What are the two systems that handle Vitamin D in the body?

One system is related to bone and skeletal health (endocrine function), and the other involves various cellular functions (paracrine and autocrine systems) affecting immune cells, cancer cells, etc.

Why is measuring Vitamin D levels in the blood not enough?

Blood tests typically measure an inactive form of Vitamin D, which doesn't reflect its availability and activity for non-skeletal systems.

What are the common misconceptions about Vitamin D supplementation?

Many people think a single blood measurement suffices for all needs, confusing skeletal health with other health aspects requiring daily Vitamin D intake.

Why do some studies about Vitamin D show no benefits?

Studies often use inadequate dosing or improper research models, such as single large doses instead of regular smaller doses.

How does Vitamin D affect cancer prevention or management?

Vitamin D can influence cancer cell activity, immune response, and potentially act as part of cancer prevention or supportive care, especially at higher doses.

Why are Vitamin D research and funding declining?

Despite evidence of wide-ranging benefits, vitamin D trials are underfunded due to the prevailing influence of unsuccessful trials and pharmaceutical interests.

What role does Vitamin D play in pregnancy and lactation?

Proper Vitamin D levels reduce pregnancy complications and improve lactation by providing sufficient levels in breast milk.

Is Vitamin D toxicity a real concern?

True toxicity is rare, and Vitamin D is generally safe even at higher doses, unless specific metabolic defects are present.

What role does magnesium play in Vitamin D metabolism?

Magnesium acts as a co-factor, enhancing Vitamin D metabolism and function within the body.

How does the body's storage of Vitamin D actually work?

Vitamin D doesn't extensively store in fat tissues but is continuously needed, necessitating regular intake for optimal function.

Your Body Is BEGGING For Vitamin D!!

00:53:13

https://www.youtube.com/watch?v=QAQ7r6jLEww

Summary

TLDRThe conversation with Professor Bruce Hollis explores the dual pathways of Vitamin D functionality in the body, delineating its roles in bone health through the endocrine system and its broader physiological effects through a separate paracrine and autocrine system. Dr. Hollis emphasizes the common misconceptions regarding Vitamin D, particularly in the context of medical research which often fails to show positive results due to flawed dosing strategies. He criticizes many clinical trials for misunderstanding Vitamin D's mechanism and for administering doses that are insufficient to realize its potential benefits beyond bone health. The discussion also touches on the need for daily intake of Vitamin D to enable its full spectrum of effects, especially in pregnancy, cancer prevention, and general immune functionality. Emerging evidence suggests the crucial role of Vitamin D in health outcomes, such as mitigating complications during childbirth and influencing gene regulation that could aid in cancer therapy. Hollis highlights that traditional supplementation often neglects the paracrine system's needs, and underscores the importance of ongoing, high-quality research to better understand Vitamin D's comprehensive benefits, despite current financial and pharmaceutical industry barriers. A substantial portion of the interview addresses the logistical and scientific challenges in vitamin D research, such as population variability and ethical care standards limiting rigorous trial designs, which informs why it is considered a contentious area with many existing studies deemed inconclusive, not necessarily reflective of vitamin D's therapeutic potential.

Takeaways

🦴 Vitamin D has dual roles: bone health and broader cellular functions.
🧪 Standard blood tests measure inactive Vitamin D, not its full potential.
🔍 Research often misinterprets Vitamin D's broader effects due to improper dosing.
💊 Regular daily doses of Vitamin D are crucial for overall health benefits.
🌞 Sun exposure contributes significantly to Vitamin D production.
🤰 Adequate Vitamin D can reduce pregnancy complications.
🛡 Vitamin D plays a role in cancer prevention and therapy.
🔬 High doses might be needed for therapeutic effects on diseases like MS.
📝 Major medical journals show resistance towards positive Vitamin D findings.
⚙️ Magnesium is crucial for optimizing Vitamin D metabolism.

Timeline

00:00:00 - 00:05:00
The discussion introduces Professor Bruce Hollis as a pioneer in vitamin D research, revealing little-known truths about vitamin D's dual systems in the body: one for skeletal integrity and another for cellular functions, controlling around 2,000 genes. Dr. Hollis discusses the misconception that blood tests accurately reflect vitamin D's role in cellular functions.
00:05:00 - 00:10:00
Dr. Hollis elaborates on the different forms of vitamin D: the supplement form that is crucial for cellular function and the intermediate form that is tested in blood, which focuses on blood calcium and skeletal maintenance. He emphasizes the importance of daily intake of vitamin D, as the supplement form doesn't last long in the body.
00:10:00 - 00:15:00
Hollis critiques the methodology of some vitamin D studies, particularly highlighting the misinterpretation of vitamin D's effectiveness when administered infrequently. He provides insight into flawed research designs where baseline vitamin D levels aren't considered, leading to misrepresented outcomes.
00:15:00 - 00:20:00
Illustrating how randomized drug trials differ from nutrient trials, he explains that nutrient trials like for vitamin D are challenging due to varying baseline levels in participants. He references successful overseas studies where vitamin D showed significant health benefits due to prevalent deficiencies.
00:20:00 - 00:25:00
Further discussing research limitations, Hollis criticizes the way some studies, including those in major journals, dismiss significant findings by enforcing study designs that obscure beneficial outcomes. He shares successful studies on vitamin D's impact on pregnancy outcomes but laments the challenges in funding and publication.
00:25:00 - 00:30:00
Hollis talks about a prostate cancer study where vitamin D showed significant tumor regression, yet faced publication challenges. He mentions vitamin D's potential in extending life for chemotherapy patients but critiques the restrictive doses allowed in trials, emphasizing the need for higher doses to see real effects.
00:30:00 - 00:35:00
Discussing vitamin D storage and supposed toxicity, Hollis explains that vitamin D is not extensively stored in fat tissue, countering a common belief. He discusses studies that link vitamin D to reduced vascular permeability and shares successes in pediatric studies around vitamin D and breastfeeding.
00:35:00 - 00:40:00
The conversation touches on the regulation and testing barriers for vitamin D research, with governmental and industry resistance due to financial interests. The role of vitamin D in disease prevention is acknowledged, but trial opportunities are dwindling due to funding issues and systemic opposition.
00:40:00 - 00:45:00
Hollis reflects on his motivations for studying vitamin D, citing its essential role from his early research in animal health. He shares how safety and efficacy findings in vitamin D led to breakthroughs in understanding its broader health benefits, despite professional skepticism.
00:45:00 - 00:53:13
Concluding the interview, Hollis stresses the importance of vitamin D education, addressing systemic flaws in how health guidelines are set. He advocates for informed supplementation policies, noting that government and scientific institutions must overcome biases to improve public health.

Mind Map

Video Q&A

What are the two systems that handle Vitamin D in the body?
One system is related to bone and skeletal health (endocrine function), and the other involves various cellular functions (paracrine and autocrine systems) affecting immune cells, cancer cells, etc.
Why is measuring Vitamin D levels in the blood not enough?
Blood tests typically measure an inactive form of Vitamin D, which doesn't reflect its availability and activity for non-skeletal systems.
What are the common misconceptions about Vitamin D supplementation?
Many people think a single blood measurement suffices for all needs, confusing skeletal health with other health aspects requiring daily Vitamin D intake.
Why do some studies about Vitamin D show no benefits?
Studies often use inadequate dosing or improper research models, such as single large doses instead of regular smaller doses.
How does Vitamin D affect cancer prevention or management?
Vitamin D can influence cancer cell activity, immune response, and potentially act as part of cancer prevention or supportive care, especially at higher doses.
Why are Vitamin D research and funding declining?
Despite evidence of wide-ranging benefits, vitamin D trials are underfunded due to the prevailing influence of unsuccessful trials and pharmaceutical interests.
What role does Vitamin D play in pregnancy and lactation?
Proper Vitamin D levels reduce pregnancy complications and improve lactation by providing sufficient levels in breast milk.
Is Vitamin D toxicity a real concern?
True toxicity is rare, and Vitamin D is generally safe even at higher doses, unless specific metabolic defects are present.
What role does magnesium play in Vitamin D metabolism?
Magnesium acts as a co-factor, enhancing Vitamin D metabolism and function within the body.
How does the body's storage of Vitamin D actually work?
Vitamin D doesn't extensively store in fat tissues but is continuously needed, necessitating regular intake for optimal function.

