The 5 Compounds that Detoxify & Protect the Brain (neuroprotectants) - Dr. Sherr

00:33:50
https://www.youtube.com/watch?v=ayhm9wn_9Fw

الملخص

TLDRThis video discusses the significance of alpha-lipoic acid, magnesium, and cortisepin for brain health. Alpha-lipoic acid acts as an essential antioxidant, modulating mitochondrial health by neutralizing free radicals and recycling vital antioxidants such as glutathione. It also stimulates the production of glutathione in the brain through the NRF2 pathway, offering protection against cognitive decline often associated with aging and environmental stressors. Magnesium, specifically magnesium threonate, is emphasized for its neuroprotective effects, aiding in relaxation and GABA production to counteract excitatory brain activity. Cortisepin, derived from the cordyceps mushroom, provides potent anti-inflammatory benefits, supporting immune system balance and enhancing deep sleep. The discussion underlines the cumulative burdens of modern life on cognitive function, advocating for proactive measures to safeguard brain health through dietary and supplemental strategies.

الوجبات الجاهزة

  • 🧠 Alpha-lipoic acid neutralizes free radicals and recycles antioxidants.
  • ✨ It activates the NRF2 pathway for enhanced glutathione production in the brain.
  • 🌀 The brain suffers from cumulative cognitive stress over time, especially post-30.
  • 🛡️ Protective measures for brain health are essential as we age.
  • 🔄 Magnesium threonate supports relaxation and neurotransmitter balance.
  • 🌱 Cortisepin has anti-inflammatory properties and enhances sleep quality.
  • ⚖️ Maintaining a balance of excitatory and inhibitory neurotransmitters is crucial.
  • 🍽️ Dietary sources of alpha-lipoic acid are limited, supplementation may be necessary.
  • 🩺 Chronic stress leads to neuroinflammation, impacting cognitive function.
  • 🌙 Deep sleep is critical for recovery and overall brain function.

الجدول الزمني

  • 00:00:00 - 00:05:00

    Alpha-lipoic acid supports mitochondria by neutralizing free radicals and recycling antioxidants like glutathione, vitamin C, and vitamin E. It upregulates the NRF2 pathway, which aids glutathione production in the brain, thus protecting cognitive function from everyday stressors that can cause brain fog and sluggishness.

  • 00:05:00 - 00:10:00

    Protecting brain function is as crucial as increasing cognitive performance, especially as we age past 30, when cognitive decline can start. Everyday factors contribute to toxic buildup and mitochondrial stress, leading to inflammation. Therefore, protective measures are necessary to maintain cognitive health.

  • 00:10:00 - 00:15:00

    Neuroinflammation, or inflammation within the brain, is often underestimated. People are becoming more aware of it, but understanding its impact on brain health remains challenging. This presents an opportunity for the use of antioxidants like alpha-lipoic acid to combat these internal stressors and inflammation.

  • 00:15:00 - 00:20:00

    Alpha-lipoic acid serves as a powerful antioxidant that also works inside the mitochondria to manage oxidative stress and neutralize toxins from heavy metals. Many people are deficient in alpha-lipoic acid due to modern lifestyle factors that increase oxidative stress, making supplementation valuable.

  • 00:20:00 - 00:25:00

    Alpha-lipoic acid increases insulin sensitivity, allowing more glucose to enter cells, thereby improving mitochondrial function. While useful for exercise recovery, care should be taken before workouts as it may mitigate needed oxidative stress. Regular supplementation is recommended for most individuals due to widespread deficiencies.

  • 00:25:00 - 00:33:50

    Magnesium is another important supplement for brain health, specifically magnesium threonate, which enhances magnesium levels in the brain and facilitates the conversion of glutamate to GABA, aiding relaxation and reducing anxiety. This mineral's deficiency is common, so supplementation can significantly improve brain function and general well-being.

اعرض المزيد

الخريطة الذهنية

فيديو أسئلة وأجوبة

  • What is alpha-lipoic acid?

    Alpha-lipoic acid is an antioxidant that helps neutralize free radicals and recycle other antioxidants like glutathione.

  • How does alpha-lipoic acid benefit brain health?

    It supports mitochondrial function, reduces oxidative stress, and stimulates glutathione production in the brain.

  • What role does magnesium play in brain health?

    Magnesium, especially magnesium threonate, helps relax the nervous system and supports neurotransmitter function.

  • What is cortisepin?

    Cortisepin is a compound derived from the cordyceps mushroom, known for its anti-inflammatory properties and ability to enhance sleep quality.

  • Why is neuroinflammation significant?

    Neuroinflammation is linked to cognitive decline and various neurological disorders.

  • What foods are high in alpha-lipoic acid?

    Food sources include liver, brewer's yeast, and spinach.

  • How can I increase my magnesium intake?

    Increase intake through diet rich in greens, nuts, and seeds, or consider magnesium supplements.

  • What are the symptoms of magnesium deficiency?

    Symptoms can include muscle cramps, fatigue, and irritability.

  • What should I know before taking alpha-lipoic acid?

    Consult a healthcare provider, especially if you have blood sugar issues, as it may lower blood glucose levels.

  • How does stress affect brain health?

    Chronic stress can lead to neuroinflammation, cognitive decline, and disrupt neurotransmitter balance.

