Memorize Enzyme Inhibition

00:02:58
https://www.youtube.com/watch?v=SqjVB8WT1xo

概要

TLDRThis video explains the three types of enzyme inhibition: competitive, uncompetitive, and non-competitive. It details how competitive inhibition involves competition for the active site, uncompetitive inhibition pertains to inhibitor binding to the ES complex, and non-competitive inhibition allows binding to either the active site or the ES complex. A unique technique is provided to memorize the graphs associated with each type of inhibition using a pencil. For competitive inhibition, the pencil is held at 1/Vmax and rotated anti-clockwise. For uncompetitive inhibition, the pencil is pushed upwards, while for non-competitive inhibition, it is held at -1/Km and rotated anti-clockwise.

収穫

  • 🧪 Understand the three enzyme inhibition types: competitive, uncompetitive, non-competitive.
  • 📊 Competitive inhibition competes for the enzyme's active site.
  • 🔗 Uncompetitive inhibition binds the enzyme-substrate complex.
  • 🔄 Non-competitive inhibition can bind both active site and ES complex.
  • ✏️ Use a pencil to memorize inhibition graphs effectively: rotate and push as needed.

タイムライン

  • 00:00:00 - 00:02:58

    In this section, the speaker introduces the topic of enzyme inhibition and explains the three types: competitive, uncompetitive, and non-competitive inhibition. Competitive inhibition occurs when the inhibitor competes with the substrate for the enzyme's active site. Uncompetitive inhibition involves the inhibitor binding to the enzyme-substrate complex. Non-competitive inhibition allows the inhibitor to bind to either the active site or the enzyme-substrate complex directly, affecting their function.

マインドマップ

ビデオQ&A

  • What are the three types of enzyme inhibition?

    The three types of enzyme inhibition are competitive inhibition, uncompetitive inhibition, and non-competitive inhibition.

  • How does competitive inhibition work?

    In competitive inhibition, the substrate and the inhibitor compete for the enzyme's active site.

  • What is uncompetitive inhibition?

    Uncompetitive inhibition occurs when the inhibitor binds to the enzyme-substrate (ES) complex.

  • How does non-competitive inhibition differ from the others?

    Non-competitive inhibition allows the inhibitor to bind to either the active site or the ES complex.

  • What is the memorization technique for graphs of inhibition?

    Use a pencil to visualize the graphs: rotate for competitive, push up for uncompetitive, and rotate for non-competitive.

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  • 00:00:00
    hey guys quit by chemistry basics here
  • 00:00:03
    let's talk about tips to remember enzyme
  • 00:00:06
    inhibition now there are three types of
  • 00:00:09
    enzyme inhibition competitive inhibition
  • 00:00:12
    uncompetitive inhibition and
  • 00:00:15
    non-competitive inhibition
  • 00:00:18
    competitive inhibition is a phenomenon
  • 00:00:21
    in which the substrate and the inhibitor
  • 00:00:22
    competes for the active site of the
  • 00:00:25
    enzyme uncompetitive inhibition is a
  • 00:00:29
    phenomenon in which inhibitor binds the
  • 00:00:32
    es complex
  • 00:00:35
    non-competitive inhibition is a
  • 00:00:38
    phenomenon in which the inhibitor can
  • 00:00:41
    either bind active site and compete with
  • 00:00:44
    the substrate or it can bind the es
  • 00:00:47
    complex directly
  • 00:00:51
    - memorized graphs of each kind of
  • 00:00:54
    enzyme inhibition all you need is a
  • 00:00:56
    pencil or a pen now to memorize the
  • 00:01:01
    graph of competitive inhibition place
  • 00:01:04
    the pencil on the graph and hold it at 1
  • 00:01:07
    by V Max value now rotate the pencil in
  • 00:01:11
    anti-clockwise direction and this will
  • 00:01:13
    be the graph of competitive inhibition
  • 00:01:16
    in competitive inhibition the value of
  • 00:01:19
    -1 by km has changed whereas the value
  • 00:01:23
    of 1 by V Max remains the same
  • 00:01:29
    for uncompetitive inhibition place the
  • 00:01:33
    pencil on the graph and push it upwards
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    this will be the graph of uncompetitive
  • 00:01:39
    inhibition you're the valley of -1 by km
  • 00:01:43
    and value of 1 by V Max have changed
  • 00:01:52
    for non-competitive inhibition a hold
  • 00:01:55
    the pencil at minus 1 by km and rotate
  • 00:01:59
    the pencil in anti-clockwise direction
  • 00:02:02
    this gives you the graph of
  • 00:02:04
    non-competitive inhibition in this case
  • 00:02:08
    the value of 1 by we max have changed
  • 00:02:11
    and the value of minus 1 by km remains
  • 00:02:15
    the same
  • 00:02:20
    let's revise this technique for
  • 00:02:22
    competitive inhibition hold the pencil
  • 00:02:24
    at 1 by V Max and rotate an
  • 00:02:28
    anti-clockwise direction
  • 00:02:31
    for uncompetitive inhibition push the
  • 00:02:35
    pencil in upwards direction
  • 00:02:39
    and for non-competitive inhibition hold
  • 00:02:43
    the pencil at minus 1 by km and rotate
  • 00:02:47
    the pencil in anti-clockwise direction
タグ
  • enzyme inhibition
  • competitive inhibition
  • uncompetitive inhibition
  • non-competitive inhibition
  • biochemistry
  • memorizations tips
  • graphs
  • active site
  • ES complex
  • substrate