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Subtitles

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00:00:00
today we're going to be talking to
00:00:01
Professor Bruce Hollis the Pioneer in
00:00:04
vitamin D research you're going to find
00:00:07
this extremely fascinating let's Dive
00:00:09
Right In so Dr Hollis I I watched one of
00:00:11
your videos and I literally had to put
00:00:14
it on pause because you said something
00:00:17
that blew me away I've never heard this
00:00:19
before in my life and I had to spend the
00:00:21
next eight hours trying to validate what
00:00:24
you said which is absolutely 100% true
00:00:26
and this little piece of information
00:00:28
will explain a lot of I think the
00:00:30
confusions that people observe when they
00:00:33
see negative research on vitamin D and a
00:00:36
lot of other things so that piece of
00:00:39
information was related to um there's
00:00:41
actually two different systems in the
00:00:45
body that deal with vitamin D uh there's
00:00:48
I guess one with bone and skeleton and
00:00:51
then there's another system for
00:00:52
everything else can you kind of just as
00:00:55
simple as possible kind of explain those
00:00:56
two
00:00:57
systems yeah the first system
00:01:00
uh the one that was discovered decades
00:01:02
ago that vitamin D was associated with
00:01:05
skeletal integrity and M maintaining um
00:01:08
blood calcium levels in a strict fashion
00:01:11
and and it's very important and it has
00:01:13
to be it has to be uh maintained all the
00:01:18
time and so that system involves uh
00:01:21
vitamin D and parathyroid hormone um
00:01:25
kidneys and that's basically referred to
00:01:28
as the endocrine function of vitamin D
00:01:30
and that's what everybody always
00:01:32
identified vitamin D with and then as
00:01:36
time went on um molecular biology came
00:01:39
into a focus they started finding um
00:01:44
cells that had the ability to respond to
00:01:46
vitamin D that had nothing to do with
00:01:49
the skeleton immune cells cancer
00:01:53
cells uh uh placental cells uh and list
00:01:58
goes on and on and it turn turns out
00:02:00
that that's the second system and is
00:02:01
called the paracrine and intercrine
00:02:03
system and that is depending on uh how
00:02:08
much vitamin D can get into these cells
00:02:10
and be activated and then carry out
00:02:12
their function I mean just in the human
00:02:16
body give or take there are 20,000
00:02:18
different genes that are controlled um
00:02:21
uh for various functions vitamin D has
00:02:24
the ability to control 10% or 2,000 of
00:02:27
those genes in one fashion or another
00:02:30
and so to to basically brush that aside
00:02:33
as a lot of my colleagues did uh just
00:02:37
saying it's it's an artifact never made
00:02:39
any sense to me so if we take a look at
00:02:42
these two systems when you get your
00:02:43
blood test done in vitamin D you're
00:02:45
looking at a the inactive version of
00:02:48
you're not looking at the type of
00:02:49
vitamin D that's going in the cells and
00:02:52
how does that relate with these two
00:02:55
different systems well here we get it
00:02:57
gets pretty technical so have you have
00:03:01
when people refer to vitamin D mostly
00:03:03
when they refer to vitamin D it's the
00:03:05
form you get when you take a supplement
00:03:07
or when you make it in your skin when
00:03:10
the Sun hits your skin um that's the we
00:03:13
call that the vitamin D or the parent
00:03:15
compound and then that compound goes
00:03:18
into the circulation it doesn't stay
00:03:20
there very long and but it gets turned
00:03:22
into another compound called 25 hydroxy
00:03:25
vitamin D and when they test your blood
00:03:28
right the immediate form
00:03:31
the intermediate form that stays in your
00:03:33
blood for weeks okay okay and that's a
00:03:36
good and a bad thing because it it stays
00:03:38
around for a long time but it's not very
00:03:40
accessible to these tissues that need
00:03:43
it it it's accessible to the kidney that
00:03:46
maintains blood calcium and then finally
00:03:50
uh the uh the that compound is turned
00:03:53
into another compound which is really
00:03:55
one of the most potent hormones known
00:03:57
and that's uh the 125 Di hydroxy vitamin
00:04:01
D and that uh that that's is what drives
00:04:06
all these Gene functions and all these
00:04:07
tissues so so the one when you go to the
00:04:10
doctor and get your blood test you're
00:04:11
looking at not the active form it's an
00:04:14
inactive form that can stay around in
00:04:16
the blood for a c several weeks it's the
00:04:20
yes it's the I'll call it the
00:04:22
reservoir okay it's the reservoir of
00:04:24
vitamin D that's being measured got
00:04:28
it and then it turns turns into the
00:04:30
active form or a certain amount will
00:04:32
turn into the active form but then how
00:04:35
does that relate to these two different
00:04:38
systems well so the in that intermediate
00:04:42
form the reservoir form can turn into
00:04:44
the active form in the kidney that's
00:04:46
highly regulated and that's what m
00:04:49
that's what regulates blood
00:04:50
calcium
00:04:52
okay that intermediate form can also go
00:04:56
into any cell in the body okay and be
00:04:59
turned in to the active form and
00:05:03
function in that given cell whether it
00:05:05
be a cancer cell to stop cancer from
00:05:08
progressing or immune cells uh to make
00:05:12
make them function in the appropriate
00:05:15
fashion and uh also the the problem with
00:05:19
that intermediate form is it's not very
00:05:22
accessible to these cells it can it's
00:05:25
it's it's bound to this protein it keeps
00:05:27
it out that's why it lasts in the blood
00:05:29
so long
00:05:31
so the the parent compound the one that
00:05:34
you take in the supplement turns out
00:05:38
it's really important because that form
00:05:40
can get into any of these cells and be
00:05:43
activated all the way down the chain to
00:05:45
the active
00:05:46
form the problem is that form disappears
00:05:49
within a
00:05:51
day yeah so so it needs to be
00:05:53
replenished every
00:05:55
day to have the full function of the
00:05:58
vitamin present say it's very it's
00:06:00
complicated that's why a lot of
00:06:02
Physicians don't pay attention to this
00:06:04
or scientists as
00:06:06
well so this this this is kind of what I
00:06:08
want to get into this this point that
00:06:10
you just mentioned because you have the
00:06:12
different types and then when people get
00:06:14
their blood tested they're assuming that
00:06:17
there's one system oh I have enough in
00:06:19
the blood so everything's going to be
00:06:21
satisfied but that's not necessarily
00:06:23
true no that's true and because the the
00:06:27
form that's being measured while it's
00:06:29
important okay it's the reservoir more
00:06:31
important
00:06:32
for maintenance of blood calcium and
00:06:35
skeleton but for the other functions the
00:06:39
only way that you can you you can be
00:06:41
sure that you have adequate Amounts is
00:06:44
basically take it every day either
00:06:47
orally or get in the Sun every day and
00:06:48
of course that's really not feasible for
00:06:50
a lot of
00:06:51
reasons so the oral consumption of
00:06:54
vitamin D on a daily or at a minimum on
00:06:58
a weekly basis
00:07:00
uh is is important because that that's
00:07:03
the that's the the Bas the base form and
00:07:06
that form comes and goes very
00:07:08
quickly
00:07:10
wow so this has to do with like halflife
00:07:13
and um breaking down some of it goes
00:07:16
down quick some stays in there so
00:07:20
now in one of your videos you me you
00:07:22
went through a bunch of studies and you
00:07:24
showed people step by step um like
00:07:28
number of studies that were that failed
00:07:30
that showed no response with vitamin D
00:07:33
and you correlated that with h well
00:07:35