عرض المزيد من ملخصات الفيديو

احصل على وصول فوري إلى ملخصات فيديو YouTube المجانية المدعومة بالذكاء الاصطناعي!
الترجمات
en
التمرير التلقائي:
  • 00:00:00
    What what alphalapoic acid can do is
  • 00:00:02
    that it helps in that mitochondria. It
  • 00:00:04
    helps neutralize free radicals directly
  • 00:00:07
    and then at the same time it recycles
  • 00:00:09
    your major antioxidants, your
  • 00:00:11
    glutathione, your vitamin C, your
  • 00:00:12
    vitamin E. It also upregulates another
  • 00:00:15
    pathway called the NRF2 pathway. The
  • 00:00:17
    NRF2 pathway is the pathway that helps
  • 00:00:18
    you produce more glutathione in your
  • 00:00:21
    brain as well. So Dr. discusser when we
  • 00:00:24
    think of brain a lot of times people
  • 00:00:25
    think of of brain performance and they
  • 00:00:27
    think of what's going to make us you
  • 00:00:29
    know perform better and at this optimal
  • 00:00:31
    state but there's almost always this
  • 00:00:33
    balance of things that are coming at us
  • 00:00:35
    things that are affecting our brain
  • 00:00:37
    negatively even decreasing our baseline
  • 00:00:40
    making it so we're just not able to
  • 00:00:41
    function at a normal cognitive level
  • 00:00:44
    right and so we get to this point where
  • 00:00:45
    we feel foggy all the time but that's
  • 00:00:48
    normal or we feel slow and sluggish all
  • 00:00:50
    the time but that's normal And it's not
  • 00:00:53
    about just optimizing and increasing the
  • 00:00:55
    power of the brain. Sometimes it's about
  • 00:00:56
    protecting the brain from just everyday
  • 00:00:58
    stress things that are out there. And uh
  • 00:01:01
    you know, you really put a lot of
  • 00:01:02
    emphasis on this in a lot of the your
  • 00:01:04
    your speakings and what you do. What are
  • 00:01:06
    some things that we can do to protect
  • 00:01:08
    our brain just throughout daily life so
  • 00:01:10
    we feel better cognitively? Yeah, I
  • 00:01:12
    think you I think you mentioned a really
  • 00:01:14
    important point there which is that it's
  • 00:01:16
    like we wake up one day and we like,
  • 00:01:19
    "Holy what just happened?" to the
  • 00:01:22
    last 10 years or something like that
  • 00:01:23
    because it's a slow build for many
  • 00:01:25
    people. It's not like today you feel
  • 00:01:27
    fantastic at a as a 25-year-old and then
  • 00:01:30
    the next day you wake up feeling like no
  • 00:01:32
    you would realize that that happened but
  • 00:01:34
    many people don't realize that it took
  • 00:01:36
    them a long time to create a toxic
  • 00:01:38
    burden most likely mitochondrial stress,
  • 00:01:41
    cellular stress, inflammation,
  • 00:01:43
    detoxification issues, all these things
  • 00:01:44
    that have happened because it's built up
  • 00:01:47
    over time. Our bodies are and our brains
  • 00:01:50
    are the most resilient between about 21
  • 00:01:52
    to 30 years of age. But as soon as that
  • 00:01:54
    30-year mark comes, things start going
  • 00:01:57
    south. And especially when you turn 40
  • 00:01:59
    or so, they've actually done some
  • 00:02:00
    interesting studies looking at how we
  • 00:02:02
    have these significant age drops. It
  • 00:02:04
    looks like around the age of 40, the age
  • 00:02:06
    of 60 or so, where things kind of really
  • 00:02:08
    start falling off the wagon for a lot of
  • 00:02:10
    people. And so it's really important to
  • 00:02:13
    think about not only, you know, the
  • 00:02:16
    protection of our brain, but the aspects
  • 00:02:18
    of what that actually means. People
  • 00:02:20
    think of protecting your brain like
  • 00:02:22
    wearing a helmet. And when I was a kid
  • 00:02:25
    and when you were a kid, we didn't do
  • 00:02:26
    that. We didn't know that helmets were
  • 00:02:28
    important. Now we wear helmets to
  • 00:02:29
    protect our brain from the outside. That
  • 00:02:31
    is good. So if my kids see somebody
  • 00:02:33
    that's driving around on a bike,
  • 00:02:35
    especially a motorcycle in Colorado
  • 00:02:36
    without a helmet, they go, "He's not
  • 00:02:38
    wearing a helmet. This is this is
  • 00:02:39
    terrible." and you know medical freedom
  • 00:02:41
    whatever they can do what they want um
  • 00:02:43
    in some states right or not medical
  • 00:02:44
    freedom but freedom whatever you want to
  • 00:02:46
    call it but so you can protect your
  • 00:02:48
    brain from the outside we know that now
  • 00:02:50
    like from with helmets although if
  • 00:02:52
    you're a football player we also know
  • 00:02:53
    that these helmets are not perfect and
  • 00:02:55
    you're still going to get concussions
  • 00:02:56
    and and things like that but the
  • 00:02:58
    question is and with my patients is how
  • 00:03:00
    can we protect our brain you know from
  • 00:03:01
    the inside and that protection is
  • 00:03:04
    because we're just we're always being
  • 00:03:06
    subject to so many different things in
  • 00:03:08
    our environment that are that we're
  • 00:03:10
    suffering from. So, yeah, I kind of look
  • 00:03:13
    at it. It's exactly like looking at like
  • 00:03:14
    a TBI from the inside out. Yeah. Right.
  • 00:03:17
    Like people don't realize the level of
  • 00:03:19
    neuroinflammation. They don't real I
  • 00:03:21
    remember 10 years ago when I was first
  • 00:03:23
    starting the channel. It was like
  • 00:03:25
    talking about inflammation in general
  • 00:03:26
    was kind of Greek to people. They were
  • 00:03:28
    like, "Oh, inflammation is that just
  • 00:03:29
    what makes my joints hurt?" It's like,
  • 00:03:30
    "Well, yes, but you know, no, no, it's
  • 00:03:32
    bigger than that, right?" Yeah. And now
  • 00:03:35
    a little bit more of what inflammation
  • 00:03:36
    is. But now we're at this like next
  • 00:03:37
    evolution where people don't really
  • 00:03:40
    understand what neuroinflammation is and
  • 00:03:42
    like this neurological stress and this
  • 00:03:44
    you know stress that we're on from the
  • 00:03:46
    inside out. It's not just about you know
  • 00:03:48
    and I know there's ways that we can
  • 00:03:49
    protect that and um one of I know we
  • 00:03:52
    talked a little bit offline before we
  • 00:03:53
    started was one of my personal favorites
  • 00:03:54
    which is alphalapoic acid. Yeah. What is
  • 00:03:57
    alphaloic acid? How does it potentially
  • 00:03:59
    protect the brain? So alphalopoic acid
  • 00:04:01
    is one of the unsung antioxidants out
  • 00:04:04
    there. People have heard of glutathione
  • 00:04:05
    and vitamin C and vitamin E. Alphalapoic
  • 00:04:09
    acid is actually the one that recycles
  • 00:04:10
    all of those to make them more effective
  • 00:04:12
    in the body. It's also itself an
  • 00:04:15
    antioxidant and it works in the
  • 00:04:17
    mitochondria specifically to help mop up
  • 00:04:20
    free electrons. And so when we make
  • 00:04:22
    energy in our mitochondria, we make
  • 00:04:25
    waste products of energy. So ATP is
  • 00:04:27
    made, we make carbon dioxide, we make
  • 00:04:29
    water, and we also make reactive oxygen
  • 00:04:30
    species. And these reactive oxygen
  • 00:04:32
    species
  • 00:04:34
    are very important. They're actually
  • 00:04:36
    signaling molecules for to have the
  • 00:04:38
    whole system understand what's actually
  • 00:04:39
    going on in the mitochondria. But the we
  • 00:04:41
    need to mop these up. We need to
  • 00:04:44
    neutralize these oxidant molecules so
  • 00:04:46
    that the system doesn't get under more
  • 00:04:48
    stress and cause more inflammation and
  • 00:04:50
    cause all the inflammatory cascades that
  • 00:04:53
    happen as a result of that. So people
  • 00:04:54
    have heard of things like uh NFCAPPA B
  • 00:04:56
    maybe. So NFCappa B is a pathway that
