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hello friends welcome back to another
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video tutorial today I am going to share
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some of the basic information about nano
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fibers these fibers are new class of
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nano material which has special
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properties that mainly due to the
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extremely high surface to volume ratio
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compared to conventional fibers so what
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are the special properties large surface
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area to volume ratio high porosity small
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pore size low density and excellent
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mechanical properties so because of this
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unique property make nano fibers as a
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suitable material for different
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applications like a purification energy
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application textile biomedical
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applications like tissue engineering
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skyfall own wound healing and wound
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dressing application like different
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applications are there so this nano
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fibers we can fabricated by different
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methods such as some of the commonly
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used fabrication techniques are electro
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spinning melt processing in the facial
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polymerization and face inversion method
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so here I'm going to discuss more about
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electro spinning so so electro spinning
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is one of the commonly used technique
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for nano fiber fabrication so from that
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we can get ultra thin fibers from
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variety of material so which include
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polymers nano composites ceramics okay
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etc so this electro spinning setup which
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consists of three main components like
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high voltage power supply a syringe pump
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with a metal needle and a conductive
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character okay so in electro spinning
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process which is classified into several
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mechanism several techniques like a
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vibration electro spinning magnetometer
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spinning siren across spinning and Babb
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spinning okay so in in an idle
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electrospinning technique when we
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applied voltage to the polymer solution
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then the polymer get charged as the
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result this Taylor cone will form that
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is the electrical repulsion forces which
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acting on the polymer solution which
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causes the drop droplet of sample to
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deform into conical shape okay so when
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the voltage is increased
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there's this surface tension of the
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polymer solution which overcome and the
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charger jet which emerged from Taylor
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corn migrated was the collector okay
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so during the migration from needle tip
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to collector the solvent which is
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present and the solution is get
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evaporate and the fibers which are
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deposited over the ground collector okay
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so this is the basic working of the
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electro spinning so in electro spinning
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there are different parameter other that
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is process parameters so this process
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parameter which control the morphology
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of the Nano fibers
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the first one is voltage so then that
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voltage this is one of the important
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parameters because if we increase the
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voltage further and the voltage will
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this will cause high jet instability as
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result the formation of bead and nano
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fiber okay so in a typical arrow
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spinning process the voltage should be
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in the ranges from 5 to 50 kV okay next
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is the flow rate so this flow rate also
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important factor which controlled the
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morphology so if we need an octave
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uniform nano fiber we need to optimize
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the flow rate okay so if hi if we
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increase the
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flow rate as the result and this beat
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formation will occur in the Nano fiber
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surface okay next is the character so
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the character in electro spinning there
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are different variety of characters are
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used commonly used characters at
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stationery our rotating one so which
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which will also affect the final design
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of the Electra span fiber okay next is
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the distance between the tip and the
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collector so normally this is one of the
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important parameter because when the
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spinning distance decreases to a
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critical length and that is a formation
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of beaded and nano fiber that is due to
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the insufficient fiber stretching and
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solvent evaporation if we increase the
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spinning distance which will provide a
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large space for jet stretching and
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longer time for solvent evaporation so
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as the result we will get a uniform nano
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fibers okay next is the nature of
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polymer solution so in that polymer
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solution the nature of polymer solution
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also umber important so the viscosity
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which plays a crucial role polymer
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viscosity okay which play an important
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role the morphology of the nano fiber so
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if we're the low viscosity which
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generate builder structure but if we
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increase the viscosity which leads the
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formation of smooth bead beautifully
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nano fiber but if we increase further
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the viscosity if English father then
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there is a chance to clog the polymer
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solution on the nozzle tip okay then
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there is no fiber formation so these are
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the important parameters in the spinning
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process okay next is fire so in this
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application but and there are because of
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the unique properties of nano fibers we
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can use this nano fiber in different
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applications especially in biomedical
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application we can
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this nano fibers and scaffold for tissue
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engineering and we can make a mat for
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wound dressing and biosensor medical
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implant application that will very
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different applications are there so here
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I'm going to discuss in detail about
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some of the application okay first one
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dressing and wound healing so in that
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normally this these nano fibers we can
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make as a mat
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and this mat we can use as a Performa
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Tyrael for wound dressing application
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and if we can enable able to incorporate
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some antibacterial agent in the husband
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material
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and we can also prevent the infection of
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the wall and which will accelerate the
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healing processes okay so this is one of
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the important application so because of
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the high surface to volume ratio which
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promote the cells cells attachment on
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the surface and the microscale
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interconnected pores which is present in
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the nano fiber which are compatible with
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gas exchange nutrient supply and control
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of fluid loss okay so this these
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properties which is which maintain the
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moisture environment and the wound site
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so that will prevent the wound
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dehydration and enhance the angiogenesis
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and collagen synthesis so this this will
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also reduce the scale formation also
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okay so this is one of the important
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applications of nano 5 book necklace
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delivery application so this nano fiber
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have unique properties that we already
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told so because of that and we can use
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this as a material in the delivery
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application okay and i ideal delivery
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system which have several features like
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hi loading capacity hi encapsulation
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efficiency simultaneous delivery of
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various therapeutics ease of operation
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and cost-effectiveness ok this none of
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fibers which matches all of these
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features so that we can use this
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nanofibers material as a material okay
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so here normally and there are different
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polymer we can use for this nano fiber
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making okay so like polycaprolactone
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polyvinyl pyrrolidone PMMA like that
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should be in biodegradable and
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biocompatible in nature okay so this
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polymers is mixing with the drag
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molecules and will get a homogeneous
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suspension or solution and this solution
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then electro spun using electro spinning
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technique and we can produce nano fibers
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okay so there are different strategy we
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can follow for making this that loaded
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nano fibers like electro spinning plus
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that dissolved so first we can we can
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dissolve in the polymer solution and
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then spin it okay so that as the result
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this molecule which is embedded into the
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Nano fibers the second approach is
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dragged loaded nano carry oh so the drug
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lord and nano carrier we can mix mix
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with the polymer and the drug molecule
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and that attaches outside the fibers
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next is electro spinning plus a drug
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post treatment so drag so these drug
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molecules or bio molecules which are
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attached outside the fibers okay next is
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and Kaushal electro spinning so through
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that we can make molecule which are
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inside a bulk into nano fiber okay so
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this is the commonly used strategy to
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make the nano fiber in drug delivery
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applications okay is tissue engineering
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so in that
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tissue engineering data is one of the
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interdisciplinary area so because which
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applies the principle of biological
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chemical engineering and science to
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general to generate tissue degeneration
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okay so in this tissue engineering
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approach there are which involve two
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main important strategy that is
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isolation of healthy cells from a
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patient and followed by the expansion in
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vitro okay so these expanded cells which
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are then shielded onto it scaffold
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biodegradable scaffold so that will
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provide the structural support and that
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also can act as a reservoir for by
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active molecules such as growth factors
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so this scaffold after some times they
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actually get replaced by new ground
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tissues from the seated cell okay so in
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this biomimic mimetic scaffold we can
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made with this nano fibers so which will
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so there are different scaffold are made
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for different tissue regeneration so
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this is also one of the important
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applications of nano fiber okay that's
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it thank you for watching this video if
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you liked this tutorial please share
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with your friends and contacts thank you
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you