that's because they they only let people
00:07:37
take it once a week or once a month
00:07:40
versus there been even been one study on
00:07:44
skeleton where they took it once a year
00:07:47
like a million units once a year and
00:07:49
then they said well this didn't work out
00:07:50
very well and that continues to be cited
00:07:52
in some facts as being harmful it's
00:07:54
idiotic oh my gosh if someone takes a
00:07:58
million um I use a vitamin D just one
00:08:01
time um I think um after after a day it
00:08:07
goes down to half and then the day later
00:08:09
it goes down to a quarter right it just
00:08:10
kind of breaks down and then goes away
00:08:12
or or it just becomes yeah it it'll
00:08:15
boost the intermediate form for a while
00:08:17
but it's a very it's horribly
00:08:20
inefficient uh of way of doing it and it
00:08:22
becomes more so if you do it once a day
00:08:24
it's efficient once a week it's less
00:08:26
efficient once a month even less
00:08:27
efficient so yeah
00:08:30
so wow as far as the the the research on
00:08:34
this
00:08:36
um what about um you know you have all
00:08:39
these most of the researchers out there
00:08:42
they're they kind of look at Cal U
00:08:44
vitamin D just just related to Bone and
00:08:46
calcium they're they're kind of just
00:08:49
almost pretending like this other system
00:08:51
doesn't exist is that true yeah
00:08:54
basically yes I mean first you have to
00:08:57
accept the fact that vitamin D has
00:08:58
functions on calcium and I mean the data
00:09:02
are all over but what what ends up
00:09:04
happening is things are run like the
00:09:06
vital trial yeah where they they give
00:09:10
too little vitamin D they give it to
00:09:14
people who in know in a randomized trial
00:09:16
who who who don't need it you know it's
00:09:20
like uh in the the the Townson
00:09:22
newsletter I mentioned to you when I was
00:09:25
discussing it with the author of that
00:09:27
paper so the gold standard for all drug
00:09:31
trials or randomized control
00:09:33
trials okay where say you have a
00:09:36
cholesterol drug and you want to test if
00:09:40
it truly will depress serum cholesterol
00:09:42
if you take it so the drug company
00:09:45
assembles uh assembles a population of
00:09:48
people and they administer half of those
00:09:50
people a drug and half of those people
00:09:53
get
00:09:54
Placebo and then they they uh analyze
00:09:59
the
00:09:59
and and look at it and of course they
00:10:02
it's in most cases it's it's
00:10:05
successful and this is how drug trials
00:10:07
are run but the drug that you're giving
00:10:10
those people the body has never seen it
00:10:13
they don't have a base level of
00:10:15
it unlike nutrients not just vitamin D
00:10:18
but any nutrient trial okay it's
00:10:21
impossible in this country to do a true
00:10:24
randomized trial because the population
00:10:27
you're dealing with has some some some
00:10:30
people have very little some people have
00:10:32
plenty but when you if you just take
00:10:35
them at random and and and randomize
00:10:39
them and give these people half of them
00:10:41
a a level of vitamin D oftentimes not
00:10:43
even enough and the other half only get
00:10:46
Placebo or and Placebo in this country
00:10:50
means they have to get the standard
00:10:51
daily
00:10:52
dose so they're not even getting
00:10:56
zero and what happens is is that it's a
00:11:00
horribly compromised study so that's
00:11:02
what vital in all these uh happens is
00:11:06
that and the other thing is when you
00:11:08
when you end it and you do your data
00:11:11
analysis wouldn't you think that you
00:11:13
might take the basil level into effect
00:11:15
when you do the analysis of the
00:11:17
data well that's illegal you can't do
00:11:20
that that that violates intent to treat
00:11:25
model okay and it absolutely ensures
00:11:28
that your trial is going to
00:11:31
fail so and I'll give you some examples
00:11:34
and I've worked primarily in pregnancy
00:11:37
we did pregn pregnancy studies and found
00:11:39
out that vitamin D decreased
00:11:41
complications of birth and but the best
00:11:44
trials were actually done overseas and
00:11:46
the best one couple were done in
00:11:49
actually in Iran and where the
00:11:51
population is generally vitamin D
00:11:53
deficient across the board and they had
00:11:57
a fairly large patient population half
00:11:59
of those women got a substantial dose of
00:12:02
vitamin D and half of those people got
00:12:04
nothing which is how you can't run a
00:12:07
trial like that in the US because you'd
00:12:09
be violating standard of care but over
00:12:12
but that's truly how Vitamin D trial
00:12:14
should be run and and and in those
00:12:18
trials we saw tremendous effects on on
00:12:22
decrease in birth complications like
00:12:23
pre-term birth and preclampsia and and
00:12:27
and diabetes and and everything else
00:12:30
fell into the treatment group if you do
00:12:33
the same trial in the US you you you
00:12:38
can't do it where our nutrition is
00:12:40
better people have better vitamin D
00:12:42
levels but when you randomize
00:12:45
them like I said everybody has some and
00:12:48
so it's not like you're given a drug
00:12:50
that has none and when and when you look
00:12:54
at the results it's totally blurred and
00:12:57
it's even you know you could I you can
00:13:00
overcome that to some degree when when
00:13:02
the statisticians would take their the
00:13:05
basil level upon study entry into effect
00:13:08
and then you analyze it like that you
00:13:10
can see effects and that and in fact
00:13:12
that's
00:13:13
why observational studies uh you know
00:13:17
when they have these big groups of
00:13:19
people and they look at vitamin D levels
00:13:22
and outcomes via cancer via pregnancy
00:13:25
and and things and it's based on a
00:13:28
lifestyle
00:13:29
okay and and uniformly those studies and
00:13:32
there's thousands of them would show
00:13:36
really big effects of vitamin D but then
00:13:38
when you went to do these randomized
00:13:40
trials and you had all these
00:13:42
complications and you can't adjust for
00:13:45
the base level all of that disappears
00:13:47
and you get no you get no effect at all
00:13:50
but if you if you submit your paper to
00:13:53
New England Journal or jamama or British
00:13:55
medical journal and you and you analyze
00:13:58
the data
00:13:59
and want to take into account basil
00:14:01
levels that violates the intent to treat
00:14:03
model and it will be rejected outright
00:14:06
wow wow so so the vital study is
00:14:09
definitely um the study that certain
00:14:12
groups are using to to tell people well
00:14:15
see see it doesn't really work yeah we
00:14:17
did the study it's
00:14:19
definitive like I've challenged the
00:14:22
authors of that
00:14:23
study to reanalyze their data taking
00:14:26
Baseline levels into account of their
00:14:28
patient and they won't do it wow
00:14:32
incredible and they didn't they even
00:14:34
call um their the amount of vitamin D
00:14:37
they were giving people a high dose at
00:14:39
2,000
00:14:41
iuse yeah that's
00:14:44
nothing per to put it in perspective I
00:14:48
I'm 73 years old I take 10,000 units of
00:14:52
vitamin D a
00:14:53
day and I have for years and my level
00:14:56
vitamin D levels are between 80 and 90
00:14:59
nanograms per
00:15:01
ML and my the my personal care physician
00:15:04
is is pretty um Progressive she uh she's
00:15:08
all for that not just with me but for
00:15:10
her entire entire clinical uh uh group
00:15:14
of of patients that she follows and so
00:15:17
she wants her patients to have a minimum
00:15:19
level of 60 that's really out there
00:15:22
compared to most you know Family Care
00:15:24
Physicians or Primary Care docs in fact
00:15:27
they'll get a level back from be at the
00:15:30
male clinic or Cleveland Clinic or
00:15:32
whatever and those those levels like
00:15:34