  • 00:04:59
    releases a whole bunch of inflammatory
  • 00:05:00
    mediators like cytoines like
  • 00:05:02
    interlucans, TNF alpha and others. When
  • 00:05:04
    the systems under more inflammation
  • 00:05:06
    under more stress in the mitochondria
  • 00:05:08
    then the whole whole system the whole
  • 00:05:10
    cell itself and the cellular ecosystem
  • 00:05:12
    becomes more inflamed. And so what what
  • 00:05:15
    what alphalapoic acid can do is that it
  • 00:05:17
    helps in that mitochondria it helps
  • 00:05:20
    neutralize free radicals directly and
  • 00:05:22
    then at the same time it recycles your
  • 00:05:24
    major antioxidants your glutathione your
  • 00:05:26
    vitamin C your vitamin E it also
  • 00:05:28
    upregulates another pathway called the
  • 00:05:30
    NRF2 pathway. The NRF2 pathway is the
  • 00:05:32
    pathway that helps you produce more
  • 00:05:34
    glutathione in your brain as well. So we
  • 00:05:37
    don't really know if glutathione that we
  • 00:05:39
    take orally gets into the brain very
  • 00:05:41
    easily and probably the nano liposomaal
  • 00:05:43
    kind of version of it but but probably
  • 00:05:45
    not the other ones very easily. There's
  • 00:05:46
    no real transporter for glutathione. We
  • 00:05:48
    know most of the glutathione is actually
  • 00:05:50
    made in your brain that you have in your
  • 00:05:52
    brain. And so you have to have all the
  • 00:05:54
    component factors of making your
  • 00:05:55
    glutathione but you have to have the the
  • 00:05:58
    stimulation of those factors to be
  • 00:06:00
    created to be combined together to make
  • 00:06:02
    your glutathione for example. So your
  • 00:06:03
    cyine for example and and other amino
  • 00:06:05
    acids that make your glutathione. And so
  • 00:06:08
    what alphalapoic acid is doing is really
  • 00:06:11
    becoming this sort of lynch pin in
  • 00:06:13
    mitochondrial support. And so many of us
  • 00:06:16
    and I test people all the time for for
  • 00:06:18
    their antioxidant levels and their their
  • 00:06:20
    oxidative stress levels. Alphalopic acid
  • 00:06:22
    levels are almost always low in people
  • 00:06:24
    almost always across the board. And
  • 00:06:27
    that's because of modern life and the
  • 00:06:28
    inflammation in our brain. And also we
  • 00:06:31
    they're subject to we have subject to
  • 00:06:32
    all these heavy metals and toxins and
  • 00:06:34
    alphamoic acid is one of the best toxin
  • 00:06:38
    neutralizers out there. It actually can
  • 00:06:40
    bind and neutralize cadmium, mercury,
  • 00:06:44
    arsenic and lead. And so there's very
  • 00:06:46
    few other compounds that are as
  • 00:06:48
    comprehensive as it is to help support
  • 00:06:51
    the brain and the rest of the body too.
  • 00:06:52
    So when it comes how is it actually so
  • 00:06:56
    it does these two things? So it works as
  • 00:06:57
    an antioxidant itself. Yeah. And then
  • 00:07:00
    it's supporting sort of the almost
  • 00:07:02
    production of our own. But one thing
  • 00:07:04
    that you said that was really
  • 00:07:04
    interesting. So we don't just make
  • 00:07:06
    glutathione in the liver. We actually
  • 00:07:08
    make it in the brain itself. Make in the
  • 00:07:09
    brain too. Yeah. I did not know that. I
  • 00:07:11
    thought it was like solely in the liver
  • 00:07:12
    thing. Yeah. The brain makes its own
  • 00:07:14
    glutathione as well. So in that case
  • 00:07:16
    alphalapoic acid can cross the bloodb
  • 00:07:17
    brain barrier. Yes. Very easily. Yeah.
  • 00:07:19
    It can very easily cross the bloodb
  • 00:07:20
    brain barrier and get across and help
  • 00:07:22
    stimulate all these pathways that we
  • 00:07:23
    just mentioned. But also, not only does
  • 00:07:25
    it do what we've described, it also
  • 00:07:27
    increases insulin sensitivity. And so
  • 00:07:30
    more, you know, you're going to have
  • 00:07:31
    more glucose that goes into the cell as
  • 00:07:33
    opposed to if you're more insulin
  • 00:07:35
    resistance. And so you have to be mildly
  • 00:07:36
    careful when you take alphaic acid
  • 00:07:38
    because some people will have a blood
  • 00:07:40
    glucose drop when they take it. But
  • 00:07:41
    that's actually beneficial for the
  • 00:07:44
    cellular health of your brain as well.
  • 00:07:46
    Um because it helps become helps the
  • 00:07:48
    mitochondria become more efficient that
  • 00:07:50
    way as well because it increases insulin
  • 00:07:51
    sensitivity. From a from an exercise
  • 00:07:54
    perspective, I know that I mean it's one
  • 00:07:56
    of the ones that's really it was
  • 00:07:58
    popularized a lot in the endurance
  • 00:07:59
    community. I remember when I was a
  • 00:08:00
    runner that was a big one be like okay
  • 00:08:01
    on the days you run more take more
  • 00:08:03
    alphalapoic acid. So is it just all kind
  • 00:08:05
    of working on that same pathway just I
  • 00:08:06
    mean as such an oxidative stressor when
  • 00:08:09
    we're when we're running or doing
  • 00:08:10
    endurance work. So yeah, I mean that's
  • 00:08:11
    actually brings up a good point though,
  • 00:08:12
    right? Because you don't necessarily
  • 00:08:14
    want to have a lot of alphalopoloic acid
  • 00:08:16
    if you're exercising, right? Because
  • 00:08:18
    you're going to mitigate some of the
  • 00:08:19
    oxidative load that might happen and the
  • 00:08:21
    hormatic stress because of exercise. But
  • 00:08:23
    if you're doing a lot of exercise and
  • 00:08:25
    especially from the like on the recovery
  • 00:08:26
    side, it could be fantastic as a way to
  • 00:08:28
    help mop up free radicals, improve
  • 00:08:30
    insulin sensitivity, and help with the
  • 00:08:32
    mitochondrial function overall as well.
  • 00:08:34
    So, do you think there's a benefit to
  • 00:08:35
    taking it u almost prophylactically like
  • 00:08:38
    before you know you're going to be going
  • 00:08:39
    into a stressful situation or anything
  • 00:08:41
    like that? Yeah, I mean I think what I
  • 00:08:42
    can say almost across the board is that
  • 00:08:44
    almost everybody that I've tested is
  • 00:08:47
    deficient in alphalogic acid. Like it's
  • 00:08:49
    almost across the board and so I think
  • 00:08:50
    almost everybody can benefit from at
  • 00:08:52
    least some of it on a regular basis. You
  • 00:08:54
    may need more of it depending on what
  • 00:08:55
    you're using it for, but in essence
  • 00:08:57
    almost all of us need the mitochondrial
  • 00:08:58
    support because we don't get a lot of
  • 00:09:00
    alpha lipoic acid in our diet. There's
  • 00:09:02
    very few sources of this as you know and
  • 00:09:04
    as a result of that it's important
  • 00:09:06
    because we have so many stresses on the
  • 00:09:07
    body now so many toxic stresses these
  • 00:09:10
    heavy metals these you know toxic
  • 00:09:11
    overload from neuroinflammation and
  • 00:09:13
    everything else that happens as a result
  • 00:09:14
    of that insulin resistance whatever like
  • 00:09:16
    almost everybody can benefit from some
  • 00:09:18
    element of having some alphaic acid on
  • 00:09:19
    board what's um I noticed when I take
  • 00:09:23
    ALA like urine smell like it's kind of
  • 00:09:25
    like an asparagusy smelly thing is that
  • 00:09:28
    like what is that? Yeah, because that's
  • 00:09:30
    because alphalapoic acid has these
  • 00:09:31
    what's called sulhydral groups. It's a
  • 00:09:33
    sulfur containing antioxidant and the
  • 00:09:35
    sulfur groups are actually what bind the
  • 00:09:39
    uh the oxidants, bind the oxidative
  • 00:09:40
    stress. So, bind the heavy metals, bind
  • 00:09:42
    the reactive oxy species and neutralize
  • 00:09:44
    them. But sulfur is also sulfury in the
  • 00:09:48
