think to myself
- 01:33:21huh I so I am so now I'm very Vigilant
- 01:33:24in who I ask advice from I think that
- 01:33:27comes with age and maturity right I
- 01:33:29think that's that's good L it was so
- 01:33:30wonderful to have you where can my
- 01:33:32audience find you you can follow me on
- 01:33:34Instagram Louisa niola I also now have
- 01:33:37YouTube which is just Louisa niola and
- 01:33:41then you can check out the neuro
- 01:33:42Athletics website for everything else
- 01:33:44that's amazing thank you so much thank
- 01:33:46you so much for having me thank you guys
- 01:33:48so much for listening to today's episode
- 01:33:49of the Reena Malik MD podcast if you
- 01:33:52like this episode please do me a solid
- 01:33:55and share this podcast with your friends
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- 01:34:06have our content Reach people around the
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