mine which are 80 or 90 will be flagged
00:15:36
as too high right and I get those I get
00:15:40
those emails from people all the
00:15:43
time wow it's just level two let's talk
00:15:47
about the normals for a second because I
00:15:48
think it's a bit of an arbitrary right
00:15:51
there's really no agreed upon range
00:15:55
definitively right there's different
00:15:57
different ideas on it
00:15:59
again if you go back to what's the
00:16:01
agreed upon range it's all based on
00:16:03
skeletal models right right and and and
00:16:06
the skeletal models that's something
00:16:09
that we haven't talked about the ranges
00:16:11
on those two systems are
00:16:14
different you can maintain a skeletal
00:16:17
model on a relatively low amount of you
00:16:20
know say 25 or 30 nanograms or maybe
00:16:23
even lower where you can maintain a
00:16:25
normal skeletal level where the other
00:16:28
system requires much higher levels in
00:16:30
that to function in a normal fashion
00:16:32
incredible what are the ranges for the
00:16:35
other system uh other than the bone in
00:16:37
the skeletal oh I I'm I'm saying if you
00:16:40
want to have cancer prevention or cancer
00:16:42
treatment it's so if you're trying to
00:16:45
prevent cancer that's one thing if you
00:16:46
have active active neoplasia that's a
00:16:49
different ball game that's that's
00:16:51
pharmacology so your levels would be
00:16:53
higher but but for prevention and
00:16:56
optimal functions I me a Minimum level
00:17:00
would be 50 so 50 to 100 and that's well
00:17:03
within the normal physiologic range in
00:17:06
Sun repleted
00:17:08
populations so if you spend a lot of
00:17:10
time and we've looked at this over the
00:17:12
years and people lifeguards or athletes
00:17:14
who are outside in the sun in in the
00:17:17
summer months or people who live in the
00:17:20
tropics who take their levels are
00:17:21
routine the 890 100 nigs that is not an
00:17:25
abnormal level from Human physiology in
00:17:27
fact that's what we all were at one
00:17:30
time this is incredible data so um so
00:17:33
you do have prevention then you have the
00:17:36
the therapeutic dose when someone has a
00:17:38
chronic inflammatory condition
00:17:40
autoimmune or cancer those levels I
00:17:44
would imagine need to be a bit over a
00:17:46
hundred right yeah or even higher I mean
00:17:49
there's a there's a an MS protocol in
00:17:52
Brazil where uh this I can't remember
00:17:55
the Cambria protocol yeah
00:17:57
KRA yeah he he they dose with several
00:18:01
hundred thousand their their levels are
00:18:03
you know 5600 nanograms to for the
00:18:06
suppression of of Ms and it has basis in
00:18:10
fact because vitamin D at those levels
00:18:13
is an immune suppressor so excuse me it
00:18:16
will it will alter the T the t- cells in
00:18:20
the favor of T2 away from T1 T1 are the
00:18:23
ones that cause autoimmune attack and so
00:18:27
vitamin D at H at those levels and and
00:18:31
some of those people show that uh those
00:18:34
vitamin D at those levels are more
00:18:36
effective than the drugs that are
00:18:37
prescribed of course vitamin D is free
00:18:40
essentially and those drugs are
00:18:41
enormously expensive to take every month
00:18:44
with severe side effects right so what
00:18:47
what about cancer you mentioned one of
00:18:49
the videos about prostate
00:18:51
cancer
00:18:52
so you know with prostate cancer um we
00:18:57
did a study more than 10 years ago now
00:19:00
where we looked at I went to at the time
00:19:03
I went into uh the chief of our urology
00:19:06
department at the Medical University of
00:19:07
South Carolina where I was on on faculty
00:19:10
and and another fellow and I went in and
00:19:13
talked to him and uh he it was a friend
00:19:15
of mine and I said to them I said look
00:19:16
we want to do a a a study in your P
00:19:20
group of patients on the patients who
00:19:22
are have active surveillance or watching
00:19:24
weight you know what that is so we you
00:19:27
go in to have your prostate your PSA is
00:19:30
going up they do a biopsy and and your
00:19:33
your your uh prostate cancer is low gr
00:19:36
say leas and six so the doctor says to
00:19:38
you well we prefer to really do nothing
00:19:42
you know we want to watch and wait which
00:19:43
means I'll we'll check back with you in
00:19:46
a year see if it's
00:19:48
worse
00:19:49
okay so we said we want to do a study on
00:19:53
these guys and what we want to do is we
00:19:55
at the time every time we did these
00:19:57
studies you had to propose how much you
00:19:59
were going to give the patient and so if
00:20:01
you go back to this period of time which
00:20:03
is in the 20056 Years some back there we
00:20:07
wanted to give a really modest dose of
00:20:09
4,000 units a day I would have liked to
00:20:12
give more but at the time you have to go
00:20:15
through an Institutional review board
00:20:17
and they have to okay it and so um and
00:20:21
and most of this unfortunately where we
00:20:23
are and stuff most of the prostate
00:20:25
cancer occurs in the African-American
00:20:27
population which are really deficient in
00:20:29
vitamin D so we approached them and we
00:20:33
said we want to do this and we want to
00:20:35
give them 4,000 units of vitamin D at
00:20:37
day um and it was an Interventional
00:20:40
trial it wasn't a randomized trial but
00:20:42
we had historical data on patients that
00:20:44
were in that in that practice and so we
00:20:48
put them on 4,000 units a day and we
00:20:51
monitored their levels and and then at
00:20:54
the end of the year they got to repeat
00:20:56
rectal biopsy for like you get for
00:20:59
prostate cancer and we looked at the the
00:21:01
cell grade and the retention or or the
00:21:04
how it progressed and in in
00:21:08
64% the tumors regressed wow wow and we
00:21:14
submitted this to Course New England
00:21:15
Journal and they wanted nothing to do
00:21:17
with it so we submit it it finally got
00:21:19
published in the journal of clinical
00:21:21
endocr endocrinology and Metabolism
00:21:23
which is a respectable uh endocrine
00:21:26
journal and uh um
00:21:29
it really went nowhere I mean if it
00:21:30
would have been a drug that a drug
00:21:32
company had it would have been worth
00:21:34
billions
00:21:35
yeah so so when when people treat cancer
00:21:39
like that like prostate cancer 4,000 is
00:21:42
nothing I'm saying take 20,000 you know
00:21:45
or more because you got cancer you're
00:21:47
not dealing in normal physiology here
00:21:50
you you're in Pharmacology you know and
00:21:52
and the push back you get if you try to
00:21:54
put these trials well I'll give you an
00:21:57
example of a of a study called the
00:21:59
Sunshine study which is a study on
00:22:03
non-resectable colon
00:22:05
cancer okay run out of Harvard and
00:22:08
several other and and in those studies
00:22:12
they were they were giving vitamin D
00:22:14
prior to giving
00:22:17
chemotherapy and to see if if priming
00:22:20
these people with a level of vitamin D
00:22:22
prior to giving them chemal therapy had
00:22:23
an
00:22:25
effect and so sure enough I mean the
00:22:28
file stud being done but the initial
00:22:29
study that was published a couple of
00:22:31
years ago after the data was looked at
00:22:34
it basically extended the patients lives
00:22:37
by two months if you primed them with
00:22:39
vitamin D and it was only like 8,000
00:22:43
maybe 10,000 units a day you know which
00:22:45
at the time I I said to the primary
00:22:47
investigator on that study I said why
00:22:49
don't we really go for you know like
00:22:53
50,000 no and and the response I got
00:22:56
back is we can't get that through the
00:22:57
IRB
00:22:59
I said these people are D you're giving
00:23:01
them you know really potent
00:23:03
chemotherapeutic drugs and you're
00:23:04
worried about giving them you know
00:23:06
vitamin D yeah right God yeah they're
00:23:10