    sense that it gives that sulfur smell.
  • 00:09:51
    And so, it's a sulfur type of smell that
  • 00:09:52
    you're getting when you're urinating out
  • 00:09:54
    your alpha lipoic acid to some degree.
  • 00:09:56
    And so the higher the amount of alphaic
  • 00:09:59
    acid you take, the more sulfur
  • 00:10:01
    containing smell your urine will have.
  • 00:10:03
    Interesting. So people that have
  • 00:10:05
    allergies to like sulfur drugs or
  • 00:10:07
    anything like that, would they have an
  • 00:10:08
    issue with it or is it So it's a good
  • 00:10:09
    question. So some people are more
  • 00:10:11
    sensitive to sulfur. Now sulfur
  • 00:10:13
    containing drugs, it's a kind of a
  • 00:10:15
    separate category. Okay. So sulfur
  • 00:10:18
    containing drugs like Bactrum, for
  • 00:10:19
    example, is a very common one. There's
  • 00:10:21
    there's also others like Lasix and
  • 00:10:22
    others that have sulfur. those drugs are
  • 00:10:25
    it's it's sort of it's a it's a man-made
  • 00:10:28
    component of making these drugs. So
  • 00:10:30
    people tend to be more sensitive to the
  • 00:10:31
    sulfur in those but there is some cross
  • 00:10:33
    reactivity. So that in the sense that
  • 00:10:35
    some people will be more sensitive to
  • 00:10:37
    sulfur containing uh things like
  • 00:10:39
    glutathione or like alphapoic acid and
  • 00:10:42
    they may get more sulfur-l like symptoms
  • 00:10:44
    of sometimes in people can cause some
  • 00:10:46
    oxidative stress itself. So, it is
  • 00:10:47
    something to be aware of, but it's
  • 00:10:48
    pretty uncommon. Again, always good to
  • 00:10:51
    start off at a lower dose and increase
  • 00:10:52
    your dose over time. When I first
  • 00:10:54
    started working with glutathione, for
  • 00:10:56
    example, it was actually in a clinic
  • 00:10:58
    where we're using it IV in people. And
  • 00:11:00
    that's not always a good idea for people
  • 00:11:01
    because because people take high amounts
  • 00:11:03
    of glutathione. The sulfur containing
  • 00:11:05
    aspects of that can cause symptoms in
  • 00:11:08
    some people. Um, but there's also the
  • 00:11:09
    sulfur binding to the toxin itself. If
  • 00:11:13
    you're binding a toxin, you better sure
  • 00:11:15
    as hell get it out of the system, too.
  • 00:11:16
    Otherwise, what happens is just goes
  • 00:11:18
    back into the system and causes
  • 00:11:19
    toxicity. So, it's really important to
  • 00:11:21
    think about, you know, this is a whole
  • 00:11:22
    another conversation about
  • 00:11:23
    detoxification and and the processes of
  • 00:11:25
    things, but if you're binding a toxin,
  • 00:11:28
    you have to get rid of it, too. So, you
  • 00:11:29
    not only want to bind it, so alphaic
  • 00:11:31
    acid helps you bind the toxin, but it's
  • 00:11:33
    not going to necessarily help you expel
  • 00:11:35
    the toxin as much. This is where binders
  • 00:11:37
    come into place. This is where sauna
  • 00:11:38
    comes into play. This is where other
  • 00:11:39
    detoxification kinds of things come into
  • 00:11:41
    play. Um but in general alpha lipopic
  • 00:11:44
    acid we're mostly deficient in it. Most
  • 00:11:46
    of us could use it on a regular basis.
  • 00:11:48
    Um be careful with it before exercise
  • 00:11:50
    maybe after for recovery especially if
  • 00:11:52
    you want that hormetic stress of it
  • 00:11:54
    overall. Okay. What's a what's another
  • 00:11:56
    thing that we can we can take for
  • 00:11:57
    neuroprotectant. So let's talk about
  • 00:11:59
    magnesium. Right. What's your favorite
  • 00:12:00
    type of magnesium? I like d magnesium
  • 00:12:02
    mate personally. That's my that's my
  • 00:12:04
    favorite or or glycinate before bed. But
  • 00:12:06
    yeah glycinate is good. Yeah. But it's
  • 00:12:08
    actually thrienate magnesium 3enate that
  • 00:12:10
    has the highest amount of magnesium that
  • 00:12:12
    gets in the system when you take it. Now
  • 00:12:14
    you can use these for all different
  • 00:12:15
    reasons. Like there's different ones for
  • 00:12:16
    sleep. There's different ones, you know,
  • 00:12:17
    for systemic effect, but for the brain
  • 00:12:20
    specifically, magnesium 3enate actually
  • 00:12:22
    is the one that gets the highest amount
  • 00:12:23
    of magnesium in it. So usually I like to
  • 00:12:25
    have my patients take a mix of these
  • 00:12:27
    things, right? Um, a mix tends to be
  • 00:12:29
    best, but magnesium 3inate is one that I
  • 00:12:31
    typically recommend because it has the
  • 00:12:32
    highest amount of magnesium that's going
  • 00:12:34
    to get into the brain itself.
  • 00:12:35
    Interesting. So is it uh what is it
  • 00:12:38
    doing from a neuroproction standpoint? I
  • 00:12:41
    know it does have a little bit of an
  • 00:12:43
    effect on an NMDA receptor um but what's
  • 00:12:46
    is it doing something else other than
  • 00:12:47
    that? So magnesium 3 and8 really it's
  • 00:12:50
    it's a carrier in the sense that really
  • 00:12:52
    what we care about is getting more
  • 00:12:53
    magnesium in the brain and then what
  • 00:12:54
    happens with magnesium magnesium is
  • 00:12:56
    responsible for thousands probably
  • 00:12:59
    enzyatic reactions in the brain. So one
  • 00:13:01
    of the major things that it does is
  • 00:13:02
    helps relax the nervous system or relax
  • 00:13:04
    the brain. does that by increasing the
  • 00:13:07
    conversion of a neurotransmitter called
  • 00:13:09
    glutamate which is our primary
  • 00:13:11
    excitatory neurotransmitter to GABA. So
  • 00:13:13
    it's one of the co-actors that are is
  • 00:13:15
    responsible. So GABA is our relaxing
  • 00:13:17
    neurotransmitter in the brain and so
  • 00:13:19
    many of us are GABA deficient these days
  • 00:13:21
    because of stress because of poor
  • 00:13:22
    conversion because lack of magnesium and
  • 00:13:24
    magnesium is one of those minerals
  • 00:13:25
    that's deficient in many people. I can't
  • 00:13:28
    remember the last statistics I read, but
  • 00:13:29
    it was like over 50% of the US
  • 00:13:31
    population is magnesium deficient. And
  • 00:13:33
    so this is a big deal and especially in
  • 00:13:35
    the brain where you know you need a lot
  • 00:13:37
    of magnesium. So magnesium converting
  • 00:13:39
    that glutamate over to GABA. It's also
  • 00:13:41
    making the GABA receptor more sensitive
  • 00:13:44
    for GABA to bind to it. So it increases
  • 00:13:46
    the affinity of GABA to bind to its
  • 00:13:49
    receptor. And so again, GABA is our
  • 00:13:51
    primary relaxing neurotransmitter. It
  • 00:13:54
    helps us calm down the firing of our
  • 00:13:55
    brain. it it's like the brakes of our
  • 00:13:58
    brain. And in addition, you were
  • 00:13:59
    mentioning this just a minute ago, but
  • 00:14:01
    magnesium also is what's called an NMDA
  • 00:14:04
    antagonist. So, it blocks the glutamate
  • 00:14:07
    receptor as well. So, it makes glutamate
  • 00:14:08
    less effective. And so, glutamate when
  • 00:14:11
    you have an overabundance of glutamate,
  • 00:14:12
    glutamate, you know, toxicity or
  • 00:14:14
    whatever you want to there's not always
  • 00:14:15
    toxicity, but it's like it's the MSG
  • 00:14:17
    syndrome. It's the MSG syndrome where
  • 00:14:19
    you feel irritable, your mood is not
  • 00:14:22
    cool, you feel tremors, feel like angry,
  • 00:14:25
    you know, that kind of thing. That's
  • 00:14:26
    your glutamate overload. And so what
  • 00:14:28
    magnesium can do is block those
  • 00:14:29
    receptors and as a result of that
  • 00:14:32
    receptor blocking, you have the capacity
  • 00:14:35
    to have less glutamate effectiveness as
  • 00:14:37
    well as more gabaurgic tone. Um,
  • 00:14:40
    magnesium is also really important for
  • 00:14:42
    energy production as you likely know and
  • 00:14:44
    it increases ATP production. It's it's a
  • 00:14:45
    co-actor on multiple of the
  • 00:14:47
    intermediates in the citric acid cycle,
  • 00:14:49
    the citric acid cycles in our
  • 00:14:50
    mitochondria that helps us make energy
  • 00:14:52
    overall. Um, it also helps regulate and
  • 00:14:55
    modulate all many other neurotransmitter
  • 00:14:58
    systems. Your dopamine system, your
  • 00:15:00
    serotonin system, your acetylcholine
  • 00:15:02
    system are all regulated by by
  • 00:15:04
    magnesium. So, if you don't have enough
  • 00:15:06
    magnesium around, you're not going to
  • 00:15:07
    feel very good is what it comes down to.
  • 00:15:09
    So, these are just some of the major
  • 00:15:11
    things that that it works on. Magnesium
  • 00:15:13
    as I mentioned has you know hundreds if
  • 00:15:15
    not thousands of of important roles in
  • 00:15:19
    the nervous system in the brain. It's
  • 00:15:21
    also visodilator as well. Also you can
  • 00:15:22
    use magnesium to help you know dilate
  • 00:15:24
    blood vessels a little bit on these at
  • 00:15:26
    high doses for you know in IV for things
  • 00:15:28
    like preeacclampsia you know in women
  • 00:15:31
    but at lower doses it's still a
  • 00:15:32
    vasoddilator and and I use it almost in
  • 00:15:36
    all my patients are getting a magnesium
  • 00:15:38
    all my patients are on alphalapillic
  • 00:15:39
    acid um because these are really
  • 00:15:42
    deficient in almost everybody I like to
  • 00:15:44
    test to see what's going on and optimize
  • 00:15:46
    to the tests and then check levels over
  • 00:15:48
    time um that's really ideal if you can
  • 00:15:51
    but finding You know, natural sources of
  • 00:15:53
    alphalopic acid are hard. I didn't talk
  • 00:15:55
    about what those are briefly. Those are
  • 00:15:56
    those are liver, uh, brewer's yeast, and
  • 00:16:00
    spinach, but be careful how much spinach
  • 00:16:01
    you eat. I don't it's not going to make
  • 00:16:02
    you popey, probably. And magnesium, um,
  • 00:16:05
    it's going to give you kidney stones
  • 00:16:07
    instead. Magnesium. Um, in general,
  • 00:16:10
    mineral content of our food is down
  • 00:16:13
    dramatically over the last 70 to 80
  • 00:16:14
    years. And so, it's hard to get enough
  • 00:16:16
    magnesium in your diet. But typically
  • 00:16:18
    this is going to be in um it would be in
  • 00:16:21
    plants ideally because plants would have
  • 00:16:23
    minerals but you don't get as much as
  • 00:16:24
    you used to. So you can get it from meat
  • 00:16:27
    obviously you can get it from um from
  • 00:16:29
    mineral water you know mineral water has
  • 00:16:30
    magnesium in it as well but not a lot.
  • 00:16:32
    So but it's it's hard it's hard to get
  • 00:16:34
    enough magnesium in your diet. What kind
  • 00:16:35
    of uh doses do you recommend for people
  • 00:16:38
    with mag 38ate? Um it's a range. What do
  • 00:16:41
    you typically see? I mean I mean I for
  • 00:16:43
    magnesium meate I take 4 to 600
  • 00:16:46
    milligrams at night. Yeah. Um, you know,
  • 00:16:48
    sometimes I'll take more. Like the thing
  • 00:16:50
    I like d magnesium melee because it's a
  • 00:16:52
    little bit slower absorbing. So I'm not
  • 00:16:54
    going to like if I do go up north of 800
  • 00:16:57
    milligrams. I'm not seat belted to the
  • 00:16:59
    toilet. You know, I feel like it's it's
  • 00:17:02
    I don't really have an issue. Maybe
  • 00:17:03
    slightly looser stools, but nothing
  • 00:17:04
    insane. Um, but with 38 I haven't really
  • 00:17:08
    messed with a whole lot. So I don't know
  • 00:17:09
    what the if the dosage would be the
  • 00:17:11
    same. It's lower. It's lower. It's
  • 00:17:12
    typically somewhere like 100 100 to 300
  • 00:17:14
    milligrams I believe. maybe a little bit
  • 00:17:16
    higher than that depending on the
  • 00:17:16
    person. It doesn't typically have any uh
  • 00:17:19
    GI effects for most people. Um it can,
  • 00:17:22
    but any any magnesium can cause GI
  • 00:17:24
    effects for some people, but the
  • 00:17:25
    magnesium citrate and magnesium oxide
  • 00:17:27
    are the ones that you want to avoid
  • 00:17:29
    unless you need them and then you can
  • 00:17:30
    take them. It's better than taking
  • 00:17:32
    Mirillax or or some other laxative to go
  • 00:17:35
    go poop. But but magnesium is is an
  • 00:17:37
    underappreciated I mean we talk about it
  • 00:17:39
    a lot now, but I think getting the
  • 00:17:41
    highest levels in the brain with three
  • 00:17:42
    and eight. often taking a mix. I often
  • 00:17:44
    have my patients take a mix of the
  • 00:17:46
    magnesiums. Sometimes take some during
  • 00:17:48
    the day and then others that you know
  • 00:17:49
    that more like the melee at night, you
  • 00:17:50
    know, that's going to help you with more
  • 00:17:51
    relaxation as well. So, it just depends
  • 00:17:53
    on the person, but like to mix it up.
  • 00:17:55
    What about uh anything else as far as a
  • 00:17:57
    neuroprotectin? Yes. So, the one I've
  • 00:17:58
    been really excited about lately is
  • 00:18:00
    something called cortisepin. And
  • 00:18:01
    cortisepin is the most active ingredient
  • 00:18:04
    in the cortiseps mushroom. You've heard
  • 00:18:06
    of the cortiseps mushroom, right? So,
  • 00:18:07
    cortiseps the mushroom itself has been
  • 00:18:09
    around. We've known about it for over,
  • 00:18:11
    you know, 10,000 years probably in
  • 00:18:12
    Chinese medicine. It's got a really cool
  • 00:18:15
    history and story. It's called the
  • 00:18:17
    zombie mushroom. Yeah. And if anybody's
  • 00:18:19
    watched the show on HBO called The Last
  • 00:18:21
    of Us, this is a show about a mutant
  • 00:18:24
    cortiseps mushroom. And the reason why
  • 00:18:26
    is that these mushrooms themselves, the
  • 00:18:27
    Cortiseps mushroom, they that get called
  • 00:18:29
    the zombie mushroom because they take
  • 00:18:31
    over the nervous system of insects and
  • 00:18:34
    they make them into zombie producing
  • 00:18:35
    factories. So they'll actually make the
  • 00:18:37
    insect, go to a place that's the perfect
  • 00:18:39
    location to grow the mushroom and then
  • 00:18:42
    take over the mushroom, eat it from the
  • 00:18:44
    take over the insect, take it take it
  • 00:18:46
    over from the inside out and make it
  • 00:18:47
    into a mushroom producing factory. So
  • 00:18:50
    back 10,000 years ago in China, they
  • 00:18:52
    would see this mushroom and see what had
  • 00:18:53
    happened and the life cycle of it and
  • 00:18:55
    they were like there's something amazing
  • 00:18:56
    about this particular mushroom to be
  • 00:18:58
    able to do that to be able to do it. And
  • 00:18:59
    so for thousands of years it's used been
  • 00:19:01
    used for cardiac health, pulmonary
  • 00:19:03
    health, kidney health. There's even good
  • 00:19:05
    studies now on cortiseps for increasing
  • 00:19:08
    V2 max training and ATP production. And
  • 00:19:10
    a lot of that's related to this compound
  • 00:19:13
    called cortisepin. So cortisepin is the
  • 00:19:16
    most active component of the mushroom.
  • 00:19:18
    It is about
  • 00:19:20
    0.03% of the mushroom itself. So very
  • 00:19:22
    small amount of the mushroom itself.
  • 00:19:24
    There's a lot of other things in there.
  • 00:19:25
    There's polyaccharides, there's
  • 00:19:26
    antioxidants, there's vitamins, other
  • 00:19:28
    things like that. But the cortisepin
  • 00:19:33
    itself is a profound anti-inflammatory
  • 00:19:36
    and it works that way because it works
  • 00:19:38
    on the adenosine system. You and I have
  • 00:19:40
    talked about adenosine a little bit