dying they got they're not GNA survive
00:23:12
you're trying to prolong their life they
00:23:14
you can't even operate on them because
00:23:16
they're too far along and you're worried
00:23:18
they're worried about giving them you
00:23:19
know a substantial and so be that as it
00:23:23
may even that the doses they gave in
00:23:25
conjunction with the chemotherapy
00:23:26
extended their lives by two months and
00:23:29
in cancer chemotherapy that's a big
00:23:32
deal okay drugs are approved on that
00:23:35
basis but it was funny because it was
00:23:38
sent to jam and and it was the initial
00:23:41
data the way it was analyzed by the
00:23:43
School of Public Health at Harvard
00:23:44
showed significance at like
00:23:47
0.0035 and and then jamama comes back
00:23:50
and says well we want you to do it this
00:23:52
way so do it that way and it comes back
00:23:55
like
00:23:56
0.045 or something and no no now we want
00:23:59
you to do it this way so then it comes
00:24:01
back at
00:24:03
0.051 and then they say okay that's good
00:24:06
but you got to say it's it's uh it's not
00:24:10
significant and we'll publish the
00:24:13
article the only thing that shows up in
00:24:15
the news was that vitamin D was not was
00:24:18
not significant in progressing in
00:24:20
treating the
00:24:21
cancer that's completely
00:24:24
false well it's it's not it's if you
00:24:27
look at if you look at your level of
00:24:29
significance like Point difference
00:24:31
between 0.005 and
00:24:33
051 so that's a that's 50 patients in a
00:24:37
thousand versus 51 patients in a I mean
00:24:41
it's just to get the it's just to get
00:24:44
the the term not significant into the
00:24:47
article holy macro so so what you're
00:24:50
saying all the time so what you're
00:24:53
saying is there there is some slight
00:24:54
resistance by these journals and I'm
00:24:57
being very sarcastic it's in the major
00:24:59
medical journals there is huge
00:25:01
resistance to
00:25:02
it there was an article that just came
00:25:05
out in Science magazine that showed that
00:25:08
vitamin D and the mechanism of how
00:25:11
through the microbiome it regulates
00:25:13
colon cancer and that actually got
00:25:16
published it it's h very technical okay
00:25:19
it's very technical but it shows the
00:25:21
mechanism how Vitamin D works at at at
00:25:25
at not at a not at an endocrine level
00:25:27
but this cellular level to regulate
00:25:30
cancer immunity in in in these
00:25:33
patients wow so so um as far as the um
00:25:39
storage of I I was under the assumption
00:25:42
that uh all this vitamin D gets stored
00:25:45
in your fat and then when you need it
00:25:47
the body pulls it out but that's no that
00:25:49
that's not that that's not true either
00:25:54
wow yeah fat soluble vitamin goes into
00:25:57
your fat when you need here and I've
00:25:59
even heard people in the old days saying
00:26:00
well you know what happens when you have
00:26:02
a bariatric surgery and you have a lot
00:26:04
of vitamin D and it pours in the vitamin
00:26:06
D toxic well that was totally
00:26:08
ridiculous I mean it doesn't it just it
00:26:11
you know it might Supply a little bit
00:26:12
but it not I mean maybe enough to to to
00:26:17
uh Supply the enderin portion for a
00:26:20
while but it definitely isn't enough to
00:26:23
supply the the cular portion because one
00:26:26
one of I think you even studied you you
00:26:28
tried to find vitamin D stored and you
00:26:30
couldn't find it or yeah we looked at we
00:26:34
looked at levels in fat so other things
00:26:36
are stored as Esters like fatty acid
00:26:38
esters and fat tissue so we we would
00:26:41
dose we would dose even humans and take
00:26:44
fat samples you know and and look for it
00:26:48
and it there was nothing special about
00:26:50
fat tissue about vitamin D being in
00:26:52
there I mean there was some in there
00:26:54
because it just distributes in tissues
00:26:56
in general but it wasn't anything
00:26:58
against a gradient where you had this
00:26:59
high level of vitamin D and fat tissue
00:27:03
wow you also mentioned the relationship
00:27:05
between vitamin D and um even the
00:27:09
endothelial layer in the inside of your
00:27:11
artery is becoming a bit
00:27:13
leaky yes some you know if you go back
00:27:16
several this wasn't my work but but it
00:27:18
it happened it was done by a group of
00:27:21
biochemists in um in
00:27:23
Utah and what they had uh they I believe
00:27:27
it's called cavernous M foration
00:27:30
syndrome where you have uh these leaky
00:27:34
vessels in your brain uh it's a it's a
00:27:38
metabolic defect and they leak fluid and
00:27:41
these guys were looking for compounds
00:27:43
that would avert or be more therapeutic
00:27:46
so these endothelial vessels wouldn't
00:27:49
weak okay my coffee machine is turning
00:27:51
off here so that's the noise of the bat
00:27:54
de so anyway they they had this system
00:27:57
where they ran thousands of compounds
00:27:59
through this to test for this
00:28:02
leakage and uh and what they found was
00:28:06
they found two compounds one of which
00:28:08
was vitamin D which they were really
00:28:09
disappointed by because uh you know good
00:28:15
old vitamin D with a stabilizer of
00:28:17
endothelial function meaning it stopped
00:28:20
the leakage and it was and the
00:28:23
interesting thing there was the parent
00:28:24
compound vitamin D itself was the most
00:28:26
potent
00:28:28
wow not to other forms but vitamin D
00:28:32
itself so you talk about the ones in
00:28:34
supplements who getting it from the Sun
00:28:36
yeah the one we're getting from the Sun
00:28:38
or in your vitamin supplement was the
00:28:40
most potent at at overcoming this
00:28:42
endothelial function you know one of the
00:28:45
other things that we did in our
00:28:46
pediatric work was in it has to do with
00:28:49
human lactation yeah so you know when I
00:28:54
go back to my graduate school days and I
00:28:56
was you know I was you know not the best
00:28:59
student because I always question my
00:29:01
mentors you know and so we were taught
00:29:04
and I was a I was a nutritional
00:29:06
biochemist by training and in the
00:29:08
training you I they would teach well you
00:29:11
know cuan milk is the perfect food for
00:29:14
the nursing infant except for one thing
00:29:16
they could get rickets if they take it
00:29:18
so you got to give them a supplement I I
00:29:21
thought that makes no sense whatsoever
00:29:23
right why how could that be and so you
00:29:26
know at time goes on and we we you know
00:29:30
we we do research and it goes for
00:29:32
decades and finally we figured out that
00:29:35
to overcome this
00:29:36
problem the mothers were taken too
00:29:39
little vitamin D by the recommendations
00:29:40
that were being made by the different
00:29:43
organizations so once we could measure
00:29:46
the stuff in milk and blood and look at
00:29:48
how much was passed into the milk from
00:29:50
the blood and um and it turned out that
00:29:55
that you a nursing a woman who's
00:29:57
lactating needs to take about 6,000
00:30:00
units a
00:30:01
day to pass enough vitamin D into her
00:30:04
milk to satisfy her infant and then the
00:30:06
infant doesn't need any doesn't need
00:30:09
drops every day she's getting enough
00:30:11
from the mother mother's taking 6,000
00:30:14
units a day and actually that has been
00:30:17
implemented in pediatric practice to
00:30:20
some degree on Progressive pediatricians
00:30:22
who actually pay attention so it's an
00:30:25
option now instead of giving uh instead
00:30:28
of giving uh the nursing infant 400
00:30:31
units drops because mother's vitamin D
00:30:33
is enough because she deficient herself
00:30:36
I I wonder if this postpartum depression
00:30:38
is related to this vitamin D because low
00:30:42
vitamin D it's possible we looked at
00:30:44
some of that but uh in our studies that
00:30:47
we ran in pregnancy but you know it's
00:30:50
it's possible but our numbers we didn't
00:30:52
have enough to really make an assessment
00:30:54
if that's true or not but it's possible
00:30:56
because vitamin D has neural
00:31:00
effects how does um this this idea of
00:31:04
vitamin D resistance on top of all these
00:31:06
other issues we have vitamin D
00:31:08
resistance you have the vitamin D
00:31:09
receptor you have certain microbes like
00:31:13
that are involved in limes disease you
00:31:15
have epin bar virus that that
00:31:17
competitively downgrade receptors on top
00:31:20
of everything else have you looked into
00:31:23
that uh I haven't I mean they're
00:31:26
hereditary they're there are people who
00:31:29
have hereditary resistance because their
00:31:31
receptors are metabolic metabolically
00:31:33
inactive yeah uh you know um it again
00:31:38
it's possible
00:31:40
but to look at those kinds of studies or
00:31:43
to run first of all at this point in
00:31:45
time nobody's getting any money to run
00:31:47
any more vitamin D trials it's over okay
00:31:50
really yeah it's over you can't you
00:31:53
can't even find a student a student who
00:31:56
would go into somebody LA to study
00:31:58
vitamin D metabolism is
00:32:00
committing career
00:32:03
suicide because you're not and this
00:32:05
isn't just in the US it's in Britain too
00:32:08
the vital study and these these articles
00:32:10
like Scientific American had totally
00:32:13
decimated vitamin D
00:32:15
research and trials are expensive to
00:32:18
run uh the government won't fund them
00:32:21
drug companies don't want them they
00:32:23
don't even want them run okay because
00:32:25
they compete with uh with drug that they
00:32:28
have in development such as the the
00:32:30
drugs for prostate cancer you have one
00:32:33
that's free that is that is pretty good
00:32:35
at at suppressing prostate cancer and uh
00:32:39
it doesn't cost anything you think the
00:32:41
pharmaceutical companies want that
00:32:42
knowledge out there it's criminal
00:32:45
totally criminal or or or in vitamin D
00:32:48
in in preventing pre-term birth or
00:32:52
complications there was a drug called
00:32:55
McKenna that was 177 hydroxy
00:32:58
progesterone remember that one isn't
00:33:00
that for cancer that was for cancer no
00:33:02
no this was for prevention of pre-term
00:33:04
birth okay okay it was injectable it was
00:33:09
I don't know what company made it it was
00:33:11
a small biotech company back in
00:33:14
2010 this company was uh was bought out
00:33:18
by a bigger company and it was U uh they
00:33:20
had this one drug 7 17 hydroxy
00:33:23
progesterone which was called McKenna it
00:33:25
was approved as a speedy uh approval by
00:33:29
the FDA there was only one problem it
00:33:32
never
00:33:33
worked it was expensive and it was a
00:33:36
absolute abject failure and two years
00:33:39
ago the FDA pulled made him pull it from
00:33:41
the
00:33:43
market and was it a progesterone or was
00:33:46
it a it was 17 hydroxy progesterone you
00:33:49
can look it up you you can you can look
00:33:51
at the history of it and uh so it was
00:33:55
doing they were proposing a something
00:33:58
that vitamin D actually does which was
00:34:00
appropriate vitamin D levels can reduce
00:34:02
pre- birth but it's free wow there's no
00:34:07
money in it no and it's yeah so yeah um
00:34:11
you also mentioned in in one of your
00:34:13
videos um um it's important to also
00:34:16
realize that vitamin D needs magnesium
00:34:18
as the
00:34:19
co-actor it does yeah it it uh you know
00:34:24
I I reviewed a lot of papers years ago
00:34:26
and I remember reviewing is one that
00:34:28
clearly showed that magnesium status was
00:34:30
a was a a potentiator of improving
00:34:35
metabolism of vitamin D within the
00:34:38
cells meaning it was a simple thing so
00:34:41
people who had better magnesium status
00:34:43
also had higher levels of the
00:34:45
intermediate form of vitamin D to 25d
00:34:47
form that you get measured and so I
00:34:50
myself was taking a a fair amount of
00:34:53
vitamin D but I really wasn't that
00:34:56
satisfied of of what my blood levels
00:34:58
were and there and I I I mentioned that
00:35:02
what people take is very individualistic
00:35:05
of how you respond some people are
00:35:07
really good metabolites some people AR
00:35:10
aren't as good they need to take a lot
00:35:12
more to get their blood levels you you
00:35:14
only know what it is if you haven't
00:35:15
tested and so I started taking magnesium
00:35:18
and and instantly increased my blood
00:35:20
levels by about
00:35:23
40% and there's no there's really no way
00:35:26
to know if your magnesium repete because
00:35:28
it's a blood measures don't really tell
00:35:30
so the only way to know it is I take I
00:35:33
think 400 milligrams a day of magnesium
00:35:36
oxides Ju Just A supplement every day
00:35:39
that and and then you know your vitamin
00:35:41
your magnesium repete for now other
00:35:43
reasons just vitamin
00:35:46
D so it's a key coor it's a what key
00:35:50
co-actor yeah and in the metabolism of
00:35:53
vitamin D so it interacts the enzyme
00:35:57
that act activates vitamin D that
00:35:59
there's two or three of them need that
00:36:01
magnesium it's a proactor absolutely
00:36:04
have you ever done any research on
00:36:06
vitamin D and
00:36:08
mitochondria I I
00:36:10
haven't well vitamin so vitamin D the
00:36:13
there's two different enzymes one of
00:36:15
them is located in the mitochondria and
00:36:17
one of them is located in the microsomes
00:36:19
different cellular components so that's
00:36:22
that's where that's where these enzymes
00:36:24
that activate vitamin D are within the
00:36:26
cell one in the mitochondria
00:36:28
at one of the micr oh wow that's kind of
00:36:30
important the mitochondria as far as
00:36:34
I'll have to look where that's what that
00:36:36
does or what if it how it influences the
00:36:38
mitochondria which
00:36:40
is so so much of a problem with so many
00:36:43
people if someone takes a higher doses
00:36:47
uh like a large dose of uh vitamin D3
00:36:49
isn't it isn't there uh some mechanism
00:36:53
that it does turn turn into inert
00:36:57
compounds I think I uh it was one was
00:37:00
called um tacol or
00:37:04
lumisol well those those are things
00:37:07
those compounds are made in the skin by
00:37:10
sun exposure it's probably one of the
00:37:12
ways that the body regulates how much
00:37:14
vitamin D so so if you're if you're pale
00:37:17
as a ghost and you go out in the Summer
00:37:20
sun and and expose yourself to 20
00:37:23
minutes or so of intense sunlight on the
00:37:26
initial exposure you'll you'll make
00:37:28
about 20,000 units of vitamin D that'll
00:37:31
be released into your blood over the
00:37:32
next day okay but then you start tanning
00:37:37
and that exposure becomes less you know
00:37:40
you you the next day you'll make less
00:37:42
and less and less and and that's where
00:37:45
the the production of these tools and
00:37:48
and lumisterol and all these things uh
00:37:52
um probably assist
00:37:55
in Banting the effect of D made by the
00:37:58
Sun but in the body once you take once
00:38:02
you take vitamin
00:38:04
D I'm not sure it's metabolized into
00:38:07
those things I think it just disappears
00:38:09
you know the body will just excrete it
00:38:11
through the bile acid functions and then
00:38:14
activate it but those what you're
00:38:16
mentioning is a control point for the
00:38:18
sun solar uh production of vitamin D in
00:38:22
your skin okay and then as far as the
00:38:26
you know you have hyperal CIA um I think
00:38:29
they have exaggerated that a bit but U
00:38:31
what's your take on um toxic doses in in
00:38:35
the research on the tox you're gonna you
00:38:37
know even people are saying oh you're
00:38:38
taking 10,000 you're gonna you're gonna
00:38:40
get kidney stones like really well
00:38:43