  • 00:19:42
    before. Adenosine has many different
  • 00:19:44
    roles. One of the main roles that it has
  • 00:19:47
    in the brain is that there's
  • 00:19:49
    neurotransmitters in the brain that bind
  • 00:19:51
    adenosine and adenosine will make you
  • 00:19:53
    feel sleepy. Adenosine gives you sleep
  • 00:19:56
    pressure. And so one of the roles of
  • 00:19:58
    cortisepin is that it works just like
  • 00:20:00
    adenosine no matter where adenosine is.
  • 00:20:03
    So in the brain it's going to work on
  • 00:20:05
    the adenosine receptors there to
  • 00:20:07
    increase sleep pressure. So you can use
  • 00:20:08
    it to increase deep sleep which is
  • 00:20:11
    fantastic. Um that's just one thing that
  • 00:20:14
    it can do. In addition, as a as a result
  • 00:20:17
    as a result of it working like adenosine
  • 00:20:18
    in the body in our DNA or on our DNA, we
  • 00:20:21
    have base pairs. We have adenosine. We
  • 00:20:23
    have guanine. We have cytosine. We have
  • 00:20:24
    thymine. I think it's adenosine,
  • 00:20:26
    guanine, and cytosine, guanine, and
  • 00:20:29
    adenosine thymine. That's that's that's
  • 00:20:30
    the how they base together. But or
  • 00:20:33
    adanine is actually what it's called. So
  • 00:20:34
    adanine is basically adenosine. So what
  • 00:20:37
    cortispan can do is actually can block
  • 00:20:40
    the replication of fast replicating
  • 00:20:44
    things
  • 00:20:45
    like microbes and potentially cancer as
  • 00:20:49
    well. So it's being studied as an
  • 00:20:51
    antimicrobial and as an anti-cancer
  • 00:20:54
    because it can block the production of
  • 00:20:56
    the DNA base pairs as it's being
  • 00:20:58
    replicated with you know with
  • 00:20:59
    polymerases that are responsible for
  • 00:21:01
    creating new RNA and new DNA that kind
  • 00:21:03
    of thing. And so it's being used in that
  • 00:21:05
    capacity. But in addition as it being
  • 00:21:07
    part of the adenosine system, it works
  • 00:21:10
    on significant anti-inflammatory
  • 00:21:12
    pathway. So it what it does is it
  • 00:21:14
    downregulates your NFCappa B pathway. So
  • 00:21:16
    we talked about that for alphapoic acid.
  • 00:21:18
    It's the same thing for your cortisepin.
  • 00:21:21
    So NFCappa B is your inflammatory
  • 00:21:22
    pathway. So we need some inflammation of
  • 00:21:24
    course, right? But we don't need a lot
  • 00:21:26
    of it. And often times our bodies have a
  • 00:21:28
    hard time shutting down inflammation
  • 00:21:29
    over time. And these cytoines and
  • 00:21:31
    interlucans and TNF alpha get released.
  • 00:21:33
    And so the cortisepin can come in and
  • 00:21:35
    downregulate your NFCappa pathway and
  • 00:21:38
    downregulate the production of all those
  • 00:21:40
    inflammatory cytoines. And there's also
  • 00:21:42
    a significant impact on your immune
  • 00:21:43
    system. And it's been studied now in
  • 00:21:45
    allergies and asthma because it can
  • 00:21:47
    regulate the balance between something
  • 00:21:48
    something called your TH1 and TH2
  • 00:21:51
    system. So these are your te- cells,
  • 00:21:53
    part of your immune system. And the
  • 00:21:54
    balance between one and two is very
  • 00:21:56
    important. If you have too much on the
  • 00:21:58
    on one side or the other, you can get an
  • 00:22:00
    imbalance and get more allergies,
  • 00:22:01
    asthma, those kinds of symptoms. And so
  • 00:22:02
    you can get a rebalance of the system
  • 00:22:04
    using the cortisepin. And so it's been
  • 00:22:06
    studied in allergies and asthma and
  • 00:22:08
    things like that too to balance that. So
  • 00:22:10
    you have this down reggulation of
  • 00:22:12
    inflammation using the cortisepin. And
  • 00:22:13
    you also have a revving up of your AMPK
  • 00:22:16
    pathways as well. So AMPK is very
  • 00:22:18
    important. It's a signaling pathway that
  • 00:22:21
    prevents us from um from creating more
  • 00:22:25
    anabolic state and it and at the same
  • 00:22:27
    time it allows a breakdown for more
  • 00:22:29
    catabolic state. So it helps you break
  • 00:22:31
    down your fats, break down your glucose,
  • 00:22:33
    but it prevents mTor from regulating
  • 00:22:35
    from from rising and so as a result of
  • 00:22:37
    that you know mtor is good if you need
  • 00:22:39
    it for exercise but you also don't want
  • 00:22:40
    too much mtor all the time because it
  • 00:22:42
    can give you a risk of you know cancer
  • 00:22:44
    degeneration and things like that. So,
  • 00:22:45
    so cortisep is working by downregulating
  • 00:22:47
    mtor upre upreulating mpk um and
  • 00:22:51
    downregulating nfcappa b. And so as a
  • 00:22:53
    result of all that you have this
  • 00:22:55
    profound capacity to decrease
  • 00:22:57
    inflammation in the system and work on
  • 00:23:01
    neuroinflammation specifically.
  • 00:23:03
    Interesting. So is it uh I mean if if
  • 00:23:06
    someone was to take just a like a
  • 00:23:08
    cortiseps mushroom yeah like they're
  • 00:23:10
    getting all these other things too. Is
  • 00:23:11
    it like that much of a concentrated
  • 00:23:13
    amount of cep? The problem that I have
  • 00:23:15
    with I take cortiseps mushroom itself is
  • 00:23:17
    I actually kind of get amped like I
  • 00:23:18
    don't like it sounds like cortisepin is
  • 00:23:21
    a little bit different. Yeah. So the
  • 00:23:23
    cortisep mushroom is typically taken in
  • 00:23:24
    the morning for that reason because it
  • 00:23:25
    does give you more of that amped feeling
  • 00:23:27
    and part of that reason is that it
  • 00:23:29
    doesn't have as much of an effect on the
  • 00:23:30
    adenosine system in the brain because of
  • 00:23:32
    the other molecules that are in uh that
  • 00:23:34
    other compounds that are in the actual
  • 00:23:36
    mushroom. This is actually what's been
  • 00:23:38
    studied to increase your V2 max. But the
  • 00:23:40
    cool way around that is you can take
  • 00:23:41
    high potency cortisepin with caffeine
  • 00:23:44
    and if you take some caffeine that's
  • 00:23:45
    going to block your adenosine receptors
  • 00:23:46
    in your brain. So all your all your
  • 00:23:48
    cortisepin is going to get diverted to
  • 00:23:50
    exercise performance overall you know
  • 00:23:52
    which is kind of fun increase. So that's
  • 00:23:53
    why you get more energy. But they're
  • 00:23:54
    using cortiseps they've been using it
  • 00:23:57
    for thousands of years as an anti-cancer
  • 00:23:59
    as an energy enhancer for those reasons.
  • 00:24:01
    But because cortisepin the way I use it
  • 00:24:03
    is a high potency like 75 or 150
  • 00:24:05
    milligs. Again in a 75 in a 1 g mushroom
  • 00:24:10
    you're going to get 0.03% cortisepin. So
  • 00:24:12
    it's a very small amount of of
  • 00:24:14
    cortisepin. So we're making a very high
  • 00:24:16
    potency overall in and and and making it
  • 00:24:18
    into a product. That way you're getting
  • 00:24:20
    this high amount of of cortisepin in the
  • 00:24:24
    system. You're getting a much more of a
  • 00:24:26
    stimulus for that deep sleep the
  • 00:24:27
    adenosine system. You can use a small
  • 00:24:29
    amount with caffeine to see that
  • 00:24:31
    performance benefit. But in general,
  • 00:24:32
    having people take it at night because
  • 00:24:34
    that's when they're going to see the the
  • 00:24:35
    deep sleep benefit. That's when they get
  • 00:24:37
    the anti-inflammatory benefit of it. Um,
  • 00:24:39
    and that's but this is one of those
  • 00:24:41
    things where and and the antimicrobial
  • 00:24:43
    benefit, too. So, it's one of those
  • 00:24:44
    things where you may not notice a
  • 00:24:45
    difference right away when you first
  • 00:24:46
    start taking it, but after taking it for