vitamin D has never been associated in
00:38:45
studies with getting kidney
00:38:47
stones wow I mean most kidney stones are
00:38:50
oxalates I mean it it can I mean so if
00:38:53
you're taking if you're worried about
00:38:54
kidney stones and vitamin D uh and if
00:38:58
people are taking high doses say they're
00:39:00
taking 30 40 50,000 units for cancer my
00:39:03
my first my recommendation would be
00:39:05
limit your Dairy
00:39:07
intake okay the other thing is that
00:39:10
before anything happens in the blood it
00:39:12
happens in the urine
00:39:14
first so if you're worried about high
00:39:17
you know high blood calcium or too much
00:39:20
vitamin D you would have your urinary
00:39:22
calcium monitored as long as there's no
00:39:25
calcium being dumped into your urine you
00:39:28
don't have a
00:39:30
problem and at 20,000 units I mean there
00:39:33
are rare genetic defects that would
00:39:36
cause uh uh uh vitamin D to become toxic
00:39:40
and one of those is a an enzyme that
00:39:43
inactivates vitamin B called the 24
00:39:46
hydroxylase in the kidney and other
00:39:48
tissues and if you have a defect in that
00:39:51
enzyme then it's potentially you could
00:39:54
become toxic but those are really rare
00:39:56
defects so if we take those out of the
00:39:59
picture how many people really end up
00:40:01
getting hypercalcemia from we never saw
00:40:06
one and all and we our studies that we
00:40:10
did in pregnancy and lactation when when
00:40:13
I propose to do these studies and back
00:40:15
then you could get this is in the early
00:40:16
2000s so when we propos to do these
00:40:19
studies in pregnancy and and and
00:40:22
pregnancy is most sensitive group you
00:40:24
can do studies in so we were proposing
00:40:27
in these studies that we were going to
00:40:28
give pregnant women 4,000 units a day
00:40:30
because that's what we calculated they
00:40:32
would need uh to become sufficient it's
00:40:35
probably low but you know you have to
00:40:36
start somewhere and at the time 2,000
00:40:39
units was the UL mean upper limit of
00:40:41
safety so we proposed 4,000 and and so
00:40:45
the the granting agency saw yeah this
00:40:47
Grant's great but we you can't do this
00:40:49
you'll kill
00:40:51
people so we said no we won't and so the
00:40:54
the the funding agency said we
00:40:57
conditionally approved this grant if you
00:40:58
go to the FDA and get an IND number
00:41:02
investigational drug number that's a
00:41:04
drug companies have to do when they come
00:41:06
up with new drugs we had to do it for
00:41:08
vitamin
00:41:09
D okay and we did it we we submitted an
00:41:12
IND it delayed the study by a year and
00:41:15
the U and the FDA granted our indd
00:41:20
application and as a consequence we had
00:41:23
massive monitoring we had monitoring
00:41:25
committees we had to report to FDA every
00:41:28
month and we never saw an adverse event
00:41:32
due to vitamin D supplementation and a
00:41:35
lot of other people used our IND for
00:41:37
other things other you know there were
00:41:40
all kinds of studies going on never once
00:41:43
was a an intake to we saw hyper Calum or
00:41:48
hypercal if if we saw it usually was due
00:41:51
to something like dehydration but it was
00:41:53
never due to vitamin D supplementation
00:41:56
in
00:41:57
incredible um know knowing the
00:42:01
importance of vitamin D like I it's a
00:42:04
one of the probably the most important
00:42:06
vitamins how did you stumble on start
00:42:09
doing research on vitamin D did you know
00:42:11
this in advance how important vitamin D
00:42:13
was for the body news started when I was
00:42:15
a graduate student at Ohio State
00:42:17
University and at the time I was in I
00:42:19
was in uh Agriculture and uh my adviser
00:42:23
at the time they were looking at a at in
00:42:26
in C CLE there's a disease called milk
00:42:28
fever it's called parrian paresis and
00:42:31
what happens is these dairy cattle are
00:42:34
bred to make massive amounts of
00:42:36
milk okay physiologically it's it's
00:42:40
physiologically it's not sustainable and
00:42:43
what happens in those cattle is they go
00:42:45
through more and more
00:42:46
lactations they become they can't
00:42:48
maintain serum calcium once lactation is
00:42:51
initiated because their blood levels of
00:42:53
calcium
00:42:54
plummet and and it turns out why that
00:42:57
happens is they're they they need to
00:43:01
mobilize bone calcium and as they get
00:43:04
older and into more and more lactation
00:43:06
Cycles it becomes impossible for them to
00:43:08
do it so once they initiate lactation
00:43:11
their blood calcium would drop to four
00:43:13
or five and they just Keel over and lay
00:43:15
there because they're you know they're
00:43:18
paralyzed and then the farmer would have
00:43:20
to dose them with high doses of calcium
00:43:23
and then the cow would stand right up
00:43:25
and then it would fall again the cow
00:43:26
would fall down so and when this happens
00:43:29
it's a big economic loss because you
00:43:31
know they got to get the cow can't breed
00:43:34
anymore and the cow can't make milk and
00:43:36
so they looked at ways to make it better
00:43:38
for the cow not to go into this
00:43:41
condition and one of the ways was to
00:43:43
give them really huge levels of vitamin
00:43:46
D uh to make it stop and it was
00:43:48
successful to some degree but there were
00:43:50
other things that were better but that's
00:43:51
how I got into this and then and then I
00:43:54
I I of course went more towards human
00:43:56
nutrition and I got I was interested in
00:43:58
the milk issue and I was interacting
00:44:01
with with uh people in in Pediatrics and
00:44:05
you know the first grant we came up with
00:44:07
it's interesting so the the first grant
00:44:09
back in what I was telling you about the
00:44:11
FDA are it was basically a safety study
00:44:14
that we were designing to look at and
00:44:16
and based around skeleton at that time
00:44:19
we didn't even know to ask the questions
00:44:22
about does vitamin D prevent pre-term
00:44:24
birth and and and uh preclampsia and and
00:44:28
pre-term diabetes and all this other
00:44:30
stuff so we ran a study and when the
00:44:33
data were analyzed this was uh uh this
00:44:36
is where it was it's frowned upon they
00:44:39
said we analyzed the data and we said
00:44:41
look at this vitamin D is is uh
00:44:44
preventing pre-term birth and it's
00:44:46
preventing complications of birth and I
00:44:48
presented it at a meeting it was in 2009
00:44:50
and and I mean the audience went crazy
00:44:54
in the wrong
00:44:56
way I mean I was attacked how dare you
00:44:58
say this you know this is heresy this
00:45:01
can't be true you know I mean it was
00:45:04
incredible so when you when you
00:45:06
introduce data like that you better be
00:45:08
prepared to be hammered wow
00:45:12
wow and then and then you know since
00:45:15
that time it's been basically it's shown
00:45:18
uh there was an article that's in that
00:45:20
uh uh that was we did called the vdart
00:45:23
study at Harvard it was done with Scott
00:45:25
Weiss who was a world rown asthma
00:45:27
specialist and we found out that vitamin
00:45:30
D could you could if you give enough
00:45:32
vitamin D especially like preconception
00:45:35
you could basically eliminate childhood
00:45:39
asthma but no one will you know you know
00:45:42
the the data are clear if you analyze it
00:45:45
in the appropriate fashion like is
00:45:47
discussed in this Townson newsletter
00:45:49
article and even wise chimes in and and
00:45:52
we learned a lot from that study like we
00:45:53
do from all these studies that you
00:45:56
needed to give more needed to correct
00:45:57
Baseline levels and you could you could
00:46:01
you know there would hardly ever be
00:46:02
another asthma childhood asthma child
00:46:04
born if the mothers were replete when
00:46:06
they conceived or even started taking it
00:46:09
early in in when they found out they're
00:46:11
pregnant uh you know most of our studies
00:46:14
were in the first trimester because
00:46:16
that's when they walk in and they figure
00:46:18
out they're pregnant you know you can't
00:46:20
to do pre-term or preconception studies
00:46:23
is hugely but that's when it would be
00:46:26
most
00:46:28
because the vitamin D deficiency in the
00:46:29
trials that we run is mostly missed in
00:46:31
the first trimester because you don't
00:46:32
even woman don't know they're pregnant
00:46:34
so you're only getting a hold of 12
00:46:36
weeks or so or maybe later than
00:46:40
that I think it's probably the most
00:46:42
important time to eat healthy and get
00:46:45
enough nutrition is when you're not born
00:46:48
before you're born yeah um incredible so
00:46:55
um wow I'm just
00:46:58
I mean it leaves you speechless because
00:47:00
you you you you have this knowledge and
00:47:03
you know and it's going away because you
00:47:07
can't nobody else can do followup brants
00:47:09
on this
00:47:10
anymore because when it goes to this the
00:47:12
government first of all the the
00:47:14
government won't you know these studies
00:47:16
that we did they cost
00:47:17
Millions uh the vital study was 30 35
00:47:21
million maybe more of to me it was
00:47:23
totally wasted money because it was our
00:47:25
studies that we did in pregnancy were
00:47:28
probably over the terms of the grants
00:47:30
were five or six million doar to do
00:47:32
these clinical studies and government
00:47:35
isn't going to Shell out that kind of
00:47:36
money anymore and the drug companies
00:47:38
will pay him not to do it
00:47:41
incredible incredible so you either
00:47:43
accept the data that we have now and and
00:47:45
I think that people should also not only
00:47:47
look at the randomized trial data that
00:47:50
that we did and and the one in and the
00:47:52
things that were done overseas where you
00:47:54
had true vitamin D deficiency you could
00:47:56
do do a real randomized trial and not
00:48:00
have it compromised by what levels were
00:48:02
in these women in the beginning and and
00:48:04
the the the other thing in our country
00:48:07
is non-compliance of the patients is a
00:48:09
serious
00:48:11
issue they don't comply oh yeah doc I
00:48:14
took the vitamin one in fact they never
00:48:16
took it at all and and you know here's
00:48:19
the other thing in intent to treat if
00:48:20
you know that those people aren't
00:48:22
complying you can't eliminate them from
00:48:23
the data analysis what no that violates
00:48:27
the intent to treat
00:48:29
Mar
00:48:31
wow wow these are this is this is this
00:48:34
is stuff that people don't know they
00:48:36
have no clue unless you're in the
00:48:37
research field so I guess in certain
00:48:40
parts of other countries around the
00:48:42
world there's probably maybe places
00:48:44
where you hopefully they'll continue
00:48:46
doing vitamin D research I don't know
00:48:48
yeah I mean you know like I said there's
00:48:50
stuff still going on in Iran you know
00:48:53
where where those countries really have
00:48:56
a really big vitamin D deficiency
00:48:58
problem because the lifesty women are in
00:48:59
barkers and they're not allowed to be in
00:49:02
the Sun and so you have a in in in
00:49:04
places in India the same way right what
00:49:06
about Saudi Arabia yeah Saudi Arabia too
00:49:10
any any of the Muslim countries where
00:49:12
they where the where the females are are
00:49:15
restricted uh have a horrible vitamin D
00:49:17
deficiency problem well you got me
00:49:20
thinking about that because they you
00:49:22
have compounded by all the diabetes they
00:49:25
have no sun no vitamin D yeah
00:49:31
incredible is there is there anything
00:49:33
else that that you want to U end off
00:49:35
with that you want people to know about
00:49:37
this has just been mind-blowing and I'm
00:49:40
gonna I I think that the only not that
00:49:42
you're never going to get well I can't
00:49:44
say never because my like my physician
00:49:47
is pretty Progressive on all this stuff
00:49:50
so there are Physicians that that are
00:49:53
but the ones who depend on their
00:49:55
professional organizations for
00:49:56
recommendations like the geriatric
00:49:58
Society like
00:49:59
OBGYN e even in in Pediatrics and if
00:50:02
they're only looking at the
00:50:03
recommendations coming out of those
00:50:05
professional societies which are solely
00:50:08
based on reports like the endocrine
00:50:11
Society like which just came out with
00:50:13
revised recommendations which are
00:50:15
ridiculous they're again they've they
00:50:17
they've decreased everything that people
00:50:20
should be taking uh going back to the
00:50:22
Institute of medicine 2010 which has
00:50:24
never been redone uh you know what you
00:50:29
you have to look at at at programs like
00:50:31
your own to educate people uh and
00:50:36
fortification is only done to highly
00:50:38
motivated
00:50:40
individuals you know or supplementation
00:50:42
I think fortification is a different
00:50:44
matter but until the government would
00:50:45
change you never you know we always
00:50:47
sought to get fortification of product
00:50:49
higher like milk for vitamin D like but
00:50:52
they don't they don't want to do it no
00:50:55
so and and and so supplementation is
00:50:57
only done is done by highly motivated
00:51:00
individuals and and how do you you know
00:51:04
how do you prove
00:51:06
prevention right you know you can look
00:51:08
at the you can look at uh observational
00:51:10
retrospective data and a lot of the data
00:51:12
that came out of the are you familiar
00:51:14
with the Physicians health study at
00:51:16
Harvard run by Walter Willet group I
00:51:19
mean it's been going since the mid 80s
00:51:21
it's health professional studies
00:51:23
basically it was Physicians or Nur nures
00:51:27
participated in this study and every
00:51:29
year they give a blood sample and every
00:51:31
year they fill a questionnaire what
00:51:33
happened to you this year did you have a
00:51:34
heart attack did you get cancer how you
00:51:37
know and then they had these blood
00:51:38
samples Bank millions of these samples
00:51:41
and what they do is then they say okay
00:51:44
we want to look at this disease related
00:51:46
to this compound and there's been a
00:51:48
number of those studies done on vitamin
00:51:50
D mostly all positive and and those data
00:51:54
are really valuable okay because those
00:51:57
look at lifestyle over a long period of
00:51:59
change but they're
00:52:00
discarded when you when studies like
00:52:03
vital say
00:52:05
yes are they still doing that study now
00:52:07
or are they is yes yeah health
00:52:09
professional study still
00:52:11
Ono okay yeah I think he's he's he was
00:52:15
involved in the what the the planetary
00:52:17
Health diet the new planetary Health
00:52:19
diet yeah oh yeah well it's involved in
00:52:22
everything the most cited scientist on
00:52:25
you know in the history of science
00:52:26
science incredible and I know Walter
00:52:28
will I've interacted with him in the
00:52:30
past quite a bit on this stuff he
00:52:32
definitely gets a lot of funding but but
00:52:34
that study that that that that those
00:52:36
health professional studies were a gold
00:52:38
mine I mean and extraordinary
00:52:41
value you know not a randomized trial
00:52:44
but there's a lot of data in there that
00:52:46
should be paid to attention should be
00:52:49
paid attention to yeah well I'm sure
00:52:52
it'll get published if if vitamin D is
00:52:54
not favorable
00:53:00
wow this has been incredible thank you
00:53:02
so much for taking your time to uh do
00:53:04
this and you're welcome I'm going to put
00:53:05
that link down below of that article
00:53:08
from the Townson report so everyone can
00:53:10
check it out but thank you so much