  • 00:24:49
    a little while, you will start seeing a
  • 00:24:50
    difference. Your your sleep will be
  • 00:24:52
    better. Your your your overall will feel
  • 00:24:54
    better the next day because the
  • 00:24:56
    inflammatory cascades are better. Like
  • 00:24:57
    I'm using it a lot in my patients with
  • 00:24:59
    chronic complex medical stuff with a lot
  • 00:25:02
    of inflammation that just not getting
  • 00:25:03
    better. I'm using people post infection.
  • 00:25:06
    Using people that have that are that
  • 00:25:07
    going on on airplanes for example and
  • 00:25:09
    then they're subject to the inflammation
  • 00:25:10
    of being on an airplane and that kind of
  • 00:25:11
    thing. Uh using it a lot in in other in
  • 00:25:14
    in other circumstances as well. Um
  • 00:25:16
    especially when you feel like
  • 00:25:16
    something's coming on like a like a
  • 00:25:18
    antimicrobial kind of thing. Like you
  • 00:25:20
    can take it for the first couple days
  • 00:25:21
    and like you see yourself getting better
  • 00:25:22
    very fast. And it's I get stories every
  • 00:25:26
    week about taking high strength
  • 00:25:27
    cortisepin and the antimicrobial aspect
  • 00:25:29
    of things especially. Yeah. You had me
  • 00:25:31
    uh start taking you know Tromune which
  • 00:25:33
    is your product that has it. You had you
  • 00:25:34
    know for for sleep issues because I
  • 00:25:36
    didn't want to take melatonin right. I
  • 00:25:37
    didn't want to like well just you know
  • 00:25:39
    take take one of these and that was I
  • 00:25:41
    mean some serious deep sleep with it.
  • 00:25:42
    And it's not like a melatoniny feeling.
  • 00:25:45
    It's just like you I mean your sleep
  • 00:25:47
    everything's normal. You just feel like
  • 00:25:49
    you got a little bit deeper sleep. So
  • 00:25:50
    that's how I first got turned on to it.
  • 00:25:52
    Um you have a product called Tromune
  • 00:25:54
    where that's the I mean that's the
  • 00:25:55
    active component is the cortisepin
  • 00:25:57
    itself and it's in that cool little kind
  • 00:25:58
    of troy form. Yeah. So you can titrate
  • 00:26:00
    your dose and do all that. Yeah. So we
  • 00:26:02
    did we came we came across cortisepin
  • 00:26:05
    when we're looking at creating something
  • 00:26:06
    called Troy which is our sleep product
  • 00:26:08
    and sleep our sleep product has eight
  • 00:26:10
    different ingredients in it. One of them
  • 00:26:11
    is cortisepin and that's the one that
  • 00:26:13
    increases deep sleep. But when we looked
  • 00:26:15
    at the research we're like this has got
  • 00:26:17
    so many other amazing potential
  • 00:26:18
    benefits. So we increase the dose. We
  • 00:26:20
    have something called tromune. As you
  • 00:26:22
    said, it's 75 milligs. If you're a
  • 00:26:24
    practitioner, it's called we have
  • 00:26:25
    something called troplomine, which is
  • 00:26:27
    150. But 75 milligrams is really great
  • 00:26:29
    for most people. And as you said, it's
  • 00:26:31
    it's a troy form. So it's it's something
  • 00:26:33
    you can easily titrate. Start with a
  • 00:26:34
    quarter, a half, or full. But I have the
  • 00:26:37
    other people like me who have four kids
  • 00:26:39
    at the house that are subject to stuff
  • 00:26:40
    all the time. I'm taking it regularly
  • 00:26:43
    like prophylactically at low doses and
  • 00:26:44
    then I increase the dose when you know
  • 00:26:46
    something's coming in the house that
  • 00:26:47
    kind of thing or I'm going traveling or
  • 00:26:50
    I'm going to be under more stressful
  • 00:26:51
    situation something like that. The other
  • 00:26:53
    way to so that's the other way to do So
  • 00:26:55
    you either take it prophylactically
  • 00:26:56
    regularly or you can take it when you
  • 00:26:57
    know you're going to be under more
  • 00:26:58
    stress. And but you mentioned the deep
  • 00:27:00
    sleep thing which is super cool because
  • 00:27:02
    I've had a number of people reach out to
  • 00:27:04
    me. They don't take arroine. They just
  • 00:27:05
    take our tromuna for sleep. And what
  • 00:27:08
    you'll find I find like when I when I
  • 00:27:10
    when I look at my data and people will
  • 00:27:11
    tell me this too is that you'll often
  • 00:27:13
    find most people get their deep sleep
  • 00:27:14
    when they first go to bed at night. What
  • 00:27:16
    tromune can do is often give you a
  • 00:27:18
    second bout of deep sleep earlier or
  • 00:27:22
    closer to the morning. Um, typically
  • 00:27:24
    around 3 or 4 o'clock in the morning is
  • 00:27:25
    when I typically find it for most
  • 00:27:26
    people. And most people aren't used to
  • 00:27:28
    getting that kind of deep sleep then.
  • 00:27:29
    Yeah. So, some people if you wake up
  • 00:27:31
    super early, you might feel like
  • 00:27:32
    slightly groggier initially when you
  • 00:27:34
    first take it. But it's not typically
  • 00:27:35
    it's not like a melatonin groggy at all.
  • 00:27:36
    Like it it goes it it wears wears out
  • 00:27:39
    very very quickly. But my wife for
  • 00:27:40
    example, if she's like feeling like
  • 00:27:42
    she's going to get sick, she'll make me
  • 00:27:44
    give her a full Troy because she know
  • 00:27:46
    she doesn't listen to me for anything.
  • 00:27:48
    So like that she actually will take
  • 00:27:50
    Trommune is like it's a huge win for me.
  • 00:27:53
    Um because she gets that cold that five
  • 00:27:57
    seven days and then she gets that cough
  • 00:27:58
    that doesn't go away for like a month.
  • 00:28:00
    And so if I can get her to take Trommune
  • 00:28:01
    right in the beginning like it's a it's
  • 00:28:03
    it's a game changer for her. And so
  • 00:28:05
    she'll ask me where the green stuff is
  • 00:28:07
    because it's green colored. And so
  • 00:28:08
    she'll take a full Tromune and she's
  • 00:28:10
    she's like a sleep champion. And people
  • 00:28:12
    like my wife that's why they live so
  • 00:28:14
    long. She has very good genetics. They
  • 00:28:16
    it's a champion sleep. like she can
  • 00:28:18
    sleep through anything and so when she
  • 00:28:20
    wakes up after tromune like a full dose
  • 00:28:22
    she might feel a little bit groggy when
  • 00:28:23
    she first wake up wakes up but she's
  • 00:28:24
    okay with that because she feels better
  • 00:28:26
    all you know so and so it's a bit of a
  • 00:28:27
    thing but some people will take it just
  • 00:28:29
    for the sleep benefit but obviously when
  • 00:28:31
    you also sleep better when you're not
  • 00:28:33
    feeling well you're going to heal better
  • 00:28:35
    too because sleep is what what our
  • 00:28:38
    parents and you know have always said is
  • 00:28:40
    the best medicine right if I can get my
  • 00:28:41
    kids to sleep I'm sure you've seen this
  • 00:28:43
    in yours I will just force my child to
  • 00:28:45
    to stay in bed for an entire day and
  • 00:28:48
    they'll be better the next day, you
  • 00:28:49
    know, if I can get them to sleep. No,
  • 00:28:50
    it's a legit. It's very legit. We have
  • 00:28:52
    our a son that's like that. This is just
  • 00:28:53
    like he's like he listens to his body.
  • 00:28:55
    He'll boom, go to bed, he'll sleep for
  • 00:28:58
    16 hours and then just be fine. Like I
  • 00:29:00
    wish I wish I wish I wish. And I do with
  • 00:29:02
    my kids. I give them a little bit of
  • 00:29:03
    tromune and it goes a long way. I mean,
  • 00:29:05
    I don't recommend doing that unless
  • 00:29:06
    you're working with a practitioner, but
  • 00:29:08
    in my kids, I use a lot of tromun. It's
  • 00:29:10
    fantastic, man. I give them like a
  • 00:29:11
    little quarter of our troi and then
  • 00:29:13
    they're better in a couple days, if not
  • 00:29:14
    if not the next day. Um, and then
  • 00:29:16
    everybody's taking it. My whole family
  • 00:29:18
    when we're traveling, uh, we'll be going
  • 00:29:19
    on spring break next week with everybody
  • 00:29:21
    and the kids and everybody will have it,
  • 00:29:22
    you know, have it, you know, make sure
  • 00:29:23
    we have it on board. Even my wife will
  • 00:29:25
    take it. Like I said, she doesn't listen
  • 00:29:26
    to me about anything. So, it's, um, it's
  • 00:29:28
    kind of fun to see her take that one,
  • 00:29:29
    but it's a fantastic anti-inflammatory.
  • 00:29:31
    So, that's that's a unique one. Our true
  • 00:29:33
    is very unique. Um, there's no other
  • 00:29:35
    companies out there that have a high
  • 00:29:36
    potency product like we do. Um, I think
  • 00:29:38
    Cortiseps is great otherwise, but what I
  • 00:29:41
    like to do for my athletes is have them
  • 00:29:42
    take a little bit of the Cortiseps, the
  • 00:29:44
    Cortisepin with caffeine in the morning.
  • 00:29:46
    It's a great pre-workout boost overall.
  • 00:29:48
    Interesting. I'll try that one. I'll try
  • 00:29:49
    that one. Yeah, it's a re kind of
  • 00:29:50
    redirecting. I'll link out to it down
  • 00:29:52
    below as well, so that way can check it
  • 00:29:54
    out. It definitely was uh out of your
  • 00:29:56
    products. It was the last one that I
  • 00:29:57
    tried. Um, and it was uh one of those
  • 00:30:01
    that where I kind of wish it was the
  • 00:30:02
    first one that I tried cuz it was just
  • 00:30:03
    it didn't it didn't occur to me just how
  • 00:30:07
    the Cortisan would work. I'm like, "Oh,
  • 00:30:08
    I've taken Cortiseps before and like all
  • 00:30:10
    I get is like a little bit of a, you
  • 00:30:11
    know, energy boost out of it." So, it
  • 00:30:12
    was really So, I'll link out to that in
  • 00:30:14
    the top line of the description. Yeah,
  • 00:30:15
    it's our sleeper product, man. like it
  • 00:30:16
    was like I'm just so impressed across
  • 00:30:19
    the board. But it's not the first thing
  • 00:30:20
    that people would think of when they
  • 00:30:22
    think of our company. But when they get
  • 00:30:24
    into our ecosystem and see what we've
  • 00:30:25
    created for me like my main stays in the
  • 00:30:29
    people that I work with are methylene
  • 00:30:31
    blue and cortisepin. So our just blue
  • 00:30:34
    and our tromune is hands down for almost
  • 00:30:36
    everybody because it's inflammatory
  • 00:30:38
    support and energy support during the
  • 00:30:40
    day and it's inflammatory support and
  • 00:30:42
    sleep support at night. And so the
  • 00:30:44
    combination has just been transformative
  • 00:30:46
    personally. I have four children.
  • 00:30:48
    Somebody's always got something. And
  • 00:30:50
    then also for my patients as well. And
  • 00:30:52
    we get tons of stories. I just got one
  • 00:30:54
    this morning before we started about how
  • 00:30:56
    amazing Tromium's working for, you know,
  • 00:30:58
    for her and for her patients. And yeah,
  • 00:31:00
    it's a fantastic fantastic compound for
  • 00:31:02
    neurop protection,
  • 00:31:04
    neuroinflammation. And I'm really
  • 00:31:06
    excited about where it's going to go,
  • 00:31:07
    what else we're going to see from it.
  • 00:31:08
    the two that I would add and one that
  • 00:31:10
    we've talked about before like for me I
  • 00:31:11
    can talk about my my personal static
  • 00:31:13
    like methylene blue for me for for brain
  • 00:31:15
    for sure we just we've done a deep dive
  • 00:31:17
    on it so it's it's uh maybe not worth
  • 00:31:19
    doing a dive on this video but
  • 00:31:21
    definitely worth mentioning and another
  • 00:31:22
    one for me which maybe not so much as a
  • 00:31:24
    neuroprotectant but for me on days that
  • 00:31:25
    I'm sleepd deprived u you know starting
  • 00:31:27
    my day with like upping it to 10 grams
  • 00:31:29
    creatine like first thing in the morning
  • 00:31:31
    because it's there's relatively recent
  • 00:31:32
    evidence on that show even in a short
  • 00:31:34
    term short-term effect on sleep
  • 00:31:36
    deprivation so it's like
  • 00:31:38
    There's always going to be those nights,
  • 00:31:39
    probably frequently, where you just
  • 00:31:40
    don't sleep well. Noticeable difference
  • 00:31:43
    by frontloading my creatine at a pretty
  • 00:31:45
    decent dose, 10 to 15 grams, which
  • 00:31:47
    sounds wild, but it's really perfectly
  • 00:31:49
    fine. And uh that makes at least gives
  • 00:31:52
    me a good solid four or five hours of
  • 00:31:55
    good working energy with my brain before
  • 00:31:56
    I start to degrade after a bad night of
  • 00:31:58
    sleep. Otherwise, I'm worth I'm I've got
  • 00:32:00
    enough adrenaline in my system to get me
  • 00:32:02
    through a couple hours. I can usually
  • 00:32:03
    wake up, you know, after four hours of
  • 00:32:04
    crappy sleep and be like, "All right, I
  • 00:32:06
    can get through two hours, but then I'm
  • 00:32:07
    worthless, you know?" Yeah. The big
  • 00:32:09
    thing with your brain too is like, let
  • 00:32:13
    it shut off, please. Right. Most of us
  • 00:32:15
    are not letting our brain shut down. And
  • 00:32:17
    so, always being sympathetically
  • 00:32:19
    dominant, always being in fight or
  • 00:32:20
    flight is really bad for your brain,
  • 00:32:23
    really bad for your stress, your
  • 00:32:24
    cortisol level rise, and your GABA
  • 00:32:26
    levels drop dramatically. And so you
  • 00:32:29
    really want to be thinking
  • 00:32:30
    about working on your gabaurgic tone,
  • 00:32:33
    working on your parasympathetic tone. So
  • 00:32:34
    I'm often very much thinking about
  • 00:32:36
    obviously supporting the brain and you
  • 00:32:38
    know from an inflammatory perspective is
  • 00:32:39
    very important like as we've been
  • 00:32:41
    discussing, but working on the GABA
  • 00:32:43
    system is really really important too.
  • 00:32:44
    So we have trocom and trot at
  • 00:32:46
    transcriptions that are really great for
  • 00:32:48
    downregulating the nervous system
  • 00:32:50
    getting the brakes back on. this doesn't
  • 00:32:52
    take the place or can at least it helps
  • 00:32:54
    to do things like learning how to shut
  • 00:32:56
    off, not be scrolling next to your phone
  • 00:32:58
    right before you go to bed, not yelling
  • 00:33:00
    at your spouse and then trying to go to
  • 00:33:02
    sleep or yelling at your employees every
  • 00:33:05
    day. Like trying to find ways to chill
  • 00:33:06
    the out would be great, right? But
  • 00:33:08
    supplementation there can be very very
  • 00:33:10
    helpful. And so that's another one
  • 00:33:11
    that's big on neuro degeneration for me
  • 00:33:13
    and neurop protection is sympathetic
  • 00:33:16
    down reggulation, parasympathetic
  • 00:33:19
    upregulation. And that's usually with
  • 00:33:20
    the GABAurgic neurotransmitter system.
  • 00:33:22
    Right on, man. Well, uh, Scott, where
  • 00:33:23
    can everyone find you, man? So, I'm at
  • 00:33:25
    on Instagram, Dr. Scott Sher, D R S O T
  • 00:33:28
    S H E R. And you can find everything
  • 00:33:30
    about transcriptions at
  • 00:33:33
    transcriptions.comcriptions. If you go
  • 00:33:34
    to our website, our blog is full of
  • 00:33:37
    great blogs on all of the things we
  • 00:33:38
    discussed today. Um, especially Cortisep
  • 00:33:41
    and obviously the zombie mushroom and
  • 00:33:43
    all the cool things about that. And, uh,
  • 00:33:45
    yeah, transcriptions.com. Right on, my
  • 00:33:47
    man. Thanks. Good to see you. Thanks,
الوسوم
  • alpha-lipoic acid
  • brain health
  • antioxidants
  • neuroinflammation
  • cortisepin
  • magnesium
  • NRF2 pathway
  • GABA
  • cognitive function
  • dietary supplements